diff --git a/annotation/src/main/java/lcsb/mapviewer/annotation/services/DrugbankXMLParser.java b/annotation/src/main/java/lcsb/mapviewer/annotation/services/DrugbankXMLParser.java
deleted file mode 100644
index 3c46d458016b39879bdb6b69a3dd3a5d15fab15e..0000000000000000000000000000000000000000
--- a/annotation/src/main/java/lcsb/mapviewer/annotation/services/DrugbankXMLParser.java
+++ /dev/null
@@ -1,404 +0,0 @@
-package lcsb.mapviewer.annotation.services;
-
-import java.io.FileInputStream;
-import java.io.FileNotFoundException;
-import java.util.ArrayList;
-import java.util.List;
-
-import javax.xml.stream.XMLInputFactory;
-import javax.xml.stream.XMLStreamConstants;
-import javax.xml.stream.XMLStreamException;
-import javax.xml.stream.XMLStreamReader;
-
-import org.apache.log4j.Logger;
-
-import lcsb.mapviewer.annotation.data.Drug;
-import lcsb.mapviewer.annotation.data.Target;
-import lcsb.mapviewer.annotation.data.TargetType;
-import lcsb.mapviewer.model.map.MiriamData;
-import lcsb.mapviewer.model.map.MiriamRelationType;
-import lcsb.mapviewer.model.map.MiriamType;
-
-/**
- * Class used for parsing and accessing data from xml drugbank database. Parser
- * was developed by Janek. I tried to comment it as best as I could, but...
- *
- * @author Piotr Gawron
- *
- */
-public class DrugbankXMLParser {
- /**
- * Default class logger.
- */
- @SuppressWarnings("unused")
- private static Logger logger = Logger.getLogger(DrugbankXMLParser.class);
-
- /**
- * ???
- */
- private static final int RELATED_INFORMATION_TAG = 3;
-
- /**
- * Node identifing drug.
- */
- static final String DRUG = "drug";
-
- /**
- * Node identifing drug identifier.
- */
- static final String DID = "drugbank-id";
-
- /**
- * Node identifing drug name.
- */
- static final String NAME = "name";
-
- /**
- * Node identifing drug description.
- */
- static final String DES = "description";
-
- /**
- * Node identifing single synonym.
- */
- static final String SY = "synonym";
-
- /**
- * Node identifing list of synonym.
- */
- static final String SYS = "synonyms";
-
- /**
- * Node identifing single target.
- */
- static final String TAR = "target";
-
- /**
- * Node identifing list of targets.
- */
- static final String TARGETS = "targets";
-
- /**
- * File with the drugbank xml file.
- */
- private String dbFile = null;
-
- /**
- * Object used to access information about organism taxonomy.
- */
- private TaxonomyBackend taxonomyBackend;
-
- /**
- * List of drugs found in the xml file.
- */
- private List<Drug> drugList = null;
-
- /**
- * Default constructor.
- *
- * @param file
- * file where data is stored
- * @param backend
- * {@link #taxonomyBackend}
- */
- public DrugbankXMLParser(String file, TaxonomyBackend backend) {
- this.dbFile = file;
- this.taxonomyBackend = backend;
- }
-
- /**
- * Transforms string representing pubmed identifiers into {@link MiriamData}
- * objects and set them to {@link Target}.
- *
- * @param target
- * where the data should be put
- * @param referencesString
- * string with pubmed identifiers
- */
- void getPubmedFromRef(Target target, String referencesString) {
- int position = 0;
- int length = "/pubmed/".length();
- while ((position = referencesString.indexOf("/pubmed/", position)) > 0) {
- position += length;
- StringBuilder tmp = new StringBuilder("");
- while (position < referencesString.length() && referencesString.charAt(position) >= '0' && referencesString.charAt(position) <= '9') {
- tmp.append(referencesString.charAt(position));
- position++;
- }
- target.addReference(new MiriamData(MiriamRelationType.BQ_BIOL_IS_DESCRIBED_BY, MiriamType.PUBMED, tmp.toString()));
- }
- }
-
- /**
- * Adds gene identifiers to the target.
- *
- * @param reader
- * xml reader used for parsing xml
- * @param target
- * where the data should be added
- * @throws XMLStreamException
- * thrown when there is a problem with xml
- */
- public void getGeneCardId(XMLStreamReader reader, Target target) throws XMLStreamException {
- boolean relevant = false;
- int event;
- while (true) {
- event = reader.next();
- if (event == XMLStreamConstants.CHARACTERS) {
- if (reader.getText().trim().equals("GeneCards")) {
- relevant = true;
- } else if (relevant && !reader.getText().trim().equals("")) {
- String identifier = reader.getText().trim();
- target.addGene(new MiriamData(MiriamRelationType.BQ_BIOL_IS_DESCRIBED_BY, MiriamType.HGNC_SYMBOL, identifier));
- relevant = false;
- }
- } else if (event == XMLStreamConstants.END_ELEMENT) {
- if (reader.getLocalName().equals("external-identifiers")) {
- break;
- }
- }
- }
- }
-
- /**
- * This function is magic...
- *
- * @param localName
- * ???
- * @param tagContent
- * ???
- * @param tagName
- * ???
- * @param rel
- * ???
- * @param target
- * ???
- * @param drug
- * ???
- * @return ???
- * @throws DrugSearchException
- * thrown when there is a problem with data coming from external
- * databases
- */
- public int targetEndElement(String localName, String tagContent, String tagName, Boolean rel, Target target, Drug drug) throws DrugSearchException {
- if (localName.equals("id")) {
- if (rel) {
- MiriamData md = new MiriamData(MiriamRelationType.BQ_BIOL_IS_DESCRIBED_BY, MiriamType.DRUGBANK_TARGET_V4, tagContent);
- target.setSource(md);
- return 0;
- }
- } else if (localName.equals("name")) {
- if (rel) {
- target.setName(tagContent);
- return 0;
- }
- } else if (localName.equals("organism")) {
- if (rel) {
- try {
- target.setOrganism(taxonomyBackend.getByName(tagContent));
- } catch (TaxonomySearchException e) {
- throw new DrugSearchException(e);
- }
- return 0;
- }
-
- } else if (localName.equals("references")) {
- if (rel) {
- return 1;
- }
- } else if (localName.equals(TAR)) {
- if (rel) {
- drug.addTarget(target);
- return 0;
- }
-
- } else if (localName.equals(TARGETS)) {
- return 2;
- } else if (localName.equals(tagName)) {
- return RELATED_INFORMATION_TAG;
- }
- return 0;
- }
-
- /**
- * Adds target to a drug.
- *
- * @param reader
- * xml reader used for parsing xml
- * @param drug
- * where target should be added
- * @throws XMLStreamException
- * thrown when there is a problem with xml
- * @throws DrugSearchException
- * thrown when there is a problem with data coming from external
- * databases
- */
- public void addTargetToDrug(XMLStreamReader reader, Drug drug) throws XMLStreamException, DrugSearchException {
- boolean relatedInformation = true;
- String tagName = null;
- String tagContent = null;
- Target target = null;
- boolean readingReferences = false;
- while (true) {
- int event = reader.next();
-
- if (event == XMLStreamConstants.START_ELEMENT) {
- if (relatedInformation) {
- if (TAR.equals(reader.getLocalName())) {
- target = new Target();
- target.setType(TargetType.SINGLE_PROTEIN);
- } else {
- relatedInformation = false;
- tagName = reader.getLocalName();
- if ("id".equals(tagName) || "name".equals(tagName) || "organism".equals(tagName)) {
- relatedInformation = true;
- }
- if ("references".equals(tagName)) {
- relatedInformation = true;
- readingReferences = true;
- }
- if ("components".equals(tagName)) {
- relatedInformation = true;
- getGeneCardId(reader, target);
- }
- }
- }
- }
- if (event == XMLStreamConstants.CHARACTERS) {
- tagContent = reader.getText().trim();
- if (readingReferences) {
- getPubmedFromRef(target, tagContent);
- }
- }
-
- if (event == XMLStreamConstants.END_ELEMENT) {
- int what = targetEndElement(reader.getLocalName(), tagContent, tagName, relatedInformation, target, drug);
- if (what == 1) {
- readingReferences = false;
- } else if (what == 2) {
- break;
- } else if (what == RELATED_INFORMATION_TAG) {
- relatedInformation = true;
- }
- }
- }
-
- }
-
- /**
- * Checks if tag is important for us or not.
- *
- * @param tagName
- * name of the tag
- * @return true if tag is relevant, <code>false</code> otherwise
- */
- public Boolean tagNameRelated(String tagName) {
- if ("drugs".equals(tagName) || DID.equals(tagName) || NAME.equals(tagName) || DES.equals(tagName) || DES.equals(tagName) || SY.equals(tagName)
- || SYS.equals(tagName)) {
- return true;
- }
- return false;
-
- }
-
- /**
- * Gets drug from xml database.
- *
- * @param drugName
- * name of the drug
- * @return drug from the database
- * @throws DrugSearchException
- * thrown when there is a problem with finding drug
- */
- public Drug findDrug(String drugName) throws DrugSearchException {
- for (Drug drug : getDrugList()) {
- if (drug.getName().equalsIgnoreCase(drugName)) {
- return drug;
- }
- for (String string : drug.getSynonyms()) {
- if (string.equalsIgnoreCase(drugName)) {
- return drug;
- }
- }
- }
- return null;
- }
-
- /**
- * Gets drug list from xml database.
- *
- * @return drug list from the database
- * @throws DrugSearchException
- * thrown when there is problem with finding drug
- */
- public List<Drug> getDrugList() throws DrugSearchException {
- if (drugList != null) {
- return drugList;
- }
- drugList = new ArrayList<Drug>();
- /*************** INIT ******************************/
- try {
- XMLInputFactory f = XMLInputFactory.newInstance();
- FileInputStream temp = new FileInputStream(dbFile);
- XMLStreamReader reader = f.createXMLStreamReader(temp);
-
- Drug drug = null;
- String tagContent = null;
- boolean relevant = true;
- String tagName = null;
- /*************** END OF INIT ***********************/
- while (reader.hasNext()) {
- int event = reader.next();
-
- if (event == XMLStreamConstants.START_ELEMENT) {
- if (relevant) {
- if (DRUG.equals(reader.getLocalName())) {
- drug = new Drug();
- } else {
- relevant = false;
- tagName = reader.getLocalName();
- if (tagNameRelated(tagName)) {
- relevant = true;
- }
- if (TARGETS.equals(tagName)) {
- relevant = true;
- addTargetToDrug(reader, drug);
- }
- }
- }
- } else if (event == XMLStreamConstants.CHARACTERS) {
- tagContent = reader.getText().trim();
- } else if (event == XMLStreamConstants.END_ELEMENT) {
- if (reader.getLocalName().equals(DID)) {
- if (relevant) {
- MiriamData md = new MiriamData(MiriamRelationType.BQ_BIOL_IS_DESCRIBED_BY, MiriamType.DRUGBANK, tagContent);
- drug.addSource(md);
- }
- } else if (reader.getLocalName().equals(NAME)) {
- if (relevant) {
- drug.setName(tagContent);
- }
- } else if (reader.getLocalName().equals(DES)) {
- if (relevant && (!"".equals(tagContent.trim()))) {
- drug.setDescription(tagContent);
- }
- } else if (reader.getLocalName().equals(DRUG)) {
- if (relevant) {
- drugList.add(drug);
- }
- } else if (reader.getLocalName().equals(SY)) {
- if (relevant) {
- drug.addSynonym(tagContent);
- }
- } else if (!relevant && tagName.equals(reader.getLocalName())) {
- relevant = true;
- }
- }
- }
-
- } catch (XMLStreamException | FileNotFoundException e) {
- throw new DrugSearchException("Problem with processing input file", e);
- }
- return drugList;
- }
-}
\ No newline at end of file
diff --git a/annotation/src/test/java/lcsb/mapviewer/annotation/services/AllServicesTests.java b/annotation/src/test/java/lcsb/mapviewer/annotation/services/AllServicesTests.java
index 1a6650a25ebfc06bb8be1dd92ed9191bf007c96d..9402bd6e150a558bd6cc3ffae65e1f86f626ab0c 100644
--- a/annotation/src/test/java/lcsb/mapviewer/annotation/services/AllServicesTests.java
+++ b/annotation/src/test/java/lcsb/mapviewer/annotation/services/AllServicesTests.java
@@ -15,7 +15,6 @@ import org.junit.runners.Suite.SuiteClasses;
ChemicalSearchExceptionTest.class, //
DrugAnnotationTest.class, //
DrugbankHTMLParserTest.class, //
- DrugbankXMLParserTest.class, //
ExternalServiceStatusTest.class, //
ExternalServiceStatusTypeTest.class, //
ImproperAnnotationsTest.class, //
diff --git a/annotation/src/test/java/lcsb/mapviewer/annotation/services/DrugbankXMLParserTest.java b/annotation/src/test/java/lcsb/mapviewer/annotation/services/DrugbankXMLParserTest.java
deleted file mode 100644
index 7f6c68fa26929e10a5c9e999118752e4306aa806..0000000000000000000000000000000000000000
--- a/annotation/src/test/java/lcsb/mapviewer/annotation/services/DrugbankXMLParserTest.java
+++ /dev/null
@@ -1,146 +0,0 @@
-package lcsb.mapviewer.annotation.services;
-
-import static org.junit.Assert.assertEquals;
-import static org.junit.Assert.assertTrue;
-import static org.junit.Assert.fail;
-import static org.mockito.Matchers.anyString;
-import static org.mockito.Mockito.when;
-
-import org.apache.log4j.Logger;
-import org.junit.Before;
-import org.junit.Test;
-import org.mockito.Mockito;
-import org.springframework.beans.factory.annotation.Autowired;
-
-import lcsb.mapviewer.annotation.AnnotationTestFunctions;
-import lcsb.mapviewer.annotation.data.Drug;
-import lcsb.mapviewer.annotation.data.Target;
-import lcsb.mapviewer.model.map.MiriamType;
-
-public class DrugbankXMLParserTest extends AnnotationTestFunctions {
- Logger logger = Logger.getLogger(DrugbankXMLParserTest.class);
-
- String file = "testFiles/target_drugbank/small_drugbank.xml";
-
- @Autowired
- TaxonomyBackend taxonomyBackend;
-
- // this should be improved, but now for performance it's done via static field
- static DrugbankXMLParser read;
-
- @Before
- public void setup() {
- if (read == null) {
- read = new DrugbankXMLParser(file, taxonomyBackend);
- }
- }
-
- @Test
- public void test1FindDrug() throws Exception {
- Drug test = read.findDrug("Urokinase");
- assertEquals(MiriamType.DRUGBANK, test.getSources().get(0).getDataType());
- assertEquals("DB00013", test.getSources().get(0).getResource());
- assertEquals("Urokinase", test.getName());
- assertEquals(
- "Low molecular weight form of human urokinase, that consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Recombinant urokinase plasminogen activator",
- test.getDescription());
- assertEquals(10, test.getTargets().size());
-
- // test.write();
- }
-
- @Test
- public void test2FindDrug() throws Exception {
- Drug test = read.findDrug("diazoxide");
- assertEquals("Diazoxide", test.getName());
- assertEquals("DB01119", test.getSources().get(0).getResource());
- assertEquals(
- "A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. [PubChem]",
- test.getDescription());
- assertEquals(6, test.getTargets().size());
- }
-
- @Test
- public void test3FindDrug() throws Exception {
- // finding synonym
- Drug test = read.findDrug("Rapamycin");
- assertEquals("Sirolimus", test.getName());
- assertEquals("DB00877", test.getSources().get(0).getResource());
- assertEquals(
- "A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. [PubChem]",
- test.getDescription());
- assertEquals(3, test.getTargets().size());
- }
-
- @Test
- public void test4FindDrug() throws Exception {
- Drug test = read.findDrug("Methylamine");
- assertEquals("Methylamine", test.getName());
- assertEquals("DB01828", test.getSources().get(0).getResource());
- assertEquals(null, test.getDescription());
- assertEquals(1, test.getTargets().size());
-
- for (Target t : test.getTargets()) {
- assertEquals("Ammonia channel", t.getName());
- assertEquals("BE0001338", t.getSource().getResource());
- assertEquals(MiriamType.DRUGBANK_TARGET_V4, t.getSource().getDataType());
