From 41d6c0b4ebc81a4836bd65c08e88bfa7a5f1b79b Mon Sep 17 00:00:00 2001 From: Piotr Gawron <piotr.gawron@uni.lu> Date: Tue, 18 Jul 2017 14:37:49 +0200 Subject: [PATCH] annotation links contain common name title --- frontend-js/src/main/js/Export.js | 10 ++++ .../src/main/js/gui/AbstractGuiElement.js | 9 ---- frontend-js/src/main/js/gui/Panel.js | 10 ++-- .../src/main/js/gui/leftPanel/GuiUtils.js | 9 +++- .../src/main/js/gui/leftPanel/LeftPanel.js | 9 ++-- .../src/main/js/gui/leftPanel/MiRnaPanel.js | 3 +- .../src/main/js/map/AbstractCustomMap.js | 9 ++++ .../src/main/js/map/CustomMapOptions.js | 8 +++ frontend-js/src/main/js/map/data/MapModel.js | 2 - frontend-js/src/main/js/minerva.js | 6 +++ frontend-js/src/test/js/Export-test.js | 10 +++- frontend-js/src/test/js/SessionData-test.js | 6 --- .../src/test/js/gui/CommentDialog-test.js | 5 -- .../src/test/js/gui/ContextMentu-test.js | 5 -- frontend-js/src/test/js/gui/Header-test.js | 5 -- frontend-js/src/test/js/gui/Legend-test.js | 5 -- .../src/test/js/gui/LoginDialog-test.js | 5 -- .../src/test/js/gui/MapContextMentu-test.js | 5 -- .../src/test/js/gui/OverviewDialog-test.js | 5 -- frontend-js/src/test/js/gui/Panel-test.js | 5 -- .../test/js/gui/SelectionContextMentu-test.js | 5 -- frontend-js/src/test/js/gui/SubMentu-test.js | 5 -- .../js/gui/export/ElementExportPanel-test.js | 50 +++++++++++++------ .../js/gui/leftPanel/AbstractPanel-test.js | 5 -- .../js/gui/leftPanel/ChemicalPanel-test.js | 5 -- .../test/js/gui/leftPanel/DrugPanel-test.js | 5 -- .../test/js/gui/leftPanel/GuiUtils-test.js | 5 -- .../test/js/gui/leftPanel/LeftPanel-test.js | 7 +-- .../test/js/gui/leftPanel/MiRnaPanel-test.js | 7 +-- .../js/gui/leftPanel/OverlayPanel-test.js | 5 -- .../js/gui/leftPanel/ProjectInfoPanel-test.js | 5 -- .../leftPanel/PublicationListDialog-test.js | 5 -- .../test/js/gui/leftPanel/SearchPanel-test.js | 5 -- .../test/js/gui/leftPanel/SubmapPanel-test.js | 5 -- .../src/test/js/gui/topMenu/TopMenu-test.js | 5 -- frontend-js/src/test/js/helper.js | 21 ++++++-- .../src/test/js/map/AbstractCustomMap-test.js | 6 --- frontend-js/src/test/js/map/CustomMap-test.js | 6 --- .../src/test/js/map/CustomMapOptions-test.js | 5 -- frontend-js/src/test/js/map/Submap-test.js | 5 -- frontend-js/src/test/js/map/TouchMap-test.js | 5 -- .../js/map/data/IdentifiedElement-test.js | 5 -- .../src/test/js/map/data/LayoutAlias-test.js | 4 -- .../src/test/js/map/data/MapModel-test.js | 4 -- .../src/test/js/map/data/Reaction-test.js | 5 -- .../test/js/map/marker/AliasMarker-test.js | 4 -- .../js/map/overlay/AbstractDbOverlay-test.js | 5 -- .../js/map/overlay/ChemicalDbOverlay-test.js | 4 -- .../js/map/overlay/CommentDbOverlay-test.js | 4 -- .../map/overlay/DbOverlayCollection-test.js | 5 -- .../test/js/map/overlay/DrugDbOverlay-test.js | 5 -- .../js/map/overlay/MiRnaDbOverlay-test.js | 5 -- .../js/map/overlay/SearchDbOverlay-test.js | 5 -- .../test/js/map/overlay/UserDbOverlay-test.js | 5 -- .../test/js/map/surface/AliasSurface-test.js | 5 -- .../js/map/surface/ReactionSurface-test.js | 6 --- .../js/map/window/AliasInfoWindow-test.js | 5 -- frontend-js/src/test/js/minerva-test.js | 6 --- frontend-js/src/test/js/mocha-config.js | 11 ++-- .../query=rotenone&token=MOCK_TOKEN_ID& | 2 +- .../query=NADH&token=MOCK_TOKEN_ID& | 2 +- .../query=aspirin&token=MOCK_TOKEN_ID& | 2 +- ...query=hsa-miR-125a-3p&token=MOCK_TOKEN_ID& | 2 +- .../projects/chemicals/ChemicalRestImpl.java | 4 +- 64 files changed, 131 insertions(+), 277 deletions(-) diff --git a/frontend-js/src/main/js/Export.js b/frontend-js/src/main/js/Export.js index 265a6fc52f..8942e41251 100644 --- a/frontend-js/src/main/js/Export.js +++ b/frontend-js/src/main/js/Export.js @@ -28,6 +28,7 @@ function Export(options) { self.setProject(options.getProject()); self.setElement(options.getElement()); + self.setConfiguration(options.getConfiguration()); self._createGui(); } @@ -128,6 +129,7 @@ Export.prototype.addTab = function(params, navElement, contentElement) { this._panels.push(new params.panelClass({ element : contentDiv, project : self.getProject(), + configuration: self.getConfiguration(), })); }; @@ -153,4 +155,12 @@ Export.prototype.init = function() { return Promise.all(promises); }; +Export.prototype.setConfiguration = function(configuration) { + this._configuration = configuration; +}; + +Export.prototype.getConfiguration = function() { + return this._configuration; +}; + module.exports = Export; diff --git a/frontend-js/src/main/js/gui/AbstractGuiElement.js b/frontend-js/src/main/js/gui/AbstractGuiElement.js index 4612ed9afe..f9a0d78f31 100644 --- a/frontend-js/src/main/js/gui/AbstractGuiElement.js +++ b/frontend-js/src/main/js/gui/AbstractGuiElement.js @@ -14,7 +14,6 @@ function AbstractGuiElement(params) { self.setElement(params.element); self.setProject(params.project); - self.setConfiguration(params.configuration); self.setMap(params.customMap); self._controlElements = []; @@ -46,14 +45,6 @@ AbstractGuiElement.prototype.getElement = function() { return this._element; }; -AbstractGuiElement.prototype.setConfiguration = function(configuration) { - this._configuration = configuration; -}; - -AbstractGuiElement.prototype.getConfiguration = function() { - return this._configuration; -}; - AbstractGuiElement.prototype.setProject = function(project) { this._project = project; }; diff --git a/frontend-js/src/main/js/gui/Panel.js b/frontend-js/src/main/js/gui/Panel.js index c8fb548235..b6a2376a3d 100644 --- a/frontend-js/src/main/js/gui/Panel.js +++ b/frontend-js/src/main/js/gui/Panel.js @@ -15,10 +15,14 @@ function Panel(params) { var self = this; - self.setGuiUtils(new GuiUtils(self.getConfiguration())); - self.setPanelName(params.panelName); + self.setParent(params.parent); + var configuration = params.configuration; + if (params.configuration === undefined) { + configuration = self.getMap().getConfiguration(); + } - this.setParent(params.parent); + self.setGuiUtils(new GuiUtils(configuration)); + self.setPanelName(params.panelName); if (params.scrollable) { $(self.getElement()).addClass("pre-scrollable"); diff --git a/frontend-js/src/main/js/gui/leftPanel/GuiUtils.js b/frontend-js/src/main/js/gui/leftPanel/GuiUtils.js index 2497ed6ad3..a2e5a8e35c 100644 --- a/frontend-js/src/main/js/gui/leftPanel/GuiUtils.js +++ b/frontend-js/src/main/js/gui/leftPanel/GuiUtils.js @@ -71,6 +71,7 @@ GuiUtils.prototype.createLink = function(url, name) { var link = document.createElement("a"); link.href = url; link.innerHTML = name; + link.target = "_blank"; link.style.textDecoration = "underline"; return link; }; @@ -87,7 +88,13 @@ GuiUtils.prototype.createAnnotationLink = function(annotation, showType) { name = article.getId(); } else { name = annotation.getResource(); - type = annotation.getType(); + var miriamType = self.getConfiguration().getMiriamTypeByName(annotation.getType()); + if (miriamType === null) { + logger.warn("Unknown miriam type: " + annotation.getType()); + type = annotation.getType(); + } else { + type = miriamType.getCommonName(); + } } var link; if (showType) { diff --git a/frontend-js/src/main/js/gui/leftPanel/LeftPanel.js b/frontend-js/src/main/js/gui/leftPanel/LeftPanel.js index 2e13fa4bf6..e41f080af3 100644 --- a/frontend-js/src/main/js/gui/leftPanel/LeftPanel.js +++ b/frontend-js/src/main/js/gui/leftPanel/LeftPanel.js @@ -145,7 +145,7 @@ LeftPanel.prototype.init = function() { return self.showElementDetails(e.arg.identifiedElements[0][0]); } else { return self.showElementDetails(undefined); - } + } }); resolve(); }); @@ -174,13 +174,14 @@ LeftPanel.prototype.showElementDetails = function(element) { }).siblings('.ui-dialog-titlebar').css("background", "gray"); } - var openTabName = $("[name='tabView'] > ul li.active a")[0].innerHTML; + var openTabName = $("[name='tabView'] > ul li.active a > .maintabdiv")[0].innerHTML; + var searchTabName = $("[name='tabView'] > ul li.active a > .maintabdiv")[1].innerHTML; var isPanelHidden = (self.getElement().style.display === "none"); if (isPanelHidden) { openTabName = undefined; } - if (element !== undefined && openTabName !== "SEARCH") { + if (element !== undefined && (openTabName.indexOf("SEARCH") === -1 || searchTabName !== "GENERIC")) { var model = self.getMap().getSubmapById(element.getModelId()).getModel(); return model.getByIdentifiedElement(element, true).then(function(bioEntity) { div.innerHTML = self.prepareElementDetailsContent(bioEntity).innerHTML; @@ -194,7 +195,7 @@ LeftPanel.prototype.showElementDetails = function(element) { }; LeftPanel.prototype.prepareElementDetailsContent = function(bioEntity) { - var guiUtils = new GuiUtils(); + var guiUtils = new GuiUtils(this.getMap().getConfiguration()); if (bioEntity instanceof Reaction) { return guiUtils.createReactionElement(bioEntity); } else if (bioEntity instanceof Alias) { diff --git a/frontend-js/src/main/js/gui/leftPanel/MiRnaPanel.js b/frontend-js/src/main/js/gui/leftPanel/MiRnaPanel.js index 9662794fa4..ae466919fd 100644 --- a/frontend-js/src/main/js/gui/leftPanel/MiRnaPanel.js +++ b/frontend-js/src/main/js/gui/leftPanel/MiRnaPanel.js @@ -27,7 +27,8 @@ MiRnaPanel.prototype.createPreamble = function(miRna) { } else { var line = document.createElement("div"); line.appendChild(guiUtils.createLabel("μRna: ")); - line.appendChild(guiUtils.createLink("http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=", miRna.getName())); + line.appendChild(guiUtils.createLink("http://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=" + miRna.getName(), miRna + .getName())); line.appendChild(guiUtils.createNewLine()); result.appendChild(line); diff --git a/frontend-js/src/main/js/map/AbstractCustomMap.js b/frontend-js/src/main/js/map/AbstractCustomMap.js index 9fb7383aa8..b2af8d2369 100644 --- a/frontend-js/src/main/js/map/AbstractCustomMap.js +++ b/frontend-js/src/main/js/map/AbstractCustomMap.js @@ -26,6 +26,7 @@ function AbstractCustomMap(model, options) { } this.setElement(options.getElement()); + this.setConfiguration(options.getConfiguration()); this.setModel(model); @@ -833,6 +834,14 @@ AbstractCustomMap.prototype.getId = function() { return this.getModel().getId(); }; +AbstractCustomMap.prototype.getConfiguration = function() { + return this._configuration; +}; + +AbstractCustomMap.prototype.setConfiguration = function(configuration) { + this._configuration = configuration; +}; + AbstractCustomMap.prototype._createMapChangedCallbacks = function() { var self = this; var sessionData = ServerConnector.getSessionData(self.getTopMap().getProject()); diff --git a/frontend-js/src/main/js/map/CustomMapOptions.js b/frontend-js/src/main/js/map/CustomMapOptions.js index 38fe67dc4b..e5a6997f59 100644 --- a/frontend-js/src/main/js/map/CustomMapOptions.js +++ b/frontend-js/src/main/js/map/CustomMapOptions.js @@ -11,6 +11,7 @@ function CustomMapOptions(params) { throw new Error("element must be defined"); } this.setElement(params.element); + this.setConfiguration(params.configuration); this.setProject(params.project); this.setProjectId(params.projectId); @@ -68,6 +69,13 @@ CustomMapOptions.prototype.setProject = function(project) { this._project = project; }; +CustomMapOptions.prototype.getConfiguration = function() { + return this._configuration; +}; +CustomMapOptions.prototype.setConfiguration = function(configuration) { + this._configuration = configuration; +}; + CustomMapOptions.prototype.getProjectId = function() { if (this.getProject() !== undefined) { return this.getProject().getProjectId(); diff --git a/frontend-js/src/main/js/map/data/MapModel.js b/frontend-js/src/main/js/map/data/MapModel.js index 1906f20879..47a3a085e7 100644 --- a/frontend-js/src/main/js/map/data/MapModel.js +++ b/frontend-js/src/main/js/map/data/MapModel.js @@ -16,8 +16,6 @@ var Reaction = require('./Reaction'); /** * Default constructor. * - * @param configuration - * {@link Configuration} used to initialize this map */ function MapModel(configuration) { diff --git a/frontend-js/src/main/js/minerva.js b/frontend-js/src/main/js/minerva.js index f277b51de5..94de429a75 100644 --- a/frontend-js/src/main/js/minerva.js +++ b/frontend-js/src/main/js/minerva.js @@ -462,6 +462,9 @@ function create(params) { // make sure that we are logged in return ServerConnector.getToken().then(function() { + return ServerConnector.getConfiguration(); + }).then(function(configuration) { + params.setConfiguration(configuration); return getProject(params); }).then(function(project) { if (project === null) { @@ -570,6 +573,9 @@ function createExport(params) { var result; // make sure that we are logged in return ServerConnector.getToken().then(function() { + return ServerConnector.getConfiguration(); + }).then(function(configuration) { + params.setConfiguration(configuration); return getProject(params); }).then(function(project) { params.setProject(project); diff --git a/frontend-js/src/test/js/Export-test.js b/frontend-js/src/test/js/Export-test.js index 0a63026bd5..dfa018e4a1 100644 --- a/frontend-js/src/test/js/Export-test.js +++ b/frontend-js/src/test/js/Export-test.js @@ -12,11 +12,17 @@ describe('Export', function() { it('default behaviour', function() { var exportObject; var project; - return ServerConnector.getProject().then(function(result) { + var configuration; + + return ServerConnector.getConfiguration().then(function(result) { + configuration = result; + return ServerConnector.getProject(); + }).then(function(result) { project = result; exportObject = new Export({ element : testDiv, - project : project + project : project, + configuration : configuration, }); return exportObject.init(); }).then(function() { diff --git a/frontend-js/src/test/js/SessionData-test.js b/frontend-js/src/test/js/SessionData-test.js index d9745cfb9f..cb9172ac8d 100644 --- a/frontend-js/src/test/js/SessionData-test.js +++ b/frontend-js/src/test/js/SessionData-test.js @@ -11,12 +11,6 @@ var assert = chai.assert; var logger = require('./logger'); describe('SessionData', function() { - - var helper; - before(function() { - helper = new Helper(); - }); - it('setShowComments', function() { var project = helper.createProject(); var session = new SessionData(project); diff --git a/frontend-js/src/test/js/gui/CommentDialog-test.js b/frontend-js/src/test/js/gui/CommentDialog-test.js index 545c9fbda2..241f894569 100644 --- a/frontend-js/src/test/js/gui/CommentDialog-test.js +++ b/frontend-js/src/test/js/gui/CommentDialog-test.js @@ -12,11 +12,6 @@ var logger = require('../logger'); describe('CommentDialog', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/ContextMentu-test.js b/frontend-js/src/test/js/gui/ContextMentu-test.js index 79c97c505a..929e52cb16 100644 --- a/frontend-js/src/test/js/gui/ContextMentu-test.js +++ b/frontend-js/src/test/js/gui/ContextMentu-test.js @@ -14,11 +14,6 @@ var logger = require('../logger'); describe('ContextMenu', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('constructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/Header-test.js b/frontend-js/src/test/js/gui/Header-test.js index 65ac4ccabc..e466d385e0 100644 --- a/frontend-js/src/test/js/gui/Header-test.js +++ b/frontend-js/src/test/js/gui/Header-test.js @@ -14,11 +14,6 @@ var logger = require('../logger'); describe('Header', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('constructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/Legend-test.js b/frontend-js/src/test/js/gui/Legend-test.js index e2d85bf6fd..7b2e70929f 100644 --- a/frontend-js/src/test/js/gui/Legend-test.js +++ b/frontend-js/src/test/js/gui/Legend-test.js @@ -14,11 +14,6 @@ var logger = require('../logger'); describe('Legend', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('constructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/LoginDialog-test.js b/frontend-js/src/test/js/gui/LoginDialog-test.js index 9e46a5c79c..75857799d2 100644 --- a/frontend-js/src/test/js/gui/LoginDialog-test.js +++ b/frontend-js/src/test/js/gui/LoginDialog-test.js @@ -13,11 +13,6 @@ var logger = require('../logger'); describe('LoginDialog', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/MapContextMentu-test.js b/frontend-js/src/test/js/gui/MapContextMentu-test.js index 5b1c49f784..a6a6354012 100644 --- a/frontend-js/src/test/js/gui/MapContextMentu-test.js +++ b/frontend-js/src/test/js/gui/MapContextMentu-test.js @@ -14,11 +14,6 @@ var logger = require('../logger'); describe('MapContextMenu', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('constructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/OverviewDialog-test.js b/frontend-js/src/test/js/gui/OverviewDialog-test.js index e48ade484f..f1b287fe93 100644 --- a/frontend-js/src/test/js/gui/OverviewDialog-test.js +++ b/frontend-js/src/test/js/gui/OverviewDialog-test.js @@ -16,11 +16,6 @@ var logger = require('../logger'); describe('OverviewDialog', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('open image', function() { return ServerConnector.readFile("testFiles/projectWithImages.json").then(function(fileContent) { var project = new Project(JSON.parse(fileContent)); diff --git a/frontend-js/src/test/js/gui/Panel-test.js b/frontend-js/src/test/js/gui/Panel-test.js index f1d8211feb..96cff6a3f3 100644 --- a/frontend-js/src/test/js/gui/Panel-test.js +++ b/frontend-js/src/test/js/gui/Panel-test.js @@ -14,11 +14,6 @@ var logger = require('../logger'); describe('Panel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('openDialog', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/SelectionContextMentu-test.js b/frontend-js/src/test/js/gui/SelectionContextMentu-test.js index 44e6562fdd..2f083e4677 100644 --- a/frontend-js/src/test/js/gui/SelectionContextMentu-test.js +++ b/frontend-js/src/test/js/gui/SelectionContextMentu-test.js @@ -14,11 +14,6 @@ var logger = require('../logger'); describe('SelectionContextMenu', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('constructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/SubMentu-test.js b/frontend-js/src/test/js/gui/SubMentu-test.js index 8d29a0e932..d2ce50aba7 100644 --- a/frontend-js/src/test/js/gui/SubMentu-test.js +++ b/frontend-js/src/test/js/gui/SubMentu-test.js @@ -14,11 +14,6 @@ var logger = require('../logger'); describe('SubMenu', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('constructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/export/ElementExportPanel-test.js b/frontend-js/src/test/js/gui/export/ElementExportPanel-test.js index 8400663507..5e7d1656cf 100644 --- a/frontend-js/src/test/js/gui/export/ElementExportPanel-test.js +++ b/frontend-js/src/test/js/gui/export/ElementExportPanel-test.js @@ -10,20 +10,18 @@ var assert = require('assert'); describe('ElementExportPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - describe('getSelectedTypes', function() { it('select single element', function() { var exportObject; var project; return ServerConnector.getProject().then(function(result) { project = result; + return ServerConnector.getConfiguration(); + }).then(function(configuration) { exportObject = new ElementExportPanel({ element : testDiv, - project : project + project : project, + configuration : configuration, }); return exportObject.init(); }).then(function() { @@ -40,14 +38,18 @@ describe('ElementExportPanel', function() { var project; var elementTypes; - return ServerConnector.getConfiguration().then(function(configuration) { + var configuration; + + return ServerConnector.getConfiguration().then(function(result) { + configuration = result; elementTypes = configuration.getElementTypes(); return ServerConnector.getProject(); }).then(function(result) { project = result; exportObject = new ElementExportPanel({ element : testDiv, - project : project + project : project, + configuration : configuration, }); return exportObject.init(); }).then(function() { @@ -70,9 +72,12 @@ describe('ElementExportPanel', function() { var project; return ServerConnector.getProject().then(function(result) { project = result; + return ServerConnector.getConfiguration(); + }).then(function(configuration) { exportObject = new ElementExportPanel({ element : testDiv, - project : project + project : project, + configuration : configuration, }); return exportObject.init(); }).then(function() { @@ -88,15 +93,18 @@ describe('ElementExportPanel', function() { var exportObject; var project; var elementTypes; + var configuration; - return ServerConnector.getConfiguration().then(function(configuration) { + return ServerConnector.getConfiguration().then(function(result) { + configuration = result; elementTypes = configuration.getElementTypes(); return ServerConnector.getProject(); }).then(function(result) { project = result; exportObject = new ElementExportPanel({ element : testDiv, - project : project + project : project, + configuration : configuration, }); return exportObject.init(); }).then(function() { @@ -119,9 +127,12 @@ describe('ElementExportPanel', function() { var project; return ServerConnector.getProject().then(function(result) { project = result; + return ServerConnector.getConfiguration(); + }).then(function(configuration) { exportObject = new ElementExportPanel({ element : testDiv, - project : project + project : project, + configuration : configuration, }); return exportObject.init(); }).then(function() { @@ -144,9 +155,12 @@ describe('ElementExportPanel', function() { var project; return ServerConnector.getProject().then(function(result) { project = result; + return ServerConnector.getConfiguration(); + }).then(function(configuration) { exportObject = new ElementExportPanel({ element : testDiv, - project : project + project : project, + configuration : configuration, }); return exportObject.init(); }).then(function() { @@ -166,9 +180,12 @@ describe('ElementExportPanel', function() { var project; return ServerConnector.getProject().then(function(result) { project = result; + return ServerConnector.getConfiguration(); + }).then(function(configuration) { exportObject = new ElementExportPanel({ element : testDiv, - project : project + project : project, + configuration : configuration, }); return exportObject.init(); }).then(function() { @@ -188,9 +205,12 @@ describe('ElementExportPanel', function() { var project; return ServerConnector.getProject().then(function(result) { project = result; + return ServerConnector.getConfiguration(); + }).then(function(configuration) { exportObject = new ElementExportPanel({ element : testDiv, - project : project + project : project, + configuration : configuration, }); return exportObject.init(); }).then(function() { diff --git a/frontend-js/src/test/js/gui/leftPanel/AbstractPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/AbstractPanel-test.js index ce24301e6a..6829269efa 100644 --- a/frontend-js/src/test/js/gui/leftPanel/AbstractPanel-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/AbstractPanel-test.js @@ -16,11 +16,6 @@ var logger = require('../../logger'); describe('AbstractDbPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var div = document.createElement("div"); diff --git a/frontend-js/src/test/js/gui/leftPanel/ChemicalPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/ChemicalPanel-test.js index 64aa202076..92d0c13fa5 100644 --- a/frontend-js/src/test/js/gui/leftPanel/ChemicalPanel-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/ChemicalPanel-test.js @@ -14,11 +14,6 @@ var logger = require('../../logger'); describe('ChemicalPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var map = helper.createCustomMap(); helper.createChemicalDbOverlay(map); diff --git a/frontend-js/src/test/js/gui/leftPanel/DrugPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/DrugPanel-test.js index b0d8d9518f..d11313f19a 100644 --- a/frontend-js/src/test/js/gui/leftPanel/DrugPanel-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/DrugPanel-test.js @@ -14,11 +14,6 @@ var logger = require('../../logger'); describe('DrugPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var map = helper.createCustomMap(); helper.createDrugDbOverlay(map); diff --git a/frontend-js/src/test/js/gui/leftPanel/GuiUtils-test.js b/frontend-js/src/test/js/gui/leftPanel/GuiUtils-test.js index 67f06072cd..3560afff81 100644 --- a/frontend-js/src/test/js/gui/leftPanel/GuiUtils-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/GuiUtils-test.js @@ -13,11 +13,6 @@ var logger = require('../../logger'); describe('GuiUtils', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var map = helper.createCustomMap(); helper.createSearchDbOverlay(map); diff --git a/frontend-js/src/test/js/gui/leftPanel/LeftPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/LeftPanel-test.js index c96f944e29..ec14348f67 100644 --- a/frontend-js/src/test/js/gui/leftPanel/LeftPanel-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/LeftPanel-test.js @@ -15,11 +15,6 @@ var logger = require('../../logger'); describe('LeftPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('constructor', function() { var map = helper.createCustomMap(); helper.createSearchDbOverlay(map); @@ -54,7 +49,7 @@ describe('LeftPanel', function() { }); var element = new IdentifiedElement({ - id : 329168, + id : 329163, type : "ALIAS", modelId : map.getId() }); diff --git a/frontend-js/src/test/js/gui/leftPanel/MiRnaPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/MiRnaPanel-test.js index f9ea4ffeb7..824f8417f7 100644 --- a/frontend-js/src/test/js/gui/leftPanel/MiRnaPanel-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/MiRnaPanel-test.js @@ -14,11 +14,6 @@ var logger = require('../../logger'); describe('MiRnaPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var map = helper.createCustomMap(); helper.createMiRnaDbOverlay(map); @@ -77,7 +72,7 @@ describe('MiRnaPanel', function() { var panel = new MiRnaPanel({ element : testDiv, - customMap : map + customMap : map, }); panel.getControlElement(PanelControlElementType.SEARCH_INPUT).value = "hsa-miR-125a-3p"; diff --git a/frontend-js/src/test/js/gui/leftPanel/OverlayPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/OverlayPanel-test.js index 8c061adfa8..86d2292aa1 100644 --- a/frontend-js/src/test/js/gui/leftPanel/OverlayPanel-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/OverlayPanel-test.js @@ -12,11 +12,6 @@ var logger = require('../../logger'); describe('OverlayPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/gui/leftPanel/ProjectInfoPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/ProjectInfoPanel-test.js index b015f021ee..7975e14ae5 100644 --- a/frontend-js/src/test/js/gui/leftPanel/ProjectInfoPanel-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/ProjectInfoPanel-test.js @@ -12,11 +12,6 @@ var logger = require('../../logger'); describe('ProjectInfoPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var div = testDiv; diff --git a/frontend-js/src/test/js/gui/leftPanel/PublicationListDialog-test.js b/frontend-js/src/test/js/gui/leftPanel/PublicationListDialog-test.js index 44dbffec74..7810667ba3 100644 --- a/frontend-js/src/test/js/gui/leftPanel/PublicationListDialog-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/PublicationListDialog-test.js @@ -12,11 +12,6 @@ var logger = require('../../logger'); describe('PublicationListDialog', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var div = testDiv; diff --git a/frontend-js/src/test/js/gui/leftPanel/SearchPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/SearchPanel-test.js index 902f9d748c..db0f47f573 100644 --- a/frontend-js/src/test/js/gui/leftPanel/SearchPanel-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/SearchPanel-test.js @@ -14,11 +14,6 @@ var logger = require('../../logger'); describe('GenericSearchPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var map = helper.createCustomMap(); helper.createSearchDbOverlay(map); diff --git a/frontend-js/src/test/js/gui/leftPanel/SubmapPanel-test.js b/frontend-js/src/test/js/gui/leftPanel/SubmapPanel-test.js index 00b2afcee7..13fd92b4fb 100644 --- a/frontend-js/src/test/js/gui/leftPanel/SubmapPanel-test.js +++ b/frontend-js/src/test/js/gui/leftPanel/SubmapPanel-test.js @@ -12,11 +12,6 @@ var logger = require('../../logger'); describe('SubmapPanel', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('contructor', function() { var div = document.createElement("div"); diff --git a/frontend-js/src/test/js/gui/topMenu/TopMenu-test.js b/frontend-js/src/test/js/gui/topMenu/TopMenu-test.js index 707ddb82c7..c698abb19b 100644 --- a/frontend-js/src/test/js/gui/topMenu/TopMenu-test.js +++ b/frontend-js/src/test/js/gui/topMenu/TopMenu-test.js @@ -14,11 +14,6 @@ var logger = require('../../logger'); describe('TopMenu', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it('constructor', function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/helper.js b/frontend-js/src/test/js/helper.js index 539ad29dbf..5c3ebf1cf2 100644 --- a/frontend-js/src/test/js/helper.js +++ b/frontend-js/src/test/js/helper.js @@ -8,6 +8,7 @@ var Alias = require("../../main/js/map/data/Alias"); var AbstractCustomMap = require("../../main/js/map/AbstractCustomMap"); var ChemicalDbOverlay = require("../../main/js/map/overlay/ChemicalDbOverlay"); var Comment = require("../../main/js/map/data/Comment"); +var Configuration = require("../../main/js/Configuration"); var CommentDbOverlay = require("../../main/js/map/overlay/CommentDbOverlay"); var CustomMap = require("../../main/js/map/CustomMap"); var CustomMapOptions = require("../../main/js/map/CustomMapOptions"); @@ -29,10 +30,21 @@ var jsdom = require('jsdom'); var GuiConnector = require('../../main/js/GuiConnector'); -function Helper() { +function Helper(configuration) { + if (configuration === undefined) { + throw new Error("Configuration must be defined"); + } + this.setConfiguration(configuration); this.idCounter = 1000000; } +Helper.prototype.setConfiguration = function(configuration) { + this._configuration = configuration; +}; +Helper.prototype.getConfiguration = function() { + return this._configuration; +}; + Helper.prototype.createCommentDbOverlay = function(map) { var result = new CommentDbOverlay({ map : map, @@ -330,7 +342,8 @@ Helper.prototype.createCustomMapOptions = function(project) { markerOptimization : true, project : project, element : testDiv, - mapDiv : testDiv + mapDiv : testDiv, + configuration : this.getConfiguration(), }); return result; @@ -357,7 +370,9 @@ Helper.prototype.createCustomMap = function(project) { */ Helper.prototype.setUrl = function(url) { var cookies = Cookies.get(); - dom.reconfigure({ url: url }); + dom.reconfigure({ + url : url + }); for ( var cookie in cookies) { Cookies.set(cookie, cookies[cookie]); } diff --git a/frontend-js/src/test/js/map/AbstractCustomMap-test.js b/frontend-js/src/test/js/map/AbstractCustomMap-test.js index 14f888c8a0..7acdd183a6 100644 --- a/frontend-js/src/test/js/map/AbstractCustomMap-test.js +++ b/frontend-js/src/test/js/map/AbstractCustomMap-test.js @@ -17,12 +17,6 @@ var assert = chai.assert; var logger = require("../logger"); describe('AbstractCustomMap', function() { - - var helper; - before(function() { - helper = new Helper(); - }); - it("Constructor", function() { var model = helper.createModel(); var options = helper.createCustomMapOptions(); diff --git a/frontend-js/src/test/js/map/CustomMap-test.js b/frontend-js/src/test/js/map/CustomMap-test.js index 8e36eeab96..539b6f60e3 100644 --- a/frontend-js/src/test/js/map/CustomMap-test.js +++ b/frontend-js/src/test/js/map/CustomMap-test.js @@ -20,12 +20,6 @@ var chai = require('chai'); var assert = chai.assert; describe('CustomMap', function() { - - var helper; - before(function() { - helper = new Helper(); - }); - describe("constructor", function() { it("default", function() { var options = helper.createCustomMapOptions(); diff --git a/frontend-js/src/test/js/map/CustomMapOptions-test.js b/frontend-js/src/test/js/map/CustomMapOptions-test.js index 116c8daee2..231352ea51 100644 --- a/frontend-js/src/test/js/map/CustomMapOptions-test.js +++ b/frontend-js/src/test/js/map/CustomMapOptions-test.js @@ -7,11 +7,6 @@ var assert = chai.assert; var logger = require('../logger'); describe('CustomMapOptions', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("contructor with invalid arg", function() { try { new CustomMapOptions({ diff --git a/frontend-js/src/test/js/map/Submap-test.js b/frontend-js/src/test/js/map/Submap-test.js index 67e4cef970..c85ff36999 100644 --- a/frontend-js/src/test/js/map/Submap-test.js +++ b/frontend-js/src/test/js/map/Submap-test.js @@ -10,11 +10,6 @@ var chai = require('chai'); var assert = chai.assert; describe('Submap', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("simple contructor", function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/map/TouchMap-test.js b/frontend-js/src/test/js/map/TouchMap-test.js index 2827e0353b..78b652fe3a 100644 --- a/frontend-js/src/test/js/map/TouchMap-test.js +++ b/frontend-js/src/test/js/map/TouchMap-test.js @@ -7,11 +7,6 @@ var chai = require('chai'); var assert = chai.assert; describe('TouchMap', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("simple contructor", function() { var map = helper.createCustomMap(); var touchMap = new TouchMap(map); diff --git a/frontend-js/src/test/js/map/data/IdentifiedElement-test.js b/frontend-js/src/test/js/map/data/IdentifiedElement-test.js index 11278297ee..46e574f5aa 100644 --- a/frontend-js/src/test/js/map/data/IdentifiedElement-test.js +++ b/frontend-js/src/test/js/map/data/IdentifiedElement-test.js @@ -14,11 +14,6 @@ var assert = chai.assert; var expect = chai.expect; describe('IdentifiedElement', function() { - var helper; - before(function() { - helper = new Helper(); - }); - beforeEach(function() { logger.flushBuffer(); }); diff --git a/frontend-js/src/test/js/map/data/LayoutAlias-test.js b/frontend-js/src/test/js/map/data/LayoutAlias-test.js index 549ea9ec2d..992fa6228c 100644 --- a/frontend-js/src/test/js/map/data/LayoutAlias-test.js +++ b/frontend-js/src/test/js/map/data/LayoutAlias-test.js @@ -10,10 +10,6 @@ var assert = require('assert'); var logger = require('../../logger'); describe('LayoutAlias', function() { - var helper; - beforeEach(function() { - helper = new Helper(); - }); it("constructor", function() { var aliasId = 908; diff --git a/frontend-js/src/test/js/map/data/MapModel-test.js b/frontend-js/src/test/js/map/data/MapModel-test.js index 92682f8555..11e2f827f8 100644 --- a/frontend-js/src/test/js/map/data/MapModel-test.js +++ b/frontend-js/src/test/js/map/data/MapModel-test.js @@ -13,10 +13,6 @@ var assert = require('chai').assert; var logger = require('../../logger'); describe('MapModel', function() { - var helper; - before(function() { - helper = new Helper(); - }); it("MapModel constructor", function() { var model = new MapModel({ diff --git a/frontend-js/src/test/js/map/data/Reaction-test.js b/frontend-js/src/test/js/map/data/Reaction-test.js index af464fb3ce..b78d4b150d 100644 --- a/frontend-js/src/test/js/map/data/Reaction-test.js +++ b/frontend-js/src/test/js/map/data/Reaction-test.js @@ -11,11 +11,6 @@ var logger = require('../../logger'); describe('Reaction', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("constructor from invalid", function() { var javaObject = { lines : [ { diff --git a/frontend-js/src/test/js/map/marker/AliasMarker-test.js b/frontend-js/src/test/js/map/marker/AliasMarker-test.js index 1422885568..ff4915011f 100644 --- a/frontend-js/src/test/js/map/marker/AliasMarker-test.js +++ b/frontend-js/src/test/js/map/marker/AliasMarker-test.js @@ -11,10 +11,6 @@ var IdentifiedElement = require('../../../../main/js/map/data/IdentifiedElement' var assert = require('assert'); describe('AliasMarker', function() { - var helper; - before(function() { - helper = new Helper(); - }); it("Constructor", function() { var map; diff --git a/frontend-js/src/test/js/map/overlay/AbstractDbOverlay-test.js b/frontend-js/src/test/js/map/overlay/AbstractDbOverlay-test.js index f6fa27053f..e2b5860975 100644 --- a/frontend-js/src/test/js/map/overlay/AbstractDbOverlay-test.js +++ b/frontend-js/src/test/js/map/overlay/AbstractDbOverlay-test.js @@ -8,11 +8,6 @@ var assert = require('assert'); var logger = require('../../logger'); describe('AbstractDbOverlay', function() { - var helper; - before(function() { - helper = new Helper(); - }); - var mapMock = { registerDbOverlay : function() { }, diff --git a/frontend-js/src/test/js/map/overlay/ChemicalDbOverlay-test.js b/frontend-js/src/test/js/map/overlay/ChemicalDbOverlay-test.js index f73b9ebddc..9de1dfbd9a 100644 --- a/frontend-js/src/test/js/map/overlay/ChemicalDbOverlay-test.js +++ b/frontend-js/src/test/js/map/overlay/ChemicalDbOverlay-test.js @@ -10,10 +10,6 @@ var ChemicalDbOverlay = require('../../../../main/js/map/overlay/ChemicalDbOverl var assert = require('assert'); describe('ChemicalDbOverlay', function() { - var helper; - before(function() { - helper = new Helper(); - }); it("constructor 1", function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/map/overlay/CommentDbOverlay-test.js b/frontend-js/src/test/js/map/overlay/CommentDbOverlay-test.js index a1e50eaca0..bfa62c538b 100644 --- a/frontend-js/src/test/js/map/overlay/CommentDbOverlay-test.js +++ b/frontend-js/src/test/js/map/overlay/CommentDbOverlay-test.js @@ -9,10 +9,6 @@ var IdentifiedElement = require('../../../../main/js/map/data/IdentifiedElement' var assert = require('assert'); describe('CommentDbOverlay', function() { - var helper; - before(function() { - helper = new Helper(); - }); it("constructor", function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/map/overlay/DbOverlayCollection-test.js b/frontend-js/src/test/js/map/overlay/DbOverlayCollection-test.js index bd705551a8..0a151e4d7a 100644 --- a/frontend-js/src/test/js/map/overlay/DbOverlayCollection-test.js +++ b/frontend-js/src/test/js/map/overlay/DbOverlayCollection-test.js @@ -9,11 +9,6 @@ var DbOverlayCollection = require('../../../../main/js/map/overlay/DbOverlayColl var assert = require('assert'); describe('DbOverlayCollection', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("constructor", function() { var map = helper.createCustomMap(); new DbOverlayCollection({ diff --git a/frontend-js/src/test/js/map/overlay/DrugDbOverlay-test.js b/frontend-js/src/test/js/map/overlay/DrugDbOverlay-test.js index 2127f16b51..ff02586679 100644 --- a/frontend-js/src/test/js/map/overlay/DrugDbOverlay-test.js +++ b/frontend-js/src/test/js/map/overlay/DrugDbOverlay-test.js @@ -11,11 +11,6 @@ var DrugDbOverlay = require('../../../../main/js/map/overlay/DrugDbOverlay'); var assert = require('assert'); describe('DrugDbOverlay', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("constructor 1", function() { var map = helper.createCustomMap(); var oc = new DrugDbOverlay({ diff --git a/frontend-js/src/test/js/map/overlay/MiRnaDbOverlay-test.js b/frontend-js/src/test/js/map/overlay/MiRnaDbOverlay-test.js index 4cc3891d08..5ef31f28e4 100644 --- a/frontend-js/src/test/js/map/overlay/MiRnaDbOverlay-test.js +++ b/frontend-js/src/test/js/map/overlay/MiRnaDbOverlay-test.js @@ -10,11 +10,6 @@ var MiRnaDbOverlay = require('../../../../main/js/map/overlay/MiRnaDbOverlay'); var assert = require('assert'); describe('MiRnaDbOverlay', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("constructor 1", function() { var map = helper.createCustomMap(); var oc = new MiRnaDbOverlay({ diff --git a/frontend-js/src/test/js/map/overlay/SearchDbOverlay-test.js b/frontend-js/src/test/js/map/overlay/SearchDbOverlay-test.js index a76e685404..7187ad08d2 100644 --- a/frontend-js/src/test/js/map/overlay/SearchDbOverlay-test.js +++ b/frontend-js/src/test/js/map/overlay/SearchDbOverlay-test.js @@ -11,11 +11,6 @@ var AbstractDbOverlay = require('../../../../main/js/map/overlay/AbstractDbOverl var assert = require('assert'); describe('SearchDbOverlay', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("constructor 1", function() { var map = helper.createCustomMap(); var oc = new SearchDbOverlay({ diff --git a/frontend-js/src/test/js/map/overlay/UserDbOverlay-test.js b/frontend-js/src/test/js/map/overlay/UserDbOverlay-test.js index 18c839c186..2c5ed20ce9 100644 --- a/frontend-js/src/test/js/map/overlay/UserDbOverlay-test.js +++ b/frontend-js/src/test/js/map/overlay/UserDbOverlay-test.js @@ -11,11 +11,6 @@ var UserDbOverlay = require('../../../../main/js/map/overlay/UserDbOverlay'); var assert = require('assert'); describe('UserDbOverlay', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("constructor 1", function() { var map = helper.createCustomMap(); var oc = new UserDbOverlay({ diff --git a/frontend-js/src/test/js/map/surface/AliasSurface-test.js b/frontend-js/src/test/js/map/surface/AliasSurface-test.js index 03ff64034b..8212e15343 100644 --- a/frontend-js/src/test/js/map/surface/AliasSurface-test.js +++ b/frontend-js/src/test/js/map/surface/AliasSurface-test.js @@ -10,11 +10,6 @@ var IdentifiedElement = require('../../../../main/js/map/data/IdentifiedElement' var assert = require('assert'); describe('AliasSurface', function() { - var helper; - before(function() { - helper = new Helper(); - }); - it("constructor", function() { var map = helper.createCustomMap(); var alias = helper.createAlias(map); diff --git a/frontend-js/src/test/js/map/surface/ReactionSurface-test.js b/frontend-js/src/test/js/map/surface/ReactionSurface-test.js index a24fdf9d87..1efa46f1a8 100644 --- a/frontend-js/src/test/js/map/surface/ReactionSurface-test.js +++ b/frontend-js/src/test/js/map/surface/ReactionSurface-test.js @@ -9,12 +9,6 @@ var assert = require('assert'); var logger = require('../../logger'); describe('ReactionSurface', function() { - - var helper; - before(function() { - helper = new Helper(); - }); - it("Constructor", function() { var map = helper.createAbstractCustomMap(); var reaction = helper.createReaction(map); diff --git a/frontend-js/src/test/js/map/window/AliasInfoWindow-test.js b/frontend-js/src/test/js/map/window/AliasInfoWindow-test.js index 4efe9d74a1..7010e8351e 100644 --- a/frontend-js/src/test/js/map/window/AliasInfoWindow-test.js +++ b/frontend-js/src/test/js/map/window/AliasInfoWindow-test.js @@ -16,11 +16,6 @@ var assert = require('assert'); var logger = require('../../logger'); describe('AliasInfoWindow', function() { - var helper; - before(function() { - helper = new Helper(); - }); - describe('constructor', function() { it("default", function() { var map = helper.createCustomMap(); diff --git a/frontend-js/src/test/js/minerva-test.js b/frontend-js/src/test/js/minerva-test.js index c6707b206f..9425790ab9 100644 --- a/frontend-js/src/test/js/minerva-test.js +++ b/frontend-js/src/test/js/minerva-test.js @@ -16,12 +16,6 @@ var assert = chai.assert; var logger = require('./logger'); describe('minerva global', function() { - - var helper; - before(function() { - helper = new Helper(); - }); - beforeEach(function() { global.scriptDiv = document.createElement("script"); global.GuiConnector = undefined; diff --git a/frontend-js/src/test/js/mocha-config.js b/frontend-js/src/test/js/mocha-config.js index db423ba524..d3c4ea5270 100644 --- a/frontend-js/src/test/js/mocha-config.js +++ b/frontend-js/src/test/js/mocha-config.js @@ -28,7 +28,7 @@ global.Option = window.Option; var originalCreateElement = document.createElement; document.createElement = function(arg) { var result = originalCreateElement.call(this, arg); - //woraround for: https://github.com/tmpvar/jsdom/issues/961 + // woraround for: https://github.com/tmpvar/jsdom/issues/961 if ("li" === arg) { result.dataset = []; } @@ -106,13 +106,16 @@ beforeEach(function() { ServerConnector.getSessionData(null).setLogin("anonymous"); - new Helper().setUrl("http://test/"); - GuiConnector.init(); - global.testDiv = document.createElement("div"); global.testDiv.id = "test"; document.body.appendChild(testDiv); + return ServerConnector.getConfiguration().then(function(configuration) { + global.helper = new Helper(configuration); + helper.setUrl("http://test/"); + GuiConnector.init(); + }); + }); afterEach(function() { diff --git a/frontend-js/testFiles/apiCalls/projects/sample/chemicals.search/query=rotenone&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/projects/sample/chemicals.search/query=rotenone&token=MOCK_TOKEN_ID& index 98813c44f1..6725ccd2d2 100644 --- a/frontend-js/testFiles/apiCalls/projects/sample/chemicals.search/query=rotenone&token=MOCK_TOKEN_ID& +++ b/frontend-js/testFiles/apiCalls/projects/sample/chemicals.search/query=rotenone&token=MOCK_TOKEN_ID& @@ -1 +1 @@ -[{"references":[{"resource":"D012402","link":"http://ctdbase.org/detail.go?type=chem&acc=D012402","id":0,"type":null},{"resource":"83-79-4","link":"http://commonchemistry.org/ChemicalDetail.aspx?ref=83-79-4","id":0,"type":null}],"synonyms":[],"name":"Rotenone","description":"A botanical insecticide that is an inhibitor of mitochondrial electron transport.","id":"Rotenone","directEvidenceReferences":[],"directEvidence":"marker/mechanism","targets":[{"targetElements":[],"references":[{"resource":"15796199","link":"http://www.ncbi.nlm.nih.gov/pubmed/15796199","type":"PUBMED","article":{"title":"In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells.","authors":["GyÊmÃ¥nt N"," Tanaka M"," Antus S"," Hohmann J"," Csuka O"," MÃ¥ndoky L"," MolnÃ¥r J."],"journal":"In vivo (Athens, Greece)","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15796199","id":"15796199","citationCount":15,"stringAuthors":"GyÊmÃ¥nt N, Tanaka M, Antus S, Hohmann J, Csuka O, MÃ¥ndoky L, MolnÃ¥r J."}}],"name":"ABCB1","targetParticipants":[{"idObject":0,"name":"ABCB1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ABCB1","summary":null,"resource":"ABCB1"}]},{"targetElements":[],"references":[{"resource":"23098804","link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","type":"PUBMED","article":{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":5,"stringAuthors":"Swarnkar S, Goswami P, Kamat PK, Patro IK, Singh S, Nath C."}}],"name":"AIF1","targetParticipants":[{"idObject":0,"name":"AIF1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AIF1","summary":null,"resource":"AIF1"}]},{"targetElements":[],"references":[{"resource":"22847264","link":"http://www.ncbi.nlm.nih.gov/pubmed/22847264","type":"PUBMED","article":{"title":"Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants.","authors":["Covy JP"," Waxman EA"," Giasson BI."],"journal":"Journal of neuroscience research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22847264","id":"22847264","citationCount":15,"stringAuthors":"Covy JP, Waxman EA, Giasson BI."}}],"name":"ATP13A2","targetParticipants":[{"idObject":0,"name":"ATP13A2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ATP13A2","summary":null,"resource":"ATP13A2"}]},{"targetElements":[],"references":[{"resource":"17209049","link":"http://www.ncbi.nlm.nih.gov/pubmed/17209049","type":"PUBMED","article":{"title":"AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.","authors":["Bogush A"," Pedrini S"," Pelta-Heller J"," Chan T"," Yang Q"," Mao Z"," Sluzas E"," Gieringer T"," Ehrlich ME."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209049","id":"17209049","citationCount":30,"stringAuthors":"Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME."}},{"resource":"18646205","link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","type":"PUBMED","article":{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":13,"stringAuthors":"Yang D, Peng C, Li X, Fan X, Li L, Ming M, Chen S, Le W."}},{"resource":"17442543","link":"http://www.ncbi.nlm.nih.gov/pubmed/17442543","type":"PUBMED","article":{"title":"Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells.","authors":["Tan QR"," Wang XZ"," Wang CY"," Liu XJ"," Chen YC"," Wang HH"," Zhang RG"," Zhen XC"," Tong Y"," Zhang ZJ."],"journal":"European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17442543","id":"17442543","citationCount":12,"stringAuthors":"Tan QR, Wang XZ, Wang CY, Liu XJ, Chen YC, Wang HH, Zhang RG, Zhen XC, Tong Y, Zhang ZJ."