1. unionBedGraphs. This is a very powerful new tool contributed by Assaf Gordon from CSHL. It will combine/merge multiple BEDGRAPH files into a single file, thus allowing comparisons of coverage (or any text-value) across multiple samples.
==New features==
1. New "distance feature" (-d) added to closestBed by Erik Arner. In addition to finding the closest feature to each feature in A, the -d option will report the distance to the closest feature in B. Overlapping features have a distance of 0.
2. New "per base depth feature" (-d) added to coverageBed. This reports the per base coverage (1-based) of each feature in file B based on the coverage of features found in file A. For example, this could report the per-base depth of sequencing reads (-a) across each capture target (-b).
==Bug Fixes==
1. Fixed bug in closestBed preventing closest features from being found for A features with start coordinates < 2048000. Thanks to Erik Arner for pointing this out.
2. Fixed minor reporting annoyances in closestBed. Thanks to Erik Arner.
3. Fixed typo/bug in genomeCoverageBed that reported negative coverage owing to numeric overflow. Thanks to Alexander Dobin for the detailed bug report.
4. Fixed other minor parsing and reporting bugs/annoyances.
Version 2.8.3 (July-25-2010)
1. Fixed bug that caused some GFF files to be misinterpreted as VCF. This prevented the detection of overlaps.
2. Added a new "-tag" option in bamToBed that allows one to choose the _numeric_ tag that will be used to populate the score field. For example, one could populate the score field with the alignment score with "-tag AS".