- assertEquals(2, t.getReferences().size());
- assertEquals(0, t.getGenes().size());
- }
-
- // test.write();
- }
-
- @Test
- public void test5FindDrug() throws Exception {
- Drug test = read.findDrug("Amantadine");
- assertEquals("Amantadine", test.getName());
- assertEquals("DB00915", test.getSources().get(0).getResource());
- assertEquals(
- "An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. [PubChem]",
- test.getDescription());
- assertEquals(3, test.getTargets().size());
- }
-
- @Test
- public void test6FindDrug() throws Exception {
-
- Drug test = read.findDrug("qwertyuiop");
- assertEquals(null, test);
- }
-
- @Test
- public void test7FindDrug() throws Exception {
- Drug test = read.findDrug("Aluminum hydroxide");
- assertEquals("Aluminum hydroxide", test.getName());
- assertEquals("DB06723", test.getSources().get(0).getResource());
- assertEquals(
- "Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.",
- test.getDescription());
- assertEquals(0, test.getTargets().size());
- }
-
- @Test
- public void testFindDrugInInvalidFile() throws Exception {
- try {
- new DrugbankXMLParser("unknown.file.bla", taxonomyBackend).findDrug("unk");
- fail("Exception expected");
-
- } catch (DrugSearchException e) {
- assertTrue(e.getMessage().contains("Problem with processing input file"));
- }
- }
-
- @Test
- public void testFindDrugWithTaxnomyBackendBroken() throws Exception {
- try {
- TaxonomyBackend taxonomyMock = Mockito.mock(TaxonomyBackend.class);
- when(taxonomyMock.getByName(anyString())).thenThrow(new TaxonomySearchException(null, null));
- new DrugbankXMLParser(file, taxonomyMock).findDrug("Amantadine");
- fail("Exception expected");
-
- } catch (DrugSearchException e) {
- assertEquals(TaxonomySearchException.class, e.getCause().getClass());
- }
- }
-}
diff --git a/annotation/testFiles/target_drugbank/drugbank.xml b/annotation/testFiles/target_drugbank/drugbank.xml
deleted file mode 100644
index 9fdb58891a788b622779aad6d93dd20c86dbaed8..0000000000000000000000000000000000000000
Binary files a/annotation/testFiles/target_drugbank/drugbank.xml and /dev/null differ
diff --git a/annotation/testFiles/target_drugbank/small_drugbank.xml b/annotation/testFiles/target_drugbank/small_drugbank.xml
deleted file mode 100644
index 088d429b35b119fb982b305171c7656c27d348b0..0000000000000000000000000000000000000000
--- a/annotation/testFiles/target_drugbank/small_drugbank.xml
+++ /dev/null
@@ -1,8589 +0,0 @@
-<?xml version="1.0" encoding="UTF-8"?>
-<drugs xmlns="http://drugbank.ca" xmlns:xs="http://www.w3.org/2001/XMLSchema-instance" schemaVersion="2.0" xs:schemaLocation="http://www.drugbank.ca/docs/drugbank.xsd">
-<drug type="biotech" created="2005-06-13 07:24:05 -0600" updated="2014-01-20 16:58:30 -0700" version="4.0">
- <drugbank-id>DB00013</drugbank-id>
- <name>Urokinase</name>
- <description>Low molecular weight form of human urokinase, that consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Recombinant urokinase plasminogen activator</description>
- <cas-number>9039-53-6</cas-number>
- <general-references># Housley C: Contract purchasing means a buyer's market. Dimens Health Serv. 1976 Apr;53(4):16, 19-20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5328</general-references>
- <synthesis-reference>Koji Sasaki, Yasukazu Harada, "Urokinase preparation for oral administration." U.S. Patent US4258030, issued November, 1975.</synthesis-reference>
- <indication>Urokinase can be used for the treatment of pulminary embolism, coronary artery thrombosis, IV catheter clearance, and venous and arterial blood clots.</indication>
- <pharmacology>Urokinase is used for the treatment of pulmonary embolisms. The low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Urokinase is the low molecular weight form. Urokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins.</pharmacology>
- <mechanism-of-action>Urokinase acts on the endogenous fibrinolytic system. It cleaves the Arg-Val bond in plasminogen to produce active plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins.</mechanism-of-action>
- <toxicity/>
- <biotransformation>Proteolysis</biotransformation>
- <absorption/>
- <half-life>12 minutes. Small fractions of the administered dose are excreted in bile and urine</half-life>
- <protein-binding/>
- <route-of-elimination>Urokinase administered by intravenous infusion is rapidly cleared by the liver. Small fractions of the administered dose are excreted in bile and urine</route-of-elimination>
- <volume-of-distribution/>
- <clearance/>
- <secondary-accession-numbers>
- <secondary-accession-number>BIOD00030</secondary-accession-number>
- <secondary-accession-number>BTD00030</secondary-accession-number>
- </secondary-accession-numbers>
- <groups>
- <group>approved</group>
- <group>withdrawn</group>
- </groups>
- <taxonomy>
- <kingdom/>
- <substructures/>
- </taxonomy>
- <synonyms>
- <synonym>U-plasminogen activator</synonym>
- <synonym>uPA</synonym>
- <synonym>Urokinase-type plasminogen activator precursor</synonym>
- </synonyms>
- <salts/>
- <brands>
- <brand>Abbokinase</brand>
- <brand>Kinlytic</brand>
- </brands>
- <mixtures/>
- <packagers>
- <packager>
- <name>Hospira Inc.</name>
- <url>http://www.hospira.com</url>
- </packager>
- <packager>
- <name>ImaRx Therapeutics</name>
- <url>http://www.imarx.com</url>
- </packager>
- <packager>
- <name>Microbix Biosystems Inc.</name>
- <url>http://www.microbix.com</url>
- </packager>
- </packagers>
- <manufacturers>
- <manufacturer generic="false">Microbix biosystems inc</manufacturer>
- </manufacturers>
- <prices/>
- <categories/>
- <affected-organisms>
- <affected-organism>Humans and other mammals</affected-organism>
- </affected-organisms>
- <dosages>
- <dosage>
- <form>Powder, for solution</form>
- <route>Intravenous</route>
- <strength/>
- </dosage>
- </dosages>
- <atc-codes>
- <atc-code>B01AD04</atc-code>
- <category/>
- </atc-codes>
- <ahfs-codes>
- <ahfs-code>20:12.20</ahfs-code>
- </ahfs-codes>
- <patents/>
- <food-interactions/>
- <drug-interactions>
- <drug-interaction>
- <drug>DB06692</drug>
- <name>Aprotinin</name>
- <description>Aprotonin may antagonize the effect of Urokinase. Monitor for decreased effects of Urokinase.</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00055</drug>
- <name>Drotrecogin alfa</name>
- <description>Increased risk of bleeding. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01381</drug>
- <name>Ginkgo biloba</name>
- <description>Increased risk of bleeding. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01404</drug>
- <name>Ginseng</name>
- <description>Increased risk of bleeding. </description>
- </drug-interaction>
- </drug-interactions>
- <protein-sequences>
- <fasta>
- <fasta>#<PolypeptideSequence:0x007f1d208d4f20></fasta>
- </fasta>
- </protein-sequences>
- <experimental-properties>
- <property>
- <kind>Melting Point</kind>
- <value>76 °C at pH 4.5</value>
- <source>Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994)</source>
- </property>
- <property>
- <kind>Hydrophobicity</kind>
- <value>-0.466</value>
- <source/>
- </property>
- <property>
- <kind>Isoelectric Point</kind>
- <value>8.66</value>
- <source/>
- </property>
- <property>
- <kind>Molecular Weight</kind>
- <value>31126.5000</value>
- <source/>
- </property>
- <property>
- <kind>Molecular Formula</kind>
- <value>C1376H2145N383O406S18</value>
- <source/>
- </property>
- </experimental-properties>
- <external-identifiers>
- <external-identifier>
- <resource>Drugs Product Database (DPD)</resource>
- <identifier>749702</identifier>
- </external-identifier>
- <external-identifier>
- <resource>National Drug Code Directory</resource>
- <identifier>24430-1003-1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank</resource>
- <identifier>X02419</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PharmGKB</resource>
- <identifier>PA451836</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P00749</identifier>
- </external-identifier>
- <external-identifier>
- <resource>Wikipedia</resource>
- <identifier>Urokinase</identifier>
- </external-identifier>
- </external-identifiers>
- <external-links>
- <external-link>
- <resource>RxList</resource>
- <url>http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Abbokinase%AE</url>
- </external-link>
- <external-link>
- <resource>Drugs.com</resource>
- <url>http://www.drugs.com/mtm/urokinase.html</url>
- </external-link>
- </external-links>
- <targets>
- <target position="1">
- <id>BE0000211</id>
- <name>Plasminogen</name>
- <organism>Human</organism>
- <actions>
- <action>activator</action>
- </actions>
- <references># Zhang X, Zhou H, Shen G, Liu Z, Hu Y, Wei W, Song S: Study on the mechanism of the annexin II-mediated co-assembly of t-PA and plasminogen. J Huazhong Univ Sci Technolog Med Sci. 2002;22(1):21-3, 76. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12658774
-# Lopez-Alemany R, Longstaff C, Hawley S, Mirshahi M, Fabregas P, Jardi M, Merton E, Miles LA, Felez J: Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase. Am J Hematol. 2003 Apr;72(4):234-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12666133
-# Hashimoto M, Oiwa K, Matsuo O, Ueshima S, Okada K, Okada Y, Okamoto S, Giddings JC, Yamamoto J: Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model. Thromb Haemost. 2003 May;89(5):820-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12719778
-# Guda K, Claffey KP, Dong M, Nambiar PR, Rosenberg DW: Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors. Mol Carcinog. 2003 May;37(1):51-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12720300
-# Chang H, Shyu KG, Lin S, Wang BW, Liu YC, Lee CC: Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells. Cell Commun Adhes. 2002 Sep-Dec;9(5-6):239-47. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12745435
-# Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11752352</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P00747">
- <name>Plasminogen</name>
- <general-function>Involved in plasmin activity</general-function>
- <specific-function>Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo</specific-function>
- <gene-name>PLG</gene-name>
- <locus>6q26</locus>
- <cellular-location>Secreted protein</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>7.25</theoretical-pi>
- <molecular-weight>90569.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:9071</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>PLG</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>PLG</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>X05199</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>387026</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P00747</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>EC 3.4.21.7</synonym>
- <synonym>Plasminogen precursor</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Plasminogen precursor
-MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT
-CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN
-GITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILE
-CEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRE
-LRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWS
-AQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTE
-QLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAG
-LTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEED
-CMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGG
-PWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRT
-RFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLE
-PTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQ
-LPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSW
-GLGCARPNKPGVYVRVSRFVTWIEGVMRNN</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>2433 bp
-ATGGAACATAAGGAAGTGGTTCTTCTACTTCTTTTATTTCTGAAATCAGGTCAAGGAGAG
-CCTCTGGATGACTATGTGAATACCCAGGGGGCTTCACTGTTCAGTGTCACTAAGAAGCAG
-CTGGGAGCAGGAAGTATAGAAGAATGTGCAGCAAAATGTGAGGAGGACGAAGAATTCACC
-TGCAGGGCATTCCAATATCACAGTAAAGAGCAACAATGTGTGATAATGGCTGAAAACAGG
-AAGTCCTCCATAATCATTAGGATGAGAGATGTAGTTTTATTTGAAAAGAAAGTGTATCTC
-TCAGAGTGCAAGACTGGGAATGGAAAGAATTACAGAGGGACGATGTCCAAAACAAAAAAT
-GGCATCACCTGTCAAAAATGGAGTTCCACTTCTCCCCACAGACCTAGATTCTCACCTGCT
-ACACACCCCTCAGAGGGACTGGAGGAGAACTACTGCAGGAATCCAGACAACGATCCGCAG
-GGGCCCTGGTGCTATACTACTGATCCAGAAAAGAGATATGACTACTGCGACATTCTTGAG
-TGTGAAGAGGAATGTATGCATTGCAGTGGAGAAAACTATGACGGCAAAATTTCCAAGACC
-ATGTCTGGACTGGAATGCCAGGCCTGGGACTCTCAGAGCCCACACGCTCATGGATACATT
-CCTTCCAAATTTCCAAACAAGAACCTGAAGAAGAATTACTGTCGTAACCCCGATAGGGAG
-CTGCGGCCTTGGTGTTTCACCACCGACCCCAACAAGCGCTGGGAACTTTGCGACATCCCC
-CGCTGCACAACACCTCCACCATCTTCTGGTCCCACCTACCAGTGTCTGAAGGGAACAGGT
-GAAAACTATCGCGGGAATGTGGCTGTTACCGTGTCCGGGCACACCTGTCAGCACTGGAGT
-GCACAGACCCCTCACACACATAACAGGACACCAGAAAACTTTCCCTGCAAAAATTTGGAT
-GAAAACTACTGCCGCAATCCTGACGGAAAAAGGGCCCCATGGTGCCATACAACCAACAGC
-CAAGTGCGGTGGGAGTACTGTAAGATACCGTCCTGTGACTCCTCCCCAGTATCCACGGAA
-CAATTGGCTCCCACAGCACCACCTGAGCTAACCCCTGTGGTCCAGGACTGCTACCATGGT
-GATGGACAGAGCTACCGAGGCACATCCTCCACCACCACCACAGGAAAGAAGTGTCAGTCT
-TGGTCATCTATGACACCACACCGGCACCAGAAGACCCCAGAAAACTACCCAAATGCTGGC
-CTGACAATGAACTACTGCAGGAATCCAGATGCCGATAAAGGCCCCTGGTGTTTTACCACA
-GACCCCAGCGTCAGGTGGGAGTACTGCAACCTGAAAAAATGCTCAGGAACAGAAGCGAGT
-GTTGTAGCACCTCCGCCTGTTGTCCTGCTTCCAAATGTAGAGACTCCTTCCGAAGAAGAC
-TGTATGTTTGGGAATGGGAAAGGATACCGAGGCAAGAGGGCGACCACTGTTACTGGGACG
-CCATGCCAGGACTGGGCTGCCCAGGAGCCCCATAGACACAGCATTTTCACTCCAGAGACA
-AATCCACGGGCGGGTCTGGAAAAAAATTACTGCCGTAACCCTGATGGTGATGTAGGTGGT
-CCCTGGTGCTACACGACAAATCCAAGAAAACTTTACGACTACTGTGATGTCCCTCAGTGT
-GCGGCCCCTTCATTTGATTGTGGGAAGCCTCAAGTGGAGCCGAAGAAATGTCCTGGAAGG
-GTTGTAGGGGGGTGTGTGGCCCACCCACATTCCTGGCCCTGGCAAGTCAGTCTTAGAACA
-AGGTTTGGAATGCACTTCTGTGGAGGCACCTTGATATCCCCAGAGTGGGTGTTGACTGCT
-GCCCACTGCTTGGAGAAGTCCCCAAGGCCTTCATCCTACAAGGTCATCCTGGGTGCACAC
-CAAGAAGTGAATCTCGAACCGCATGTTCAGGAAATAGAAGTGTCTAGGCTGTTCTTGGAG
-CCCACACGAAAAGATATTGCCTTGCTAAAGCTAAGCAGTCCTGCCGTCATCACTGACAAA
-GTAATCCCAGCTTGTCTGCCATCCCCAAATTATGTGGTCGCTGACCGGACCGAATGTTTC
-ATCACTGGCTGGGGAGAAACCCAAGGTACTTTTGGAGCTGGCCTTCTCAAGGAAGCCCAG
-CTCCCTGTGATTGAGAATAAAGTGTGCAATCGCTATGAGTTTCTGAATGGAAGAGTCCAA
-TCCACCGAACTCTGTGCTGGGCATTTGGCCGGAGGCACTGACAGTTGCCAGGGTGACAGT
-GGAGGGCCTCTGGTTTGCTTCGAGAAGGACAAATACATTTTACAAGGAGTCACTTCTTGG
-GGTCTTGGCTGTGCACGCCCCAATAAGCCTGGTGTCTATGTTCGTGTTTCAAGGTTTGTT
-ACTTGGATTGAGGGAGTGATGAGAAATAATTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00051</identifier>
- <name>Kringle</name>
- </pfam>
- <pfam>
- <identifier>PF00089</identifier>
- <name>Trypsin</name>
- </pfam>
- <pfam>
- <identifier>PF00024</identifier>
- <name>PAN_1</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>calcium ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>peptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>endopeptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>serine-type endopeptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>plasmin activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>regulation of body fluids</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>hemostasis</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>blood coagulation</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>macromolecule metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>proteolysis</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>organismal physiological process</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="2">