}}],"name":"BDNF","targetParticipants":[{"idObject":0,"name":"BDNF","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BDNF","summary":null,"resource":"BDNF"}]},{"targetElements":[],"references":[{"resource":"19019832","link":"http://www.ncbi.nlm.nih.gov/pubmed/19019832","type":"PUBMED","article":{"title":"Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.","authors":["Tapryal N"," Mukhopadhyay C"," Das D"," Fox PL"," Mukhopadhyay CK."],"journal":"The Journal of Biological Chemistry","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19019832","id":"19019832","citationCount":18,"stringAuthors":"Tapryal N, Mukhopadhyay C, Das D, Fox PL, Mukhopadhyay CK."}},{"resource":"18804145","link":"http://www.ncbi.nlm.nih.gov/pubmed/18804145","type":"PUBMED","article":{"title":"Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice.","authors":["Kaneko K"," Hineno A"," Yoshida K"," Ikeda S."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18804145","id":"18804145","citationCount":11,"stringAuthors":"Kaneko K, Hineno A, Yoshida K, Ikeda S."}}],"name":"CP","targetParticipants":[{"idObject":0,"name":"CP","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CP","summary":null,"resource":"CP"}]},{"targetElements":[],"references":[{"resource":"24764117","link":"http://www.ncbi.nlm.nih.gov/pubmed/24764117","type":"PUBMED","article":{"title":"RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB.","authors":["Cheng SY"," Oh S"," Velasco M"," Ta C"," Montalvo J"," Calderone A."],"journal":"Journal of biochemical and molecular toxicology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24764117","id":"24764117","citationCount":1,"stringAuthors":"Cheng SY, Oh S, Velasco M, Ta C, Montalvo J, Calderone A."}}],"name":"DDIT4","targetParticipants":[{"idObject":0,"name":"DDIT4","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DDIT4","summary":null,"resource":"DDIT4"}]},{"targetElements":[],"references":[{"resource":"20887679","link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","type":"PUBMED","article":{"title":"Dopamine Dâ‚ÄÅ¼Ë and Dâ‚‚ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2,"stringAuthors":"Paul J, Nandhu MS, Kuruvilla KP, Paulose CS."}}],"name":"DRD1","targetParticipants":[{"idObject":0,"name":"DRD1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DRD1","summary":null,"resource":"DRD1"}]},{"targetElements":[],"references":[{"resource":"18289173","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH, Huang JY, Ching CH, Chuang JI."}},{"resource":"20887679","link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","type":"PUBMED","article":{"title":"Dopamine Dâ‚ÄÅ¼Ë and Dâ‚‚ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2,"stringAuthors":"Paul J, Nandhu MS, Kuruvilla KP, Paulose CS."}}],"name":"DRD2","targetParticipants":[{"idObject":0,"name":"DRD2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DRD2","summary":null,"resource":"DRD2"}]},{"targetElements":[],"references":[{"resource":"11078378","link":"http://www.ncbi.nlm.nih.gov/pubmed/11078378","type":"PUBMED","article":{"title":"Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro.","authors":["Yuki K"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Suzuki T"," Hayashi J"," Goto K"," Yamaguchi I."],"journal":"Journal of cardiovascular pharmacology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11078378","id":"11078378","citationCount":9,"stringAuthors":"Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Suzuki T, Hayashi J, Goto K, Yamaguchi I."}},{"resource":"11707688","link":"http://www.ncbi.nlm.nih.gov/pubmed/11707688","type":"PUBMED","article":{"title":"Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes.","authors":["Yuhki KI"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Maeda S"," Goto K"," Yamaguchi I"," Suzuki T."],"journal":"Journal of cardiovascular pharmacology","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11707688","id":"11707688","citationCount":7,"stringAuthors":"Yuhki KI, Miyauchi T, Kakinuma Y, Murakoshi N, Maeda S, Goto K, Yamaguchi I, Suzuki T."}},{"resource":"22928487","link":"http://www.ncbi.nlm.nih.gov/pubmed/22928487","type":"PUBMED","article":{"title":"Mitochondrial ROS-K+ channel signaling pathway regulated secretion of human pulmonary artery endothelial cells.","authors":["Ouyang JS"," Li YP"," Li CY"," Cai C"," Chen CS"," Chen SX"," Chen YF"," Yang L"," Xie YP."],"journal":"Free radical research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22928487","id":"22928487","citationCount":5,"stringAuthors":"Ouyang JS, Li YP, Li CY, Cai C, Chen CS, Chen SX, Chen YF, Yang L, Xie YP."}}],"name":"EDN1","targetParticipants":[{"idObject":0,"name":"EDN1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EDN1","summary":null,"resource":"EDN1"}]},{"targetElements":[],"references":[{"resource":"18646205","link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","type":"PUBMED","article":{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":13,"stringAuthors":"Yang D, Peng C, Li X, Fan X, Li L, Ming M, Chen S, Le W."}}],"name":"GDNF","targetParticipants":[{"idObject":0,"name":"GDNF","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GDNF","summary":null,"resource":"GDNF"}]},{"targetElements":[],"references":[{"resource":"23098804","link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","type":"PUBMED","article":{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":5,"stringAuthors":"Swarnkar S, Goswami P, Kamat PK, Patro IK, Singh S, Nath C."}}],"name":"GFAP","targetParticipants":[{"idObject":0,"name":"GFAP","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GFAP","summary":null,"resource":"GFAP"}]},{"targetElements":[],"references":[{"resource":"17079513","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17070561","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["SÃ¥nchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," BenedàJ."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"SÃ¥nchez-Reus MI, Gómez del Rio MA, Iglesias I, Elorza M, Slowing K, BenedàJ."}},{"resource":"15904944","link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","type":"PUBMED","article":{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-JimÊnez MF"," SÃ¥nchez-Reus MI"," Cascales M"," AndrÊs D"," BenedàJ."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":14,"stringAuthors":"Molina-JimÊnez MF, SÃ¥nchez-Reus MI, Cascales M, AndrÊs D, BenedàJ."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J, Liu W, Nakamura K, Berry MJ."}}],"name":"GPX1","targetParticipants":[{"idObject":0,"name":"GPX1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPX1","summary":null,"resource":"GPX1"}]},{"targetElements":[],"references":[{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}}],"name":"GSTA4","targetParticipants":[{"idObject":0,"name":"GSTA4","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSTA4","summary":null,"resource":"GSTA4"}]},{"targetElements":[],"references":[{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}}],"name":"GSTM1","targetParticipants":[{"idObject":0,"name":"GSTM1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSTM1","summary":null,"resource":"GSTM1"}]},{"targetElements":[],"references":[{"resource":"19131585","link":"http://www.ncbi.nlm.nih.gov/pubmed/19131585","type":"PUBMED","article":{"title":"Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.","authors":["Han Z"," Varadharaj S"," Giedt RJ"," Zweier JL"," Szeto HH"," Alevriadou BR."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19131585","id":"19131585","citationCount":34,"stringAuthors":"Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, Alevriadou BR."}},{"resource":"24451142","link":"http://www.ncbi.nlm.nih.gov/pubmed/24451142","type":"PUBMED","article":{"title":"Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy.","authors":["Lin TK"," Chen SD"," Chuang YC"," Lin HY"," Huang CR"," Chuang JH"," Wang PW"," Huang ST"," Tiao MM"," Chen JB"," Liou CW."],"journal":"International journal of molecular sciences","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24451142","id":"24451142","citationCount":27,"stringAuthors":"Lin TK, Chen SD, Chuang YC, Lin HY, Huang CR, Chuang JH, Wang PW, Huang ST, Tiao MM, Chen JB, Liou CW."}},{"resource":"17702527","link":"http://www.ncbi.nlm.nih.gov/pubmed/17702527","type":"PUBMED","article":{"title":"Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening.","authors":["Coe KJ"," Jia Y"," Ho HK"," Rademacher P"," Bammler TK"," Beyer RP"," Farin FM"," Woodke L"," Plymate SR"," Fausto N"," Nelson SD."],"journal":"Chemical research in toxicology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17702527","id":"17702527","citationCount":23,"stringAuthors":"Coe KJ, Jia Y, Ho HK, Rademacher P, Bammler TK, Beyer RP, Farin FM, Woodke L, Plymate SR, Fausto N, Nelson SD."}},{"resource":"22659318","link":"http://www.ncbi.nlm.nih.gov/pubmed/22659318","type":"PUBMED","article":{"title":"Cadmium-induced apoptosis in the BJAB human B cell line: involvement of PKC/ERK1/2/JNK signaling pathways in HO-1 expression.","authors":["Nemmiche S"," Chabane-Sari D"," Kadri M"," Guiraud P."],"journal":"Toxicology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22659318","id":"22659318","citationCount":16,"stringAuthors":"Nemmiche S, Chabane-Sari D, Kadri M, Guiraud P."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J, Liu W, Nakamura K, Berry MJ."}},{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}},{"resource":"26276080","link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","type":"PUBMED","article":{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":3,"stringAuthors":"Qin J, Wu M, Yu S, Gao X, Zhang J, Dong X, Ji J, Zhang Y, Zhou L, Zhang Q, Ding F."}}],"name":"HMOX1","targetParticipants":[{"idObject":0,"name":"HMOX1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX1","summary":null,"resource":"HMOX1"}]},{"targetElements":[],"references":[{"resource":"27979718","link":"http://www.ncbi.nlm.nih.gov/pubmed/27979718","type":"PUBMED","article":{"title":"Neonatal rotenone lesions cause onset of hyperactivity during juvenile and adulthood in the rat.","authors":["Ishido M"," Suzuki J"," Masuo Y."],"journal":"Toxicology letters","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27979718","id":"27979718","citationCount":0,"stringAuthors":"Ishido M, Suzuki J, Masuo Y."}}],"name":"HSPA1A","targetParticipants":[{"idObject":0,"name":"HSPA1A","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA1A","summary":null,"resource":"HSPA1A"}]},{"targetElements":[],"references":[{"resource":"16565515","link":"http://www.ncbi.nlm.nih.gov/pubmed/16565515","type":"PUBMED","article":{"title":"Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.","authors":["Jin J"," Hulette C"," Wang Y"," Zhang T"," Pan C"," Wadhwa R"," Zhang J."],"journal":"Molecular & cellular proteomics : MCP","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16565515","id":"16565515","citationCount":110,"stringAuthors":"Jin J, Hulette C, Wang Y, Zhang T, Pan C, Wadhwa R, Zhang J."}},{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}}],"name":"HSPA9","targetParticipants":[{"idObject":0,"name":"HSPA9","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA9","summary":null,"resource":"HSPA9"}]},{"targetElements":[],"references":[{"resource":"27900601","link":"http://www.ncbi.nlm.nih.gov/pubmed/27900601","type":"PUBMED","article":{"title":"RNA-Seq Expression Analysis of Enteric Neuron Cells with Rotenone Treatment and Prediction of Regulated Pathways.","authors":["Guan Q"," Wang X"," Jiang Y"," Zhao L"," Nie Z"," Jin L."],"journal":"Neurochemical research","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27900601","id":"27900601","citationCount":0,"stringAuthors":"Guan Q, Wang X, Jiang Y, Zhao L, Nie Z, Jin L."}}],"name":"IGF2","targetParticipants":[{"idObject":0,"name":"IGF2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IGF2","summary":null,"resource":"IGF2"}]},{"targetElements":[],"references":[{"resource":"11950692","link":"http://www.ncbi.nlm.nih.gov/pubmed/11950692","type":"PUBMED","article":{"title":"Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia.","authors":["Pearlstein DP"," Ali MH"," Mungai PT"," Hynes KL"," Gewertz BL"," Schumacker PT."],"journal":"Arteriosclerosis, thrombosis, and vascular biology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11950692","id":"11950692","citationCount":54,"stringAuthors":"Pearlstein DP, Ali MH, Mungai PT, Hynes KL, Gewertz BL, Schumacker PT."}},{"resource":"15135310","link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","type":"PUBMED","article":{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":27,"stringAuthors":"McMillian M, Nie AY, Parker JB, Leone A, Kemmerer M, Bryant S, Herlich J, Yieh L, Bittner A, Liu X, Wan J, Johnson MD."}},{"resource":"16837928","link":"http://www.ncbi.nlm.nih.gov/pubmed/16837928","type":"PUBMED","article":{"title":"Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells.","authors":["Ishola DA"," Post JA"," van Timmeren MM"," Bakker SJ"," Goldschmeding R"," Koomans HA"," Braam B"," Joles JA."],"journal":"Kidney international","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16837928","id":"16837928","citationCount":26,"stringAuthors":"Ishola DA, Post JA, van Timmeren MM, Bakker SJ, Goldschmeding R, Koomans HA, Braam B, Joles JA."}},{"resource":"19635391","link":"http://www.ncbi.nlm.nih.gov/pubmed/19635391","type":"PUBMED","article":{"title":"Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.","authors":["Monroe RK"," Halvorsen SW."],"journal":"Neurotoxicology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19635391","id":"19635391","citationCount":16,"stringAuthors":"Monroe RK, Halvorsen SW."}},{"resource":"22745725","link":"http://www.ncbi.nlm.nih.gov/pubmed/22745725","type":"PUBMED","article":{"title":"Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.","authors":["Paulus P"," Ockelmann P"," Tacke S"," Karnowski N"," Ellinghaus P"," Scheller B"," Holfeld J"," Urbschat A"," Zacharowski K."],"journal":"PloS one","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22745725","id":"22745725","citationCount":10,"stringAuthors":"Paulus P, Ockelmann P, Tacke S, Karnowski N, Ellinghaus P, Scheller B, Holfeld J, Urbschat A, Zacharowski K."}},{"resource":"24830863","link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","type":"PUBMED","article":{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":8,"stringAuthors":"Ai Q, Jing Y, Jiang R, Lin L, Dai J, Che Q, Zhou D, Jia M, Wan J, Zhang L."}},{"resource":"23867654","link":"http://www.ncbi.nlm.nih.gov/pubmed/23867654","type":"PUBMED","article":{"title":"Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes.","authors":["Kim NH"," Hong BK"," Choi SY"," Moo Kwon H"," Cho CS"," Yi EC"," Kim WU."],"journal":"Experimental & molecular medicine","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23867654","id":"23867654","citationCount":5,"stringAuthors":"Kim NH, Hong BK, Choi SY, Moo Kwon H, Cho CS, Yi EC, Kim WU."}}],"name":"IL6","targetParticipants":[{"idObject":0,"name":"IL6","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IL6","summary":null,"resource":"IL6"}]},{"targetElements":[],"references":[{"resource":"18619942","link":"http://www.ncbi.nlm.nih.gov/pubmed/18619942","type":"PUBMED","article":{"title":"Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway.","authors":["Wang G"," Zeng J"," Shen CY"," Wang ZQ"," Chen SD."],"journal":"Biochemical and biophysical research communications","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18619942","id":"18619942","citationCount":3,"stringAuthors":"Wang G, Zeng J, Shen CY, Wang ZQ, Chen SD."}}],"name":"KCNJ4","targetParticipants":[{"idObject":0,"name":"KCNJ4","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=KCNJ4","summary":null,"resource":"KCNJ4"}]},{"targetElements":[],"references":[{"resource":"19625511","link":"http://www.ncbi.nlm.nih.gov/pubmed/19625511","type":"PUBMED","article":{"title":"LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.","authors":["Saha S"," Guillily MD"," Ferree A"," Lanceta J"," Chan D"," Ghosh J"," Hsu CH"," Segal L"," Raghavan K"," Matsumoto K"," Hisamoto N"," Kuwahara T"," Iwatsubo T"," Moore L"," Goldstein L"," Cookson M"," Wolozin B."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19625511","id":"19625511","citationCount":97,"stringAuthors":"Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B."}},{"resource":"19741132","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL."}},{"resource":"19692353","link":"http://www.ncbi.nlm.nih.gov/pubmed/19692353","type":"PUBMED","article":{"title":"Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.","authors":["Venderova K"," Kabbach G"," Abdel-Messih E"," Zhang Y"," Parks RJ"," Imai Y"," Gehrke S"," Ngsee J"," Lavoie MJ"," Slack RS"," Rao Y"," Zhang Z"," Lu B"," Haque ME"," Park DS."],"journal":"Human molecular genetics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19692353","id":"19692353","citationCount":78,"stringAuthors":"Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS."}},{"resource":"18322385","link":"http://www.ncbi.nlm.nih.gov/pubmed/18322385","type":"PUBMED","article":{"title":"Investigating convergent actions of genes linked to familial Parkinson's disease.","authors":["Wolozin B"," Saha S"," Guillily M"," Ferree A"," Riley M."],"journal":"Neuro-degenerative diseases","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18322385","id":"18322385","citationCount":19,"stringAuthors":"Wolozin B, Saha S, Guillily M, Ferree A, Riley M."}}],"name":"LRRK2","targetParticipants":[{"idObject":0,"name":"LRRK2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LRRK2","summary":null,"resource":"LRRK2"}]},{"targetElements":[],"references":[{"resource":"16449798","link":"http://www.ncbi.nlm.nih.gov/pubmed/16449798","type":"PUBMED","article":{"title":"Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.","authors":["Hsieh CC"," Papaconstantinou J."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16449798","id":"16449798","citationCount":84,"stringAuthors":"Hsieh CC, Papaconstantinou J."}}],"name":"MAP3K5","targetParticipants":[{"idObject":0,"name":"MAP3K5","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MAP3K5","summary":null,"resource":"MAP3K5"}]},{"targetElements":[],"references":[{"resource":"16219024","link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","type":"PUBMED","article":{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":76,"stringAuthors":"Höglinger GU, Lannuzel A, Khondiker ME, Michel PP, Duyckaerts C, Féger J, Champy P, Prigent A, Medja F, Lombes A, Oertel WH, Ruberg M, Hirsch EC."}},{"resource":"16930453","link":"http://www.ncbi.nlm.nih.gov/pubmed/16930453","type":"PUBMED","article":{"title":"Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.","authors":["Dickey CA"," Ash P"," Klosak N"," Lee WC"," Petrucelli L"," Hutton M"," Eckman CB."],"journal":"Molecular neurodegeneration","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16930453","id":"16930453","citationCount":17,"stringAuthors":"Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB."}}],"name":"MAPT","targetParticipants":[{"idObject":0,"name":"MAPT","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MAPT","summary":null,"resource":"MAPT"}]},{"targetElements":[],"references":[{"resource":"24374061","link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","type":"PUBMED","article":{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":12,"stringAuthors":"Corona JC, de Souza SC, Duchen MR."}},{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}}],"name":"NQO1","targetParticipants":[{"idObject":0,"name":"NQO1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NQO1","summary":null,"resource":"NQO1"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR."}},{"resource":"19741132","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL."}},{"resource":"16573651","link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","type":"PUBMED","article":{"title":"Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.","authors":["Casarejos MJ"," Menéndez J"," Solano RM"," RodrÃÂÂguez-Navarro JA"," GarcÃÂÂa de Yébenes J"," Mena MA."],"journal":"Journal of neurochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","id":"16573651","citationCount":66,"stringAuthors":"Casarejos MJ, Menéndez J, Solano RM, RodrÃÂÂguez-Navarro JA, GarcÃÂÂa de Yébenes J, Mena MA."}},{"resource":"22872702","link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","type":"PUBMED","article":{"title":"ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.","authors":["Joselin AP"," Hewitt SJ"," Callaghan SM"," Kim RH"," Chung YH"," Mak TW"," Shen J"," Slack RS"," Park DS."],"journal":"Human molecular genetics","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","id":"22872702","citationCount":59,"stringAuthors":"Joselin AP, Hewitt SJ, Callaghan SM, Kim RH, Chung YH, Mak TW, Shen J, Slack RS, Park DS."}},{"resource":"17687034","link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","type":"PUBMED","article":{"title":"Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.","authors":["Wang C"," Lu R"," Ouyang X"," Ho MW"," Chia W"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","id":"17687034","citationCount":52,"stringAuthors":"Wang C, Lu R, Ouyang X, Ho MW, Chia W, Yu F, Lim KL."}},{"resource":"16517603","link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","type":"PUBMED","article":{"title":"Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.","authors":["Rosen KM"," Veereshwarayya V"," Moussa CE"," Fu Q"," Goldberg MS"," Schlossmacher MG"," Shen J"," Querfurth HW."],"journal":"The Journal of Biological Chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","id":"16517603","citationCount":45,"stringAuthors":"Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW."}}],"name":"PARK2","targetParticipants":[{"idObject":0,"name":"PARK2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PARK2","summary":null,"resource":"PARK2"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR."}},{"resource":"16439141","link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","type":"PUBMED","article":{"title":"Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":131,"stringAuthors":"Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, Cookson MR, Greenamyre JT."}},{"resource":"17459145","link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","type":"PUBMED","article":{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":68,"stringAuthors":"Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, Taniguchi T, Yoshimoto K, Kaneko M, Okuma Y, Taira T, Ariga H, Shimohama S."}},{"resource":"18377993","link":"http://www.ncbi.nlm.nih.gov/pubmed/18377993","type":"PUBMED","article":{"title":"Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.","authors":["Lev N"," Ickowicz D"," Melamed E"," Offen D."],"journal":"Neurotoxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18377993","id":"18377993","citationCount":59,"stringAuthors":"Lev N, Ickowicz D, Melamed E, Offen D."}},{"resource":"18331584","link":"http://www.ncbi.nlm.nih.gov/pubmed/18331584","type":"PUBMED","article":{"title":"Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease.","authors":["Liu F"," Nguyen JL"," Hulleman JD"," Li L"," Rochet JC."],"journal":"Journal of neurochemistry","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18331584","id":"18331584","citationCount":48,"stringAuthors":"Liu F, Nguyen JL, Hulleman JD, Li L, Rochet JC."}},{"resource":"18930142","link":"http://www.ncbi.nlm.nih.gov/pubmed/18930142","type":"PUBMED","article":{"title":"DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone.","authors":["Mullett SJ"," Hinkle DA."],"journal":"Neurobiology of disease","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18930142","id":"18930142","citationCount":43,"stringAuthors":"Mullett SJ, Hinkle DA."