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  1. Jun 30, 2010
    • Aaron's avatar
      Multiple changes. · 184656c1
      Aaron authored
      	1.  Added support for VCF 4.0.  BED.end is based on the size of the REF allele in the VCF entry.
      	2.  Fixed a bug in BamReader.cpp that bombed when seq and qual are == "*"
      	3.  Changed the Makefiles to inherit flags from the master Makefile in the root directory.
      	4.  Fixed a bug in bedToBam to created incorrect CIGAR strings for the first block.
      184656c1
  2. Jun 29, 2010
  3. Jun 07, 2010
    • Aaron's avatar
      Large, performance-related commit. · f792d8eb
      Aaron authored
      	1. Created separate structs for BED and BEDCOV in order to reduce memory consumption.  Savings of ~30%.
      	2. Changed the binning approach to make 16kb bins the most granular.  IntersectBed is now 1/3 faster as a result.
      	3. Templated the parsing and reporting functions in bedFile.  Had to move them to the header file to avoid linker complications.
      	4. Added CHRPOS as a common type.
      f792d8eb
  4. May 03, 2010
    • Aaron's avatar
      Multiple changes. · 7b52f3e3
      Aaron authored
      	1. Added BAM support to windowBed.
      	2. Forced correct BEDPE ordering for bamToBed.
      	3. Added default overlapFraction = 0.0 to bedFile prototype.
      7b52f3e3
  5. Apr 26, 2010
  6. Apr 22, 2010
    • Aaron's avatar
      Several changes: · 628eff12
      Aaron authored
      	1. Added an enum for BED line status in an effort to handle
                 header and blank lines in an input file.
      	2. Modified the Open/Get/Close idiom to only test against
                 BED_INVALID status.  Only intersectBed and bedFile.cpp
                 were updated.
      	3. Added AddBamTag to BaumAux.h
      	4. Wrote bamFillMateSeq
      628eff12
  7. Apr 15, 2010
  8. Apr 12, 2010
    • Aaron's avatar
      Added the -wao option to intersectBed. · 27234494
      Aaron authored
      	- Allows one to report 0 overlap for non-overlapping A features
      	- Changed all private memeber variables to use "_VAR" notation.
      	- Added convenience functions for reporting overlaps.
      27234494
  9. Mar 17, 2010
    • Aaron's avatar
      Improvements to coverageBed · f733cafd
      Aaron authored
      	1. Added the -hist option (credit to Jose Bras).
      	2. Substantially improved the speed by using a depth iterator instead of copying the depth map for each feature in B when computing coverage.
      f733cafd
  10. Feb 12, 2010
    • Aaron's avatar
      Fixed several bugs and improved BAM performance. · 2fe5a837
      Aaron authored
      	1. Fixed bug to "re-allow" track and "browser" lines.
      	2. Fixed bug in reporting BEDPE overlaps.
      	3. Fixed bug when using type "notboth" with BAM files in pairToBed.
      	4. When comparing BAM files to BED/GFF annotations with intersectBed or pairToBed, the __aligned__ sequence is used, rather than the __original__ sequence.
      2fe5a837
  11. Jan 28, 2010
  12. Jan 04, 2010
  13. Jan 03, 2010
  14. Jan 01, 2010
  15. Dec 20, 2009
    • Aaron's avatar
      GFF support seems to work. Improved bedFile.cpp. · c0d4e8a4
      Aaron authored
      	1. Got parseGffLine working
      	2. Added GFF support to the reportBed* methods.
      	3. Cleaned up the stdin / parsing logic and centralized it within bedFile.cpp.
      	This removes some of the complexity from each of the tools and tidies the codebase
      	overall.
      c0d4e8a4
  16. Dec 19, 2009
  17. Nov 18, 2009
  18. Nov 14, 2009
  19. Sep 18, 2009
    • Aaron's avatar
      Version 2.2.0 · 952c45ad
      Aaron authored
      === Notable changes in this release ===
      1.  coverageBed will optionally only count features in BED file A (e.g. sequencing reads) that overlap with
      	the intervals/windows in BED file B.  This has been requested several times recently and facilitates CHiP-Seq and
      	RNA-Seq experiments.
      
      2.  intersectBed can now require a minimum __reciprocal__ overlap between intervals in BED A and BED B.  For example,
      	previously, if one used -f 0.90, it required that a feature in B overlap 90% of the feature in A for the "hit"
      	to be reported.  If one adds the -r (reciprocal) option, the hit must also cover 90% of the feature in B.  This helps
      	to exclude overlaps between say small features in A and large features in B:
      
      	A ==========
      	B  **********************************************************
      
      	-f 0.50 (Reported), whereas -f 0.50 -r (Not reported)
      
      3.  The score field has been changed to be a string.  While this deviates from the UCSC definition, it allows one to track
      	much more meaningful information about a feature/interval.  For example, score could now be:
      
      	7.31E-05  (a p-value)
      	0.334577  (mean enrichment)
      	2:2.2:40:2 (several values encoded in a string)
      
      4.  closestBed now, by default, reports __all__ intervals in B that overlap equally with an interval in A.  Previously, it
      	merely reported the first such feature that appeared in B.  Here's a cartoon explaining the difference.
      
      	**Prior behavior**
      
      	A	 ==============
      	B.1        				++++++++++++++
      	B.2       				++++++++++++++
      	B.3               				+++++++++
      
      	-----------------------------------------
      	Result = B.1 			++++++++++++++
      
      	**Current behavior**
      
      	A	 ==============
      	B.1        				++++++++++++++
      	B.2       				++++++++++++++
      	B.3               				+++++++++
      
      	-----------------------------------------
      	Result = B.1 			++++++++++++++
      			 B.2 			++++++++++++++
      
      	Using the -t option, one can also choose to report either the first or the last entry in B in the event of a tie.
      
      5.  Several other minor changes to the algorithms have been made to increase speed a bit.
      952c45ad
  20. Sep 14, 2009
  21. Jul 22, 2009
    • Aaron's avatar
      Version 2.1.1 · 235f6e7a
      Aaron authored
      	1. Added limits.h to bedFile.h to prevent compilation errors on some systems.
      	2. Fixed the bedFile.cpp parsing logic to allow proper parsing of track and browser lines
      235f6e7a
  22. Jun 25, 2009
  23. Jun 15, 2009
    • Aaron's avatar
      VERSION 2.1.0 · 23c77070
      Aaron authored
      	1. Fixed a bug in peIntersectBed that prevented -a from being correctly handled when passed via stdin.
      	2. Added new functionality to coverageBed that calculates the density of coverage.
      	3. Fixed bug in genomeCoverageBed.
      23c77070
  24. May 05, 2009
    • Aaron Quinlan's avatar
      Strandedness. reportBed in bedFile. peIntersect · ac52b452
      Aaron Quinlan authored
      	1. Added strandedness to relevant programs (e.g. intersectBed, mergeBed, etc.)
      	2. Moved reportBed and reportBedRange to bedFile.cpp to clean up code
      	3. Sped up file parsing.  Added lineFileUtilities.cpp
      	4. Added peIntersectBed
      ac52b452
  25. Apr 26, 2009
  26. Apr 24, 2009
  27. Apr 09, 2009
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