- <id>BE0000717</id>
- <name>Urokinase plasminogen activator surface receptor</name>
- <organism>Human</organism>
- <actions/>
- <references># Czekay RP, Aertgeerts K, Curriden SA, Loskutoff DJ: Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins. J Cell Biol. 2003 Mar 3;160(5):781-91. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12615913
-# Fuchs T, Allgayer H: Transcriptional regulation of the urokinase receptor (u-PAR)--a central molecule of invasion and metastasis. Biol Chem. 2003 May;384(5):755-61. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12817472
-# Kanse SM, Chavakis T, Al-Fakhri N, Hersemeyer K, Monard D, Preissner KT: Reciprocal regulation of urokinase receptor (CD87)-mediated cell adhesion by plasminogen activator inhibitor-1 and protease nexin-1. J Cell Sci. 2004 Jan 26;117(Pt 3):477-85. Epub 2003 Dec 16. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14679304
-# Beaufort N, Leduc D, Rousselle JC, Magdolen V, Luther T, Namane A, Chignard M, Pidard D: Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G. J Immunol. 2004 Jan 1;172(1):540-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14688365
-# Guerrero J, Santibanez JF, Gonzalez A, Martinez J: EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases. Exp Cell Res. 2004 Jan 1;292(1):201-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14720519
-# Gutova M, Najbauer J, Gevorgyan A, Metz MZ, Weng Y, Shih CC, Aboody KS: Identification of uPAR-positive chemoresistant cells in small cell lung cancer. PLoS One. 2007 Feb 28;2(2):e243. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17327908</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="Q03405">
- <name>Urokinase plasminogen activator surface receptor</name>
- <general-function>Involved in U-plasminogen activator receptor activity</general-function>
- <specific-function>Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form</specific-function>
- <gene-name>PLAUR</gene-name>
- <locus>19q13</locus>
- <cellular-location>Isoform 1:Cell membrane; lipid-anchor; GPI- anchor. Isoform 2:Secreted protein (Probable)</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>6.64</theoretical-pi>
- <molecular-weight>36978.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:9053</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>PLAUR</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>PLAUR</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>X51675</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>37605</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>Q03405</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>CD87 antigen</synonym>
- <synonym>Monocyte activation antigen Mo3</synonym>
- <synonym>U- PAR</synonym>
- <synonym>uPAR</synonym>
- <synonym>Urokinase plasminogen activator surface receptor precursor</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Urokinase plasminogen activator surface receptor precursor
-MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEEL
-ELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISC
-GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
-FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGP
-MNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDV
-QYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1008 bp
-ATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCCTCT
-TGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCC
-CTGGGACAGGACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTG
-GAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCAACAGGACCCTGAGCTATCGG
-ACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAG
-GGCAACTCTGGCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGT
-GGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGAGCCTGCAGTGCCGCAGCCCT
-GAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCA
-AAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGT
-TTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAG
-GGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAG
-GGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCC
-ATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACCGAAAAACCAAAGCTATATGGTA
-AGAGGCTGTGCAACCGCCTCAATGTGCCAACATGCCCACCTGGGTGACGCCTTCAGCATG
-AACCACATTGATGTCTCCTGCTGTACTAAAAGTGGCTGTAACCACCCAGACCTGGATGTC
-CAGTACCGCAGTGGGGCTGCTCCTCAGCCTGGCCCTGCCCATCTCAGCCTCACCATCACC
-CTGCTAATGACTGCCAGACTGTGGGGAGGCACTCTCCTCTGGACCTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00021</identifier>
- <name>UPAR_LY6</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>signal transducer activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>U-plasminogen activator receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cell communication</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>signal transduction</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cell surface receptor linked signal transduction</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="3">
- <id>BE0000895</id>
- <name>Urokinase-type plasminogen activator</name>
- <organism>Human</organism>
- <actions/>
- <references># Bell WR: Present-day thrombolytic therapy: therapeutic agents--pharmacokinetics and pharmacodynamics. Rev Cardiovasc Med. 2002;3 Suppl 2:S34-44. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12556741
-# Gamberi G, Serra M, Ragazzini P, Magagnoli G, Pazzaglia L, Ponticelli F, Ferrari C, Zanasi M, Bertoni F, Picci P, Benassi MS: Identification of markers of possible prognostic value in 57 giant cell tumors of bone. Oncol Rep. 2003 Mar-Apr;10(2):351-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12579271
-# Zhang G, Kim H, Cai X, Lopez-Guisa JM, Alpers CE, Liu Y, Carmeliet P, Eddy AA: Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy. J Am Soc Nephrol. 2003 May;14(5):1254-71. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12707394
-# Chang H, Shyu KG, Lin S, Wang BW, Liu YC, Lee CC: Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells. Cell Commun Adhes. 2002 Sep-Dec;9(5-6):239-47. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12745435
-# Wielockx B, Libert C: Serine proteases of the fibrinolysis pathway are not involved in lethal hepatitis and fibrinogen breakdown induced by tumor necrosis factor. Cytokine. 2003 Mar 21;21(6):281-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12824001</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P00749">
- <name>Urokinase-type plasminogen activator</name>
- <general-function>Involved in chemotaxis and signal transduction activity</general-function>
- <specific-function>Specifically cleave the zymogen plasminogen to form the active enzyme plasmin</specific-function>
- <gene-name>PLAU</gene-name>
- <locus>10q24</locus>
- <cellular-location>Secreted protein</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>8.48</theoretical-pi>
- <molecular-weight>48526.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:9052</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>PLAU</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>PLAU</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>X02419</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>1834524</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P00749</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>EC 3.4.21.73</synonym>
- <synonym>U-plasminogen activator</synonym>
- <synonym>uPA</synonym>
- <synonym>Urokinase-type plasminogen activator precursor</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Urokinase-type plasminogen activator precursor
-MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
-HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
-YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
-GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLG
-RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
-PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
-CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
-SHTKEENGLAL</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1296 bp
-ATGAGAGCCCTGCTGGCGCGCCTGCTTCTCTGCGTCCTGGTCGTGAGCGACTCCAAAGGC
-AGCAATGAACTTCATCAAGTTCCATCGAACTGTGACTGTCTAAATGGAGGAACATGTGTG
-TCCAACAAGTACTTCTCCAACATTCACTGGTGCAACTGCCCAAAGAAATTCGGAGGGCAG
-CACTGTGAAATAGATAAGTCAAAAACCTGCTATGAGGGGAATGGTCACTTTTACCGAGGA
-AAGGCCAGCACTGACACCATGGGCCGGCCCTGCCTGCCCTGGAACTCTGCCACTGTCCTT
-CAGCAAACGTACCATGCCCACAGATCTGATGCTCTTCAGCTGGGCCTGGGGAAACATAAT
-TACTGCAGGAACCCAGACAACCGGAGGCGACCCTGGTGCTATGTGCAGGTGGGCCTAAAG
-CCGCTTGTCCAAGAGTGCATGGTGCATGACTGCGCAGATGGAAAAAAGCCCTCCTCTCCT
-CCAGAAGAATTAAAATTTCAGTGTGGCCAAAAGACTCTGAGGCCCCGCTTTAAGATTATT
-GGGGGAGAATTCACCACCATCGAGAACCAGCCCTGGTTTGCGGCCATCTACAGGAGGCAC
-CGGGGGGGCTCTGTCACCTACGTGTGTGGAGGCAGCCTCATGAGCCCTTGCTGGGTGATC
-AGCGCCACACACTGCTTCATTGATTACCCAAAGAAGGAGGACTACATCGTCTACCTGGGT
-CGCTCAAGGCTTAACTCCAACACGCAAGGGGAGATGAAGTTTGAGGTGGAAAACCTCATC
-CTACACAAGGACTACAGCGCTGACACGCTTGCTCACCACAACGACATTGCCTTGCTGAAG
-ATCCGTTCCAAGGAGGGCAGGTGTGCGCAGCCATCCCGGACTATACAGACCATCTGCCTG
-CCCTCGATGTATAACGATCCCCAGTTTGGCACAAGCTGTGAGATCACTGGCTTTGGAAAA
-GAGAATTCTACCGACTATCTCTATCCGGAGCAGCTGAAAATGACTGTTGTGAAGCTGATT
-TCCCACCGGGAGTGTCAGCAGCCCCACTACTACGGCTCTGAAGTCACCACCAAAATGCTG
-TGTGCTGCTGACCCACAGTGGAAAACAGATTCCTGCCAGGGAGACTCAGGGGGACCCCTC
-GTCTGTTCCCTCCAAGGCCGCATGACTTTGACTGGAATTGTGAGCTGGGGCCGTGGATGT
-GCCCTGAAGGACAAGCCAGGCGTCTACACGAGAGTCTCACACTTCTTACCCTGGATCCGC
-AGTCACACCAAGGAAGAGAATGGCCTGGCCCTCTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00051</identifier>
- <name>Kringle</name>
- </pfam>
- <pfam>
- <identifier>PF00089</identifier>
- <name>Trypsin</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>peptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>endopeptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>serine-type endopeptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>macromolecule metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>proteolysis</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="4">
- <id>BE0001088</id>
- <name>Tissue-type plasminogen activator</name>
- <organism>Human</organism>
- <actions/>
- <references># Chang H, Shyu KG, Lin S, Wang BW, Liu YC, Lee CC: Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells. Cell Commun Adhes. 2002 Sep-Dec;9(5-6):239-47. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12745435
-# Lindholt JS, Jorgensen B, Shi GP, Henneberg EW: Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2003 Jun;25(6):546-51. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12787697
-# Aleman C, Alegre J, Monasterio J, Segura RM, Armadans L, Angles A, Varela E, Ruiz E, Fernandez de Sevilla T: Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions. Clin Sci (Lond). 2003 Nov;105(5):601-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12826021
-# Wells RG, Havens PL: Intrapleural fibrinolysis for parapneumonic effusion and empyema in children. Radiology. 2003 Aug;228(2):370-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12893898
-# Stief TW, Bunder R, Richter A, Maisch B, Renz H, Fareed J: In vitro simulation of therapeutic plasmatic fibrinolysis. Clin Appl Thromb Hemost. 2003 Jul;9(3):211-20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14507109</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P00750">
- <name>Tissue-type plasminogen activator</name>
- <general-function>Involved in plasminogen activator activity</general-function>
- <specific-function>Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Play a direct role in facilitating neuronal migration</specific-function>
- <gene-name>PLAT</gene-name>
- <locus>8p12</locus>
- <cellular-location>Secreted protein; extracellular space</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>7.81</theoretical-pi>
- <molecular-weight>62917.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:9051</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>PLAT</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>PLAT</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>L00153</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>339834</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P00750</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Alteplase</synonym>
- <synonym>EC 3.4.21.68</synonym>
- <synonym>Reteplase</synonym>
- <synonym>t- PA</synonym>
- <synonym>t-plasminogen activator</synonym>
- <synonym>Tissue-type plasminogen activator precursor</synonym>
- <synonym>tPA</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Tissue-type plasminogen activator precursor
-MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
-LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
-IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
-NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
-SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
-LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
-ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
-QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
-LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
-DVPGVYTKVTNYLDWIRDNMRP</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1689 bp
-ATGGATGCAATGAAGAGAGGGCTCTGCTGTGTGCTGCTGCTGTGTGGAGCAGTCTTCGTT
-TCGCCCAGCCAGGAAATCCATGCCCGATTCAGAAGAGGAGCCAGATCTTACCAAGTGATC
-TGCAGAGATGAAAAAACGCAGATGATATACCAGCAACATCAGTCATGGCTGCGCCCTGTG
-CTCAGAAGCAACCGGGTGGAATATTGCTGGTGCAACAGTGGCAGGGCACAGTGCCACTCA
-GTGCCTGTCAAAAGTTGCAGCGAGCCAAGGTGTTTCACCGGGGGCACCTGCCAGCAGGCC
-CTGTACTTCTCAGATTTCGTGTGCCAGTGCCCCGAAGGATTTGCTGGGAAGTGCTGTGAA
-ATAGATACCAGGGCCACGTGCTACGAGGACCAGGGCATCAGCTACAGGGGCACGTGGAGC
-ACAGCGGAGAGTGGCGCCGAGTGCACCAACTGGAACAGCAGCGCGTTGGCCCAGAAGCCC
-TACAGCGGGCGGAGGCCAGATGCCATCAGGCTGGGCCTGGGGAACCACAACTACTGCAGA
-AACCCAGATCGAGACTCAAAGCCCTGGTGCTACGTCTTTAAGGCGGGGAAGTACAGCTCA
-GAGTTCTGCAGCACCCCTGCCTGCTCTGAGGGAAACAGTGACTGCTACTTTGGGAATGGG
-TCAGCCTACCGTGGCACGCACAGCCTCACCGAGTCGGGTGCCTCCTGCCTCCCGTGGAAT
-TCCATGATCCTGATAGGCAAGGTTTACACAGCACAGAACCCCAGTGCCCAGGCACTGGGC
-CTGGGCAAACATAATTACTGCCGGAATCCTGATGGGGATGCCAAGCCCTGGTGCCACGTG
-CTGAAGAACCGCAGGCTGACGTGGGAGTACTGTGATGTGCCCTCCTGCTCCACCTGCGGC
-CTGAGACAGTACAGCCAGCCTCAGTTTCGCATCAAAGGAGGGCTCTTCGCCGACATCGCC
-TCCCACCCCTGGCAGGCTGCCATCTTTGCCAAGCACAGGAGGTCGCCCGGAGAGCGGTTC
-CTGTGCGGGGGCATACTCATCAGCTCCTGCTGGATTCTCTCTGCCGCCCACTGCTTCCAG
-GAGAGGTTTCCGCCCCACCACCTGACGGTGATCTTGGGCAGAACATACCGGGTGGTCCCT
-GGCGAGGAGGAGCAGAAATTTGAAGTCGAAAAATACATTGTCCATAAGGAATTCGATGAT
-GACACTTACGACAATGACATTGCGCTGCTGCAGCTGAAATCGGATTCGTCCCGCTGTGCC
-CAGGAGAGCAGCGTGGTCCGCACTGTGTGCCTTCCCCCGGCGGACCTGCAGCTGCCGGAC
-TGGACGGAGTGTGAGCTCTCCGGCTACGGCAAGCATGAGGCCTTGTCTCCTTTCTATTCG
-GAGCGGCTGAAGGAGGCTCATGTCAGACTGTACCCATCCAGCCGCTGCACATCACAACAT
-TTACTTAACAGAACAGTCACCGACAACATGCTGTGTGCTGGAGACACTCGGAGCGGCGGG
-CCCCAGGCAAACTTGCACGACGCCTGCCAGGGCGATTCGGGAGGCCCCCTGGTGTGTCTG
-AACGATGGCCGCATGACTTTGGTGGGCATCATCAGCTGGGGCCTGGGCTGTGGACAGAAG
-GATGTCCCGGGTGTGTACACCAAGGTTACCAACTACCTAGACTGGATTCGTGACAACATG
-CGACCGTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00008</identifier>
- <name>EGF</name>
- </pfam>
- <pfam>
- <identifier>PF00051</identifier>
- <name>Kringle</name>
- </pfam>
- <pfam>
- <identifier>PF00089</identifier>
- <name>Trypsin</name>
- </pfam>
- <pfam>
- <identifier>PF00039</identifier>
- <name>fn1</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>extracellular region</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>plasminogen activator activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>peptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>endopeptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>serine-type endopeptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>macromolecule metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>proteolysis</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="5">
- <id>BE0000240</id>
- <name>Plasminogen activator inhibitor 1</name>
- <organism>Human</organism>
- <actions/>
- <references># Gamberi G, Serra M, Ragazzini P, Magagnoli G, Pazzaglia L, Ponticelli F, Ferrari C, Zanasi M, Bertoni F, Picci P, Benassi MS: Identification of markers of possible prognostic value in 57 giant cell tumors of bone. Oncol Rep. 2003 Mar-Apr;10(2):351-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12579271
-# Shetty S, Bdeir K, Cines DB, Idell S: Induction of plasminogen activator inhibitor-1 by urokinase in lung epithelial cells. J Biol Chem. 2003 May 16;278(20):18124-31. Epub 2003 Mar 17. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12642587
-# Hellgren M: Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost. 2003 Apr;29(2):125-30. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12709915
-# Chang H, Shyu KG, Lin S, Wang BW, Liu YC, Lee CC: Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells. Cell Commun Adhes. 2002 Sep-Dec;9(5-6):239-47. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12745435
-# Gerstein ES, Shcherbakov AM, Kaz'min AI, Ognerubov NA, Kushlinskii NE: [Urokinase and tissue type plasminogen activators and their type-1 inhibitor (PAI-1) in gastric cancer] Vopr Onkol. 2003;49(2):165-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12785198</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P05121">
- <name>Plasminogen activator inhibitor 1</name>
- <general-function>Involved in serine-type endopeptidase inhibitor activity</general-function>
- <specific-function>This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis</specific-function>
- <gene-name>SERPINE1</gene-name>
- <locus>7q21.3-q22</locus>
- <cellular-location>Secreted protein</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>7.22</theoretical-pi>
- <molecular-weight>45061.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:8583</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>SERPINE1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>SERPINE1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>X04429</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>35272</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P05121</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Endothelial plasminogen activator inhibitor</synonym>
- <synonym>PAI</synonym>
- <synonym>PAI-1</synonym>
- <synonym>Plasminogen activator inhibitor 1 precursor</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Plasminogen activator inhibitor 1 precursor
-MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
-GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
-FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
-DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
-GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
-FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
-STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1209 bp
-ATGCAGATGTCTCCAGCCCTCACCTGCCTAGTCCTGGGCCTGGCCCTTGTCTTTGGTGAA
-GGGTCTGCTGTGCACCATCCCCCATCCTACGTGGCCCACCTGGCCTCAGACTTCGGGGTG
-AGGGTGTTTCAGCAGGTGGCGCAGGCCTCCAAGGACCGCAACGTGGTTTTCTCACCCTAT
-GGGGTGGCCTCGGTGTTGGCCATGCTCCAGCTGACAACAGGAGGAGAAACCCAGCAGCAG
-ATTCAAGCAGCTATGGGATTCAAGATTGATGACAAGGGCATGGCCCCCGCCCTCCGGCAT
-CTGTACAAGGAGCTCATGGGGCCATGGAACAAGGACGAGATCAGCACCACAGACGCGATC
-TTCGTCCAGCGGGATCTGAAGCTGGTCCAGGGCTTCATGCCCCACTTCTTCAGGCTGTTC
-CGGAGCACGGTCAAGCAAGTGGACTTTTCAGAGGTGGAGAGAGCCAGATTCATCATCAAT
-GACTGGGTGAAGACACACACAAAAGGTATGATCAGCAACTTGCTTGGGAAAGGAGCCGTG
-GACCAGCTGACACGGCTGGTGCTGGTGAATGCCCTCTACTTCAACGGCCAGTGGAAGACT
-CCCTTCCCCGACTCCAGCACCCACCGCCGCCTCTTCCACAAATCAGACGGCAGCACTGTC
-TCTGTGCCCATGATGGCTCAGACCAACAAGTTCAACTATACTGAGTTCACCACGCCCGAT
-GGCCATTACTACGACATCCTGGAACTGCCCTACCACGGGGACACCCTCAGCATGTTCATT
-GCTGCCCCTTATGAAAAAGAGGTGCCTCTCTCTGCCCTCACCAACATTCTGAGTGCCCAG
-CTCATCAGCCACTGGAAAGGCAACATGACCAGGCTGCCCCGCCTCCTGGTTCTGCCCAAG
-TTCTCCCTGGAGACTGAAGTCGACCTCAGGAAGCCCCTAGAGAACCTGGGAATGACCGAC
-ATGTTCAGACAGTTTCAGGCTGACTTCACGAGTCTTTCAGACCAAGAGCCTCTCCACGTC
-GCGCAGGCGCTGCAGAAAGTGAAGATCGAGGTGAACGAGAGTGGCACGGTGGCCTCCTCA
-TCCACAGCTGTCATAGTCTCAGCCCGCATGGCCCCCGAGGAGATCATCATGGACAGACCC
-TTCCTCTTTGTGGTCCGGCACAACCCCACAGGAACAGTCCTTTTCATGGGCCAAGTGATG
-GAACCCTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00079</identifier>
- <name>Serpin</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>enzyme regulator activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>enzyme inhibitor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>protease inhibitor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>endopeptidase inhibitor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>serine-type endopeptidase inhibitor activity</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="6">
- <id>BE0000969</id>
- <name>Plasminogen activator inhibitor 2</name>
- <organism>Human</organism>
- <actions/>
- <references># Swartz JM, Bystrom J, Dyer KD, Nitto T, Wynn TA, Rosenberg HF: Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes. J Leukoc Biol. 2004 Oct;76(4):812-9. Epub 2004 Jul 26. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15277569
-# Wygrecka M, Markart P, Ruppert C, Kuchenbuch T, Fink L, Bohle RM, Grimminger F, Seeger W, Gunther A: Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application. Thromb Haemost. 2004 Sep;92(3):529-40. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15351849
-# Iglesias D, Alegre J, Aleman C, Ruiz E, Soriano T, Armadans LI, Segura RM, Angles A, Monasterio J, de Sevilla TF: Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions. Eur Respir J. 2005 Jan;25(1):104-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15640330
-# Grebenchtchikov N, Maguire TM, Riisbro R, Geurts-Moespot A, O'Donovan N, Schmitt M, McGreal G, McDermott E, O'Higgins N, Brunner N, Sweep CG, Duffy MJ: Measurement of plasminogen activator system components in plasma and tumor tissue extracts obtained from patients with breast cancer: an EORTC Receptor and Biomarker Group collaboration. Oncol Rep. 2005 Jul;14(1):235-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15944795
-# Fernandez-Soria V, Lleonart ME, Diaz-Fuertes M, Villuendas R, Sanchez-Prieto R, Fabra A, Ramon Y Cajal S: Adenovirus E1A orchestrates the urokinase-plasminogen activator system and upregulates PAI-2 expression, supporting a tumor suppressor effect. Int J Oncol. 2006 Jan;28(1):143-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16327990</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P05120">
- <name>Plasminogen activator inhibitor 2</name>
- <general-function>Involved in serine-type endopeptidase inhibitor activity</general-function>
- <specific-function>Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1</specific-function>
- <gene-name>SERPINB2</gene-name>
- <locus>18q21.3</locus>
- <cellular-location>Cytoplasm. Secreted protein; extracellular space</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>5.34</theoretical-pi>
- <molecular-weight>46597.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:8584</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>SERPINB2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>SERPINB2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>J02685</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>189545</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P05120</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Monocyte Arg-serpin</synonym>
- <synonym>PAI-2</synonym>
- <synonym>Placental plasminogen activator inhibitor</synonym>
- <synonym>Plasminogen activator inhibitor 2 precursor</synonym>
- <synonym>Urokinase inhibitor</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Plasminogen activator inhibitor 2 precursor
-MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQF
-NEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGN
-YLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGK
-IPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREK
-LNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKM
-AEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMV
-DVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1248 bp
-ATGGAGGATCTTTGTGTGGCAAACACACTCTTTGCCCTCAATTTATTCAAGCATCTGGCA
-AAAGCAAGCCCCACCCAGAACCTCTTCCTCTCCCCATGGAGCATCTCGTCCACCATGGCC
-ATGGTCTACATGGGCTCCAGGGGCAGCACCGAAGACCAGATGGCCAAGGTGCTTCAGTTT
-AATGAAGTGGGAGCCAATGCAGTTACCCCCATGACTCCAGAGAACTTTACCAGCTGTGGG
-TTCATGCAGCAGATCCAGAAGGGTAGTTATCCTGATGCGATTTTGCAGGCACAAGCTGCA
-GATAAAATCCATTCATCCTTCCGCTCTCTCAGCTCTGCAATCAATGCATCCACAGGGGAT
-TATTTACTGGAAAGTGTCAATAAGCTGTTTGGTGAGAAGTCTGCGAGCTTCCGGGAAGAA
-TATATTCGACTCTGTCAGAAATATTACTCCTCAGAACCCCAGGCAGTAGACTTCCTAGAA
-TGTGCAGAAGAAGCTAGAAAAAAGATTAATTCCTGGGTCAAGACTCAAACCAAAGGCAAA
-ATCCCAAACTTGTTACCTGAAGGTTCTGTAGATGGGGATACCAGGATGGTCCTGGTGAAT
-GCTGTCTACTTCAAAGGAAAGTGGAAAACTCCATTTGAGAAGAAACTAAATGGGCTTTAT
-CCTTTCCGTGTAAACTCGGCTCAGCGCACACCTGTACAGATGATGTACTTGCGTGAAAAG
-CTAAACATTGGATACATAGAAGACCTAAAGGCTCAGATTCTAGAACTCCCATATGCTGGA
-GATGTTAGCATGTTCTTGTTGCTTCCAGATGAAATTGCCGATGTGTCCACTGGCTTGGAG
-CTGCTGGAAAGTGAAATAACCTATGACAAACTCAACAAGTGGACCAGCAAAGACAAAATG
-GCTGAAGATGAAGTTGAGGTATACATACCCCAGTTCAAATTAGAAGAGCATTATGAACTC
-AGATCCATTCTGAGAAGCATGGGCATGGAGGACGCCTTCAACAAGGGACGGGCCAATTTC
-TCAGGGATGTCGGAGAGGAATGACCTGTTTCTTTCTGAAGTGTTCCACCAAGCCATGGTG
-GATGTGAATGAGGAGGGCACTGAAGCAGCCGCTGGCACAGGAGGTGTTATGACAGGGAGA
-ACTGGACATGGAGGCCCACAGTTTGTGGCAGATCATCCGTTTCTTTTTCTTATTATGCAT
-AAGATAACCAAGTGCATTTTATTTTTCGGCAGATTTTGCTCACCCTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00079</identifier>
- <name>Serpin</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>enzyme regulator activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>enzyme inhibitor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>protease inhibitor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>endopeptidase inhibitor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>serine-type endopeptidase inhibitor activity</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="7">
- <id>BE0002112</id>
- <name>Plasma serine protease inhibitor</name>
- <organism>Human</organism>
- <actions/>
- <references># Uhrin P, Schofer C, Zaujec J, Ryban L, Hilpert M, Weipoltshammer K, Jerabek I, Pirtzkall I, Furtmuller M, Dewerchin M, Binder BR, Geiger M: Male fertility and protein C inhibitor/plasminogen activator inhibitor-3 (PCI): localization of PCI in mouse testis and failure of single plasminogen activator knockout to restore spermatogenesis in PCI-deficient mice. Fertil Steril. 2007 Oct;88(4S):1049-1057. Epub 2007 Apr 16. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17434507
-# Espana F, Navarro S, Medina P, Zorio E, Estelles A: The role of protein C inhibitor in human reproduction. Semin Thromb Hemost. 2007 Feb;33(1):41-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17253188
-# Odet F, Guyot R, Leduque P, Le Magueresse-Battistoni B: Evidence for similar expression of protein C inhibitor and the urokinase-type plasminogen activator system during mouse testis development. Endocrinology. 2004 Mar;145(3):1481-9. Epub 2003 Nov 26. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14645112</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P05154">
- <name>Plasma serine protease inhibitor</name>
- <general-function/>
- <specific-function>Inhibits activated protein C as well as plasminogen activators</specific-function>
- <gene-name>SERPINA5</gene-name>
- <locus>14q32.1</locus>
- <cellular-location>Secreted protein</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>9.76</theoretical-pi>
- <molecular-weight>45702.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:8723</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>SERPINA5</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>SERPINA5</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>J02639</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>180550</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P05154</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Acrosomal serine protease inhibitor</synonym>
- <synonym>PAI-3</synonym>
- <synonym>PAI3</synonym>
- <synonym>PCI</synonym>
- <synonym>Plasma serine protease inhibitor precursor</synonym>
- <synonym>Plasminogen activator inhibitor 3</synonym>
- <synonym>Protein C inhibitor</synonym>
- <synonym>Serpin A5</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Plasma serine protease inhibitor
-MQLFLLLCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAA
-PSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQ
-PRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQT
-KGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSRED
-QYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQLE
-LYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGT
-RAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNILFLGKVNRP</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1221 bp
-ATGCAGCTCTTCCTCCTCTTGTGCCTGGTGCTTCTCAGCCCTCAGGGGGCCTCCCTTCAC
-CGCCACCACCCCCGGGAGATGAAGAAGAGAGTCGAGGACCTCCATGTAGGTGCCACGGTG
-GCCCCCAGCAGCAGAAGGGACTTTACCTTTGACCTCTACAGGGCCTTGGCTTCCGCTGCC
-CCCAGCCAGAACATCTTCTTCTCCCCTGTGAGCATCTCCATGAGCCTGGCCATGCTCTCC
-CTGGGGGCTGGGTCCAGCACAAAGATGCAGATCCTGGAGGGCCTGGGCCTCAACCTCCAG
-AAAAGCTCAGAGAAGGAGCTGCACAGAGGCTTTCAGCAGCTCCTTCAGGAACTCAACCAG
-CCCAGAGATGGCTTCCAGCTGAGCCTCGGCAATGCCCTTTTCACCGACCTGGTGGTAGAC
-CTGCAGGACACCTTCGTAAGTGCCATGAAGACGCTGTACCTGGCAGACACTTTCCCCACC
-AACTTTAGGGACTCTGCAGGGGCCATGAAGCAGATCAATGATTATGTGGCAAAGCAAACG
-AAGGGCAAGATTGTGGACTTGCTTAAGAACCTCGATAGCAATGCGGTCGTGATCATGGTG
-AATTACATCTTCTTTAAAGCTAAGTGGGAGACAAGCTTCAACCACAAAGGCACCCAAGAG
-CAAGACTTCTACGTGACCTCGGAGACTGTGGTGCGGGTACCCATGATGAGCCGCGAGGAT
-CAGTATCACTACCTCCTGGACCGGAACCTCTCCTGCAGGGTGGTGGGGGTCCCCTACCAA
-GGCAATGCCACGGCTTTGTTCATTCTCCCCAGTGAGGGAAAGATGCAGCAGGTGGAGAAT
-GGACTGAGTGAGAAAACGCTGAGGAAGTGGCTTAAGATGTTCAAAAAGAGGCAGCTCGAG
-CTTTACCTTCCCAAATTCTCCATTGAGGGCTCCTATCAGCTGGAGAAAGTCCTCCCCAGT
-CTGGGGATCAGTAACGTCTTCACCTCCCATGCTGATCTGTCCCGCATCAGCAACCACTCA
-AATATCCAGGTGTCTGAGATGGTGCACAAAGCTGTGGTGGAGGTGGACGAGTCGGGAACC
-AGAGCAGCGGCAGCCACGGGGACAATCTTCACTTTCAGGTCGGCCCGCCTGAACTCTCAG
-AGGCTAGTGTTCAACAGGCCCTTTCTGATGTTCATTGTGGATAACAACATCCTCTTCCTT
-GGCAAAGTGAACCGCCCCTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00079</identifier>