}},{"resource":"16624565","link":"http://www.ncbi.nlm.nih.gov/pubmed/16624565","type":"PUBMED","article":{"title":"Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase.","authors":["Pisani A"," Martella G"," Tscherter A"," Costa C"," Mercuri NB"," Bernardi G"," Shen J"," Calabresi P."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16624565","id":"16624565","citationCount":23,"stringAuthors":"Pisani A, Martella G, Tscherter A, Costa C, Mercuri NB, Bernardi G, Shen J, Calabresi P."}},{"resource":"22898350","link":"http://www.ncbi.nlm.nih.gov/pubmed/22898350","type":"PUBMED","article":{"title":"DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy.","authors":["Gao H"," Yang W"," Qi Z"," Lu L"," Duan C"," Zhao C"," Yang H."],"journal":"Journal of molecular biology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22898350","id":"22898350","citationCount":21,"stringAuthors":"Gao H, Yang W, Qi Z, Lu L, Duan C, Zhao C, Yang H."}},{"resource":"19063952","link":"http://www.ncbi.nlm.nih.gov/pubmed/19063952","type":"PUBMED","article":{"title":"Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.","authors":["Ashley AK"," Hanneman WH"," Katoh T"," Moreno JA"," Pollack A"," Tjalkens RB"," Legare ME."],"journal":"Toxicology letters","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19063952","id":"19063952","citationCount":15,"stringAuthors":"Ashley AK, Hanneman WH, Katoh T, Moreno JA, Pollack A, Tjalkens RB, Legare ME."}}],"name":"PARK7","targetParticipants":[{"idObject":0,"name":"PARK7","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PARK7","summary":null,"resource":"PARK7"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR."}},{"resource":"19492085","link":"http://www.ncbi.nlm.nih.gov/pubmed/19492085","type":"PUBMED","article":{"title":"Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.","authors":["Sandebring A"," Thomas KJ"," Beilina A"," van der Brug M"," Cleland MM"," Ahmad R"," Miller DW"," Zambrano I"," Cowburn RF"," Behbahani H"," Cedazo-MÃÂÂnguez A"," Cookson MR."],"journal":"PloS one","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19492085","id":"19492085","citationCount":93,"stringAuthors":"Sandebring A, Thomas KJ, Beilina A, van der Brug M, Cleland MM, Ahmad R, Miller DW, Zambrano I, Cowburn RF, Behbahani H, Cedazo-MÃÂÂnguez A, Cookson MR."}},{"resource":"16226715","link":"http://www.ncbi.nlm.nih.gov/pubmed/16226715","type":"PUBMED","article":{"title":"Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.","authors":["Deng H"," Jankovic J"," Guo Y"," Xie W"," Le W."],"journal":"Biochemical and biophysical research communications","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16226715","id":"16226715","citationCount":72,"stringAuthors":"Deng H, Jankovic J, Guo Y, Xie W, Le W."}},{"resource":"21421046","link":"http://www.ncbi.nlm.nih.gov/pubmed/21421046","type":"PUBMED","article":{"title":"PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.","authors":["Wang HL"," Chou AH"," Wu AS"," Chen SY"," Weng YH"," Kao YC"," Yeh TH"," Chu PJ"," Lu CS."],"journal":"Biochimica et biophysica acta","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21421046","id":"21421046","citationCount":40,"stringAuthors":"Wang HL, Chou AH, Wu AS, Chen SY, Weng YH, Kao YC, Yeh TH, Chu PJ, Lu CS."}},{"resource":"20464527","link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","type":"PUBMED","article":{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":14,"stringAuthors":"George S, Mok SS, Nurjono M, Ayton S, Finkelstein DI, Masters CL, Li QX, Culvenor JG."}}],"name":"PINK1","targetParticipants":[{"idObject":0,"name":"PINK1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PINK1","summary":null,"resource":"PINK1"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR."}},{"resource":"19741132","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL."}},{"resource":"16573651","link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","type":"PUBMED","article":{"title":"Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.","authors":["Casarejos MJ"," Menéndez J"," Solano RM"," RodrÃÂÂguez-Navarro JA"," GarcÃÂÂa de Yébenes J"," Mena MA."],"journal":"Journal of neurochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","id":"16573651","citationCount":66,"stringAuthors":"Casarejos MJ, Menéndez J, Solano RM, RodrÃÂÂguez-Navarro JA, GarcÃÂÂa de Yébenes J, Mena MA."}},{"resource":"22872702","link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","type":"PUBMED","article":{"title":"ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.","authors":["Joselin AP"," Hewitt SJ"," Callaghan SM"," Kim RH"," Chung YH"," Mak TW"," Shen J"," Slack RS"," Park DS."],"journal":"Human molecular genetics","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","id":"22872702","citationCount":59,"stringAuthors":"Joselin AP, Hewitt SJ, Callaghan SM, Kim RH, Chung YH, Mak TW, Shen J, Slack RS, Park DS."}},{"resource":"17687034","link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","type":"PUBMED","article":{"title":"Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.","authors":["Wang C"," Lu R"," Ouyang X"," Ho MW"," Chia W"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","id":"17687034","citationCount":52,"stringAuthors":"Wang C, Lu R, Ouyang X, Ho MW, Chia W, Yu F, Lim KL."}},{"resource":"16517603","link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","type":"PUBMED","article":{"title":"Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.","authors":["Rosen KM"," Veereshwarayya V"," Moussa CE"," Fu Q"," Goldberg MS"," Schlossmacher MG"," Shen J"," Querfurth HW."],"journal":"The Journal of Biological Chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","id":"16517603","citationCount":45,"stringAuthors":"Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW."}}],"name":"PRKN","targetParticipants":[{"idObject":0,"name":"PRKN","type":"HGNC Symbol","link":null,"summary":null,"resource":"PRKN"}]},{"targetElements":[],"references":[{"resource":"21383081","link":"http://www.ncbi.nlm.nih.gov/pubmed/21383081","type":"PUBMED","article":{"title":"Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model.","authors":["Choi WS"," Palmiter RD"," Xia Z."],"journal":"The Journal of cell biology","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21383081","id":"21383081","citationCount":65,"stringAuthors":"Choi WS, Palmiter RD, Xia Z."}},{"resource":"18579341","link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","type":"PUBMED","article":{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":27,"stringAuthors":"Sai Y, Wu Q, Le W, Ye F, Li Y, Dong Z."}},{"resource":"26276080","link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","type":"PUBMED","article":{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":3,"stringAuthors":"Qin J, Wu M, Yu S, Gao X, Zhang J, Dong X, Ji J, Zhang Y, Zhou L, Zhang Q, Ding F."}},{"resource":"25496994","link":"http://www.ncbi.nlm.nih.gov/pubmed/25496994","type":"PUBMED","article":{"title":"JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.","authors":["Choi WS"," Kim HW"," Xia Z."],"journal":"Toxicology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25496994","id":"25496994","citationCount":2,"stringAuthors":"Choi WS, Kim HW, Xia Z."}}],"name":"SLC18A2","targetParticipants":[{"idObject":0,"name":"SLC18A2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SLC18A2","summary":null,"resource":"SLC18A2"}]},{"targetElements":[],"references":[{"resource":"18289173","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH, Huang JY, Ching CH, Chuang JI."}},{"resource":"18579341","link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","type":"PUBMED","article":{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":27,"stringAuthors":"Sai Y, Wu Q, Le W, Ye F, Li Y, Dong Z."}},{"resource":"23567316","link":"http://www.ncbi.nlm.nih.gov/pubmed/23567316","type":"PUBMED","article":{"title":"Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life.","authors":["Tien LT"," Kaizaki A"," Pang Y"," Cai Z"," Bhatt AJ"," Fan LW."],"journal":"Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23567316","id":"23567316","citationCount":6,"stringAuthors":"Tien LT, Kaizaki A, Pang Y, Cai Z, Bhatt AJ, Fan LW."}},{"resource":"18206288","link":"http://www.ncbi.nlm.nih.gov/pubmed/18206288","type":"PUBMED","article":{"title":"The role of dopamine transporter in selective toxicity of manganese and rotenone.","authors":["Hirata Y"," Suzuno H"," Tsuruta T"," Oh-hashi K"," Kiuchi K."],"journal":"Toxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18206288","id":"18206288","citationCount":4,"stringAuthors":"Hirata Y, Suzuno H, Tsuruta T, Oh-hashi K, Kiuchi K."}}],"name":"SLC6A3","targetParticipants":[{"idObject":0,"name":"SLC6A3","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SLC6A3","summary":null,"resource":"SLC6A3"}]},{"targetElements":[],"references":[{"resource":"11100151","link":"http://www.ncbi.nlm.nih.gov/pubmed/11100151","type":"PUBMED","article":{"title":"Chronic systemic pesticide exposure reproduces features of Parkinson's disease.","authors":["Betarbet R"," Sherer TB"," MacKenzie G"," Garcia-Osuna M"," Panov AV"," Greenamyre JT."],"journal":"Nature neuroscience","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11100151","id":"11100151","citationCount":1330,"stringAuthors":"Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT."}},{"resource":"12177198","link":"http://www.ncbi.nlm.nih.gov/pubmed/12177198","type":"PUBMED","article":{"title":"An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.","authors":["Sherer TB"," Betarbet R"," Stout AK"," Lund S"," Baptista M"," Panov AV"," Cookson MR"," Greenamyre JT."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12177198","id":"12177198","citationCount":240,"stringAuthors":"Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT."}},{"resource":"16439141","link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","type":"PUBMED","article":{"title":"Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":131,"stringAuthors":"Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, Cookson MR, Greenamyre JT."}},{"resource":"11445065","link":"http://www.ncbi.nlm.nih.gov/pubmed/11445065","type":"PUBMED","article":{"title":"Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.","authors":["Uversky VN"," Li J"," Fink AL."],"journal":"FEBS letters","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11445065","id":"11445065","citationCount":124,"stringAuthors":"Uversky VN, Li J, Fink AL."}},{"resource":"16239214","link":"http://www.ncbi.nlm.nih.gov/pubmed/16239214","type":"PUBMED","article":{"title":"Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.","authors":["Ved R"," Saha S"," Westlund B"," Perier C"," Burnam L"," Sluder A"," Hoener M"," Rodrigues CM"," Alfonso A"," Steer C"," Liu L"," Przedborski S"," Wolozin B."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239214","id":"16239214","citationCount":120,"stringAuthors":"Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B."}},{"resource":"24290359","link":"http://www.ncbi.nlm.nih.gov/pubmed/24290359","type":"PUBMED","article":{"title":"Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.","authors":["Ryan SD"," Dolatabadi N"," Chan SF"," Zhang X"," Akhtar MW"," Parker J"," Soldner F"," Sunico CR"," Nagar S"," Talantova M"," Lee B"," Lopez K"," Nutter A"," Shan B"," Molokanova E"," Zhang Y"," Han X"," Nakamura T"," Masliah E"," Yates JR"," Nakanishi N"," Andreyev AY"," Okamoto S"," Jaenisch R"," Ambasudhan R"," Lipton SA."],"journal":"Cell","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24290359","id":"24290359","citationCount":88,"stringAuthors":"Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Nakamura T, Masliah E, Yates JR, Nakanishi N, Andreyev AY, Okamoto S, Jaenisch R, Ambasudhan R, Lipton SA."}},{"resource":"16219024","link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","type":"PUBMED","article":{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":76,"stringAuthors":"Höglinger GU, Lannuzel A, Khondiker ME, Michel PP, Duyckaerts C, Féger J, Champy P, Prigent A, Medja F, Lombes A, Oertel WH, Ruberg M, Hirsch EC."}},{"resource":"23205266","link":"http://www.ncbi.nlm.nih.gov/pubmed/23205266","type":"PUBMED","article":{"title":"Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice.","authors":["Pan-Montojo F"," Schwarz M"," Winkler C"," Arnhold M"," O'Sullivan GA"," Pal A"," Said J"," Marsico G"," Verbavatz JM"," Rodrigo-Angulo M"," Gille G"," Funk RH"," Reichmann H."],"journal":"Scientific reports","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23205266","id":"23205266","citationCount":71,"stringAuthors":"Pan-Montojo F, Schwarz M, Winkler C, Arnhold M, O'Sullivan GA, Pal A, Said J, Marsico G, Verbavatz JM, Rodrigo-Angulo M, Gille G, Funk RH, Reichmann H."}},{"resource":"17459145","link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","type":"PUBMED","article":{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":68,"stringAuthors":"Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, Taniguchi T, Yoshimoto K, Kaneko M, Okuma Y, Taira T, Ariga H, Shimohama S."}},{"resource":"19628769","link":"http://www.ncbi.nlm.nih.gov/pubmed/19628769","type":"PUBMED","article":{"title":"Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.","authors":["Yu WH"," Dorado B"," Figueroa HY"," Wang L"," Planel E"," Cookson MR"," Clark LN"," Duff KE."],"journal":"The American journal of pathology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19628769","id":"19628769","citationCount":65,"stringAuthors":"Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE."}},{"resource":"18514418","link":"http://www.ncbi.nlm.nih.gov/pubmed/18514418","type":"PUBMED","article":{"title":"Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells.","authors":["Shavali S"," Brown-Borg HM"," Ebadi M"," Porter J."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18514418","id":"18514418","citationCount":62,"stringAuthors":"Shavali S, Brown-Borg HM, Ebadi M, Porter J."}},{"resource":"17131421","link":"http://www.ncbi.nlm.nih.gov/pubmed/17131421","type":"PUBMED","article":{"title":"RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.","authors":["Fountaine TM"," Wade-Martins R."],"journal":"Journal of neuroscience research","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131421","id":"17131421","citationCount":56,"stringAuthors":"Fountaine TM, Wade-Martins R."}},{"resource":"19626387","link":"http://www.ncbi.nlm.nih.gov/pubmed/19626387","type":"PUBMED","article":{"title":"Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.","authors":["Monti B"," Gatta V"," Piretti F"," Raffaelli SS"," Virgili M"," Contestabile A."],"journal":"Neurotoxicity research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19626387","id":"19626387","citationCount":49,"stringAuthors":"Monti B, Gatta V, Piretti F, Raffaelli SS, Virgili M, Contestabile A."}},{"resource":"15099020","link":"http://www.ncbi.nlm.nih.gov/pubmed/15099020","type":"PUBMED","article":{"title":"Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.","authors":["Dalfó E"," Gómez-Isla T"," Rosa JL"," Nieto Bodelón M"," Cuadrado Tejedor M"," Barrachina M"," Ambrosio S"," Ferrer I."],"journal":"Journal of neuropathology and experimental neurology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15099020","id":"15099020","citationCount":45,"stringAuthors":"Dalfó E, Gómez-Isla T, Rosa JL, Nieto Bodelón M, Cuadrado Tejedor M, Barrachina M, Ambrosio S, Ferrer I."}},{"resource":"19114014","link":"http://www.ncbi.nlm.nih.gov/pubmed/19114014","type":"PUBMED","article":{"title":"Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells.","authors":["Borland MK"," Trimmer PA"," Rubinstein JD"," Keeney PM"," Mohanakumar K"," Liu L"," Bennett JP."],"journal":"Molecular neurodegeneration","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19114014","id":"19114014","citationCount":44,"stringAuthors":"Borland MK, Trimmer PA, Rubinstein JD, Keeney PM, Mohanakumar K, Liu L, Bennett JP."}},{"resource":"18289173","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH, Huang JY, Ching CH, Chuang JI."}},{"resource":"15280438","link":"http://www.ncbi.nlm.nih.gov/pubmed/15280438","type":"PUBMED","article":{"title":"Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells.","authors":["Watabe M"," Nakaki T."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15280438","id":"15280438","citationCount":27,"stringAuthors":"Watabe M, Nakaki T."}},{"resource":"15114628","link":"http://www.ncbi.nlm.nih.gov/pubmed/15114628","type":"PUBMED","article":{"title":"1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells.","authors":["Shavali S"," Carlson EC"," Swinscoe JC"," Ebadi M."],"journal":"Journal of neuroscience research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15114628","id":"15114628","citationCount":23,"stringAuthors":"Shavali S, Carlson EC, Swinscoe JC, Ebadi M."}},{"resource":"19857570","link":"http://www.ncbi.nlm.nih.gov/pubmed/19857570","type":"PUBMED","article":{"title":"Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.","authors":["Kalivendi SV"," Yedlapudi D"," Hillard CJ"," Kalyanaraman B."],"journal":"Free radical biology & medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19857570","id":"19857570","citationCount":22,"stringAuthors":"Kalivendi SV, Yedlapudi D, Hillard CJ, Kalyanaraman B."}},{"resource":"20414966","link":"http://www.ncbi.nlm.nih.gov/pubmed/20414966","type":"PUBMED","article":{"title":"Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.","authors":["Zhang H"," Jia H"," Liu J"," Ao N"," Yan B"," Shen W"," Wang X"," Li X"," Luo C"," Liu J."],"journal":"Journal of cellular and molecular medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20414966","id":"20414966","citationCount":21,"stringAuthors":"Zhang H, Jia H, Liu J, Ao N, Yan B, Shen W, Wang X, Li X, Luo C, Liu J."}},{"resource":"23153578","link":"http://www.ncbi.nlm.nih.gov/pubmed/23153578","type":"PUBMED","article":{"title":"Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.","authors":["Cannon JR"," Geghman KD"," Tapias V"," Sew T"," Dail MK"," Li C"," Greenamyre JT."],"journal":"Experimental neurology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23153578","id":"23153578","citationCount":17,"stringAuthors":"Cannon JR, Geghman KD, Tapias V, Sew T, Dail MK, Li C, Greenamyre JT."}},{"resource":"20464527","link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","type":"PUBMED","article":{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":14,"stringAuthors":"George S, Mok SS, Nurjono M, Ayton S, Finkelstein DI, Masters CL, Li QX, Culvenor JG."}},{"resource":"12151787","link":"http://www.ncbi.nlm.nih.gov/pubmed/12151787","type":"PUBMED","article":{"title":"Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro.","authors":["Lehmensiek V"," Tan EM"," Schwarz J"," Storch A."],"journal":"Neuroreport","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12151787","id":"12151787","citationCount":13,"stringAuthors":"Lehmensiek V, Tan EM, Schwarz J, Storch A."}},{"resource":"23535362","link":"http://www.ncbi.nlm.nih.gov/pubmed/23535362","type":"PUBMED","article":{"title":"Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.","authors":["Chorfa A"," Bétemps D"," Morignat E"," Lazizzera C"," Hogeveen K"," Andrieu T"," Baron T."],"journal":"Toxicological sciences : an official journal of the Society of Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23535362","id":"23535362","citationCount":11,"stringAuthors":"Chorfa A, Bétemps D, Morignat E, Lazizzera C, Hogeveen K, Andrieu T, Baron T."}},{"resource":"26075822","link":"http://www.ncbi.nlm.nih.gov/pubmed/26075822","type":"PUBMED","article":{"title":"shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.","authors":["Zharikov AD"," Cannon JR"," Tapias V"," Bai Q"," Horowitz MP"," Shah V"," El Ayadi A"," Hastings TG"," Greenamyre JT"," Burton EA."],"journal":"The Journal of clinical investigation","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26075822","id":"26075822","citationCount":9,"stringAuthors":"Zharikov AD, Cannon JR, Tapias V, Bai Q, Horowitz MP, Shah V, El Ayadi A, Hastings TG, Greenamyre JT, Burton EA."}},{"resource":"23984410","link":"http://www.ncbi.nlm.nih.gov/pubmed/23984410","type":"PUBMED","article":{"title":"Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition.","authors":["Sala G"," Arosio A"," Stefanoni G"," Melchionda L"," Riva C"," Marinig D"," Brighina L"," Ferrarese C."],"journal":"BioMed Research International","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23984410","id":"23984410","citationCount":8,"stringAuthors":"Sala G, Arosio A, Stefanoni G, Melchionda L, Riva C, Marinig D, Brighina L, Ferrarese C."}},{"resource":"17690729","link":"http://www.ncbi.nlm.nih.gov/pubmed/17690729","type":"PUBMED","article":{"title":"alpha-Synuclein redistributed and aggregated in rotenone-induced Parkinson's disease rats.","authors":["Feng Y"," Liang ZH"," Wang T"," Qiao X"," Liu HJ"," Sun SG."],"journal":"Neuroscience bulletin","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17690729","id":"17690729","citationCount":8,"stringAuthors":"Feng Y, Liang ZH, Wang T, Qiao X, Liu HJ, Sun SG."}},{"resource":"25433145","link":"http://www.ncbi.nlm.nih.gov/pubmed/25433145","type":"PUBMED","article":{"title":"The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway.","authors":["Yuan YH"," Yan WF"," Sun JD"," Huang JY"," Mu Z"," Chen NH."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25433145","id":"25433145","citationCount":8,"stringAuthors":"Yuan YH, Yan WF, Sun JD, Huang JY, Mu Z, Chen NH."}},{"resource":"26031332","link":"http://www.ncbi.nlm.nih.gov/pubmed/26031332","type":"PUBMED","article":{"title":"Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.","authors":["Hou YS"," Guan JJ"," Xu HD"," Wu F"," Sheng R"," Qin ZH."],"journal":"Molecular and cellular biology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26031332","id":"26031332","citationCount":5,"stringAuthors":"Hou YS, Guan JJ, Xu HD, Wu F, Sheng R, Qin ZH."}},{"resource":"23244436","link":"http://www.ncbi.nlm.nih.gov/pubmed/23244436","type":"PUBMED","article":{"title":"Environmental toxicants as extrinsic epigenetic factors for parkinsonism: studies employing transgenic C. elegans model.","authors":["Jadiya P"," Nazir A."],"journal":"CNS & neurological disorders drug targets","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23244436","id":"23244436","citationCount":5,"stringAuthors":"Jadiya P, Nazir A."}},{"resource":"25430725","link":"http://www.ncbi.nlm.nih.gov/pubmed/25430725","type":"PUBMED","article":{"title":"Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson's disease male Wistar rat model and effect of melatonin administration.","authors":["Mattam U"," Jagota A."],"journal":"Biogerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25430725","id":"25430725","citationCount":3,"stringAuthors":"Mattam U, Jagota A."}},{"resource":"27133439","link":"http://www.ncbi.nlm.nih.gov/pubmed/27133439","type":"PUBMED","article":{"title":"Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.","authors":["Sala G"," Marinig D"," Riva C"," Arosio A"," Stefanoni G"," Brighina L"," Formenti M"," Alberghina L"," Colangelo AM"," Ferrarese C."],"journal":"Neurotoxicology","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27133439","id":"27133439","citationCount":2,"stringAuthors":"Sala G, Marinig D, Riva C, Arosio A, Stefanoni G, Brighina L, Formenti M, Alberghina L, Colangelo AM, Ferrarese C."