Appendix: for ewa
- plugins tests (requirements):
- disease association (LRRK2 at leat 2x; PRKN at leat 1x);
- exploration (check on element TFAM in advanced map)
- At least 1 species (S) in multiple compartments and multiple submaps (including the main map).
- The depth of the exploration tree starting in S should be at least 2
- S should be connected to the neighbours as reactant, product and modifier
- S should be involved in reactions which are of type inhibition, negative influence and anything else from {inhibition, unknown inhibition, negative influence, unknown negative influence}
- guide;
- GSEA (check on advanced map)
- Existence of two overlays (such as PD substantia nigra)
- One should cover about 50% of at least two pathways, so that the pathways show as enriched. One of the pathways should be in a submap and one in the main map
- The other should cover at least 50% of a pathway which is not covered by the first overlay