- <name>Serpin</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>enzyme regulator activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>enzyme inhibitor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>protease inhibitor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>endopeptidase inhibitor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>serine-type endopeptidase inhibitor activity</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="8">
- <id>BE0000942</id>
- <name>Low-density lipoprotein receptor-related protein 2</name>
- <organism>Human</organism>
- <actions/>
- <references># Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
-# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
-# Kanalas JJ: Effect of the nephritogenic autoantibody of Heymann's nephritis on plasminogen-binding to gp330 and activation by urokinase. Biochim Biophys Acta. 1993 Nov 25;1225(1):101-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8241286
-# Kanalas JJ: Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330. Arch Biochem Biophys. 1992 Dec;299(2):255-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1280065
-# Korenberg JR, Argraves KM, Chen XN, Tran H, Strickland DK, Argraves WS: Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). Genomics. 1994 Jul 1;22(1):88-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7959795</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P98164">
- <name>Low-density lipoprotein receptor-related protein 2</name>
- <general-function>Involved in calcium ion binding</general-function>
- <specific-function>May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release</specific-function>
- <gene-name>LRP2</gene-name>
- <locus>2q24-q31</locus>
- <cellular-location>Membrane; single-pass type I membrane protein</cellular-location>
- <transmembrane-regions>4424-4446</transmembrane-regions>
- <theoretical-pi>4.68</theoretical-pi>
- <molecular-weight>521933.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:6694</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>LRP2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>LRP2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>U33837</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>1809240</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P98164</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Glycoprotein 330</synonym>
- <synonym>gp330</synonym>
- <synonym>Low-density lipoprotein receptor-related protein 2 precursor</synonym>
- <synonym>Megalin</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Low-density lipoprotein receptor-related protein 2 precursor
-MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEI
-GCAVVTCQQGYFKCQSEGQCIPSSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC
-IPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT
-EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWV
-CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN
-TSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQ
-KCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVES
-QNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNK
-IYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLER
-AFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSL
-IPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYAT
-NPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIR
-GIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAA
-NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYL
-FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD
-GLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHL
-KSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNE
-PPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECI
-PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE
-KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC
-IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS
-DEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCL
-GHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFL
-LANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLV
-ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR
-RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALD
-PRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLD
-YMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVM
-YNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC
-LRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE
-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTL
-IANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEH
-LECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQY
-EVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL
-FSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHV
-DVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLY
-FTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFL
-DCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTP
-YGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAE
-VNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS
-LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTV
-IASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGY
-LYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTL
-TGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI
-NTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC
-GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC
-DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR
-TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQH
-WYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKR
-HQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC
-GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDG
-SDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSIS
-GCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAP
-GYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKR
-LYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN
-GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVII
-STKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTI
-YWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLC
-LIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSD
-GSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ
-CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDC
-GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCH
-PVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDH
-YNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGA
-YCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH
-EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL
-GCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH
-CRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQD
-EEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKY
-VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF
-WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYD
-GTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRI
-FHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP
-CRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGAL
-AIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAI
-DRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSE
-IVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLP
-AKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>13968 bp
-ATGGATCGCGGGCCGGCAGCAGTGGCGTGCACGCTGCTCCTGGCTCTCGTCGCCTGCCTA
-GCGCCGGCCAGTGGCCAAGAATGTGACAGTGCGCATTTTCGCTGTGGAAGTGGGCATTGC
-ATCCCTGCAGACTGGAGGTGTGATGGGACCAAAGACTGTTCAGATGACGCGGATGAAATT
-GGCTGCGCTGTTGTGACCTGCCAGCAGGGCTATTTCAAGTGCCAGAGTGAGGGACAATGC
-ATCCCCAGCTCCTGGGTGTGTGACCAAGATCAAGACTGTGATGATGGCTCAGATGAACGT
-CAAGATTGCTCACAAAGTACATGCTCAAGTCATCAGATAACATGCTCCAATGGTCAGTGT
-ATCCCAAGTGAATACAGGTGCGACCACGTCAGAGACTGCCCCGATGGAGCTGATGAGAAT
-GACTGCCAGTACCCAACATGTGAGCAGCTTACTTGTGACAATGGGGCCTGCTATAACACC
-AGTCAGAAGTGTGATTGGAAAGTTGATTGCAGGGACTCCTCAGATGAAATCAACTGCACT
-GAGATATGCTTGCACAATGAGTTTTCATGTGGCAATGGAGAGTGTATCCCTCGTGCTTAT
-GTCTGTGACCATGACAATGATTGCCAAGACGGCAGTGATGAACATGCTTGCAACTATCCG
-ACCTGCGGTGGTTACCAGTTCACTTGCCCCAGTGGCCGATGCATTTATCAAAACTGGGTT
-TGTGATGGAGAAGATGACTGTAAAGATAATGGAGATGAAGATGGATGTGAAAGCGGTCCT
-CATGATGTTCATAAATGTTCCCCAAGAGAATGGTCTTGCCCAGAGTCGGGACGATGCATC
-TCCATTTATAAAGTTTGTGATGGGATTTTAGATTGCCCAGGAAGAGAAGATGAAAACAAC
-ACTAGTACCGGAAAATACTGTAGTATGACTCTGTGCTCTGCCTTGAACTGCCAGTACCAG
-TGCCATGAGACGCCGTATGGAGGAGCGTGTTTTTGTCCCCCAGGTTATATCATCAACCAC
-AATGACAGCCGTACCTGTGTTGAGTTTGATGATTGCCAGATATGGGGAATTTGTGACCAG
-AAGTGTGAAAGCCGACCTGGCCGTCACCTGTGCCACTGTGAAGAAGGGTATATCTTGGAG
-CGTGGACAGTATTGCAAAGCTAATGATTCCTTTGGCGAGGCCTCCATTATCTTCTCCAAT
-GGTCGGGATTTGTTAATTGGTGATATTCATGGAAGGAGCTTCCGGATCCTAGTGGAGTCT
-CAGAATCGTGGAGTGGCCGTGGGTGTGGCTTTCCACTATCACCTGCAAAGAGTTTTTTGG
-ACAGACACCGTGCAAAATAAGGTTTTTTCAGTTGACATTAATGGTTTAAATATCCAAGAG
-GTTCTCAATGTTTCTGTTGAAACCCCAGAGAACCTGGCTGTGGACTGGGTTAATAATAAA
-ATCTATCTAGTGGAAACCAAGGTCAACCGCATAGATATGGTAAATTTGGATGGAAGCTAT
-CGGGTTACCCTTATAACTGAAAACTTGGGGCATCCTAGAGGAATTGCCGTGGACCCAACT
-GTTGGTTATTTATTTTTCTCAGATTGGGAGAGCCTTTCTGGGGAACCTAAGCTGGAAAGG
-GCATTCATGGATGGCAGCAACCGTAAAGACTTGGTGAAAACAAAGCTGGGATGGCCTGCT
-GGGGTAACTCTGGATATGATATCGAAGCGTGTTTACTGGGTTGACTCTCGGTTTGATTAC
-ATTGAAACTGTAACTTATGATGGAATTCAAAGGAAGACTGTAGTTCATGGAGGCTCCCTC
-ATTCCTCATCCCTTTGGAGTAAGCTTATTTGAAGGTCAGGTGTTCTTTACAGATTGGACA
-AAGATGGCCGTGCTGAAGGCAAACAAGTTCACAGAGACCAACCCACAAGTGTACTACCAG
-GCTTCCCTGAGGCCCTATGGAGTGACTGTTTACCATTCCCTCAGACAGCCCTATGCTACC
-AATCCGTGTAAAGATAACAATGGGGGCTGTGAGCAGGTCTGTGTTCTCAGCCACAGAACA
-GATAATGATGGTTTGGGTTTCCGTTGCAAGTGCACATTCGGCTTCCAACTGGATACAGAT
-GAGCGCCACTGCATTGCTGTTCAGAATTTCCTCATTTTTTCATCCCAAGTTGCTATTCGT
-GGGATCCCGTTCACCTTGTCTACCCAGGAAGATGTCATGGTTCCAGTTTCGGGGAATCCT
-TCTTTCTTTGTCGGGATTGATTTTGACGCCCAGGACAGCACTATCTTTTTTTCAGATATG
-TCAAAACACATGATTTTTAAGCAAAAGATTGATGGCACAGGAAGAGAAATTCTCGCAGCT
-AACAGGGTGGAAAATGTTGAAAGTTTGGCTTTTGATTGGATTTCAAAGAATCTCTATTGG
-ACAGACTCTCATTACAAGAGTATCAGTGTCATGAGGCTAGCTGATAAAACGAGACGCACA
-GTAGTTCAGTATTTAAATAACCCACGGTCGGTGGTAGTTCATCCTTTTGCCGGGTATCTA
-TTCTTCACTGATTGGTTCCGTCCTGCTAAAATTATGAGAGCATGGAGTGACGGATCTCAC
-CTCTTGCCTGTAATAAACACTACTCTTGGATGGCCCAATGGCTTGGCCATCGATTGGGCT
-GCTTCACGATTGTACTGGGTAGATGCCTATTTTGATAAAATTGAGCACAGCACCTTTGAT
-GGTTTAGACAGAAGAAGACTGGGCCATATAGAGCAGATGACACATCCGTTTGGACTTGCC
-ATCTTTGGAGAGCATTTATTTTTTACTGACTGGAGACTGGGTGCCATTATTCGAGTCAGG
-AAAGCAGATGGTGGAGAAATGACAGTTATCCGAAGTGGCATTGCTTACATACTGCATTTG
-AAATCGTATGATGTCAACATCCAGACTGGTTCTAACGCCTGTAATCAACCCACGCATCCT
-AACGGTGACTGCAGCCACTTCTGCTTCCCGGTGCCAAATTTCCAGCGAGTGTGTGGGTGC
-CCTTATGGAATGAGGCTGGCTTCCAATCACTTGACATGCGAGGGGGACCCAACCAATGAA
-CCACCCACGGAGCAGTGTGGCTTATTTTCCTTCCCCTGTAAAAATGGCAGATGTGTGCCC
-AATTACTATCTCTGTGATGGAGTCGATGATTGTCATGATAACAGTGATGAGCAACTATGT
-GGCACACTTAATAATACCTGTTCATCTTCGGCGTTCACCTGTGGCCATGGGGAGTGCATT
-CCTGCACACTGGCGCTGTGACAAACGCAACGACTGTGTGGATGGCAGTGATGAGCACAAC
-TGCCCCACCCACGCACCTGCTTCCTGCCTTGACACCCAATACACCTGTGATAATCACCAG
-TGTATCTCAAAGAACTGGGTCTGTGACACAGACAATGATTGTGGGGATGGATCTGATGAA
-AAGAACTGCAATTCGACAGAGACATGCCAACCTAGTCAGTTTAATTGCCCCAATCATCGA
-TGTATTGACCTATCGTTTGTCTGTGATGGTGACAAGGATTGTGTTGATGGATCTGATGAG
-GTTGGTTGTGTATTAAACTGTACTGCTTCTCAATTCAAGTGTGCCAGTGGGGATAAATGT
-ATTGGCGTCACAAATCGTTGTGATGGTGTTTTTGATTGCAGTGACAACTCGGATGAAGCG
-GGCTGTCCAACCAGGCCTCCTGGTATGTGCCACTCAGATGAATTTCAGTGCCAAGAAGAT
-GGTATCTGCATCCCGAACTTCTGGGAATGTGATGGGCATCCAGACTGCCTCTATGGATCT
-GATGAGCACAATGCCTGTGTCCCCAAGACTTGCCCTTCATCATATTTCCACTGTGACAAC
-GGAAACTGCATCCACAGGGCATGGCTCTGTGATCGGGACAATGACTGCGGGGATATGAGT
-GATGAGAAGGACTGCCCTACTCAGCCCTTTCGCTGTCCTAGTTGGCAATGGCAGTGTCTT
-GGCCATAACATCTGTGTGAATCTGAGTGTAGTGTGTGATGGCATCTTTGACTGCCCCAAT
-GGGACAGATGAGTCCCCACTTTGCAATGGGAACAGCTGCTCAGATTTCAATGGTGGTTGT
-ACTCACGAGTGTGTTCAAGAGCCCTTTGGGGCTAAATGCCTATGTCCATTGGGATTCTTA
-CTTGCCAATGATTCTAAGACCTGTGAAGACATAGATGAATGTGATATTCTAGGCTCTTGT
-AGCCAGCACTGTTACAATATGAGAGGTTCTTTCCGGTGCTCGTGTGATACAGGCTACATG
-TTAGAAAGTGATGGGAGGACTTGCAAAGTTACAGCATCTGAGAGTCTGCTGTTACTTGTG
-GCAAGTCAGAACAAAATTATTGCCGACAGTGTCACCTCCCAGGTCCACAATATCTATTCA
-TTGGTCGAGAATGGTTCTTACATTGTAGCTGTTGATTTTGATTCAATTAGTGGTCGTATC
-TTTTGGTCTGATGCAACTCAGGGTAAAACCTGGAGTGCGTTTCAAAATGGAACGGACAGA
-AGAGTGGTATTTGACAGTAGCATCATCTTGACTGAAACTATTGCAATAGATTGGGTAGGT
-CGTAATCTTTACTGGACAGACTATGCTCTGGAAACAATTGAAGTCTCCAAAATTGATGGG
-AGCCACAGGACTGTGCTGATTAGTAAAAACCTAACAAATCCAAGAGGACTAGCATTAGAT
-CCCAGAATGAATGAGCATCTACTGTTCTGGTCTGACTGGGGCCACCACCCTCGCATCGAG
-CGAGCCAGCATGGACGGCAGCATGCGCACTGTCATTGTCCAGGACAAGATCTTCTGGCCC
-TGCGGCTTAACTATTGACTACCCCAACAGACTGCTCTACTTCATGGACTCCTATCTTGAT
-TACATGGACTTTTGCGATTATAATGGACACCATCGGAGACAGGTGATAGCCAGTGATTTG
-ATTATACGGCACCCCTATGCCCTAACTCTCTTTGAAGACTCTGTGTACTGGACTGACCGT
-GCTACTCGTCGGGTTATGCGAGCCAACAAGTGGCATGGAGGGAACCAGTCAGTTGTAATG
-TATAATATTCAATGGCCCCTTGGGATTGTTGCGGTTCATCCTTCGAAACAACCAAATTCC
-GTGAATCCATGTGCCTTTTCCCGCTGCAGCCATCTCTGCCTGCTTTCCTCACAGGGGCCT
-CATTTTTACTCCTGTGTTTGTCCTTCAGGATGGAGTCTGTCTCCTGATCTCCTGAATTGC
-TTGAGAGATGATCAACCTTTCTTAATAACTGTAAGGCAACATATAATTTTTGGAATCTCC
-CTTAATCCTGAGGTGAAGAGCAATGATGCTATGGTCCCCATAGCAGGGATACAGAATGGT
-TTAGATGTTGAATTTGATGATGCTGAGCAATACATCTATTGGGTTGAAAATCCAGGTGAA
-ATTCACAGAGTGAAGACAGATGGCACCAACAGGACAGTATTTGCTTCTATATCTATGGTG
-GGGCCTTCTATGAACCTGGCCTTAGATTGGATTTCAAGAAACCTTTATTCTACCAATCCT
-AGAACTCAGTCAATCGAGGTTTTGACACTCCACGGAGATATCAGATACAGAAAAACATTG
-ATTGCCAATGATGGGACAGCTCTTGGAGTTGGCTTTCCAATTGGCATAACTGTTGATCCT
-GCTCGTGGGAAGCTGTACTGGTCAGACCAAGGAACTGACAGTGGGGTTCCTGCCAAGATC
-GCCAGTGCTAACATGGATGGCACATCTGTGAAAACTCTCTTTACTGGGAACCTCGAACAC
-CTGGAGTGTGTCACTCTTGACATCGAAGAGCAGAAACTCTACTGGGCAGTCACTGGAAGA
-GGAGTGATTGAAAGAGGAAACGTGGATGGAACAGATCGGATGATCCTGGTACACCAGCTT
-TCCCACCCCTGGGGAATTGCAGTCCATGATTCTTTCCTTTATTATACTGATGAACAGTAT
-GAGGTCATTGAAAGAGTTGATAAGGCCACTGGGGCCAACAAAATAGTCTTGAGAGATAAT
-GTTCCAAATCTGAGGGGTCTTCAAGTTTATCACAGACGCAATGCCGCCGAATCCTCAAAT
-GGCTGTAGCAACAACATGAATGCCTGTCAGCAGATTTGCCTGCCTGTACCAGGAGGATTG
-TTTTCCTGCGCCTGTGCCACTGGATTTAAACTCAATCCTGATAATCGGTCCTGCTCTCCA
-TATAACTCTTTCATTGTTGTTTCAATGCTGTCTGCAATCAGAGGCTTTAGCTTGGAATTG
-TCAGATCATTCAGAAACCATGGTGCCGGTGGCAGGCCAAGGACGAAACGCACTGCATGTG
-GATGTGGATGTGTCCTCTGGCTTTATTTATTGGTGTGATTTTAGCAGCTCAGTGGCATCT
-GATAATGCGATCCGTAGAATTAAACCAGATGGATCTTCTCTGATGAACATTGTGACACAT
-GGAATAGGAGAAAATGGAGTCCGGGGTATTGCAGTGGATTGGGTAGCAGGAAATCTTTAT
-TTCACCAATGCCTTTGTTTCTGAAACACTGATAGAAGTTCTGCGGATCAATACTACTTAC
-CGCCGTGTTCTTCTTAAAGTCACAGTGGACATGCCTAGGCATATTGTTGTAGATCCCAAG
-AACAGATACCTCTTCTGGGCTGACTATGGGCAGAGACCAAAGATTGAGCGTTCTTTCCTT
-GACTGTACCAATCGAACAGTGCTTGTGTCAGAGGGCATTGTCACACCACGGGGCTTGGCA
-GTGGACCGAAGTGATGGCTACGTTTATTGGGTTGATGATTCTTTAGATATAATTGCAAGG
-ATTCGTATCAATGGAGAGAACTCTGAAGTGATTCGTTATGGCAGTCGTTACCCAACTCCT
-TATGGCATCACTGTTTTTGAAAATTCTATCATATGGGTAGATAGGAATTTGAAAAAGATC
-TTCCAAGCCAGCAAGGAACCAGAGAACACAGAGCCACCCACAGTGATAAGAGACAATATC
-AACTGGCTAAGAGATGTGACCATCTTTGACAAGCAAGTCCAGCCCCGGTCACCAGCAGAG
-GTCAACAACAACCCTTGCTTGGAAAACAATGGTGGGTGCTCTCATCTCTGCTTTGCTCTG
-CCTGGATTGCACACCCCAAAATGTGACTGTGCCTTTGGGACCCTGCAAAGTGATGGCAAG
-AATTGTGCCATTTCAACAGAAAATTTCCTCATCTTTGCCTTGTCTAATTCCTTGAGAAGC
-TTACACTTGGACCCTGAAAACCATAGCCCACCTTTCCAAACAATAAATGTGGAAAGAACT
-GTCATGTCTCTAGACTATGACAGTGTAAGTGATAGAATCTACTTCACACAAAATTTAGCC
-TCTGGAGTTGGACAGATTTCCTATGCCACCCTGTCTTCAGGGATCCATACTCCAACTGTC
-ATTGCTTCAGGTATAGGGACTGCTGATGGCATTGCCTTTGACTGGATTACTAGAAGAATT
-TATTACAGTGACTACCTCAACCAGATGATTAATTCCATGGCTGAAGATGGGTCTAACCGC