}},{"resource":"24002177","link":"http://www.ncbi.nlm.nih.gov/pubmed/24002177","type":"PUBMED","article":{"title":"14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity might be via its isoform 14-3-3epsilon's involvement in autophagy.","authors":["Sai Y"," Peng K"," Ye F"," Zhao X"," Zhao Y"," Zou Z"," Cao J"," Dong Z."],"journal":"Cellular and molecular neurobiology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24002177","id":"24002177","citationCount":1,"stringAuthors":"Sai Y, Peng K, Ye F, Zhao X, Zhao Y, Zou Z, Cao J, Dong Z."}},{"resource":"17041725","link":"http://www.ncbi.nlm.nih.gov/pubmed/17041725","type":"PUBMED","article":{"title":"[Overexpression of alpha-synuclein in SH-SY5Y cells partially protected against oxidative stress induced by rotenone].","authors":["Liu YY"," Zhao HY"," Zhao CL"," Duan CL"," Lu LL"," Yang H."],"journal":"Sheng li xue bao : [Acta physiologica Sinica]","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17041725","id":"17041725","citationCount":0,"stringAuthors":"Liu YY, Zhao HY, Zhao CL, Duan CL, Lu LL, Yang H."}}],"name":"SNCA","targetParticipants":[{"idObject":0,"name":"SNCA","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SNCA","summary":null,"resource":"SNCA"}]},{"targetElements":[],"references":[{"resource":"17079513","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17070561","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," BenedàJ."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"Sánchez-Reus MI, Gómez del Rio MA, Iglesias I, Elorza M, Slowing K, BenedàJ."}},{"resource":"23639798","link":"http://www.ncbi.nlm.nih.gov/pubmed/23639798","type":"PUBMED","article":{"title":"Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster.","authors":["Sudati JH"," Vieira FA"," Pavin SS"," Dias GR"," Seeger RL"," Golombieski R"," Athayde ML"," Soares FA"," Rocha JB"," Barbosa NV."],"journal":"Neurotoxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23639798","id":"23639798","citationCount":17,"stringAuthors":"Sudati JH, Vieira FA, Pavin SS, Dias GR, Seeger RL, Golombieski R, Athayde ML, Soares FA, Rocha JB, Barbosa NV."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J, Liu W, Nakamura K, Berry MJ."}},{"resource":"24374061","link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","type":"PUBMED","article":{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":12,"stringAuthors":"Corona JC, de Souza SC, Duchen MR."}},{"resource":"21807080","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M, Negro S, Slowing K, Fernández-Carballido A, Barcia E."}},{"resource":"22447502","link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","type":"PUBMED","article":{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":3,"stringAuthors":"Amberg JJ, Schreier TM, Gaikowski MP."}}],"name":"SOD1","targetParticipants":[{"idObject":0,"name":"SOD1","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SOD1","summary":null,"resource":"SOD1"}]},{"targetElements":[],"references":[{"resource":"18032788","link":"http://www.ncbi.nlm.nih.gov/pubmed/18032788","type":"PUBMED","article":{"title":"Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.","authors":["Chen Y"," McMillan-Ward E"," Kong J"," Israels SJ"," Gibson SB."],"journal":"Journal of cell science","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18032788","id":"18032788","citationCount":167,"stringAuthors":"Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB."}},{"resource":"16179351","link":"http://www.ncbi.nlm.nih.gov/pubmed/16179351","type":"PUBMED","article":{"title":"Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress.","authors":["Hu Y"," Rosen DG"," Zhou Y"," Feng L"," Yang G"," Liu J"," Huang P."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16179351","id":"16179351","citationCount":103,"stringAuthors":"Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, Huang P."}},{"resource":"10463952","link":"http://www.ncbi.nlm.nih.gov/pubmed/10463952","type":"PUBMED","article":{"title":"Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death.","authors":["Kiningham KK"," Oberley TD"," Lin S"," Mattingly CA"," St Clair DK."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10463952","id":"10463952","citationCount":48,"stringAuthors":"Kiningham KK, Oberley TD, Lin S, Mattingly CA, St Clair DK."}},{"resource":"17079513","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17070561","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," BenedàJ."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"Sánchez-Reus MI, Gómez del Rio MA, Iglesias I, Elorza M, Slowing K, BenedàJ."}},{"resource":"15904944","link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","type":"PUBMED","article":{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-Jiménez MF"," Sánchez-Reus MI"," Cascales M"," Andrés D"," BenedàJ."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":14,"stringAuthors":"Molina-Jiménez MF, Sánchez-Reus MI, Cascales M, Andrés D, BenedàJ."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J, Liu W, Nakamura K, Berry MJ."}},{"resource":"21807080","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M, Negro S, Slowing K, Fernández-Carballido A, Barcia E."}},{"resource":"19818760","link":"http://www.ncbi.nlm.nih.gov/pubmed/19818760","type":"PUBMED","article":{"title":"Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cells.","authors":["Kadota Y"," Suzuki S"," Ideta S"," Fukinbara Y"," Kawakami T"," Imai H"," Nakagawa Y"," Sato M."],"journal":"European journal of pharmacology","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19818760","id":"19818760","citationCount":7,"stringAuthors":"Kadota Y, Suzuki S, Ideta S, Fukinbara Y, Kawakami T, Imai H, Nakagawa Y, Sato M."}},{"resource":"8989910","link":"http://www.ncbi.nlm.nih.gov/pubmed/8989910","type":"PUBMED","article":{"title":"Increased manganese superoxide dismutase activity, protein, and mRNA levels and concurrent induction of tumor necrosis factor alpha in radiation-initiated Syrian hamster cells.","authors":["Otero G"," Avila MA"," Emfietzoglou D"," Clerch LB"," Massaro D"," Notario V."],"journal":"Molecular carcinogenesis","year":1996,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8989910","id":"8989910","citationCount":7,"stringAuthors":"Otero G, Avila MA, Emfietzoglou D, Clerch LB, Massaro D, Notario V."}},{"resource":"22447502","link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","type":"PUBMED","article":{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":3,"stringAuthors":"Amberg JJ, Schreier TM, Gaikowski MP."}},{"resource":"25843018","link":"http://www.ncbi.nlm.nih.gov/pubmed/25843018","type":"PUBMED","article":{"title":"Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats.","authors":["Singh AK"," Pandey SK"," Saha G"," Gattupalli NK."],"journal":"Experimental gerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25843018","id":"25843018","citationCount":2,"stringAuthors":"Singh AK, Pandey SK, Saha G, Gattupalli NK."}}],"name":"SOD2","targetParticipants":[{"idObject":0,"name":"SOD2","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SOD2","summary":null,"resource":"SOD2"}]},{"targetElements":[],"references":[{"resource":"10878378","link":"http://www.ncbi.nlm.nih.gov/pubmed/10878378","type":"PUBMED","article":{"title":"Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin.","authors":["Chandel NS"," Trzyna WC"," McClintock DS"," Schumacker PT."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10878378","id":"10878378","citationCount":153,"stringAuthors":"Chandel NS, Trzyna WC, McClintock DS, Schumacker PT."}},{"resource":"10973919","link":"http://www.ncbi.nlm.nih.gov/pubmed/10973919","type":"PUBMED","article":{"title":"Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species.","authors":["Deshpande SS"," Angkeow P"," Huang J"," Ozaki M"," Irani K."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10973919","id":"10973919","citationCount":97,"stringAuthors":"Deshpande SS, Angkeow P, Huang J, Ozaki M, Irani K."}},{"resource":"7532384","link":"http://www.ncbi.nlm.nih.gov/pubmed/7532384","type":"PUBMED","article":{"title":"Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione.","authors":["Duval DL"," Sieg DJ"," Billings RE."],"journal":"Archives of biochemistry and biophysics","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7532384","id":"7532384","citationCount":35,"stringAuthors":"Duval DL, Sieg DJ, Billings RE."}},{"resource":"17356569","link":"http://www.ncbi.nlm.nih.gov/pubmed/17356569","type":"PUBMED","article":{"title":"Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation.","authors":["Zhou F"," Wu JY"," Sun XL"," Yao HH"," Ding JH"," Hu G."],"journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17356569","id":"17356569","citationCount":34,"stringAuthors":"Zhou F, Wu JY, Sun XL, Yao HH, Ding JH, Hu G."}},{"resource":"19012619","link":"http://www.ncbi.nlm.nih.gov/pubmed/19012619","type":"PUBMED","article":{"title":"Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation.","authors":["Zhou F"," Yao HH"," Wu JY"," Ding JH"," Sun T"," Hu G."],"journal":"Journal of cellular and molecular medicine","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19012619","id":"19012619","citationCount":32,"stringAuthors":"Zhou F, Yao HH, Wu JY, Ding JH, Sun T, Hu G."}},{"resource":"15135310","link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","type":"PUBMED","article":{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":27,"stringAuthors":"McMillian M, Nie AY, Parker JB, Leone A, Kemmerer M, Bryant S, Herlich J, Yieh L, Bittner A, Liu X, Wan J, Johnson MD."}},{"resource":"17015749","link":"http://www.ncbi.nlm.nih.gov/pubmed/17015749","type":"PUBMED","article":{"title":"Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.","authors":["Nair AS"," Shishodia S"," Ahn KS"," Kunnumakkara AB"," Sethi G"," Aggarwal BB."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015749","id":"17015749","citationCount":26,"stringAuthors":"Nair AS, Shishodia S, Ahn KS, Kunnumakkara AB, Sethi G, Aggarwal BB."}},{"resource":"22623043","link":"http://www.ncbi.nlm.nih.gov/pubmed/22623043","type":"PUBMED","article":{"title":"Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice.","authors":["Kang HW"," Kim JM"," Cha MY"," Jung HC"," Song IS"," Kim JS."],"journal":"Digestive diseases and sciences","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22623043","id":"22623043","citationCount":18,"stringAuthors":"Kang HW, Kim JM, Cha MY, Jung HC, Song IS, Kim JS."}},{"resource":"18841906","link":"http://www.ncbi.nlm.nih.gov/pubmed/18841906","type":"PUBMED","article":{"title":"Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.","authors":["Dat NT"," Lee JH"," Lee K"," Hong YS"," Kim YH"," Lee JJ."],"journal":"Journal of natural products","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18841906","id":"18841906","citationCount":17,"stringAuthors":"Dat NT, Lee JH, Lee K, Hong YS, Kim YH, Lee JJ."}},{"resource":"16257489","link":"http://www.ncbi.nlm.nih.gov/pubmed/16257489","type":"PUBMED","article":{"title":"The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.","authors":["Liu X"," Wu JY"," Zhou F"," Sun XL"," Yao HH"," Yang Y"," Ding JH"," Hu G."],"journal":"Neuroscience letters","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16257489","id":"16257489","citationCount":16,"stringAuthors":"Liu X, Wu JY, Zhou F, Sun XL, Yao HH, Yang Y, Ding JH, Hu G."}},{"resource":"25086357","link":"http://www.ncbi.nlm.nih.gov/pubmed/25086357","type":"PUBMED","article":{"title":"Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.","authors":["Du C"," Jin M"," Hong Y"," Li Q"," Wang XH"," Xu JM"," Wang F"," Zhang Y"," Jia J"," Liu CF"," Hu LF."],"journal":"Biochemical and biophysical research communications","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25086357","id":"25086357","citationCount":8,"stringAuthors":"Du C, Jin M, Hong Y, Li Q, Wang XH, Xu JM, Wang F, Zhang Y, Jia J, Liu CF, Hu LF."}},{"resource":"24830863","link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","type":"PUBMED","article":{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":8,"stringAuthors":"Ai Q, Jing Y, Jiang R, Lin L, Dai J, Che Q, Zhou D, Jia M, Wan J, Zhang L."}},{"resource":"21807080","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M, Negro S, Slowing K, Fernández-Carballido A, Barcia E."}},{"resource":"23593274","link":"http://www.ncbi.nlm.nih.gov/pubmed/23593274","type":"PUBMED","article":{"title":"Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells.","authors":["Chang CY"," Choi DK"," Lee DK"," Hong YJ"," Park EJ."],"journal":"PloS one","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23593274","id":"23593274","citationCount":8,"stringAuthors":"Chang CY, Choi DK, Lee DK, Hong YJ, Park EJ."}},{"resource":"15720824","link":"http://www.ncbi.nlm.nih.gov/pubmed/15720824","type":"PUBMED","article":{"title":"Rotenone, a mitochondrial electron transport inhibitor, ameliorates ischemia-reperfusion-induced intestinal mucosal damage in rats.","authors":["Ichikawa H"," Takagi T"," Uchiyama K"," Higashihara H"," Katada K"," Isozaki Y"," Naito Y"," Yoshida N"," Yoshikawa T."],"journal":"Redox report : communications in free radical research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15720824","id":"15720824","citationCount":7,"stringAuthors":"Ichikawa H, Takagi T, Uchiyama K, Higashihara H, Katada K, Isozaki Y, Naito Y, Yoshida N, Yoshikawa T."}},{"resource":"23645222","link":"http://www.ncbi.nlm.nih.gov/pubmed/23645222","type":"PUBMED","article":{"title":"Rotenone could activate microglia through NFκB associated pathway.","authors":["Yuan YH"," Sun JD"," Wu MM"," Hu JF"," Peng SY"," Chen NH."],"journal":"Neurochemical research","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23645222","id":"23645222","citationCount":7,"stringAuthors":"Yuan YH, Sun JD, Wu MM, Hu JF, Peng SY, Chen NH."}},{"resource":"25481089","link":"http://www.ncbi.nlm.nih.gov/pubmed/25481089","type":"PUBMED","article":{"title":"Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.","authors":["Khalil WK"," Assaf N"," ElShebiney SA"," Salem NA."],"journal":"Neurochemistry international","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25481089","id":"25481089","citationCount":5,"stringAuthors":"Khalil WK, Assaf N, ElShebiney SA, Salem NA."}}],"name":"TNF","targetParticipants":[{"idObject":0,"name":"TNF","type":"HGNC Symbol","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TNF","summary":null,"resource":"TNF"}]}]}] \ No newline at end of file +[{"references":[{"resource":"D012402","link":"http://ctdbase.org/detail.go?type=chem&acc=D012402","id":0,"type":"TOXICOGENOMIC_CHEMICAL"},{"resource":"83-79-4","link":"http://commonchemistry.org/ChemicalDetail.aspx?ref=83-79-4","id":0,"type":"CAS"}],"synonyms":[],"name":"Rotenone","description":"A botanical insecticide that is an inhibitor of mitochondrial electron transport.","id":"Rotenone","directEvidenceReferences":[],"directEvidence":"marker/mechanism","targets":[{"targetElements":[],"references":[{"resource":"15796199","link":"http://www.ncbi.nlm.nih.gov/pubmed/15796199","type":"PUBMED","article":{"title":"In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells.","authors":["GyÊmÃ¥nt N"," Tanaka M"," Antus S"," Hohmann J"," Csuka O"," MÃ¥ndoky L"," MolnÃ¥r J."],"journal":"In vivo (Athens, Greece)","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15796199","id":"15796199","citationCount":15,"stringAuthors":"GyÊmÃ¥nt N, Tanaka M, Antus S, Hohmann J, Csuka O, MÃ¥ndoky L, MolnÃ¥r J."}}],"name":"ABCB1","targetParticipants":[{"resource":"ABCB1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ABCB1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23098804","link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","type":"PUBMED","article":{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":5,"stringAuthors":"Swarnkar S, Goswami P, Kamat PK, Patro IK, Singh S, Nath C."}}],"name":"AIF1","targetParticipants":[{"resource":"AIF1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=AIF1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"22847264","link":"http://www.ncbi.nlm.nih.gov/pubmed/22847264","type":"PUBMED","article":{"title":"Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants.","authors":["Covy JP"," Waxman EA"," Giasson BI."],"journal":"Journal of neuroscience research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22847264","id":"22847264","citationCount":15,"stringAuthors":"Covy JP, Waxman EA, Giasson BI."}}],"name":"ATP13A2","targetParticipants":[{"resource":"ATP13A2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=ATP13A2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17209049","link":"http://www.ncbi.nlm.nih.gov/pubmed/17209049","type":"PUBMED","article":{"title":"AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.","authors":["Bogush A"," Pedrini S"," Pelta-Heller J"," Chan T"," Yang Q"," Mao Z"," Sluzas E"," Gieringer T"," Ehrlich ME."],"journal":"The Journal of biological chemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17209049","id":"17209049","citationCount":30,"stringAuthors":"Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME."}},{"resource":"18646205","link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","type":"PUBMED","article":{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":13,"stringAuthors":"Yang D, Peng C, Li X, Fan X, Li L, Ming M, Chen S, Le W."}},{"resource":"17442543","link":"http://www.ncbi.nlm.nih.gov/pubmed/17442543","type":"PUBMED","article":{"title":"Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells.","authors":["Tan QR"," Wang XZ"," Wang CY"," Liu XJ"," Chen YC"," Wang HH"," Zhang RG"," Zhen XC"," Tong Y"," Zhang ZJ."],"journal":"European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17442543","id":"17442543","citationCount":12,"stringAuthors":"Tan QR, Wang XZ, Wang CY, Liu XJ, Chen YC, Wang HH, Zhang RG, Zhen XC, Tong Y, Zhang ZJ."}}],"name":"BDNF","targetParticipants":[{"resource":"BDNF","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=BDNF","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"19019832","link":"http://www.ncbi.nlm.nih.gov/pubmed/19019832","type":"PUBMED","article":{"title":"Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.","authors":["Tapryal N"," Mukhopadhyay C"," Das D"," Fox PL"," Mukhopadhyay CK."],"journal":"The Journal of Biological Chemistry","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19019832","id":"19019832","citationCount":18,"stringAuthors":"Tapryal N, Mukhopadhyay C, Das D, Fox PL, Mukhopadhyay CK."}},{"resource":"18804145","link":"http://www.ncbi.nlm.nih.gov/pubmed/18804145","type":"PUBMED","article":{"title":"Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice.","authors":["Kaneko K"," Hineno A"," Yoshida K"," Ikeda S."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18804145","id":"18804145","citationCount":11,"stringAuthors":"Kaneko K, Hineno A, Yoshida K, Ikeda S."}}],"name":"CP","targetParticipants":[{"resource":"CP","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=CP","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"24764117","link":"http://www.ncbi.nlm.nih.gov/pubmed/24764117","type":"PUBMED","article":{"title":"RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB.","authors":["Cheng SY"," Oh S"," Velasco M"," Ta C"," Montalvo J"," Calderone A."],"journal":"Journal of biochemical and molecular toxicology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24764117","id":"24764117","citationCount":1,"stringAuthors":"Cheng SY, Oh S, Velasco M, Ta C, Montalvo J, Calderone A."}}],"name":"DDIT4","targetParticipants":[{"resource":"DDIT4","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DDIT4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20887679","link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","type":"PUBMED","article":{"title":"Dopamine Dâ‚ÄÅ¼Ë and Dâ‚‚ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2,"stringAuthors":"Paul J, Nandhu MS, Kuruvilla KP, Paulose CS."}}],"name":"DRD1","targetParticipants":[{"resource":"DRD1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DRD1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18289173","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH, Huang JY, Ching CH, Chuang JI."}},{"resource":"20887679","link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","type":"PUBMED","article":{"title":"Dopamine Dâ‚ÄÅ¼Ë and Dâ‚‚ receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine.","authors":["Paul J"," Nandhu MS"," Kuruvilla KP"," Paulose CS."],"journal":"Neurological research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20887679","id":"20887679","citationCount":2,"stringAuthors":"Paul J, Nandhu MS, Kuruvilla KP, Paulose CS."}}],"name":"DRD2","targetParticipants":[{"resource":"DRD2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=DRD2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"11078378","link":"http://www.ncbi.nlm.nih.gov/pubmed/11078378","type":"PUBMED","article":{"title":"Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro.","authors":["Yuki K"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Suzuki T"," Hayashi J"," Goto K"," Yamaguchi I."],"journal":"Journal of cardiovascular pharmacology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11078378","id":"11078378","citationCount":9,"stringAuthors":"Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Suzuki T, Hayashi J, Goto K, Yamaguchi I."}},{"resource":"11707688","link":"http://www.ncbi.nlm.nih.gov/pubmed/11707688","type":"PUBMED","article":{"title":"Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes.","authors":["Yuhki KI"," Miyauchi T"," Kakinuma Y"," Murakoshi N"," Maeda S"," Goto K"," Yamaguchi I"," Suzuki T."],"journal":"Journal of cardiovascular pharmacology","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11707688","id":"11707688","citationCount":7,"stringAuthors":"Yuhki KI, Miyauchi T, Kakinuma Y, Murakoshi N, Maeda S, Goto K, Yamaguchi I, Suzuki T."}},{"resource":"22928487","link":"http://www.ncbi.nlm.nih.gov/pubmed/22928487","type":"PUBMED","article":{"title":"Mitochondrial ROS-K+ channel signaling pathway regulated secretion of human pulmonary artery endothelial cells.","authors":["Ouyang JS"," Li YP"," Li CY"," Cai C"," Chen CS"," Chen SX"," Chen YF"," Yang L"," Xie YP."],"journal":"Free radical research","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22928487","id":"22928487","citationCount":5,"stringAuthors":"Ouyang JS, Li YP, Li CY, Cai C, Chen CS, Chen SX, Chen YF, Yang L, Xie YP."}}],"name":"EDN1","targetParticipants":[{"resource":"EDN1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=EDN1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18646205","link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","type":"PUBMED","article":{"title":"Pitx3-transfected astrocytes secrete brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor and protect dopamine neurons in mesencephalon cultures.","authors":["Yang D"," Peng C"," Li X"," Fan X"," Li L"," Ming M"," Chen S"," Le W."],"journal":"Journal of neuroscience research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18646205","id":"18646205","citationCount":13,"stringAuthors":"Yang D, Peng C, Li X, Fan X, Li L, Ming M, Chen S, Le W."}}],"name":"GDNF","targetParticipants":[{"resource":"GDNF","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GDNF","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23098804","link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","type":"PUBMED","article":{"title":"Rotenone-induced neurotoxicity in rat brain areas: a study on neuronal and neuronal supportive cells.","authors":["Swarnkar S"," Goswami P"," Kamat PK"," Patro IK"," Singh S"," Nath C."],"journal":"Neuroscience","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23098804","id":"23098804","citationCount":5,"stringAuthors":"Swarnkar S, Goswami P, Kamat PK, Patro IK, Singh S, Nath C."