- Jun 30, 2010
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Aaron authored
1. Added support for VCF 4.0. BED.end is based on the size of the REF allele in the VCF entry. 2. Fixed a bug in BamReader.cpp that bombed when seq and qual are == "*" 3. Changed the Makefiles to inherit flags from the master Makefile in the root directory. 4. Fixed a bug in bedToBam to created incorrect CIGAR strings for the first block.
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- Jun 29, 2010
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Aaron authored
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Aaron authored
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Aaron authored
1. Reset BED.strand to be string instead of char in the interest of generality. 2. Fixed bug in genomeCoverageBed where NULL entries where genome summaries were err. reported with -bga. 3. Fixed bug in closestBed where NULL entries were err. reported when BED > 6. 4. Standardized the Open, Get, Close idiom per improvements from Gordon Assaf. 5. Add "split" logic to bamToBed.
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- Jun 07, 2010
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Aaron authored
1. Created separate structs for BED and BEDCOV in order to reduce memory consumption. Savings of ~30%. 2. Changed the binning approach to make 16kb bins the most granular. IntersectBed is now 1/3 faster as a result. 3. Templated the parsing and reporting functions in bedFile. Had to move them to the header file to avoid linker complications. 4. Added CHRPOS as a common type.
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- May 03, 2010
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Aaron authored
1. Added BAM support to windowBed. 2. Forced correct BEDPE ordering for bamToBed. 3. Added default overlapFraction = 0.0 to bedFile prototype.
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- Apr 26, 2010
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Aaron authored
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- Apr 22, 2010
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Aaron authored
1. Added an enum for BED line status in an effort to handle header and blank lines in an input file. 2. Modified the Open/Get/Close idiom to only test against BED_INVALID status. Only intersectBed and bedFile.cpp were updated. 3. Added AddBamTag to BaumAux.h 4. Wrote bamFillMateSeq
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- Apr 15, 2010
- Apr 12, 2010
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Aaron authored
- Allows one to report 0 overlap for non-overlapping A features - Changed all private memeber variables to use "_VAR" notation. - Added convenience functions for reporting overlaps.
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- Mar 17, 2010
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Aaron authored
1. Added the -hist option (credit to Jose Bras). 2. Substantially improved the speed by using a depth iterator instead of copying the depth map for each feature in B when computing coverage.
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- Feb 12, 2010
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Aaron authored
1. Fixed bug to "re-allow" track and "browser" lines. 2. Fixed bug in reporting BEDPE overlaps. 3. Fixed bug when using type "notboth" with BAM files in pairToBed. 4. When comparing BAM files to BED/GFF annotations with intersectBed or pairToBed, the __aligned__ sequence is used, rather than the __original__ sequence.
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- Jan 28, 2010
- Jan 04, 2010
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Aaron authored
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- Jan 03, 2010
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Aaron authored
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- Jan 01, 2010
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Aaron authored
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- Dec 20, 2009
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Aaron authored
1. Got parseGffLine working 2. Added GFF support to the reportBed* methods. 3. Cleaned up the stdin / parsing logic and centralized it within bedFile.cpp. This removes some of the complexity from each of the tools and tidies the codebase overall.
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- Dec 19, 2009
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Aaron authored
Not thoroughly tested but looks good so far. Initial cut at a GFF parser...needs work.
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- Nov 18, 2009
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Aaron authored
Ready for publication release. Checked all of the help messages. Cleaned up some inconsistencies.
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- Nov 14, 2009
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Aaron authored
Working on maskFastaFromBed, permuteBed and addFlanksBed
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- Sep 18, 2009
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Aaron authored
=== Notable changes in this release === 1. coverageBed will optionally only count features in BED file A (e.g. sequencing reads) that overlap with the intervals/windows in BED file B. This has been requested several times recently and facilitates CHiP-Seq and RNA-Seq experiments. 2. intersectBed can now require a minimum __reciprocal__ overlap between intervals in BED A and BED B. For example, previously, if one used -f 0.90, it required that a feature in B overlap 90% of the feature in A for the "hit" to be reported. If one adds the -r (reciprocal) option, the hit must also cover 90% of the feature in B. This helps to exclude overlaps between say small features in A and large features in B: A ========== B ********************************************************** -f 0.50 (Reported), whereas -f 0.50 -r (Not reported) 3. The score field has been changed to be a string. While this deviates from the UCSC definition, it allows one to track much more meaningful information about a feature/interval. For example, score could now be: 7.31E-05 (a p-value) 0.334577 (mean enrichment) 2:2.2:40:2 (several values encoded in a string) 4. closestBed now, by default, reports __all__ intervals in B that overlap equally with an interval in A. Previously, it merely reported the first such feature that appeared in B. Here's a cartoon explaining the difference. **Prior behavior** A ============== B.1 ++++++++++++++ B.2 ++++++++++++++ B.3 +++++++++ ----------------------------------------- Result = B.1 ++++++++++++++ **Current behavior** A ============== B.1 ++++++++++++++ B.2 ++++++++++++++ B.3 +++++++++ ----------------------------------------- Result = B.1 ++++++++++++++ B.2 ++++++++++++++ Using the -t option, one can also choose to report either the first or the last entry in B in the event of a tie. 5. Several other minor changes to the algorithms have been made to increase speed a bit.
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- Sep 14, 2009
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Aaron authored
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- Jul 22, 2009
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Aaron authored
1. Added limits.h to bedFile.h to prevent compilation errors on some systems. 2. Fixed the bedFile.cpp parsing logic to allow proper parsing of track and browser lines
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- Jun 25, 2009
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Aaron authored
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- Jun 15, 2009
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Aaron authored
1. Fixed a bug in peIntersectBed that prevented -a from being correctly handled when passed via stdin. 2. Added new functionality to coverageBed that calculates the density of coverage. 3. Fixed bug in genomeCoverageBed.
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- May 05, 2009
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Aaron Quinlan authored
1. Added strandedness to relevant programs (e.g. intersectBed, mergeBed, etc.) 2. Moved reportBed and reportBedRange to bedFile.cpp to clean up code 3. Sped up file parsing. Added lineFileUtilities.cpp 4. Added peIntersectBed
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- Apr 26, 2009
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Aaron Quinlan authored
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Aaron Quinlan authored
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Aaron Quinlan authored
1. Cleaned up the whitespace in bedFile.cpp and bedFile.h 2. Added a check in bedFile.cpp to detect if the BED file is space-delimited.
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- Apr 24, 2009
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Aaron Quinlan authored
1. Thanks to Loyal Goff at CSAIL/Broad for help identifying misssing includes. 2. Updated README to reflect this.
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- Apr 09, 2009
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Aaron Quinlan authored
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