-ACTGTGATAGCCCGCGTTCCAAAACCAAGAGCAATTGTGTTAGATCCCTGCCAAGGGTAC
-CTGTACTGGGCTGACTGGGATACACATGCCAAAATCGAGAGAGCCACATTGGGAGGAAAC
-TTCCGGGTACCCATTGTGAACAGCAGTCTGGTCATGCCCAGTGGGCTGACTCTGGACTAT
-GAAGAGGACCTTCTCTACTGGGTGGATGCTAGTCTGCAGAGGATTGAACGCAGCACTCTG
-ACGGGCGTGGATCGTGAAGTCATTGTCAATGCAGCCGTTCATGCTTTTGGCTTGACTCTC
-TATGGCCAGTATATTTACTGGACTGACTTGTACACACAAAGAATTTACCGAGCTAACAAA
-TATGACGGGTCAGGTCAGATTGCAATGACCACAAATTTGCTCTCCCAGCCCAGGGGAATC
-AACACTGTTGTGAAGAACCAGAAACAACAGTGTAACAATCCTTGTGAACAGTTTAATGGG
-GGCTGCAGCCATATCTGTGCACCAGGTCCAAATGGTGCCGAGTGCCAGTGTCCACATGAG
-GGCAACTGGTATTTGGCCAACAACAGGAAGCACTGCATTGTGGACAATGGTGAACGATGT
-GGTGCATCTTCCTTCACCTGCTCCAATGGGCGCTGCATCTCGGAAGAGTGGAAGTGTGAT
-AATGACAACGACTGTGGGGATGGCAGTGATGAGATGGAAAGTGTCTGTGCACTTCACACC
-TGCTCACCGACAGCCTTCACCTGTGCCAATGGGCGATGTGTCCAATACTCTTACCGCTGT
-GATTACTACAATGACTGTGGTGATGGCAGTGATGAGGCAGGGTGCCTGTTCAGGGACTGC
-AATGCCACCACGGAGTTTATGTGCAATAACAGAAGGTGCATACCTCGTGAGTTTATCTGC
-AATGGTGTAGACAACTGCCATGATAATAACACTTCAGATGAGAAAAATTGCCCTGATCGC
-ACTTGCCAGTCTGGATACACAAAATGTCATAATTCAAATATTTGTATTCCTCGCGTTTAT
-TTGTGTGACGGAGACAATGACTGTGGAGATAACAGTGATGAAAACCCTACTTATTGCACC
-ACTCACACATGCAGCAGCAGTGAGTTCCAATGCGCATCTGGGCGCTGTATTCCTCAACAT
-TGGTATTGTGATCAAGAAACAGATTGTTTTGATGCCTCTGATGAACCTGCCTCTTGTGGT
-CACTCTGAGCGAACATGCCTAGCTGATGAGTTCAAGTGTGATGGTGGGAGGTGCATCCCA
-AGCGAATGGATCTGTGACGGTGATAATGACTGTGGGGATATGAGTGACGAGGATAAAAGG
-CACCAGTGTCAGAATCAAAACTGCTCGGATTCCGAGTTTCTCTGTGTAAATGACAGACCT
-CCGGACAGGAGGTGCATTCCCCAGTCTTGGGTCTGTGATGGCGATGTGGATTGTACTGAC
-GGCTACGATGAGAATCAGAATTGCACCAGGAGAACTTGCTCTGAAAATGAATTCACCTGT
-GGTTACGGACTGTGTATCCCAAAGATATTCAGGTGTGACCGGCACAATGACTGTGGTGAC
-TATAGCGACGAGAGGGGCTGCTTATACCAGACTTGCCAACAGAATCAGTTTACCTGTCAG
-AACGGGCGCTGCATTAGTAAAACCTTCGTCTGTGATGAGGATAATGACTGTGGAGACGGA
-TCTGATGAGCTGATGCACCTGTGCCACACCCCAGAACCCACGTGTCCACCTCACGAGTTC
-AAGTGTGACAATGGGCGCTGCATCGAGATGATGAAACTCTGCAACCACCTAGATGACTGT
-TTGGACAACAGCGATGAGAAAGGCTGTGGCATTAATGAATGCCATGACCCTTCAATCAGT
-GGCTGCGATCACAACTGCACAGACACCTTAACCAGTTTCTATTGTTCCTGTCGTCCTGGT
-TACAAGCTCATGTCTGACAAGCGGACTTGTGTTGATATTGATGAATGCACAGAGATGCCT
-TTTGTCTGTAGCCAGAAGTGTGAGAATGTAATAGGCTCCTACATCTGTAAGTGTGCCCCA
-GGCTACCTCCGAGAACCAGATGGAAAGACCTGCCGGCAAAACAGTAACATCGAACCCTAT
-CTCATTTTTAGCAACCGTTACTATTTGAGAAATTTAACTATAGATGGCTATTTTTACTCC
-CTCATCTTGGAAGGACTGGACAATGTTGTGGCATTAGATTTTGACCGAGTAGAGAAGAGA
-TTGTATTGGATTGATACACAGAGGCAAGTCATTGAGAGAATGTTTCTGAATAAGACAAAC
-AAGGAGACAATCATAAACCACAGACTACCAGCTGCAGAAAGTCTGGCTGTAGACTGGGTT
-TCCAGAAAGCTCTACTGGTTGGATGCCCGCCTGGATGGCCTCTTTGTCTCTGACCTCAAT
-GGTGGACACCGCCGCATGCTGGCCCAGCACTGTGTGGATGCCAACAACACCTTCTGCTTT
-GATAATCCCAGAGGACTTGCCCTTCACCCTCAATATGGGTACCTCTACTGGGCAGACTGG
-GGTCACCGCGCATACATTGGGAGAGTAGGCATGGATGGAACCAACAAGTCTGTGATAATC
-TCCACCAAGTTAGAGTGGCCTAATGGCATCACCATTGATTACACCAATGATCTACTCTAC
-TGGGCAGATGCCCACCTGGGTTACATAGAGTACTCTGATTTGGAGGGCCACCATCGACAC
-ACGGTGTATGATGGGGCACTGCCTCACCCTTTCGCTATTACCATTTTTGAAGACACTATT
-TATTGGACAGATTGGAATACAAGGACAGTGGAAAAGGGAAACAAATATGATGGATCAAAT
-AGACAGACACTGGTGAACACAACACACAGACCATTTGACATCCATGTGTACCATCCATAT
-AGGCAGCCCATTGTGAGCAATCCCTGTGGTACCAACAATGGTGGCTGTTCTCATCTCTGC
-CTCATCAAGCCAGGAGGAAAAGGGTTCACTTGCGAGTGTCCAGATGACTTCCGCACCCTT
-CAACTGAGTGGCAGCACCTACTGCATGCCCATGTGCTCCAGCACCCAGTTCCTGTGCGCT
-AACAATGAAAAGTGCATTCCTATCTGGTGGAAATGTGATGGACAGAAAGACTGCTCAGAT
-GGCTCTGATGAACTGGCCCTTTGCCCGCAGCGCTTCTGCCGACTGGGACAGTTCCAGTGC
-AGTGACGGCAACTGCACCAGCCCGCAGACTTTATGCAATGCTCACCAAAATTGCCCTGAT
-GGGTCTGATGAAGACCGTCTTCTTTGTGAGAATCACCACTGTGACTCCAATGAATGGCAG
-TGCGCCAACAAACGTTGCATCCCAGAATCCTGGCAGTGTGACACATTTAACGACTGTGAG
-GATAACTCAGATGAAGACAGTTCCCACTGTGCCAGCAGGACCTGCCGGCCGGGCCAGTTT
-CGGTGTGCTAATGGCCGCTGCATCCCGCAGGCCTGGAAGTGTGATGTGGATAATGATTGT
-GGAGACCACTCGGATGAGCCCATTGAAGAATGCATGAGCTCTGCCCATCTCTGTGACAAC
-TTCACAGAATTCAGCTGCAAAACAAATTACCGCTGCATCCCAAAGTGGGCCGTGTGCAAT
-GGTGTAGATGACTGCAGGGACAACAGTGATGAGCAAGGCTGTGAGGAGAGGACATGCCAT
-CCTGTGGGGGATTTCCGCTGTAAAAATCACCACTGCATCCCTCTTCGTTGGCAGTGTGAT
-GGGCAAAATGACTGTGGAGATAACTCAGATGAGGAAAACTGTGCTCCCCGGGAGTGCACA
-GAGAGCGAGTTTCGATGTGTCAATCAGCAGTGCATTCCCTCGCGATGGATCTGTGACCAT
-TACAACGACTGTGGGGACAACTCAGATGAACGGGACTGTGAGATGAGGACCTGCCATCCT
-GAATATTTTCAGTGTACAAGTGGACATTGTGTACACAGTGAACTGAAATGCGATGGATCC
-GCTGACTGTTTGGATGCGTCTGATGAAGCTGATTGTCCCACACGCTTTCCTGATGGTGCA
-TACTGCCAGGCTACTATGTTCGAATGCAAAAACCATGTTTGTATCCCGCCATATTGGAAA
-TGTGATGGCGATGATGACTGTGGCGATGGTTCAGATGAAGAACTTCACCTGTGCTTGGAT
-GTTCCCTGTAATTCACCAAACCGTTTCCGGTGTGACAACAATCGCTGCATTTATAGTCAT
-GAGGTGTGCAATGGTGTGGATGACTGTGGAGATGGAACTGATGAGACAGAGGAGCACTGT
-AGAAAACCGACCCCTAAACCTTGTACAGAATATGAATATAAGTGTGGCAATGGGCATTGC
-ATTCCACATGACAATGTGTGTGATGATGCCGATGACTGTGGTGACTGGTCCGATGAACTG
-GGTTGCAATAAAGGAAAAGAAAGAACATGTGCTGAAAATATATGCGAGCAAAATTGTACC
-CAATTAAATGAAGGAGGATTTATCTGCTCCTGTACAGCTGGGTTCGAAACCAATGTTTTT
-GACAGAACCTCCTGTCTAGATATCAATGAATGTGAACAATTTGGGACTTGTCCCCAGCAC
-TGCAGAAATACCAAAGGAAGTTATGAGTGTGTCTGTGCTGATGGCTTCACGTCTATGAGT
-GACCGCCCTGGAAAACGATGTGCAGCTGAGGGTAGCTCTCCTTTGTTGCTACTGCCTGAC
-AATGTCCGAATTCGAAAATATAATCTCTCATCTGAGAGGTTCTCAGAGTATCTTCAAGAT
-GAGGAATATATCCAAGCTGTTGATTATGATTGGGATCCCAAGGACATAGGCCTCAGTGTT
-GTGTATTACACTGTGCGAGGGGAGGGCTCTAGGTTTGGTGCTATCAAACGTGCCTACATC
-CCCAACTTTGAATCCGGCCGCAATAATCTTGTGCAGGAAGTTGACCTGAAACTGAAATAC
-GTAATGCAGCCAGATGGAATAGCAGTGGACTGGGTTGGAAGGCATATTTACTGGTCAGAT
-GTCAAGAATAAACGCATTGAGGTGGCTAAACTTGATGGAAGGTACAGAAAGTGGCTGATT
-TCCACTGACCTGGACCAACCAGCTGCTATTGCTGTGAATCCCAAACTAGGGCTTATGTTC
-TGGACTGACTGGGGAAAGGAACCTAAAATCGAGTCTGCCTGGATGAATGGAGAGGACCGC
-AACATCCTGGTTTTCGAGGACCTTGGTTGGCCAACTGGCCTTTCTATCGATTATTTGAAC
-AATGACCGAATCTACTGGAGTGACTTCAAGGAGGACGTTATTGAAACCATAAAATATGAT
-GGGACTGATAGGAGAGTCATTGCAAAGGAAGCAATGAACCCTTACAGCCTGGACATCTTT
-GAAGACCAGTTATACTGGATATCTAAGGAAAAGGGAGAAGTATGGAAACAAAATAAATTT
-GGGCAAGGAAAGAAAGAGAAAACGCTGGTAGTGAACCCTTGGCTCACTCAAGTTCGAATC
-TTTCATCAACTCAGATACAATAAGTCAGTGCCCAACCTTTGCAAACAGATCTGCAGCCAC
-CTCTGCCTTCTGAGACCTGGAGGATACAGCTGTGCCTGTCCCCAAGGCTCCAGCTTTATA
-GAGGGGAGCACCACTGAGTGTGATGCAGCCATCGAACTGCCTATCAACCTGCCCCCCCCA
-TGCAGGTGCATGCACGGAGGAAATTGCTATTTTGATGAGACTGACCTCCCCAAATGCAAG
-TGTCCTAGCGGCTACACCGGAAAATATTGTGAAATGGCGTTTTCAAAAGGCATCTCTCCA
-GGAACAACCGCAGTAGCTGTGCTGTTGACAATCCTCTTGATCGTCGTAATTGGAGCTCTG
-GCAATTGCAGGATTCTTCCACTATAGAAGGACCGGCTCCCTTTTGCCTGCTCTGCCCAAG
-CTGCCAAGCTTAAGCAGTCTCGTCAAGCCCTCTGAAAATGGGAATGGGGTGACCTTCAGA
-TCAGGGGCAGATCTTAACATGGATATTGGAGTGTCTGGTTTTGGACCTGAGACTGCTATT
-GACAGGTCAATGGCAATGAGTGAAGACTTTGTCATGGAAATGGGGAAGCAGCCCATAATA
-TTTGAAAACCCAATGTACTCAGCCAGAGACAGTGCTGTCAAAGTGGTTCAGCCAATCCAG
-GTGACTGTATCTGAAAATGTGGATAATAAGAATTATGGAAGTCCCATAAACCCTTCTGAG
-ATAGTTCCAGAGACAAACCCAACTTCACCAGCTGCTGATGGAACTCAGGTGACAAAATGG
-AATCTCTTCAAACGAAAATCTAAACAAACTACCAACTTTGAAAATCCAATCTATGCACAG
-ATGGAGAACGAGCAAAAGGAAAGTGTTGCTGCGACACCACCTCCATCACCTTCGCTCCCT
-GCTAAGCCTAAGCCTCCTTCGAGAAGAGACCCAACTCCAACCTATTCTGCAACAGAAGAC
-ACTTTTAAAGACACCGCAAATCTTGTTAAAGAAGACTCTGAAGTATAG</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00008</identifier>
- <name>EGF</name>
- </pfam>
- <pfam>
- <identifier>PF07645</identifier>
- <name>EGF_CA</name>
- </pfam>
- <pfam>
- <identifier>PF00057</identifier>
- <name>Ldl_recept_a</name>
- </pfam>
- <pfam>
- <identifier>PF00058</identifier>
- <name>Ldl_recept_b</name>
- </pfam>
- <pfam>
- <identifier>PF07974</identifier>
- <name>EGF_2</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>calcium ion binding</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="9">
- <id>BE0001656</id>
- <name>Suppressor of tumorigenicity 14 protein</name>
- <organism>Human</organism>
- <actions/>
- <references># Suzuki M, Kobayashi H, Kanayama N, Saga Y, Suzuki M, Lin CY, Dickson RB, Terao T: Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase. J Biol Chem. 2004 Apr 9;279(15):14899-908. Epub 2004 Jan 27. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14747469
-# Kirchhofer D, Peek M, Li W, Stamos J, Eigenbrot C, Kadkhodayan S, Elliott JM, Corpuz RT, Lazarus RA, Moran P: Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1. J Biol Chem. 2003 Sep 19;278(38):36341-9. Epub 2003 Jun 18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12815039</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="Q9Y5Y6">
- <name>Suppressor of tumorigenicity 14 protein</name>
- <general-function>Involved in protease activity</general-function>
- <specific-function>Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site</specific-function>
- <gene-name>ST14</gene-name>
- <locus>11q24-q25</locus>
- <cellular-location>Membrane; single-pass type II membrane protein (Probable)</cellular-location>
- <transmembrane-regions>56-76</transmembrane-regions>
- <theoretical-pi>6.53</theoretical-pi>
- <molecular-weight>94770.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:11344</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>ST14</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>ST14</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>AF118224</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>6647302</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>Q9Y5Y6</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>EC 3.4.21.109</synonym>
- <synonym>Matriptase</synonym>
- <synonym>Membrane-type serine protease 1</synonym>
- <synonym>MT-SP1</synonym>
- <synonym>Prostamin</synonym>
- <synonym>Serine protease 14</synonym>
- <synonym>Serine protease TADG-15</synonym>
- <synonym>Tumor-associated differentially-expressed gene 15 protein</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Suppressor of tumorigenicity protein 14
-MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
-VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
-KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
-LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
-HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
-YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
-PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
-NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
-SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
-SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
-DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
-DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
-AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
-PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
-RLPLFRDWIKENTGV</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>2568 bp
-ATGGGGAGCGATCGGGCCCGCAAGGGCGGAGGGGGCCCGAAGGACTTCGGCGCGGGACTC
-AAGTACAACTCCCGGCACGAGAAAGTGAATGGCTTGGAGGAAGGCGTGGAGTTCCTGCCA
-GTCAACAACGTCAAGAAGGTGGAAAAGCATGGCCCGGGGCGCTGGGTGGTGCTGGCAGCC
-GTGCTGATCGGCCTCCTCTTGGTCTTGCTGGGGATCGGCTTCCTGGTGTGGCATTTGCAG
-TACCGGGACGTGCGTGTCCAGAAGGTCTTCAATGGCTACATGAGGATCACAAATGAGAAT
-TTTGTGGATGCCTACGAGAACTCCAACTCCACTGAGTTTGTAAGCCTGGCCAGCAAGGTG
-AAGGACGCGCTGAAGCTGCTGTACAGCGGAGTCCCATTCCTGGGCCCCTACCACAAGGAG
-TCGGCTGTGACGGCCTTCAGCGAGGGCAGCGTCATCGCCTACTACTGGTCTGAGTTCAGC
-ATCCCGCAGCACCTGGTGGAGGAGGCCGAGCGCGTCATGGCCGAGGAGCGCGTAGTCATG
-CTGCCCCCGCGGGCGCGCTCCCTGAAGTCCTTTGTGGTCACCTCAGTGGTGGCTTTCCCC
-ACGGACTCCAAAACAGTACAGAGGACCCAGGACAACAGCTGCAGCTTTGGCCTGCACGCC
-CGCGGTGTGGAGCTGATGCGCTTCACCACGCCCGGCTTCCCTGACAGCCCCTACCCCGCT
-CATGCCCGCTGCCAGTGGGCCCTGCGGGGGGACGCCGACTCAGTGCTGAGCCTCACCTTC
-CGCAGCTTTGACCTTGCGTCCTGCGACGAGCGCGGCAGCGACCTGGTGACGGTGTACAAC
-ACCCTGAGCCCCATGGAGCCCCACGCCCTGGTGCAGTTGTGTGGCACCTACCCTCCCTCC
-TACAACCTGACCTTCCACTCCTCCCAGAACGTCCTGCTCATCACACTGATAACCAACACT
-GAGCGGCGGCATCCCGGCTTTGAGGCCACCTTCTTCCAGCTGCCTAGGATGAGCAGCTGT
-GGAGGCCGCTTACGTAAAGCCCAGGGGACATTCAACAGCCCCTACTACCCAGGCCACTAC
-CCACCCAACATTGACTGCACATGGAACATTGAGGTGCCCAACAACCAGCATGTGAAGGTG
-CGCTTCAAATTCTTCTACCTGCTGGAGCCCGGCGTGCCTGCGGGCACCTGCCCCAAGGAC
-TACGTGGAGATCAATGGGGAGAAATACTGCGGAGAGAGGTCCCAGTTCGTCGTCACCAGC
-AACAGCAACAAGATCACAGTTCGCTTCCACTCAGATCAGTCCTACACCGACACCGGCTTC
-TTAGCTGAATACCTCTCCTACGACTCCAGTGACCCATGCCCGGGGCAGTTCACGTGCCGC
-ACGGGGCGGTGTATCCGGAAGGAGCTGCGCTGTGATGGCTGGGCCGACTGCACCGACCAC
-AGCGATGAGCTCAACTGCAGTTGCGACGCCGGCCACCAGTTCACGTGCAAGAACAAGTTC
-TGCAAGCCCCTCTTCTGGGTCTGCGACAGTGTGAACGACTGCGGAGACAACAGCGACGAG
-CAGGGGTGCAGTTGTCCGGCCCAGACCTTCAGGTGTTCCAATGGGAAGTGCCTCTCGAAA
-AGCCAGCAGTGCAATGGGAAGGACGACTGTGGGGACGGGTCCGACGAGGCCTCCTGCCCC
-AAGGTGAACGTCGTCACTTGTACCAAACACACCTACCGCTGCCTCAATGGGCTCTGCTTG
-AGCAAGGGCAACCCTGAGTGTGACGGGAAGGAGGACTGTAGCGACGGCTCAGATGAGAAG
-GACTGCGACTGTGGGCTGCGGTCATTCACGAGACAGGCTCGTGTTGTTGGGGGCACGGAT
-GCGGATGAGGGCGAGTGGCCCTGGCAGGTAAGCCTGCATGCTCTGGGCCAGGGCCACATC
-TGCGGTGCTTCCCTCATCTCTCCCAACTGGCTGGTCTCTGCCGCACACTGCTACATCGAT
-GACAGAGGATTCAGGTACTCAGACCCCACGCAGTGGACGGCCTTCCTGGGCTTGCACGAC
-CAGAGCCAGCGCAGCGCCCCTGGGGTGCAGGAGCGCAGGCTCAAGCGCATCATCTCCCAC
-CCCTTCTTCAATGACTTCACCTTCGACTATGACATCGCGCTGCTGGAGCTGGAGAAACCG
-GCAGAGTACAGCTCCATGGTGCGGCCCATCTGCCTGCCGGACGCCTCCCATGTCTTCCCT
-GCCGGCAAGGCCATCTGGGTCACGGGCTGGGGACACACCCAGTATGGAGGCACTGGCGCG
-CTGATCCTGCAAAAGGGTGAGATCCGCGTCATCAACCAGACCACCTGCGAGAACCTCCTG
-CCGCAGCAGATCACGCCGCGCATGATGTGCGTGGGCTTCCTCAGCGGCGGCGTGGACTCC
-TGCCAGGGTGATTCCGGGGGACCCCTGTCCAGCGTGGAGGCGGATGGGCGGATCTTCCAG
-GCCGGTGTGGTGAGCTGGGGAGACGGCTGCGCTCAGAGGAACAAGCCAGGCGTGTACACA
-AGGCTCCCTCTGTTTCGGGACTGGATCAAAGAGAACACTGGGGTATAG</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00089</identifier>
- <name>Trypsin</name>
- </pfam>
- <pfam>
- <identifier>PF00057</identifier>
- <name>Ldl_recept_a</name>
- </pfam>
- <pfam>
- <identifier>PF00431</identifier>
- <name>CUB</name>
- </pfam>
- <pfam>
- <identifier>PF01390</identifier>
- <name>SEA</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>peptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>endopeptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>serine-type endopeptidase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>macromolecule metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>proteolysis</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="10">
- <id>BE0002113</id>
- <name>Nidogen-1</name>
- <organism>Human</organism>
- <actions/>
- <references># Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
-# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423
-# Stephens RW, Aumailley M, Timpl R, Reisberg T, Tapiovaara H, Myohanen H, Murphy-Ullrich J, Vaheri A: Urokinase binding to laminin-nidogen. Structural requirements and interactions with heparin. Eur J Biochem. 1992 Aug 1;207(3):937-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1499567</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P14543">
- <name>Nidogen-1</name>
- <general-function/>
- <specific-function>Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions</specific-function>
- <gene-name>NID1</gene-name>
- <locus>1q43</locus>
- <cellular-location>Secreted protein</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>4.96</theoretical-pi>
- <molecular-weight>136454.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:7821</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>NID1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>NID1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>M30269</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>189209</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P14543</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Entactin</synonym>
- <synonym>Nidogen-1 precursor</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Nidogen-1
-MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDLELEDGDDFVSPALELS
-GALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFGAVAPFLADLDTTDGLGKV
-YYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESVAPYQGPSRDPDQKGKRNTFQ
-AVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFA
-NDRESIENLAKSSNSGQQGVWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLAT
-TRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSPRRAATERPLGPPTERTRSFQLAVETF
-HQQHPQVIDVDEVEETGVVFSYNTDSRQTCANNRHQCSVHAECRDYATGFCCSCVAGYTG
-NGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIVFENTDLHSYVVMNHGRSYTAISTIPETV
-GYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFTRQAEVTFVGHPGNLVIKQRFSGI
-DEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHYSTSVITSSSTREYTVTEPERDGAS
-PSRIYTYQWRQTITFQECVHDDSRPALPSTQQLSVDSVFVLYNQEEKILRYAFSNSIGPV
-REGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSV
-CGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYT
-GGSSYTCSCLPGFSGDGQACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCV
-PGEVEKTRCQHEREHILGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVD
-RDGREVEGTRTRPGMTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLE
-GNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDL
-GSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYW
-TDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQ
-PSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITT
-ALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIERK</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>3744 bp
-ATGTTGGCCTCGAGCAGCCGGATCCGGGCTGCGTGGACGCGGGCGCTGCTGCTGCCGCTG
-CTGCTGGCGGGGCCTGTGGGCTGCCTGAGCCGCCAGGAGCTCTTTCCCTTCGGCCCCGGA
-CAGGGGGACCTGGAGCTGGAGGACGGGGATGACTTCGTCTCTCCTGCCCTGGAGCTGAGT
-GGGGCGCTCCGCTTCTACGACAGATCCGACATCGACGCAGTCTACGTCACCACAAATGGC
-ATCATTGCTACGAGTGAACCCCCGGCCAAAGAATCCCATCCCGGGCTCTTCCCACCAACA
-TTCGGTGCAGTCGCCCCTTTCCTGGCGGACTTGGACACGACCGATGGCCTGGGGAAGGTT
-TATTATCGAGAAGACTTATCCCCCTCCATCACTCAGCGAGCAGCAGAGTGTGTCCACAGA
-GGGTTCCCGGAGATCTCTTTCCAGCCTAGTAGCGCGGTGGTTGTCACTTGGGAATCCGTG
-GCCCCCTACCAAGGGCCCAGCAGGGACCCAGACCAGAAAGGCAAGAGAAACACGTTCCAG
-GCTGTTCTAGCCTCCTCTGATTCCAGCTCCTATGCCATTTTCCTTTATCCTGAGGATGGT
-CTGCAGTTCCATACGACATTCTCAAAGAAGGAAAACAACCAAGTTCCTGCCGTGGTTGCA
-TTCAGTCAAGGTTCAGTGGGATTCTTATGGAAGAGCAACGGAGCTTATAACATATTTGCT
-AATGACAGGGAATCAATTGAAAATTTGGCCAAGAGTAGTAACTCTGGGCAGCAGGGTGTC
-TGGGTGTTTGAGATTGGGAGTCCAGCCACCACCAATGGCGTGGTGCCTGCAGACGTGATC
-CTCGGAACTGAAGATGGGGCAGAGTATGATGATGAGGATGAAGATTATGACCTGGCGACC
-ACTCGTCTGGGCCTGGAGGATGTGGGCACCACGCCCTTCTCCTACAAGGCTCTGAGAAGG
-GGAGGTGCTGACACATACAGTGTGCCCAGCGTCCTCTCCCCGCGCCGGGCAGCTACCGAA
-AGGCCCCTTGGACCTCCCACAGAGAGAACCAGGTCTTTCCAGTTGGCAGTGGAGACTTTT
-CACCAGCAGCACCCTCAGGTCATAGATGTGGATGAAGTTGAGGAAACAGGAGTTGTTTTC
-AGCTATAACACGGATTCCCGCCAGACGTGTGCTAACAACAGACACCAGTGCTCGGTGCAC
-GCAGAGTGCAGGGACTACGCCACGGGCTTCTGCTGCAGCTGTGTCGCTGGCTATACGGGC
-AATGGCAGGCAATGTGTTGCAGAAGGTTCCCCCCAGCGAGTCAATGGCAAGGTGAAAGGA
-AGGATCTTTGTGGGGAGCAGCCAGGTCCCCATTGTCTTTGAGAACACTGACCTCCACTCT
-TACGTAGTAATGAACCACGGGCGCTCCTACACAGCCATCAGCACCATTCCCGAGACCGTT
-GGATATTCTCTGCTTCCACTGGCCCCAGTTGGAGGCATCATTGGATGGATGTTTGCAGTG
-GAGCAGGACGGATTCAAGAATGGGTTCAGCATCACCGGGGGTGAGTTCACTCGCCAGGCT
-GAGGTGACCTTCGTGGGGCACCCGGGCAATCTGGTCATTAAGCAGCGGTTCAGCGGCATC
-GATGAGCATGGGCACCTGACCATCGACACGGAGCTGGAGGGCCGCGTGCCGCAGATTCCG
-TTCGGCTCCTCCGTGCACATTGAGCCCTACACGGAGCTGTACCACTACTCCACCTCAGTG
-ATCACTTCCTCCTCCACCCGGGAGTACACGGTGACTGAGCCCGAGCGAGATGGGGCATCT
-CCTTCACGCATCTACACTTACCAGTGGCGCCAGACCATCACCTTCCAGGAATGCGTCCAC
-GATGACTCCCGGCCAGCCCTGCCCAGCACCCAGCAGCTCTCGGTGGACAGCGTGTTCGTC
-CTGTACAACCAGGAGGAGAAGATCTTGCGCTACGCTTTCAGCAACTCCATTGGGCCTGTG
-AGGGAAGGCTCCCCTGATGCTCTTCAGAATCCCTGCTACATCGGCACTCATGGGTGTGAC
-ACCAACGCGGCCTGTCGCCCTGGTCCCAGGACACAGTTCACCTGCGAGTGCTCCATCGGC
-TTCCGAGGAGACGGGCGAACCTGCTATGATATTGATGAATGTTCAGAACAACCCTCAGTG
-TGTGGGAGCCACACAATCTGCAATAATCACCCAGGAACCTTCCGCTGCGAGTGTGTGGAG
-GGCTACCAGTTTTCAGATGAGGGAACGTGTGTGGCTGTCGTGGACCAGCGCCCCATCAAC
-TACTGTGAAACTGGCCTTCATAACTGCGACATACCCCAGCGGGCCCAGTGTATCTACACA
-GGAGGCTCCTCCTACACCTGTTCCTGCTTGCCAGGCTTTTCTGGGGATGGCCAAGCCTGC
-CAAGATGTAGATGAATGCCAGCCAAGCCGATGTCACCCTGACGCCTTCTGCTACAACACT
-CCAGGCTCTTTCACGTGCCAGTGCAAACCTGGTTATCAGGGAGACGGCTTCCGTTGCGTG
-CCCGGAGAGGTGGAGAAAACCCGGTGCCAGCACGAGCGAGAACACATTCTCGGGGCAGCG
-GGGGCGACAGACCCACAGCGACCCATTCCTCCGGGGCTGTTCGTTCCTGAGTGCGATGCG
-CACGGGCACTACGCGCCCACCCAGTGCCACGGCAGCACCGGCTACTGCTGGTGCGTGGAT
-CGCGACGGCCGCGAGGTGGAGGGCACCAGGACCAGGCCCGGGATGACGCCCCCGTGTCTG
-AGTACAGTGGCTCCCCCGATTCACCAAGGACCTGCGGTGCCTACCGCCGTGATCCCCTTG
-CCTCCTGGGACCCATTTACTCTTTGCCCAGACTGGGAAGATTGAGCGCCTGCCCCTGGAG
-GGAAATACCATGAGGAAGACAGAAGCAAAGGCGTTCCTTCATGTCCCGGCTAAAGTCATC
-ATTGGACTGGCCTTTGACTGCGTGGACAAGATGGTTTACTGGACGGACATCACTGAGCCT
-TCCATTGGGAGAGCTAGTCTACATGGTGGAGAGCCAACCACCATCATTAGACAAGATCTT
-GGAAGTCCAGAAGGTATCGCTGTTGATCACCTTGGCCGCAACATCTTCTGGACAGACTCT
-AACCTGGATCGAATAGAAGTGGCGAAGCTGGACGGCACGCAGCGCCGGGTGCTCTTTGAG
-ACTGACCTGGTGAATCCCAGAGGCATTGTAACGGATTCCGTGAGAGGGAACCTTTACTGG
-ACAGACTGGAACAGAGATAACCCCAAGATTGAAACTTCCTACATGGACGGCACGAACCGG
-AGGATCCTTGTGCAGGATGACCTGGGCTTGCCCAATGGACTGCACTTCGATGCGTTCTCA
-TCTCAGCTCTGCTGGGTGGATGCAGGCACCAATCGGGCGGAATGCCTGAACCCCAGTCAG
-CCCAGCAGACGCAAGGCTCTCGAAGGGCTCCAGTATCCTTTTGCTGTGACGAGCTACGGG
-AAGAATCTGTATTTCACAGACTGGAAGATGAATTCCGTGGTTGCTCTCGATCTTGCAATT
-TCCAAGGAGACGGATGCTTTCCAACCCCACAAGCAGACCCGGCTGTATGGCATCACCACG
-GCCCTGTCTCAGTGTCCGCAAGGCCATAACTACTGCTCAGTGAACAATGGCGGCTGCACC
-CACCTATGCTTGGCCACCCCAGGGAGCAGGACCTGCCGTTGCCCTGACAACACCTTGGGA
-GTTGACTGTATCGAACGGAAATGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00008</identifier>
- <name>EGF</name>
- </pfam>
- <pfam>
- <identifier>PF07645</identifier>
- <name>EGF_CA</name>
- </pfam>
- <pfam>
- <identifier>PF00058</identifier>
- <name>Ldl_recept_b</name>
- </pfam>
- <pfam>
- <identifier>PF00086</identifier>
- <name>Thyroglobulin_1</name>
- </pfam>
- <pfam>
- <identifier>PF06119</identifier>
- <name>NIDO</name>
- </pfam>
- <pfam>
- <identifier>PF07474</identifier>
- <name>G2F</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>calcium ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cell adhesion</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cell-substrate adhesion</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cell-matrix adhesion</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- </targets>
- <enzymes/>
- <carriers/>
- <transporters/>
-</drug><drug type="small molecule" created="2005-06-13 07:24:05 -0600" updated="2013-09-16 17:12:16 -0600" version="4.0">
- <drugbank-id>DB00877</drugbank-id>
- <name>Sirolimus</name>
- <description>A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. [PubChem]</description>
- <cas-number>53123-88-9</cas-number>
- <general-references># Pritchard DI: Sourcing a chemical succession for cyclosporin from parasites and human pathogens. Drug Discov Today. 2005 May 15;10(10):688-91. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15896681
-# Shuchman M: Trading restenosis for thrombosis? New questions about drug-eluting stents. N Engl J Med. 2006 Nov 9;355(19):1949-52. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17093244
-# Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR: Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 2005 Aug 15;65(16):7052-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16103051
-# Chan S: Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br J Cancer. 2004 Oct 18;91(8):1420-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15365568
-# Graziani EI: Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs. Nat Prod Rep. 2009 May;26(5):602-9. Epub 2009 Mar 5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19387497</general-references>
- <synthesis-reference>Madhup K. Dhaon, Chi-nung Hsiao, Subhash R. Patel, Peter J. Bonk, Sanjay R. Chemburkar, Yong Y. Chen, "One pot synthesis of tetrazole derivatives of sirolimus." U.S. Patent US20080167335, issued July 10, 2008.</synthesis-reference>
- <indication>For the prophylaxis of organ rejection in patients receiving renal transplants.</indication>
- <pharmacology>Sirolimus, a macrocyclic lactone produced by <i>Streptomyces hygroscopicus</i>, is an immunosuppressive agent indicated for the prophylaxis of organ rejection in patients receiving renal transplants. It is recommended that sirolimus be used in a regimen with cyclosporine and corticosteroids.</pharmacology>
- <mechanism-of-action>Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressants. Sirolimus also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus:FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the progression from the G1 to the S phase of the cell cycle.</mechanism-of-action>
- <toxicity/>
- <biotransformation/>
- <absorption/>
- <half-life>57-63 hours</half-life>
- <protein-binding>92%</protein-binding>
- <route-of-elimination/>
- <volume-of-distribution/>
- <clearance/>
- <secondary-accession-numbers>
- <secondary-accession-number>APRD00178</secondary-accession-number>
- <secondary-accession-number>DB02439</secondary-accession-number>
- </secondary-accession-numbers>
- <groups>
- <group>approved</group>
- </groups>
- <taxonomy>
- <kingdom/>
- <substructures/>
- </taxonomy>
- <synonyms>
- <synonym>(-)-Rapamycin</synonym>
- <synonym>Rapamycin</synonym>
- </synonyms>
- <salts/>
- <brands>
- <brand>Rapamune</brand>
- </brands>
- <mixtures/>
- <packagers>
- <packager>
- <name>Cardinal Health</name>
- <url>http://www.cardinal.com</url>
- </packager>
- <packager>
- <name>Hangzhou Zhongmei Huadong Pharmaceutical Co. Ltd.</name>
- <url>http://www.zmhdpharm.com</url>
- </packager>
- <packager>
- <name>Lake Erie Medical and Surgical Supply</name>
- <url/>
- </packager>
- <packager>
- <name>Patheon Inc.</name>
- <url>http://www.patheon.com</url>
- </packager>
- <packager>
- <name>Poli Industria Chimica SPA</name>
- <url>http://www.poli.it</url>
- </packager>
- <packager>
- <name>Wyeth Pharmaceuticals</name>
- <url>http://www.wyeth.com</url>
- </packager>
- </packagers>
- <manufacturers>
- <manufacturer generic="false">Wyeth pharmaceuticals inc</manufacturer>
- </manufacturers>
- <prices>
- <price>
- <description>Rapamune 0.5 mg tablet</description>
- <cost currency="USD">5.86</cost>
- <unit>tablet</unit>
- </price>
- <price>
- <description>Rapamune 1 mg tablet</description>
- <cost currency="USD">11.95</cost>
- <unit>tablet</unit>
- </price>
- <price>
- <description>Rapamune 1 mg/ml Solution</description>
- <cost currency="USD">12.19</cost>
- <unit>ml</unit>
- </price>
- <price>
- <description>Rapamune 2 mg tablet</description>
- <cost currency="USD">20.59</cost>
- <unit>tablet</unit>
- </price>
- </prices>
- <categories>
- <category>Immunosuppressive Agents</category>
- <category>Antifungal Agents</category>
- <category>Anti-Bacterial Agents</category>
- <category>Antibiotics, Antineoplastic</category>
- </categories>
- <affected-organisms>
- <affected-organism>Humans and other mammals</affected-organism>
- </affected-organisms>
- <dosages>
- <dosage>
- <form>Solution</form>
- <route>Oral</route>
- <strength/>
- </dosage>
- <dosage>
- <form>Tablet</form>
- <route>Oral</route>
- <strength/>
- </dosage>
- </dosages>
- <atc-codes>
- <atc-code>L04AA10</atc-code>
- <category/>
- </atc-codes>
- <ahfs-codes>
- <ahfs-code>92:00.00</ahfs-code>
- </ahfs-codes>
- <patents>
- <patent>
- <number>5989591</number>
- <country>United States</country>
- <approved>1998-09-11</approved>
- <expires>2018-09-11</expires>
- </patent>
- <patent>
- <number>5212155</number>
- <country>United States</country>
- <approved>1993-05-18</approved>
- <expires>2010-05-18</expires>
- </patent>
- <patent>
- <number>2293793</number>
- <country>Canada</country>
- <approved>2006-07-11</approved>
- <expires>2018-06-11</expires>
- </patent>
- <patent>
- <number>2103571</number>
- <country>Canada</country>
- <approved>2003-04-29</approved>
- <expires>2012-02-21</expires>
- </patent>
- </patents>
- <food-interactions/>
- <drug-interactions>
- <drug-interaction>
- <drug>DB01072</drug>
- <name>Atazanavir</name>
- <description>Increases the effect and toxicity of immunosuppressant</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB08873</drug>
- <name>Boceprevir </name>
- <description>Boceprevir increases levels of sirolimus by affecting CYP3A4 metabolism. Concomitant therapy requires close monitoring. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01211</drug>
- <name>Clarithromycin</name>
- <description>The macrolide, clarithromycin, may increase the serum concentration of sirolimus.</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00091</drug>
- <name>Cyclosporine</name>
- <description>Increases the effect and toxicity of sirolimus</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00343</drug>
- <name>Diltiazem</name>
- <description>Increases the effect and toxicity of sirolimus</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB04855</drug>
- <name>Dronedarone</name>
- <description>Sirolimus is a CYP3A substrate with a narrow therapeutic index thus concomitant therapy with dronedarone will increase plasma levels of sirolimus. Monitor plasma concentrations and adjust dose accordingly. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00199</drug>
- <name>Erythromycin</name>
- <description>The macrolide, erythromycin, may increase the serum concentration of sirolimus.</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01320</drug>
- <name>Fosphenytoin</name>
- <description>The hydantoin decreases sirolimus levels</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01167</drug>
- <name>Itraconazole</name>
- <description>Itraconazole may increase the effect and toxicity of sirolimus.</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01026</drug>
- <name>Ketoconazole</name>
- <description>Ketoconazole may increase the effect and toxicity of sirolimus.</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00252</drug>
- <name>Phenytoin</name>
- <description>The hydantoin decreases sirolimus levels</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00615</drug>
- <name>Rifabutin</name>
- <description>The rifamycin decreases the effect of sirolimus</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01045</drug>
- <name>Rifampicin</name>
- <description>The rifamycin decreases the effect of sirolimus</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB06372</drug>
- <name>Rilonacept</name>
- <description>results in increased immunosuppressive effects; increases the risk of infection. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00864</drug>
- <name>Tacrolimus</name>
- <description>Sirolimus may decrease the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Sirolimus therapy is initiated, discontinued or altered.</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00976</drug>
- <name>Telithromycin</name>
- <description>Telithromycin may reduce clearance of Sirolimus. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sirolimus if Telithromycin is initiated, discontinued or dose changed.</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00932</drug>
- <name>Tipranavir</name>
- <description>Tipranavir may affect the efficacy/toxicity of Sirolimus. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00519</drug>