}}],"name":"GFAP","targetParticipants":[{"resource":"GFAP","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GFAP","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17079513","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17070561","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["SÃ¥nchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," BenedàJ."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"SÃ¥nchez-Reus MI, Gómez del Rio MA, Iglesias I, Elorza M, Slowing K, BenedàJ."}},{"resource":"15904944","link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","type":"PUBMED","article":{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-JimÊnez MF"," SÃ¥nchez-Reus MI"," Cascales M"," AndrÊs D"," BenedàJ."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":14,"stringAuthors":"Molina-JimÊnez MF, SÃ¥nchez-Reus MI, Cascales M, AndrÊs D, BenedàJ."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J, Liu W, Nakamura K, Berry MJ."}}],"name":"GPX1","targetParticipants":[{"resource":"GPX1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPX1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}}],"name":"GSTA4","targetParticipants":[{"resource":"GSTA4","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSTA4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}}],"name":"GSTM1","targetParticipants":[{"resource":"GSTM1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GSTM1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"19131585","link":"http://www.ncbi.nlm.nih.gov/pubmed/19131585","type":"PUBMED","article":{"title":"Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.","authors":["Han Z"," Varadharaj S"," Giedt RJ"," Zweier JL"," Szeto HH"," Alevriadou BR."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19131585","id":"19131585","citationCount":34,"stringAuthors":"Han Z, Varadharaj S, Giedt RJ, Zweier JL, Szeto HH, Alevriadou BR."}},{"resource":"24451142","link":"http://www.ncbi.nlm.nih.gov/pubmed/24451142","type":"PUBMED","article":{"title":"Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy.","authors":["Lin TK"," Chen SD"," Chuang YC"," Lin HY"," Huang CR"," Chuang JH"," Wang PW"," Huang ST"," Tiao MM"," Chen JB"," Liou CW."],"journal":"International journal of molecular sciences","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24451142","id":"24451142","citationCount":27,"stringAuthors":"Lin TK, Chen SD, Chuang YC, Lin HY, Huang CR, Chuang JH, Wang PW, Huang ST, Tiao MM, Chen JB, Liou CW."}},{"resource":"17702527","link":"http://www.ncbi.nlm.nih.gov/pubmed/17702527","type":"PUBMED","article":{"title":"Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening.","authors":["Coe KJ"," Jia Y"," Ho HK"," Rademacher P"," Bammler TK"," Beyer RP"," Farin FM"," Woodke L"," Plymate SR"," Fausto N"," Nelson SD."],"journal":"Chemical research in toxicology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17702527","id":"17702527","citationCount":23,"stringAuthors":"Coe KJ, Jia Y, Ho HK, Rademacher P, Bammler TK, Beyer RP, Farin FM, Woodke L, Plymate SR, Fausto N, Nelson SD."}},{"resource":"22659318","link":"http://www.ncbi.nlm.nih.gov/pubmed/22659318","type":"PUBMED","article":{"title":"Cadmium-induced apoptosis in the BJAB human B cell line: involvement of PKC/ERK1/2/JNK signaling pathways in HO-1 expression.","authors":["Nemmiche S"," Chabane-Sari D"," Kadri M"," Guiraud P."],"journal":"Toxicology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22659318","id":"22659318","citationCount":16,"stringAuthors":"Nemmiche S, Chabane-Sari D, Kadri M, Guiraud P."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J, Liu W, Nakamura K, Berry MJ."}},{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}},{"resource":"26276080","link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","type":"PUBMED","article":{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":3,"stringAuthors":"Qin J, Wu M, Yu S, Gao X, Zhang J, Dong X, Ji J, Zhang Y, Zhou L, Zhang Q, Ding F."}}],"name":"HMOX1","targetParticipants":[{"resource":"HMOX1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"27979718","link":"http://www.ncbi.nlm.nih.gov/pubmed/27979718","type":"PUBMED","article":{"title":"Neonatal rotenone lesions cause onset of hyperactivity during juvenile and adulthood in the rat.","authors":["Ishido M"," Suzuki J"," Masuo Y."],"journal":"Toxicology letters","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27979718","id":"27979718","citationCount":0,"stringAuthors":"Ishido M, Suzuki J, Masuo Y."}}],"name":"HSPA1A","targetParticipants":[{"resource":"HSPA1A","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA1A","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"16565515","link":"http://www.ncbi.nlm.nih.gov/pubmed/16565515","type":"PUBMED","article":{"title":"Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.","authors":["Jin J"," Hulette C"," Wang Y"," Zhang T"," Pan C"," Wadhwa R"," Zhang J."],"journal":"Molecular & cellular proteomics : MCP","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16565515","id":"16565515","citationCount":110,"stringAuthors":"Jin J, Hulette C, Wang Y, Zhang T, Pan C, Wadhwa R, Zhang J."}},{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}}],"name":"HSPA9","targetParticipants":[{"resource":"HSPA9","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=HSPA9","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"27900601","link":"http://www.ncbi.nlm.nih.gov/pubmed/27900601","type":"PUBMED","article":{"title":"RNA-Seq Expression Analysis of Enteric Neuron Cells with Rotenone Treatment and Prediction of Regulated Pathways.","authors":["Guan Q"," Wang X"," Jiang Y"," Zhao L"," Nie Z"," Jin L."],"journal":"Neurochemical research","year":2017,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27900601","id":"27900601","citationCount":0,"stringAuthors":"Guan Q, Wang X, Jiang Y, Zhao L, Nie Z, Jin L."}}],"name":"IGF2","targetParticipants":[{"resource":"IGF2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IGF2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"11950692","link":"http://www.ncbi.nlm.nih.gov/pubmed/11950692","type":"PUBMED","article":{"title":"Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia.","authors":["Pearlstein DP"," Ali MH"," Mungai PT"," Hynes KL"," Gewertz BL"," Schumacker PT."],"journal":"Arteriosclerosis, thrombosis, and vascular biology","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11950692","id":"11950692","citationCount":54,"stringAuthors":"Pearlstein DP, Ali MH, Mungai PT, Hynes KL, Gewertz BL, Schumacker PT."}},{"resource":"15135310","link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","type":"PUBMED","article":{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":27,"stringAuthors":"McMillian M, Nie AY, Parker JB, Leone A, Kemmerer M, Bryant S, Herlich J, Yieh L, Bittner A, Liu X, Wan J, Johnson MD."}},{"resource":"16837928","link":"http://www.ncbi.nlm.nih.gov/pubmed/16837928","type":"PUBMED","article":{"title":"Albumin-bound fatty acids induce mitochondrial oxidant stress and impair antioxidant responses in proximal tubular cells.","authors":["Ishola DA"," Post JA"," van Timmeren MM"," Bakker SJ"," Goldschmeding R"," Koomans HA"," Braam B"," Joles JA."],"journal":"Kidney international","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16837928","id":"16837928","citationCount":26,"stringAuthors":"Ishola DA, Post JA, van Timmeren MM, Bakker SJ, Goldschmeding R, Koomans HA, Braam B, Joles JA."}},{"resource":"19635391","link":"http://www.ncbi.nlm.nih.gov/pubmed/19635391","type":"PUBMED","article":{"title":"Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.","authors":["Monroe RK"," Halvorsen SW."],"journal":"Neurotoxicology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19635391","id":"19635391","citationCount":16,"stringAuthors":"Monroe RK, Halvorsen SW."}},{"resource":"22745725","link":"http://www.ncbi.nlm.nih.gov/pubmed/22745725","type":"PUBMED","article":{"title":"Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.","authors":["Paulus P"," Ockelmann P"," Tacke S"," Karnowski N"," Ellinghaus P"," Scheller B"," Holfeld J"," Urbschat A"," Zacharowski K."],"journal":"PloS one","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22745725","id":"22745725","citationCount":10,"stringAuthors":"Paulus P, Ockelmann P, Tacke S, Karnowski N, Ellinghaus P, Scheller B, Holfeld J, Urbschat A, Zacharowski K."}},{"resource":"24830863","link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","type":"PUBMED","article":{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":8,"stringAuthors":"Ai Q, Jing Y, Jiang R, Lin L, Dai J, Che Q, Zhou D, Jia M, Wan J, Zhang L."}},{"resource":"23867654","link":"http://www.ncbi.nlm.nih.gov/pubmed/23867654","type":"PUBMED","article":{"title":"Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes.","authors":["Kim NH"," Hong BK"," Choi SY"," Moo Kwon H"," Cho CS"," Yi EC"," Kim WU."],"journal":"Experimental & molecular medicine","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23867654","id":"23867654","citationCount":5,"stringAuthors":"Kim NH, Hong BK, Choi SY, Moo Kwon H, Cho CS, Yi EC, Kim WU."}}],"name":"IL6","targetParticipants":[{"resource":"IL6","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=IL6","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18619942","link":"http://www.ncbi.nlm.nih.gov/pubmed/18619942","type":"PUBMED","article":{"title":"Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway.","authors":["Wang G"," Zeng J"," Shen CY"," Wang ZQ"," Chen SD."],"journal":"Biochemical and biophysical research communications","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18619942","id":"18619942","citationCount":3,"stringAuthors":"Wang G, Zeng J, Shen CY, Wang ZQ, Chen SD."}}],"name":"KCNJ4","targetParticipants":[{"resource":"KCNJ4","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=KCNJ4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"19625511","link":"http://www.ncbi.nlm.nih.gov/pubmed/19625511","type":"PUBMED","article":{"title":"LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.","authors":["Saha S"," Guillily MD"," Ferree A"," Lanceta J"," Chan D"," Ghosh J"," Hsu CH"," Segal L"," Raghavan K"," Matsumoto K"," Hisamoto N"," Kuwahara T"," Iwatsubo T"," Moore L"," Goldstein L"," Cookson M"," Wolozin B."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19625511","id":"19625511","citationCount":97,"stringAuthors":"Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B."}},{"resource":"19741132","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL."}},{"resource":"19692353","link":"http://www.ncbi.nlm.nih.gov/pubmed/19692353","type":"PUBMED","article":{"title":"Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.","authors":["Venderova K"," Kabbach G"," Abdel-Messih E"," Zhang Y"," Parks RJ"," Imai Y"," Gehrke S"," Ngsee J"," Lavoie MJ"," Slack RS"," Rao Y"," Zhang Z"," Lu B"," Haque ME"," Park DS."],"journal":"Human molecular genetics","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19692353","id":"19692353","citationCount":78,"stringAuthors":"Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS."}},{"resource":"18322385","link":"http://www.ncbi.nlm.nih.gov/pubmed/18322385","type":"PUBMED","article":{"title":"Investigating convergent actions of genes linked to familial Parkinson's disease.","authors":["Wolozin B"," Saha S"," Guillily M"," Ferree A"," Riley M."],"journal":"Neuro-degenerative diseases","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18322385","id":"18322385","citationCount":19,"stringAuthors":"Wolozin B, Saha S, Guillily M, Ferree A, Riley M."}}],"name":"LRRK2","targetParticipants":[{"resource":"LRRK2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=LRRK2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"16449798","link":"http://www.ncbi.nlm.nih.gov/pubmed/16449798","type":"PUBMED","article":{"title":"Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.","authors":["Hsieh CC"," Papaconstantinou J."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16449798","id":"16449798","citationCount":84,"stringAuthors":"Hsieh CC, Papaconstantinou J."}}],"name":"MAP3K5","targetParticipants":[{"resource":"MAP3K5","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MAP3K5","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"16219024","link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","type":"PUBMED","article":{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":76,"stringAuthors":"Höglinger GU, Lannuzel A, Khondiker ME, Michel PP, Duyckaerts C, Féger J, Champy P, Prigent A, Medja F, Lombes A, Oertel WH, Ruberg M, Hirsch EC."}},{"resource":"16930453","link":"http://www.ncbi.nlm.nih.gov/pubmed/16930453","type":"PUBMED","article":{"title":"Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.","authors":["Dickey CA"," Ash P"," Klosak N"," Lee WC"," Petrucelli L"," Hutton M"," Eckman CB."],"journal":"Molecular neurodegeneration","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16930453","id":"16930453","citationCount":17,"stringAuthors":"Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB."}}],"name":"MAPT","targetParticipants":[{"resource":"MAPT","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=MAPT","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"24374061","link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","type":"PUBMED","article":{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":12,"stringAuthors":"Corona JC, de Souza SC, Duchen MR."}},{"resource":"23186747","link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","type":"PUBMED","article":{"title":"Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling.","authors":["Yap YW"," Chen MJ"," Peng ZF"," Manikandan J"," Ng JM"," Llanos RM"," La Fontaine S"," Beart PM"," Cheung NS."],"journal":"Neurochemistry international","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23186747","id":"23186747","citationCount":5,"stringAuthors":"Yap YW, Chen MJ, Peng ZF, Manikandan J, Ng JM, Llanos RM, La Fontaine S, Beart PM, Cheung NS."}}],"name":"NQO1","targetParticipants":[{"resource":"NQO1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=NQO1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR."}},{"resource":"19741132","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL."}},{"resource":"16573651","link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","type":"PUBMED","article":{"title":"Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.","authors":["Casarejos MJ"," Menéndez J"," Solano RM"," RodrÃÂÂguez-Navarro JA"," GarcÃÂÂa de Yébenes J"," Mena MA."],"journal":"Journal of neurochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","id":"16573651","citationCount":66,"stringAuthors":"Casarejos MJ, Menéndez J, Solano RM, RodrÃÂÂguez-Navarro JA, GarcÃÂÂa de Yébenes J, Mena MA."}},{"resource":"22872702","link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","type":"PUBMED","article":{"title":"ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.","authors":["Joselin AP"," Hewitt SJ"," Callaghan SM"," Kim RH"," Chung YH"," Mak TW"," Shen J"," Slack RS"," Park DS."],"journal":"Human molecular genetics","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","id":"22872702","citationCount":59,"stringAuthors":"Joselin AP, Hewitt SJ, Callaghan SM, Kim RH, Chung YH, Mak TW, Shen J, Slack RS, Park DS."}},{"resource":"17687034","link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","type":"PUBMED","article":{"title":"Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.","authors":["Wang C"," Lu R"," Ouyang X"," Ho MW"," Chia W"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","id":"17687034","citationCount":52,"stringAuthors":"Wang C, Lu R, Ouyang X, Ho MW, Chia W, Yu F, Lim KL."}},{"resource":"16517603","link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","type":"PUBMED","article":{"title":"Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.","authors":["Rosen KM"," Veereshwarayya V"," Moussa CE"," Fu Q"," Goldberg MS"," Schlossmacher MG"," Shen J"," Querfurth HW."],"journal":"The Journal of Biological Chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","id":"16517603","citationCount":45,"stringAuthors":"Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW."}}],"name":"PARK2","targetParticipants":[{"resource":"PARK2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PARK2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR."}},{"resource":"16439141","link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","type":"PUBMED","article":{"title":"Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":131,"stringAuthors":"Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, Cookson MR, Greenamyre JT."}},{"resource":"17459145","link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","type":"PUBMED","article":{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":68,"stringAuthors":"Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, Taniguchi T, Yoshimoto K, Kaneko M, Okuma Y, Taira T, Ariga H, Shimohama S."}},{"resource":"18377993","link":"http://www.ncbi.nlm.nih.gov/pubmed/18377993","type":"PUBMED","article":{"title":"Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.","authors":["Lev N"," Ickowicz D"," Melamed E"," Offen D."],"journal":"Neurotoxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18377993","id":"18377993","citationCount":59,"stringAuthors":"Lev N, Ickowicz D, Melamed E, Offen D."}},{"resource":"18331584","link":"http://www.ncbi.nlm.nih.gov/pubmed/18331584","type":"PUBMED","article":{"title":"Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease.","authors":["Liu F"," Nguyen JL"," Hulleman JD"," Li L"," Rochet JC."],"journal":"Journal of neurochemistry","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18331584","id":"18331584","citationCount":48,"stringAuthors":"Liu F, Nguyen JL, Hulleman JD, Li L, Rochet JC."}},{"resource":"18930142","link":"http://www.ncbi.nlm.nih.gov/pubmed/18930142","type":"PUBMED","article":{"title":"DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone.","authors":["Mullett SJ"," Hinkle DA."],"journal":"Neurobiology of disease","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18930142","id":"18930142","citationCount":43,"stringAuthors":"Mullett SJ, Hinkle DA."}},{"resource":"16624565","link":"http://www.ncbi.nlm.nih.gov/pubmed/16624565","type":"PUBMED","article":{"title":"Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase.","authors":["Pisani A"," Martella G"," Tscherter A"," Costa C"," Mercuri NB"," Bernardi G"," Shen J"," Calabresi P."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16624565","id":"16624565","citationCount":23,"stringAuthors":"Pisani A, Martella G, Tscherter A, Costa C, Mercuri NB, Bernardi G, Shen J, Calabresi P."}},{"resource":"22898350","link":"http://www.ncbi.nlm.nih.gov/pubmed/22898350","type":"PUBMED","article":{"title":"DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy.","authors":["Gao H"," Yang W"," Qi Z"," Lu L"," Duan C"," Zhao C"," Yang H."],"journal":"Journal of molecular biology","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22898350","id":"22898350","citationCount":21,"stringAuthors":"Gao H, Yang W, Qi Z, Lu L, Duan C, Zhao C, Yang H."}},{"resource":"19063952","link":"http://www.ncbi.nlm.nih.gov/pubmed/19063952","type":"PUBMED","article":{"title":"Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.","authors":["Ashley AK"," Hanneman WH"," Katoh T"," Moreno JA"," Pollack A"," Tjalkens RB"," Legare ME."],"journal":"Toxicology letters","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19063952","id":"19063952","citationCount":15,"stringAuthors":"Ashley AK, Hanneman WH, Katoh T, Moreno JA, Pollack A, Tjalkens RB, Legare ME."}}],"name":"PARK7","targetParticipants":[{"resource":"PARK7","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PARK7","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR."}},{"resource":"19492085","link":"http://www.ncbi.nlm.nih.gov/pubmed/19492085","type":"PUBMED","article":{"title":"Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.","authors":["Sandebring A"," Thomas KJ"," Beilina A"," van der Brug M"," Cleland MM"," Ahmad R"," Miller DW"," Zambrano I"," Cowburn RF"," Behbahani H"," Cedazo-MÃÂÂnguez A"," Cookson MR."],"journal":"PloS one","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19492085","id":"19492085","citationCount":93,"stringAuthors":"Sandebring A, Thomas KJ, Beilina A, van der Brug M, Cleland MM, Ahmad R, Miller DW, Zambrano I, Cowburn RF, Behbahani H, Cedazo-MÃÂÂnguez A, Cookson MR."}},{"resource":"16226715","link":"http://www.ncbi.nlm.nih.gov/pubmed/16226715","type":"PUBMED","article":{"title":"Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.","authors":["Deng H"," Jankovic J"," Guo Y"," Xie W"," Le W."],"journal":"Biochemical and biophysical research communications","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16226715","id":"16226715","citationCount":72,"stringAuthors":"Deng H, Jankovic J, Guo Y, Xie W, Le W."}},{"resource":"21421046","link":"http://www.ncbi.nlm.nih.gov/pubmed/21421046","type":"PUBMED","article":{"title":"PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.","authors":["Wang HL"," Chou AH"," Wu AS"," Chen SY"," Weng YH"," Kao YC"," Yeh TH"," Chu PJ"," Lu CS."],"journal":"Biochimica et biophysica acta","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21421046","id":"21421046","citationCount":40,"stringAuthors":"Wang HL, Chou AH, Wu AS, Chen SY, Weng YH, Kao YC, Yeh TH, Chu PJ, Lu CS."}},{"resource":"20464527","link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","type":"PUBMED","article":{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":14,"stringAuthors":"George S, Mok SS, Nurjono M, Ayton S, Finkelstein DI, Masters CL, Li QX, Culvenor JG."}}],"name":"PINK1","targetParticipants":[{"resource":"PINK1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=PINK1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"20940149","link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","type":"PUBMED","article":{"title":"DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.","authors":["Thomas KJ"," McCoy MK"," Blackinton J"," Beilina A"," van der Brug M"," Sandebring A"," Miller D"," Maric D"," Cedazo-Minguez A"," Cookson MR."],"journal":"Human molecular genetics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20940149","id":"20940149","citationCount":148,"stringAuthors":"Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Maric D, Cedazo-Minguez A, Cookson MR."}},{"resource":"19741132","link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","type":"PUBMED","article":{"title":"Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.","authors":["Ng CH"," Mok SZ"," Koh C"," Ouyang X"," Fivaz ML"," Tan EK"," Dawson VL"," Dawson TM"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19741132","id":"19741132","citationCount":90,"stringAuthors":"Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL."}},{"resource":"16573651","link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","type":"PUBMED","article":{"title":"Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline.","authors":["Casarejos MJ"," Menéndez J"," Solano RM"," RodrÃÂÂguez-Navarro JA"," GarcÃÂÂa de Yébenes J"," Mena MA."],"journal":"Journal of neurochemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16573651","id":"16573651","citationCount":66,"stringAuthors":"Casarejos MJ, Menéndez J, Solano RM, RodrÃÂÂguez-Navarro JA, GarcÃÂÂa de Yébenes J, Mena MA."}},{"resource":"22872702","link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","type":"PUBMED","article":{"title":"ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.","authors":["Joselin AP"," Hewitt SJ"," Callaghan SM"," Kim RH"," Chung YH"," Mak TW"," Shen J"," Slack RS"," Park DS."],"journal":"Human molecular genetics","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22872702","id":"22872702","citationCount":59,"stringAuthors":"Joselin AP, Hewitt SJ, Callaghan SM, Kim RH, Chung YH, Mak TW, Shen J, Slack RS, Park DS."}},{"resource":"17687034","link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","type":"PUBMED","article":{"title":"Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.","authors":["Wang C"," Lu R"," Ouyang X"," Ho MW"," Chia W"," Yu F"," Lim KL."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17687034","id":"17687034","citationCount":52,"stringAuthors":"Wang C, Lu R, Ouyang X, Ho MW, Chia W, Yu F, Lim KL."}},{"resource":"16517603","link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","type":"PUBMED","article":{"title":"Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.","authors":["Rosen KM"," Veereshwarayya V"," Moussa CE"," Fu Q"," Goldberg MS"," Schlossmacher MG"," Shen J"," Querfurth HW."],"journal":"The Journal of Biological Chemistry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16517603","id":"16517603","citationCount":45,"stringAuthors":"Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW."}}],"name":"PRKN","targetParticipants":[{"resource":"PRKN","link":null,"id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"21383081","link":"http://www.ncbi.nlm.nih.gov/pubmed/21383081","type":"PUBMED","article":{"title":"Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model.","authors":["Choi WS"," Palmiter RD"," Xia Z."],"journal":"The Journal of cell biology","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21383081","id":"21383081","citationCount":65,"stringAuthors":"Choi WS, Palmiter RD, Xia Z."}},{"resource":"18579341","link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","type":"PUBMED","article":{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":27,"stringAuthors":"Sai Y, Wu Q, Le W, Ye F, Li Y, Dong Z."}},{"resource":"26276080","link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","type":"PUBMED","article":{"title":"Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson's disease.","authors":["Qin J"," Wu M"," Yu S"," Gao X"," Zhang J"," Dong X"," Ji J"," Zhang Y"," Zhou L"," Zhang Q"," Ding F."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26276080","id":"26276080","citationCount":3,"stringAuthors":"Qin J, Wu M, Yu S, Gao X, Zhang J, Dong X, Ji J, Zhang Y, Zhou L, Zhang Q, Ding F."}},{"resource":"25496994","link":"http://www.ncbi.nlm.nih.gov/pubmed/25496994","type":"PUBMED","article":{"title":"JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.","authors":["Choi WS"," Kim HW"," Xia Z."],"journal":"Toxicology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25496994","id":"25496994","citationCount":2,"stringAuthors":"Choi WS, Kim HW, Xia Z."}}],"name":"SLC18A2","targetParticipants":[{"resource":"SLC18A2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SLC18A2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18289173","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH, Huang JY, Ching CH, Chuang JI."}},{"resource":"18579341","link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","type":"PUBMED","article":{"title":"Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism.","authors":["Sai Y"," Wu Q"," Le W"," Ye F"," Li Y"," Dong Z."],"journal":"Toxicology in vitro : an international journal published in association with BIBRA","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18579341","id":"18579341","citationCount":27,"stringAuthors":"Sai Y, Wu Q, Le W, Ye F, Li Y, Dong Z."}},{"resource":"23567316","link":"http://www.ncbi.nlm.nih.gov/pubmed/23567316","type":"PUBMED","article":{"title":"Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life.","authors":["Tien LT"," Kaizaki A"," Pang Y"," Cai Z"," Bhatt AJ"," Fan LW."],"journal":"Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23567316","id":"23567316","citationCount":6,"stringAuthors":"Tien LT, Kaizaki A, Pang Y, Cai Z, Bhatt AJ, Fan LW."}},{"resource":"18206288","link":"http://www.ncbi.nlm.nih.gov/pubmed/18206288","type":"PUBMED","article":{"title":"The role of dopamine transporter in selective toxicity of manganese and rotenone.","authors":["Hirata Y"," Suzuno H"," Tsuruta T"," Oh-hashi K"," Kiuchi K."],"journal":"Toxicology","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18206288","id":"18206288","citationCount":4,"stringAuthors":"Hirata Y, Suzuno H, Tsuruta T, Oh-hashi K, Kiuchi K."}}],"name":"SLC6A3","targetParticipants":[{"resource":"SLC6A3","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SLC6A3","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"11100151","link":"http://www.ncbi.nlm.nih.gov/pubmed/11100151","type":"PUBMED","article":{"title":"Chronic systemic pesticide exposure reproduces features of Parkinson's disease.","authors":["Betarbet R"," Sherer TB"," MacKenzie G"," Garcia-Osuna M"," Panov AV"," Greenamyre JT."],"journal":"Nature neuroscience","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11100151","id":"11100151","citationCount":1330,"stringAuthors":"Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT."}},{"resource":"12177198","link":"http://www.ncbi.nlm.nih.gov/pubmed/12177198","type":"PUBMED","article":{"title":"An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.","authors":["Sherer TB"," Betarbet R"," Stout AK"," Lund S"," Baptista M"," Panov AV"," Cookson MR"," Greenamyre JT."],"journal":"The Journal of neuroscience : the official journal of the Society for Neuroscience","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12177198","id":"12177198","citationCount":240,"stringAuthors":"Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT."}},{"resource":"16439141","link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","type":"PUBMED","article":{"title":"Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system.","authors":["Betarbet R"," Canet-Aviles RM"," Sherer TB"," Mastroberardino PG"," McLendon C"," Kim JH"," Lund S"," Na HM"," Taylor G"," Bence NF"," Kopito R"," Seo BB"," Yagi T"," Yagi A"," Klinefelter G"," Cookson MR"," Greenamyre JT."],"journal":"Neurobiology of disease","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16439141","id":"16439141","citationCount":131,"stringAuthors":"Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, Cookson MR, Greenamyre JT."}},{"resource":"11445065","link":"http://www.ncbi.nlm.nih.gov/pubmed/11445065","type":"PUBMED","article":{"title":"Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.","authors":["Uversky VN"," Li J"," Fink AL."],"journal":"FEBS letters","year":2001,"link":"http://www.ncbi.nlm.nih.gov/pubmed/11445065","id":"11445065","citationCount":124,"stringAuthors":"Uversky VN, Li J, Fink AL."}},{"resource":"16239214","link":"http://www.ncbi.nlm.nih.gov/pubmed/16239214","type":"PUBMED","article":{"title":"Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.","authors":["Ved R"," Saha S"," Westlund B"," Perier C"," Burnam L"," Sluder A"," Hoener M"," Rodrigues CM"," Alfonso A"," Steer C"," Liu L"," Przedborski S"," Wolozin B."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16239214","id":"16239214","citationCount":120,"stringAuthors":"Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B."}},{"resource":"24290359","link":"http://www.ncbi.nlm.nih.gov/pubmed/24290359","type":"PUBMED","article":{"title":"Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.","authors":["Ryan SD"," Dolatabadi N"," Chan SF"," Zhang X"," Akhtar MW"," Parker J"," Soldner F"," Sunico CR"," Nagar S"," Talantova M"," Lee B"," Lopez K"," Nutter A"," Shan B"," Molokanova E"," Zhang Y"," Han X"," Nakamura T"," Masliah E"," Yates JR"," Nakanishi N"," Andreyev AY"," Okamoto S"," Jaenisch R"," Ambasudhan R"," Lipton SA."],"journal":"Cell","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24290359","id":"24290359","citationCount":88,"stringAuthors":"Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Nakamura T, Masliah E, Yates JR, Nakanishi N, Andreyev AY, Okamoto S, Jaenisch R, Ambasudhan R, Lipton SA."}},{"resource":"16219024","link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","type":"PUBMED","article":{"title":"The mitochondrial complex I inhibitor rotenone triggers a cerebral tauopathy.","authors":["Höglinger GU"," Lannuzel A"," Khondiker ME"," Michel PP"," Duyckaerts C"," Féger J"," Champy P"," Prigent A"," Medja F"," Lombes A"," Oertel WH"," Ruberg M"," Hirsch EC."],"journal":"Journal of neurochemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16219024","id":"16219024","citationCount":76,"stringAuthors":"Höglinger GU, Lannuzel A, Khondiker ME, Michel PP, Duyckaerts C, Féger J, Champy P, Prigent A, Medja F, Lombes A, Oertel WH, Ruberg M, Hirsch EC."}},{"resource":"23205266","link":"http://www.ncbi.nlm.nih.gov/pubmed/23205266","type":"PUBMED","article":{"title":"Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice.","authors":["Pan-Montojo F"," Schwarz M"," Winkler C"," Arnhold M"," O'Sullivan GA"," Pal A"," Said J"," Marsico G"," Verbavatz JM"," Rodrigo-Angulo M"," Gille G"," Funk RH"," Reichmann H."],"journal":"Scientific reports","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23205266","id":"23205266","citationCount":71,"stringAuthors":"Pan-Montojo F, Schwarz M, Winkler C, Arnhold M, O'Sullivan GA, Pal A, Said J, Marsico G, Verbavatz JM, Rodrigo-Angulo M, Gille G, Funk RH, Reichmann H."}},{"resource":"17459145","link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","type":"PUBMED","article":{"title":"Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.","authors":["Inden M"," Kitamura Y"," Takeuchi H"," Yanagida T"," Takata K"," Kobayashi Y"," Taniguchi T"," Yoshimoto K"," Kaneko M"," Okuma Y"," Taira T"," Ariga H"," Shimohama S."],"journal":"Journal of neurochemistry","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17459145","id":"17459145","citationCount":68,"stringAuthors":"Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, Taniguchi T, Yoshimoto K, Kaneko M, Okuma Y, Taira T, Ariga H, Shimohama S."}},{"resource":"19628769","link":"http://www.ncbi.nlm.nih.gov/pubmed/19628769","type":"PUBMED","article":{"title":"Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein.","authors":["Yu WH"," Dorado B"," Figueroa HY"," Wang L"," Planel E"," Cookson MR"," Clark LN"," Duff KE."],"journal":"The American journal of pathology","year":2009,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19628769","id":"19628769","citationCount":65,"stringAuthors":"Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE."}},{"resource":"18514418","link":"http://www.ncbi.nlm.nih.gov/pubmed/18514418","type":"PUBMED","article":{"title":"Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells.","authors":["Shavali S"," Brown-Borg HM"," Ebadi M"," Porter J."],"journal":"Neuroscience letters","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18514418","id":"18514418","citationCount":62,"stringAuthors":"Shavali S, Brown-Borg HM, Ebadi M, Porter J."}},{"resource":"17131421","link":"http://www.ncbi.nlm.nih.gov/pubmed/17131421","type":"PUBMED","article":{"title":"RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.","authors":["Fountaine TM"," Wade-Martins R."],"journal":"Journal of neuroscience research","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17131421","id":"17131421","citationCount":56,"stringAuthors":"Fountaine TM, Wade-Martins R."}},{"resource":"19626387","link":"http://www.ncbi.nlm.nih.gov/pubmed/19626387","type":"PUBMED","article":{"title":"Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein.","authors":["Monti B"," Gatta V"," Piretti F"," Raffaelli SS"," Virgili M"," Contestabile A."],"journal":"Neurotoxicity research","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19626387","id":"19626387","citationCount":49,"stringAuthors":"Monti B, Gatta V, Piretti F, Raffaelli SS, Virgili M, Contestabile A."}},{"resource":"15099020","link":"http://www.ncbi.nlm.nih.gov/pubmed/15099020","type":"PUBMED","article":{"title":"Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.","authors":["Dalfó E"," Gómez-Isla T"," Rosa JL"," Nieto Bodelón M"," Cuadrado Tejedor M"," Barrachina M"," Ambrosio S"," Ferrer I."],"journal":"Journal of neuropathology and experimental neurology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15099020","id":"15099020","citationCount":45,"stringAuthors":"Dalfó E, Gómez-Isla T, Rosa JL, Nieto Bodelón M, Cuadrado Tejedor M, Barrachina M, Ambrosio S, Ferrer I."}},{"resource":"19114014","link":"http://www.ncbi.nlm.nih.gov/pubmed/19114014","type":"PUBMED","article":{"title":"Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells.","authors":["Borland MK"," Trimmer PA"," Rubinstein JD"," Keeney PM"," Mohanakumar K"," Liu L"," Bennett JP."],"journal":"Molecular neurodegeneration","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19114014","id":"19114014","citationCount":44,"stringAuthors":"Borland MK, Trimmer PA, Rubinstein JD, Keeney PM, Mohanakumar K, Liu L, Bennett JP."}},{"resource":"18289173","link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","type":"PUBMED","article":{"title":"Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats.","authors":["Lin CH"," Huang JY"," Ching CH"," Chuang JI."],"journal":"Journal of pineal research","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18289173","id":"18289173","citationCount":32,"stringAuthors":"Lin CH, Huang JY, Ching CH, Chuang JI."}},{"resource":"15280438","link":"http://www.ncbi.nlm.nih.gov/pubmed/15280438","type":"PUBMED","article":{"title":"Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells.","authors":["Watabe M"," Nakaki T."],"journal":"The Journal of pharmacology and experimental therapeutics","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15280438","id":"15280438","citationCount":27,"stringAuthors":"Watabe M, Nakaki T."}},{"resource":"15114628","link":"http://www.ncbi.nlm.nih.gov/pubmed/15114628","type":"PUBMED","article":{"title":"1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells.","authors":["Shavali S"," Carlson EC"," Swinscoe JC"," Ebadi M."],"journal":"Journal of neuroscience research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15114628","id":"15114628","citationCount":23,"stringAuthors":"Shavali S, Carlson EC, Swinscoe JC, Ebadi M."}},{"resource":"19857570","link":"http://www.ncbi.nlm.nih.gov/pubmed/19857570","type":"PUBMED","article":{"title":"Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease.","authors":["Kalivendi SV"," Yedlapudi D"," Hillard CJ"," Kalyanaraman B."],"journal":"Free radical biology & medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19857570","id":"19857570","citationCount":22,"stringAuthors":"Kalivendi SV, Yedlapudi D, Hillard CJ, Kalyanaraman B."}},{"resource":"20414966","link":"http://www.ncbi.nlm.nih.gov/pubmed/20414966","type":"PUBMED","article":{"title":"Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.","authors":["Zhang H"," Jia H"," Liu J"," Ao N"," Yan B"," Shen W"," Wang X"," Li X"," Luo C"," Liu J."],"journal":"Journal of cellular and molecular medicine","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20414966","id":"20414966","citationCount":21,"stringAuthors":"Zhang H, Jia H, Liu J, Ao N, Yan B, Shen W, Wang X, Li X, Luo C, Liu J."}},{"resource":"23153578","link":"http://www.ncbi.nlm.nih.gov/pubmed/23153578","type":"PUBMED","article":{"title":"Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment.","authors":["Cannon JR"," Geghman KD"," Tapias V"," Sew T"," Dail MK"," Li C"," Greenamyre JT."],"journal":"Experimental neurology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23153578","id":"23153578","citationCount":17,"stringAuthors":"Cannon JR, Geghman KD, Tapias V, Sew T, Dail MK, Li C, Greenamyre JT."}},{"resource":"20464527","link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","type":"PUBMED","article":{"title":"α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment.","authors":["George S"," Mok SS"," Nurjono M"," Ayton S"," Finkelstein DI"," Masters CL"," Li QX"," Culvenor JG."],"journal":"Journal of molecular neuroscience : MN","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/20464527","id":"20464527","citationCount":14,"stringAuthors":"George S, Mok SS, Nurjono M, Ayton S, Finkelstein DI, Masters CL, Li QX, Culvenor JG."}},{"resource":"12151787","link":"http://www.ncbi.nlm.nih.gov/pubmed/12151787","type":"PUBMED","article":{"title":"Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro.","authors":["Lehmensiek V"," Tan EM"," Schwarz J"," Storch A."],"journal":"Neuroreport","year":2002,"link":"http://www.ncbi.nlm.nih.gov/pubmed/12151787","id":"12151787","citationCount":13,"stringAuthors":"Lehmensiek V, Tan EM, Schwarz J, Storch A."}},{"resource":"23535362","link":"http://www.ncbi.nlm.nih.gov/pubmed/23535362","type":"PUBMED","article":{"title":"Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.","authors":["Chorfa A"," Bétemps D"," Morignat E"," Lazizzera C"," Hogeveen K"," Andrieu T"," Baron T."],"journal":"Toxicological sciences : an official journal of the Society of Toxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23535362","id":"23535362","citationCount":11,"stringAuthors":"Chorfa A, Bétemps D, Morignat E, Lazizzera C, Hogeveen K, Andrieu T, Baron T."}},{"resource":"26075822","link":"http://www.ncbi.nlm.nih.gov/pubmed/26075822","type":"PUBMED","article":{"title":"shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.","authors":["Zharikov AD"," Cannon JR"," Tapias V"," Bai Q"," Horowitz MP"," Shah V"," El Ayadi A"," Hastings TG"," Greenamyre JT"," Burton EA."],"journal":"The Journal of clinical investigation","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26075822","id":"26075822","citationCount":9,"stringAuthors":"Zharikov AD, Cannon JR, Tapias V, Bai Q, Horowitz MP, Shah V, El Ayadi A, Hastings TG, Greenamyre JT, Burton EA."}},{"resource":"23984410","link":"http://www.ncbi.nlm.nih.gov/pubmed/23984410","type":"PUBMED","article":{"title":"Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition.","authors":["Sala G"," Arosio A"," Stefanoni G"," Melchionda L"," Riva C"," Marinig D"," Brighina L"," Ferrarese C."],"journal":"BioMed Research International","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23984410","id":"23984410","citationCount":8,"stringAuthors":"Sala G, Arosio A, Stefanoni G, Melchionda L, Riva C, Marinig D, Brighina L, Ferrarese C."}},{"resource":"17690729","link":"http://www.ncbi.nlm.nih.gov/pubmed/17690729","type":"PUBMED","article":{"title":"alpha-Synuclein redistributed and aggregated in rotenone-induced Parkinson's disease rats.","authors":["Feng Y"," Liang ZH"," Wang T"," Qiao X"," Liu HJ"," Sun SG."],"journal":"Neuroscience bulletin","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17690729","id":"17690729","citationCount":8,"stringAuthors":"Feng Y, Liang ZH, Wang T, Qiao X, Liu HJ, Sun SG."}},{"resource":"25433145","link":"http://www.ncbi.nlm.nih.gov/pubmed/25433145","type":"PUBMED","article":{"title":"The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway.","authors":["Yuan YH"," Yan WF"," Sun JD"," Huang JY"," Mu Z"," Chen NH."],"journal":"Toxicology letters","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25433145","id":"25433145","citationCount":8,"stringAuthors":"Yuan YH, Yan WF, Sun JD, Huang JY, Mu Z, Chen NH."}},{"resource":"26031332","link":"http://www.ncbi.nlm.nih.gov/pubmed/26031332","type":"PUBMED","article":{"title":"Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.","authors":["Hou YS"," Guan JJ"," Xu HD"," Wu F"," Sheng R"," Qin ZH."],"journal":"Molecular and cellular biology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/26031332","id":"26031332","citationCount":5,"stringAuthors":"Hou YS, Guan JJ, Xu HD, Wu F, Sheng R, Qin ZH."}},{"resource":"23244436","link":"http://www.ncbi.nlm.nih.gov/pubmed/23244436","type":"PUBMED","article":{"title":"Environmental toxicants as extrinsic epigenetic factors for parkinsonism: studies employing transgenic C. elegans model.","authors":["Jadiya P"," Nazir A."],"journal":"CNS & neurological disorders drug targets","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23244436","id":"23244436","citationCount":5,"stringAuthors":"Jadiya P, Nazir A."}},{"resource":"25430725","link":"http://www.ncbi.nlm.nih.gov/pubmed/25430725","type":"PUBMED","article":{"title":"Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson's disease male Wistar rat model and effect of melatonin administration.","authors":["Mattam U"," Jagota A."],"journal":"Biogerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25430725","id":"25430725","citationCount":3,"stringAuthors":"Mattam U, Jagota A."}},{"resource":"27133439","link":"http://www.ncbi.nlm.nih.gov/pubmed/27133439","type":"PUBMED","article":{"title":"Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.","authors":["Sala G"," Marinig D"," Riva C"," Arosio A"," Stefanoni G"," Brighina L"," Formenti M"," Alberghina L"," Colangelo AM"," Ferrarese C."],"journal":"Neurotoxicology","year":2016,"link":"http://www.ncbi.nlm.nih.gov/pubmed/27133439","id":"27133439","citationCount":2,"stringAuthors":"Sala G, Marinig D, Riva C, Arosio A, Stefanoni G, Brighina L, Formenti M, Alberghina L, Colangelo AM, Ferrarese C."}},{"resource":"24002177","link":"http://www.ncbi.nlm.nih.gov/pubmed/24002177","type":"PUBMED","article":{"title":"14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity might be via its isoform 14-3-3epsilon's involvement in autophagy.","authors":["Sai Y"," Peng K"," Ye F"," Zhao X"," Zhao Y"," Zou Z"," Cao J"," Dong Z."],"journal":"Cellular and molecular neurobiology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24002177","id":"24002177","citationCount":1,"stringAuthors":"Sai Y, Peng K, Ye F, Zhao X, Zhao Y, Zou Z, Cao J, Dong Z."}},{"resource":"17041725","link":"http://www.ncbi.nlm.nih.gov/pubmed/17041725","type":"PUBMED","article":{"title":"[Overexpression of alpha-synuclein in SH-SY5Y cells partially protected against oxidative stress induced by rotenone].","authors":["Liu YY"," Zhao HY"," Zhao CL"," Duan CL"," Lu LL"," Yang H."],"journal":"Sheng li xue bao : [Acta physiologica Sinica]","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17041725","id":"17041725","citationCount":0,"stringAuthors":"Liu YY, Zhao HY, Zhao CL, Duan CL, Lu LL, Yang H."}}],"name":"SNCA","targetParticipants":[{"resource":"SNCA","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SNCA","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"17079513","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17070561","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," BenedàJ."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"Sánchez-Reus MI, Gómez del Rio MA, Iglesias I, Elorza M, Slowing K, BenedàJ."}},{"resource":"23639798","link":"http://www.ncbi.nlm.nih.gov/pubmed/23639798","type":"PUBMED","article":{"title":"Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster.","authors":["Sudati JH"," Vieira FA"," Pavin SS"," Dias GR"," Seeger RL"," Golombieski R"," Athayde ML"," Soares FA"," Rocha JB"," Barbosa NV."],"journal":"Neurotoxicology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23639798","id":"23639798","citationCount":17,"stringAuthors":"Sudati JH, Vieira FA, Pavin SS, Dias GR, Seeger RL, Golombieski R, Athayde ML, Soares FA, Rocha JB, Barbosa NV."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J, Liu W, Nakamura K, Berry MJ."}},{"resource":"24374061","link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","type":"PUBMED","article":{"title":"PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1.","authors":["Corona JC"," de Souza SC"," Duchen MR."],"journal":"Experimental neurology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24374061","id":"24374061","citationCount":12,"stringAuthors":"Corona JC, de Souza SC, Duchen MR."}},{"resource":"21807080","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M, Negro S, Slowing K, Fernández-Carballido A, Barcia E."}},{"resource":"22447502","link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","type":"PUBMED","article":{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":3,"stringAuthors":"Amberg JJ, Schreier TM, Gaikowski MP."}}],"name":"SOD1","targetParticipants":[{"resource":"SOD1","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SOD1","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"18032788","link":"http://www.ncbi.nlm.nih.gov/pubmed/18032788","type":"PUBMED","article":{"title":"Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.","authors":["Chen Y"," McMillan-Ward E"," Kong J"," Israels SJ"," Gibson SB."],"journal":"Journal of cell science","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18032788","id":"18032788","citationCount":167,"stringAuthors":"Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB."}},{"resource":"16179351","link":"http://www.ncbi.nlm.nih.gov/pubmed/16179351","type":"PUBMED","article":{"title":"Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress.","authors":["Hu Y"," Rosen DG"," Zhou Y"," Feng L"," Yang G"," Liu J"," Huang P."],"journal":"The Journal of biological chemistry","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16179351","id":"16179351","citationCount":103,"stringAuthors":"Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, Huang P."}},{"resource":"10463952","link":"http://www.ncbi.nlm.nih.gov/pubmed/10463952","type":"PUBMED","article":{"title":"Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death.","authors":["Kiningham KK"," Oberley TD"," Lin S"," Mattingly CA"," St Clair DK."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":1999,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10463952","id":"10463952","citationCount":48,"stringAuthors":"Kiningham KK, Oberley TD, Lin S, Mattingly CA, St Clair DK."}},{"resource":"17079513","link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","type":"PUBMED","article":{"title":"Microtubule: a common target for parkin and Parkinson's disease toxins.","authors":["Feng J."],"journal":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17079513","id":"17079513","citationCount":34,"stringAuthors":"Feng J."}},{"resource":"17070561","link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","type":"PUBMED","article":{"title":"Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.","authors":["Sánchez-Reus MI"," Gómez del Rio MA"," Iglesias I"," Elorza M"," Slowing K"," BenedàJ."],"journal":"Neuropharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17070561","id":"17070561","citationCount":21,"stringAuthors":"Sánchez-Reus MI, Gómez del Rio MA, Iglesias I, Elorza M, Slowing K, BenedàJ."}},{"resource":"15904944","link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","type":"PUBMED","article":{"title":"Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.","authors":["Molina-Jiménez MF"," Sánchez-Reus MI"," Cascales M"," Andrés D"," BenedàJ."],"journal":"Toxicology and applied pharmacology","year":2005,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15904944","id":"15904944","citationCount":14,"stringAuthors":"Molina-Jiménez MF, Sánchez-Reus MI, Cascales M, Andrés D, BenedàJ."}},{"resource":"17657281","link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","type":"PUBMED","article":{"title":"The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.","authors":["Panee J"," Liu W"," Nakamura K"," Berry MJ."],"journal":"International journal of biological sciences","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17657281","id":"17657281","citationCount":13,"stringAuthors":"Panee J, Liu W, Nakamura K, Berry MJ."}},{"resource":"21807080","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M, Negro S, Slowing K, Fernández-Carballido A, Barcia E."}},{"resource":"19818760","link":"http://www.ncbi.nlm.nih.gov/pubmed/19818760","type":"PUBMED","article":{"title":"Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cells.","authors":["Kadota Y"," Suzuki S"," Ideta S"," Fukinbara Y"," Kawakami T"," Imai H"," Nakagawa Y"," Sato M."],"journal":"European journal of pharmacology","year":2010,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19818760","id":"19818760","citationCount":7,"stringAuthors":"Kadota Y, Suzuki S, Ideta S, Fukinbara Y, Kawakami T, Imai H, Nakagawa Y, Sato M."}},{"resource":"8989910","link":"http://www.ncbi.nlm.nih.gov/pubmed/8989910","type":"PUBMED","article":{"title":"Increased manganese superoxide dismutase activity, protein, and mRNA levels and concurrent induction of tumor necrosis factor alpha in radiation-initiated Syrian hamster cells.","authors":["Otero G"," Avila MA"," Emfietzoglou D"," Clerch LB"," Massaro D"," Notario V."],"journal":"Molecular carcinogenesis","year":1996,"link":"http://www.ncbi.nlm.nih.gov/pubmed/8989910","id":"8989910","citationCount":7,"stringAuthors":"Otero G, Avila MA, Emfietzoglou D, Clerch LB, Massaro D, Notario V."}},{"resource":"22447502","link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","type":"PUBMED","article":{"title":"Molecular responses differ between sensitive silver carp and tolerant bighead carp and bigmouth buffalo exposed to rotenone.","authors":["Amberg JJ"," Schreier TM"," Gaikowski MP."],"journal":"Fish physiology and biochemistry","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22447502","id":"22447502","citationCount":3,"stringAuthors":"Amberg JJ, Schreier TM, Gaikowski MP."}},{"resource":"25843018","link":"http://www.ncbi.nlm.nih.gov/pubmed/25843018","type":"PUBMED","article":{"title":"Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats.","authors":["Singh AK"," Pandey SK"," Saha G"," Gattupalli NK."],"journal":"Experimental gerontology","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25843018","id":"25843018","citationCount":2,"stringAuthors":"Singh AK, Pandey SK, Saha G, Gattupalli NK."}}],"name":"SOD2","targetParticipants":[{"resource":"SOD2","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=SOD2","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"10878378","link":"http://www.ncbi.nlm.nih.gov/pubmed/10878378","type":"PUBMED","article":{"title":"Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin.","authors":["Chandel NS"," Trzyna WC"," McClintock DS"," Schumacker PT."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10878378","id":"10878378","citationCount":153,"stringAuthors":"Chandel NS, Trzyna WC, McClintock DS, Schumacker PT."}},{"resource":"10973919","link":"http://www.ncbi.nlm.nih.gov/pubmed/10973919","type":"PUBMED","article":{"title":"Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species.","authors":["Deshpande SS"," Angkeow P"," Huang J"," Ozaki M"," Irani K."],"journal":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","year":2000,"link":"http://www.ncbi.nlm.nih.gov/pubmed/10973919","id":"10973919","citationCount":97,"stringAuthors":"Deshpande SS, Angkeow P, Huang J, Ozaki M, Irani K."}},{"resource":"7532384","link":"http://www.ncbi.nlm.nih.gov/pubmed/7532384","type":"PUBMED","article":{"title":"Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione.","authors":["Duval DL"," Sieg DJ"," Billings RE."],"journal":"Archives of biochemistry and biophysics","year":1995,"link":"http://www.ncbi.nlm.nih.gov/pubmed/7532384","id":"7532384","citationCount":35,"stringAuthors":"Duval DL, Sieg DJ, Billings RE."}},{"resource":"17356569","link":"http://www.ncbi.nlm.nih.gov/pubmed/17356569","type":"PUBMED","article":{"title":"Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation.","authors":["Zhou F"," Wu JY"," Sun XL"," Yao HH"," Ding JH"," Hu G."],"journal":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","year":2007,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17356569","id":"17356569","citationCount":34,"stringAuthors":"Zhou F, Wu JY, Sun XL, Yao HH, Ding JH, Hu G."}},{"resource":"19012619","link":"http://www.ncbi.nlm.nih.gov/pubmed/19012619","type":"PUBMED","article":{"title":"Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation.","authors":["Zhou F"," Yao HH"," Wu JY"," Ding JH"," Sun T"," Hu G."],"journal":"Journal of cellular and molecular medicine","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/19012619","id":"19012619","citationCount":32,"stringAuthors":"Zhou F, Yao HH, Wu JY, Ding JH, Sun T, Hu G."}},{"resource":"15135310","link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","type":"PUBMED","article":{"title":"Inverse gene expression patterns for macrophage activating hepatotoxicants and peroxisome proliferators in rat liver.","authors":["McMillian M"," Nie AY"," Parker JB"," Leone A"," Kemmerer M"," Bryant S"," Herlich J"," Yieh L"," Bittner A"," Liu X"," Wan J"," Johnson MD."],"journal":"Biochemical pharmacology","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15135310","id":"15135310","citationCount":27,"stringAuthors":"McMillian M, Nie AY, Parker JB, Leone A, Kemmerer M, Bryant S, Herlich J, Yieh L, Bittner A, Liu X, Wan J, Johnson MD."}},{"resource":"17015749","link":"http://www.ncbi.nlm.nih.gov/pubmed/17015749","type":"PUBMED","article":{"title":"Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.","authors":["Nair AS"," Shishodia S"," Ahn KS"," Kunnumakkara AB"," Sethi G"," Aggarwal BB."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/17015749","id":"17015749","citationCount":26,"stringAuthors":"Nair AS, Shishodia S, Ahn KS, Kunnumakkara AB, Sethi G, Aggarwal BB."}},{"resource":"22623043","link":"http://www.ncbi.nlm.nih.gov/pubmed/22623043","type":"PUBMED","article":{"title":"Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice.","authors":["Kang HW"," Kim JM"," Cha MY"," Jung HC"," Song IS"," Kim JS."],"journal":"Digestive diseases and sciences","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22623043","id":"22623043","citationCount":18,"stringAuthors":"Kang HW, Kim JM, Cha MY, Jung HC, Song IS, Kim JS."}},{"resource":"18841906","link":"http://www.ncbi.nlm.nih.gov/pubmed/18841906","type":"PUBMED","article":{"title":"Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.","authors":["Dat NT"," Lee JH"," Lee K"," Hong YS"," Kim YH"," Lee JJ."],"journal":"Journal of natural products","year":2008,"link":"http://www.ncbi.nlm.nih.gov/pubmed/18841906","id":"18841906","citationCount":17,"stringAuthors":"Dat NT, Lee JH, Lee K, Hong YS, Kim YH, Lee JJ."}},{"resource":"16257489","link":"http://www.ncbi.nlm.nih.gov/pubmed/16257489","type":"PUBMED","article":{"title":"The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.","authors":["Liu X"," Wu JY"," Zhou F"," Sun XL"," Yao HH"," Yang Y"," Ding JH"," Hu G."],"journal":"Neuroscience letters","year":2006,"link":"http://www.ncbi.nlm.nih.gov/pubmed/16257489","id":"16257489","citationCount":16,"stringAuthors":"Liu X, Wu JY, Zhou F, Sun XL, Yao HH, Yang Y, Ding JH, Hu G."}},{"resource":"25086357","link":"http://www.ncbi.nlm.nih.gov/pubmed/25086357","type":"PUBMED","article":{"title":"Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.","authors":["Du C"," Jin M"," Hong Y"," Li Q"," Wang XH"," Xu JM"," Wang F"," Zhang Y"," Jia J"," Liu CF"," Hu LF."],"journal":"Biochemical and biophysical research communications","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25086357","id":"25086357","citationCount":8,"stringAuthors":"Du C, Jin M, Hong Y, Li Q, Wang XH, Xu JM, Wang F, Zhang Y, Jia J, Liu CF, Hu LF."}},{"resource":"24830863","link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","type":"PUBMED","article":{"title":"Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.","authors":["Ai Q"," Jing Y"," Jiang R"," Lin L"," Dai J"," Che Q"," Zhou D"," Jia M"," Wan J"," Zhang L."],"journal":"International immunopharmacology","year":2014,"link":"http://www.ncbi.nlm.nih.gov/pubmed/24830863","id":"24830863","citationCount":8,"stringAuthors":"Ai Q, Jing Y, Jiang R, Lin L, Dai J, Che Q, Zhou D, Jia M, Wan J, Zhang L."}},{"resource":"21807080","link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","type":"PUBMED","article":{"title":"An effective novel delivery strategy of rasagiline for Parkinson's disease.","authors":["Fernández M"," Negro S"," Slowing K"," Fernández-Carballido A"," Barcia E."],"journal":"International journal of pharmaceutics","year":2011,"link":"http://www.ncbi.nlm.nih.gov/pubmed/21807080","id":"21807080","citationCount":8,"stringAuthors":"Fernández M, Negro S, Slowing K, Fernández-Carballido A, Barcia E."}},{"resource":"23593274","link":"http://www.ncbi.nlm.nih.gov/pubmed/23593274","type":"PUBMED","article":{"title":"Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells.","authors":["Chang CY"," Choi DK"," Lee DK"," Hong YJ"," Park EJ."],"journal":"PloS one","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23593274","id":"23593274","citationCount":8,"stringAuthors":"Chang CY, Choi DK, Lee DK, Hong YJ, Park EJ."}},{"resource":"15720824","link":"http://www.ncbi.nlm.nih.gov/pubmed/15720824","type":"PUBMED","article":{"title":"Rotenone, a mitochondrial electron transport inhibitor, ameliorates ischemia-reperfusion-induced intestinal mucosal damage in rats.","authors":["Ichikawa H"," Takagi T"," Uchiyama K"," Higashihara H"," Katada K"," Isozaki Y"," Naito Y"," Yoshida N"," Yoshikawa T."],"journal":"Redox report : communications in free radical research","year":2004,"link":"http://www.ncbi.nlm.nih.gov/pubmed/15720824","id":"15720824","citationCount":7,"stringAuthors":"Ichikawa H, Takagi T, Uchiyama K, Higashihara H, Katada K, Isozaki Y, Naito Y, Yoshida N, Yoshikawa T."}},{"resource":"23645222","link":"http://www.ncbi.nlm.nih.gov/pubmed/23645222","type":"PUBMED","article":{"title":"Rotenone could activate microglia through NFκB associated pathway.","authors":["Yuan YH"," Sun JD"," Wu MM"," Hu JF"," Peng SY"," Chen NH."],"journal":"Neurochemical research","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23645222","id":"23645222","citationCount":7,"stringAuthors":"Yuan YH, Sun JD, Wu MM, Hu JF, Peng SY, Chen NH."}},{"resource":"25481089","link":"http://www.ncbi.nlm.nih.gov/pubmed/25481089","type":"PUBMED","article":{"title":"Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis.","authors":["Khalil WK"," Assaf N"," ElShebiney SA"," Salem NA."],"journal":"Neurochemistry international","year":2015,"link":"http://www.ncbi.nlm.nih.gov/pubmed/25481089","id":"25481089","citationCount":5,"stringAuthors":"Khalil WK, Assaf N, ElShebiney SA, Salem NA."}}],"name":"TNF","targetParticipants":[{"resource":"TNF","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=TNF","id":0,"type":"HGNC_SYMBOL"}]}]}] \ No newline at end of file diff --git a/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID& index f23119257d..358201fdef 100644 --- a/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID& +++ b/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=NADH&token=MOCK_TOKEN_ID& @@ -1 +1 @@ -[{"brandNames":[],"references":[{"resource":"DB00157","link":"http://www.drugbank.ca/drugs/DB00157","id":0,"type":null}],"synonyms":["1,4-dihydronicotinamide adenine dinucleotide","DPNH","NAD reduced form","Nicotinamide adenine dinucleotide (reduced)","Nicotinamide-adenine dinucleotide, reduced","Reduced nicotinamide adenine diphosphate","Reduced nicotinamide-adenine dinucleotide"],"name":"NADH","description":"NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed)","id":"NADH","targets":[],"bloodBrainBarrier":"YES"}] \ No newline at end of file +[{"brandNames":[],"references":[{"resource":"DB00157","link":"http://www.drugbank.ca/drugs/DB00157","id":0,"type":"DRUGBANK"}],"synonyms":["1,4-dihydronicotinamide adenine dinucleotide","DPNH","NAD reduced form","Nicotinamide adenine dinucleotide (reduced)","Nicotinamide-adenine dinucleotide, reduced","Reduced nicotinamide adenine diphosphate","Reduced nicotinamide-adenine dinucleotide"],"name":"NADH","description":"NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed)","id":"NADH","targets":[],"bloodBrainBarrier":"YES"}] \ No newline at end of file diff --git a/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=aspirin&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=aspirin&token=MOCK_TOKEN_ID& index 63b1d24d74..6aac976db2 100644 --- a/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=aspirin&token=MOCK_TOKEN_ID& +++ b/frontend-js/testFiles/apiCalls/projects/sample/drugs.search/query=aspirin&token=MOCK_TOKEN_ID& @@ -1 +1 @@ -[{"brandNames":["Acenterine","Acetophen","Adiro","Aspergum","Aspro","Bayer Aspirin","Easprin","Empirin","Nu-seals","Rhodine","Rhonal","Solprin","Solprin acid","St. Joseph Aspirin for Adults","Tasprin"],"references":[{"resource":"DB00945","link":"http://www.drugbank.ca/drugs/DB00945","id":0,"type":null},{"resource":"CHEMBL25","link":"https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL25","id":0,"type":null}],"synonyms":["2-Acetoxybenzenecarboxylic acid","2-Acetoxybenzoic acid","Acetylsalicylate","Acetylsalicylsäure","acide 2-(acÊtyloxy)benzoïque","acide acÊtylsalicylique","Ã¥cido acetilsalicÃÂÂlico","Acidum acetylsalicylicum","ASA","Aspirin","Azetylsalizylsäure","o-acetoxybenzoic acid","O-acetylsalicylic acid","o-carboxyphenyl acetate","Polopiryna","salicylic acid acetate","8-hour bayer","ACETYLSALICYLIC ACID","ASPIRIN","Acetosalic Acid","Acetylsalicylic Acid","Bayer extra strength aspirin for migraine pain","Ecotrin","Equi-Prin","Measurin","Salicylic Acid Acetate"],"name":"ASPIRIN","description":"The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) ","id":"ASPIRIN","targets":[],"bloodBrainBarrier":"YES"}] \ No newline at end of file +[{"brandNames":["Acenterine","Acetophen","Adiro","Aspergum","Aspro","Bayer Aspirin","Easprin","Empirin","Nu-seals","Rhodine","Rhonal","Solprin","Solprin acid","St. Joseph Aspirin for Adults","Tasprin"],"references":[{"resource":"DB00945","link":"http://www.drugbank.ca/drugs/DB00945","id":0,"type":"DRUGBANK"},{"resource":"CHEMBL25","link":"https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL25","id":0,"type":"CHEMBL_COMPOUND"}],"synonyms":["2-Acetoxybenzenecarboxylic acid","2-Acetoxybenzoic acid","Acetylsalicylate","Acetylsalicylsäure","acide 2-(acÊtyloxy)benzoïque","acide acÊtylsalicylique","Ã¥cido acetilsalicÃÂÂlico","Acidum acetylsalicylicum","ASA","Aspirin","Azetylsalizylsäure","o-acetoxybenzoic acid","O-acetylsalicylic acid","o-carboxyphenyl acetate","Polopiryna","salicylic acid acetate","8-hour bayer","ACETYLSALICYLIC ACID","ASPIRIN","Acetosalic Acid","Acetylsalicylic Acid","Bayer extra strength aspirin for migraine pain","Ecotrin","Equi-Prin","Measurin","Salicylic Acid Acetate"],"name":"ASPIRIN","description":"The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) ","id":"ASPIRIN","targets":[],"bloodBrainBarrier":"YES"}] \ No newline at end of file diff --git a/frontend-js/testFiles/apiCalls/projects/sample/miRnas.search/query=hsa-miR-125a-3p&token=MOCK_TOKEN_ID& b/frontend-js/testFiles/apiCalls/projects/sample/miRnas.search/query=hsa-miR-125a-3p&token=MOCK_TOKEN_ID& index ec80d22735..a4bc30403b 100644 --- a/frontend-js/testFiles/apiCalls/projects/sample/miRnas.search/query=hsa-miR-125a-3p&token=MOCK_TOKEN_ID& +++ b/frontend-js/testFiles/apiCalls/projects/sample/miRnas.search/query=hsa-miR-125a-3p&token=MOCK_TOKEN_ID& @@ -1 +1 @@ -[{"name":"hsa-miR-125a-3p","id":"hsa-miR-125a-3p","targets":[{"targetElements":[],"references":[{"resource":"23606749","link":"http://www.ncbi.nlm.nih.gov/pubmed/23606749","type":"PUBMED","article":{"title":"microRNA-125a-3p reduces cell proliferation and migration by targeting Fyn.","authors":["Ninio-Many L"," Grossman H"," Shomron N"," Chuderland D"," Shalgi R."],"journal":"Journal of cell science","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23606749","id":"23606749","citationCount":18,"stringAuthors":"Ninio-Many L, Grossman H, Shomron N, Chuderland D, Shalgi R."}}],"name":"FYN","targetParticipants":[{"resource":"FYN","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=FYN","id":0,"type":null}]},{"targetElements":[],"references":[{"resource":"22644326","link":"http://www.ncbi.nlm.nih.gov/pubmed/22644326","type":"PUBMED","article":{"title":"MicroRNA-125a inhibits cell growth by targeting glypican-4.","authors":["Feng C"," Li J"," Ruan J"," Ding K."],"journal":"Glycoconjugate journal","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22644326","id":"22644326","citationCount":6,"stringAuthors":"Feng C, Li J, Ruan J, Ding K."}}],"name":"GPC4","targetParticipants":[{"resource":"GPC4","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPC4","id":0,"type":null}]},{"targetElements":[],"references":[{"resource":"23525486","link":"http://www.ncbi.nlm.nih.gov/pubmed/23525486","type":"PUBMED","article":{"title":"MiRNA-125a-3p is a negative regulator of the RhoA-actomyosin pathway in A549 cells.","authors":["Huang B"," Luo W"," Sun L"," Zhang Q"," Jiang L"," Chang J"," Qiu X"," Wang E."],"journal":"International journal of oncology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23525486","id":"23525486","citationCount":8,"stringAuthors":"Huang B, Luo W, Sun L, Zhang Q, Jiang L, Chang J, Qiu X, Wang E."}}],"name":"RHOA","targetParticipants":[{"resource":"RHOA","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=RHOA","id":0,"type":null}]}]}] \ No newline at end of file +[{"name":"hsa-miR-125a-3p","id":"hsa-miR-125a-3p","targets":[{"targetElements":[],"references":[{"resource":"23606749","link":"http://www.ncbi.nlm.nih.gov/pubmed/23606749","type":"PUBMED","article":{"title":"microRNA-125a-3p reduces cell proliferation and migration by targeting Fyn.","authors":["Ninio-Many L"," Grossman H"," Shomron N"," Chuderland D"," Shalgi R."],"journal":"Journal of cell science","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23606749","id":"23606749","citationCount":18,"stringAuthors":"Ninio-Many L, Grossman H, Shomron N, Chuderland D, Shalgi R."}}],"name":"FYN","targetParticipants":[{"resource":"FYN","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=FYN","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"22644326","link":"http://www.ncbi.nlm.nih.gov/pubmed/22644326","type":"PUBMED","article":{"title":"MicroRNA-125a inhibits cell growth by targeting glypican-4.","authors":["Feng C"," Li J"," Ruan J"," Ding K."],"journal":"Glycoconjugate journal","year":2012,"link":"http://www.ncbi.nlm.nih.gov/pubmed/22644326","id":"22644326","citationCount":6,"stringAuthors":"Feng C, Li J, Ruan J, Ding K."}}],"name":"GPC4","targetParticipants":[{"resource":"GPC4","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=GPC4","id":0,"type":"HGNC_SYMBOL"}]},{"targetElements":[],"references":[{"resource":"23525486","link":"http://www.ncbi.nlm.nih.gov/pubmed/23525486","type":"PUBMED","article":{"title":"MiRNA-125a-3p is a negative regulator of the RhoA-actomyosin pathway in A549 cells.","authors":["Huang B"," Luo W"," Sun L"," Zhang Q"," Jiang L"," Chang J"," Qiu X"," Wang E."],"journal":"International journal of oncology","year":2013,"link":"http://www.ncbi.nlm.nih.gov/pubmed/23525486","id":"23525486","citationCount":8,"stringAuthors":"Huang B, Luo W, Sun L, Zhang Q, Jiang L, Chang J, Qiu X, Wang E."}}],"name":"RHOA","targetParticipants":[{"resource":"RHOA","link":"http://www.genenames.org/cgi-bin/gene_symbol_report?match=RHOA","id":0,"type":"HGNC_SYMBOL"}]}]}] \ No newline at end of file diff --git a/rest-api/src/main/java/lcsb/mapviewer/api/projects/chemicals/ChemicalRestImpl.java b/rest-api/src/main/java/lcsb/mapviewer/api/projects/chemicals/ChemicalRestImpl.java index e3f6631dd2..0c125d5fce 100644 --- a/rest-api/src/main/java/lcsb/mapviewer/api/projects/chemicals/ChemicalRestImpl.java +++ b/rest-api/src/main/java/lcsb/mapviewer/api/projects/chemicals/ChemicalRestImpl.java @@ -171,9 +171,9 @@ public class ChemicalRestImpl extends BaseRestImpl { Map<String, Object> result = new HashMap<>(); result.put("name", target.getName()); result.put("references", createAnnotations(target.getReferences())); - List<AnnotationView> participants = new ArrayList<>(); + List<Object> participants = new ArrayList<>(); for (GeneRow row : target.getProteins()) { - participants.add(row.getAnnotation()); + participants.add(createAnnotation(row.getAnnotation())); } result.put("targetParticipants", participants); -- GitLab