- <name>Trandolapril</name>
- <description>Increased risk of angioedema. Monitor for signs and symptoms of facial and systemic edema and/or erythema.</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00072</drug>
- <name>Trastuzumab</name>
- <description>Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00582</drug>
- <name>Voriconazole</name>
- <description>Voriconazole may increase the serum concentration of sirolimus likely by inhibition of CYP3A4-mediated metabolism or p-glyprotein transport of sirolimus. Consider alternate therapy or reduce the dose of sirolimus and monitor serum levels during concomitant therapy. </description>
- </drug-interaction>
- </drug-interactions>
- <calculated-properties>
- <property>
- <kind>logP</kind>
- <value>4.85</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>logS</kind>
- <value>-5.7</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>Water Solubility</kind>
- <value>1.73e-03 g/l</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>logP</kind>
- <value>7.45</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>IUPAC Name</kind>
- <value>(1R,9S,12S,15R,18R,19R,21R,23S,30S,32S,35R)-1,18-dihydroxy-12-[(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Traditional IUPAC Name</kind>
- <value>(1R,9S,12S,15R,18R,19R,21R,23S,30S,32S,35R)-1,18-dihydroxy-12-[(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Weight</kind>
- <value>914.1719</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Monoisotopic Weight</kind>
- <value>913.555141619</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>SMILES</kind>
- <value>[H][C@@]1(C[C@H](C)[C@]2([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]3([H])CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](O)[C@@H](C1)OC</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Formula</kind>
- <value>C51H79NO13</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChI</kind>
- <value>InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33+,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChIKey</kind>
- <value>InChIKey=QFJCIRLUMZQUOT-KLHQEZAJSA-N</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polar Surface Area (PSA)</kind>
- <value>195.43</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Refractivity</kind>
- <value>250.66</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polarizability</kind>
- <value>100.46</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Rotatable Bond Count</kind>
- <value>6</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Acceptor Count</kind>
- <value>12</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Donor Count</kind>
- <value>3</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>pKa (strongest acidic)</kind>
- <value>9.96</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>pKa (strongest basic)</kind>
- <value>-3</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Physiological Charge</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Number of Rings</kind>
- <value>4</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Bioavailability</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>MDDR-Like Rule</kind>
- <value>true</value>
- <source>ChemAxon</source>
- </property>
- </calculated-properties>
- <experimental-properties>
- <property>
- <kind>logP</kind>
- <value>4.3</value>
- <source/>
- </property>
- </experimental-properties>
- <external-identifiers>
- <external-identifier>
- <resource>ChEBI</resource>
- <identifier>9168</identifier>
- </external-identifier>
- <external-identifier>
- <resource>Drugs Product Database (DPD)</resource>
- <identifier>2243237</identifier>
- </external-identifier>
- <external-identifier>
- <resource>KEGG Compound</resource>
- <identifier>C07909</identifier>
- </external-identifier>
- <external-identifier>
- <resource>KEGG Drug</resource>
- <identifier>D00753</identifier>
- </external-identifier>
- <external-identifier>
- <resource>BindingDB</resource>
- <identifier>50240955</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PharmGKB</resource>
- <identifier>PA451365</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PDB</resource>
- <identifier>ARD</identifier>
- </external-identifier>
- <external-identifier>
- <resource>Wikipedia</resource>
- <identifier>Sirolimus</identifier>
- </external-identifier>
- </external-identifiers>
- <external-links>
- <external-link>
- <resource>RxList</resource>
- <url>http://www.rxlist.com/cgi/generic2/sirolimus.htm</url>
- </external-link>
- <external-link>
- <resource>Drugs.com</resource>
- <url>http://www.drugs.com/cdi/sirolimus.html</url>
- </external-link>
- </external-links>
- <targets>
- <target position="1">
- <id>BE0002386</id>
- <name>Serine/threonine-protein kinase mTOR</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references># Dowling RJ, Topisirovic I, Fonseca BD, Sonenberg N: Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta. 2010 Mar;1804(3):433-9. Epub 2009 Dec 11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20005306
-# Shuuin T, Karashima H: [Mammalian target of rapamycin, its mode of action and clinical response in metastatic clear cell carcinoma] Gan To Kagaku Ryoho. 2009 Jul;36(7):1076-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19620795
-# Sehgal SN: Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc. 2003 May;35(3 Suppl):7S-14S. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12742462
-# Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11752352</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P42345">
- <name>Serine/threonine-protein kinase mTOR</name>
- <general-function>Involved in binding</general-function>
- <specific-function>Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex</specific-function>
- <gene-name>MTOR</gene-name>
- <locus>1p36.2</locus>
- <cellular-location/>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>7.17</theoretical-pi>
- <molecular-weight>288896.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:3942</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>FRAP1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>FRAP1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>L34075</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P42345</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>FK506-binding protein 12- rapamycin complex-associated protein 1</synonym>
- <synonym>Mammalian target of rapamycin</synonym>
- <synonym>mTOR</synonym>
- <synonym>Rapamycin target protein</synonym>
- <synonym>RAPT1</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>FKBP12-rapamycin complex-associated protein
-MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
-TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
-VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
-TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
-AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
-KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESR
-CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
-LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
-TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
-KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
-QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
-VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
-MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
-LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
-LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
-VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
-DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
-SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
-VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVD
-RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
-RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
-STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
-AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
-VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
-GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
-WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
-QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
-ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
-PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
-QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
-VLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSP
-TPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
-EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
-KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
-ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
-WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
-QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
-SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
-MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
-PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITC
-HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
-VELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
-VPTQVELLIKQATSHENLCQCYIGWCPFW</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>7650 bp
-ATGCTTGGAACCGGACCTGCCGCCGCCACCACCGCTGCCACCACATCTAGCAATGTGAGC
-GTCCTGCAGCAGTTTGCCAGTGGCCTAAAGAGCCGGAATGAGGAAACCAGGGCCAAAGCC
-GCCAAGGAGCTCCAGCACTATGTCACCATGGAACTCCGAGAGATGAGTCAAGAGGAGTCT
-ACTCGCTTCTATGACCAACTGAACCATCACATTTTTGAATTGGTTTCCAGCTCAGATGCC
-AATGAGAGGAAAGGTGGCATCTTGGCCATAGCTAGCCTCATAGGAGTGGAAGGTGGGAAT
-GCCACCCGAATTGGCAGATTTGCCAACTATCTTCGGAACCTCCTCCCCTCCAATGACCCA
-GTTGTCATGGAAATGGCATCCAAGGCCATTGGCCGTCTTGCCATGGCAGGGGACACTTTT
-ACCGCTGAGTACGTGGAATTTGAGGTGAAGCGAGCCCTGGAATGGCTGGGTGCTGACCGC
-AATGAGGGCCGGAGACATGCAGCTGTCCTGGTTCTCCGTGAGCTGGCCATCAGCGTCCCT
-ACCTTCTTCTTCCAGCAAGTGCAACCCTTCTTTGACAACATTTTTGTGGCCGTGTGGGAC
-CCCAAACAGGCCATCCGTGAGGGAGCTGTAGCCGCCCTTCGTGCCTGTCTGATTCTCACA
-ACCCAGCGTGAGCCGAAGGAGATGCAGAAGCCTCAGTGGTACAGGCACACATTTGAAGAA
-GCAGAGAAGGGATTTGATGAGACCTTGGCCAAAGAGAAGGGCATGAATCGGGATGATCGG
-ATCCATGGAGCCTTGTTGATCCTTAACGAGCTGGTCCGAATCAGCAGCATGGAGGGAGAG
-CGTCTGAGAGAAGAAATGGAAGAAATCACACAGCAGCAGCTGGTACACGACAAGTACTGC
-AAAGATCTCATGGGCTTCGGAACAAAACCTCGTCACATTACCCCCTTCACCAGTTTCCAG
-GCTGTACAGCCCCAGCAGTCAAATGCCTTGGTGGGGCTGCTGGGGTACAGCTCTCACCAA
-GGCCTCATGGGATTTGGGACCTCCCCCAGTCCAGCTAAGTCCACCCTGGTGGAGAGCCGG
-TGTTGCAGAGACTTGATGGAGGAGAAATTTGATCAGGTGTGCCAGTGGGTGCTGAAATGC
-AGGAATAGCAAGAACTCGCTGATCCAAATGACAATCCTTAATTTGTTGCCCCGCTTGGCT
-GCATTCCGACCTTCTGCCTTCACAGATACCCAGTATCTCCAAGATACCATGAACCATGTC
-CTAAGCTGTGTCAAGAAGGAGAAGGAACGTACAGCGGCCTTCCAAGCCCTGGGGCTACTT
-TCTGTGGCTGTGAGGTCTGAGTTTAAGGTCTATTTGCCTCGCGTGCTGGACATCATCCGA
-GCGGCCCTGCCCCCAAAGGACTTCGCCCATAAGAGGCAGAAGGCAATGCAGGTGGACGCC
-ACAGTCTTCACTTGCATCAGCATGCTGGCTCGAGCAATGGGGCCAGGCATCCAGCAGGAT
-ATCAAGGAGCTGCTGGAGCCCATGCTGGCAGTGGGACTAAGCCCTGCCCTCACTGCAGTG
-CTCTACGACCTGAGCCGTCAGATTCCACAGCTAAAGAAGGACATTCAAGATGGGCTACTG
-AAAATGCTGTCCCTGGTCCTTATGCACAAACCCCTTCGCCACCCAGGCATGCCCAAGGGC
-CTGGCCCATCAGCTGGCCTCTCCTGGCCTCACGACCCTCCCTGAGGCCAGCGATGTGGGC
-AGCATCACTCTTGCCCTCCGAACGCTTGGCAGCTTTGAATTTGAAGGCCACTCTCTGACC
-CAATTTGTTCGCCACTGTGCGGATCATTTCCTGAACAGTGAGCACAAGGAGATCCGCATG
-GAGGCTGCCCGCACCTGCTCCCGCCTGCTCACACCCTCCATCCACCTCATCAGTGGCCAT
-GCTCATGTGGTTAGCCAGACCGCAGTGCAAGTGGTGGCAGATGTGCTTAGCAAACTGCTC
-GTAGTTGGGATAACAGATCCTGACCCTGACATTCGCTACTGTGTCTTGGCGTCCCTGGAC
-GAGCGCTTTGATGCACACCTGGCCCAGGCGGAGAACTTGCAGGCCTTGTTTGTGGCTCTG
-AATGACCAGGTGTTTGAGATCCGGGAGCTGGCCATCTGCACTGTGGGCCGACTCAGTAGC
-ATGAACCCTGCCTTTGTCATGCCTTTCCTGCGCAAGATGCTCATCCAGATTTTGACAGAG
-TTGGAGCACAGTGGGATTGGAAGAATCAAAGAGCAGAGTGCCCGCATGCTGGGGCACCTG
-GTCTCCAATGCCCCCCGACTCATCCGCCCCTACATGGAGCCTATTCTGAAGGCATTAATT
-TTGAAACTGAAAGATCCAGACCCTGATCCAAACCCAGGTGTGATCAATAATGTCCTGGCA
-ACAATAGGAGAATTGGCACAGGTTAGTGGCCTGGAAATGAGGAAATGGGTTGATGAACTT
-TTTATTATCATCATGGACATGCTCCAGGATTCCTCTTTGTTGGCCAAAAGGCAGGTGGCT
-CTGTGGACCCTGGGACAGTTGGTGGCCAGCACTGGCTATGTAGTAGAGCCCTACAGGAAG
-TACCCTACTTTGCTTGAGGTGCTACTGAATTTTCTGAAGACTGAGCAGAACCAGGGTACA
-CGCAGAGAGGCCATCCGTGTGTTAGGGCTTTTAGGGGCTTTGGATCCTTACAAGCACAAA
-GTGAACATTGGCATGATAGACCAGTCCCGGGATGCCTCTGCTGTCAGCCTGTCAGAATCC
-AAGTCAAGTCAGGATTCCTCTGACTATAGCACTAGTGAAATGCTGGTCAACATGGGAAAC
-TTGCCTCTGGATGAGTTCTACCCAGCTGTGTCCATGGTGGCCCTGATGCGGATCTTCCGA
-GACCAGTCACTCTCTCATCATCACACCATGGTTGTCCAGGCCATCACCTTCATCTTCAAG
-TCCCTGGGACTCAAATGTGTGCAGTTCCTGCCCCAGGTCATGCCCACGTTCCTTAATGTC
-ATTCGAGTCTGTGATGGGGCCATCCGGGAATTTTTGTTCCAGCAGCTGGGAATGTTGGTG
-TCCTTTGTGAAGAGCCACATCAGACCTTATATGGATGAAATAGTCACCCTCATGAGAGAA
-TTCTGGGTCATGAACACCTCAATTCAGAGCACGATCATTCTTCTCATTGAGCAAATTGTG
-GTAGCTCTTGGGGGTGAATTTAAGCTCTACCTGCCCCAGCTGATCCCACACATGCTGCGT
-GTCTTCATGCATGACAACAGCCCAGGCCGCATTGTCTCTATCAAGTTACTGGCTGCAATC
-CAGCTGTTTGGCGCCAACCTGGATGACTACCTGCATTTACTGCTGCCTCCTATTGTTAAG
-TTGTTTGATGCCCCTGAAGCTCCACTGCCATCTCGAAAGGCAGCGCTAGAGACTGTGGAC
-CGCCTGACGGAGTCCCTGGATTTCACTGACTATGCCTCCCGGATCATTCACCCTATTGTT
-CGAACACTGGACCAGAGCCCAGAACTGCGCTCCACAGCCATGGACACGCTGTCTTCACTT
-GTTTTTCAGCTGGGGAAGAAGTACCAAATTTTCATTCCAATGGTGAATAAAGTTCTGGTG
-CGACACCGAATCAATCATCAGCGCTATGATGTGCTCATCTGCAGAATTGTCAAGGGATAC
-ACACTTGCTGATGAAGAGGAGGATCCTTTGATTTACCAGCATCGGATGCTTAGGAGTGGC
-CAAGGGGATGCATTGGCTAGTGGACCAGTGGAAACAGGACCCATGAAGAAACTGCACGTC
-AGCACCATCAACCTCCAAAAGGCCTGGGGCGCTGCCAGGAGGGTCTCCAAAGATGACTGG
-CTGGAATGGCTGAGACGGCTGAGCCTGGAGCTGCTGAAGGACTCATCATCGCCCTCCCTG
-CGCTCCTGCTGGGCCCTGGCACAGGCCTACAACCCGATGGCCAGGGATCTCTTCAATGCT
-GCATTTGTGTCCTGCTGGTCTGAACTGAATGAAGATCAACAGGATGAGCTCATCAGAAGC
-ATCGAGTTGGCCCTCACCTCACAAGACATCGCTGAAGTCACACAGACCCTCTTAAACTTG
-GCTGAATTCATGGAACACAGTGACAAGGGCCCCCTGCCACTGAGAGATGACAATGGCATT
-GTTCTGCTGGGTGAGAGAGCTGCCAAGTGCCGAGCATATGCCAAAGCACTACACTACAAA
-GAACTGGAGTTCCAGAAAGGCCCCACCCCTGCCATTCTAGAATCTCTCATCAGCATTAAT
-AATAAGCTACAGCAGCCGGAGGCAGCGGCCGGAGTGTTAGAATATGCCATGAAACACTTT
-GGAGAGCTGGAGATCCAGGCTACCTGGTATGAGAAACTGCACGAGTGGGAGGATGCCCTT
-GTGGCCTATGACAAGAAAATGGACACCAACAAGGACGACCCAGAGCTGATGCTGGGCCGC
-ATGCGCTGCCTCGAGGCCTTGGGGGAATGGGGTCAACTCCACCAGCAGTGCTGTGAAAAG
-TGGACCCTGGTTAATGATGAGACCCAAGCCAAGATGGCCCGGATGGCTGCTGCAGCTGCA
-TGGGGTTTAGGTCAGTGGGACAGCATGGAAGAATACACCTGTATGATCCCTCGGGACACC
-CATGATGGGGCATTTTATAGAGCTGTGCTGGCACTGCATCAGGACCTCTTCTCCTTGGCA
-CAACAGTGCATTGACAAGGCCAGGGACCTGCTGGATGCTGAATTAACTGCAATGGCAGGA
-GAGAGTTACAGTCGGGCATATGGGGCCATGGTTTCTTGCCACATGCTGTCCGAGCTGGAG
-GAGGTTATCCAGTACAAACTTGTCCCCGAGCGACGAGAGATCATCCGCCAGATCTGGTGG
-GAGAGACTGCAGGGCTGCCAGCGTATCGTAGAGGACTGGCAGAAAATCCTTATGGTGCGG
-TCCCTTGTGGTCAGCCCTCATGAAGACATGAGAACCTGGCTCAAGTATGCAAGCCTGTGC
-GGCAAGAGTGGCAGGCTGGCTCTTGCTCATAAAACTTTAGTGTTGCTCCTGGGAGTTGAT
-CCGTCTCGGCAACTTGACCATCCTCTGCCAACAGTTCACCCTCAGGTGACCTATGCCTAC
-ATGAAAAACATGTGGAAGAGTGCCCGCAAGATCGATGCCTTCCAGCACATGCAGCATTTT
-GTCCAGACCATGCAGCAACAGGCCCAGCATGCCATCGCTACTGAGGACCAGCAGCATAAG
-CAGGAACTGCACAAGCTCATGGCCCGATGCTTCCTGAAACTTGGAGAGTGGCAGCTGAAT
-CTACAGGGCATCAATGAGAGCACAATCCCCAAAGTGCTGCAGTACTACAGCGCCGCCACA
-GAGCACGACCGCAGCTGGTACAAGGCCTGGCATGCGTGGGCAGTGATGAACTTCGAAGCT
-GTGCTACACTACAAACATCAGAACCAAGCCCGCGATGAGAAGAAGAAACTGCGTCATGCC
-AGCGGGGCCAACATCACCAACGCCACCACTGCCGCCACCACGGCCGCCACTGCCACCACC
-ACTGCCAGCACCGAGGGCAGCAACAGTGAGAGCGAGGCCGAGAGCACCGAGAACAGCCCC
-ACCCCATCGCCGCTGCAGAAGAAGGTCACTGAGGATCTGTCCAAAACCCTCCTGATGTAC
-ACGGTGCCTGCCGTCCAGGGCTTCTTCCGTTCCATCTCCTTGTCACGAGGCAACAACCTC
-CAGGATACACTCAGAGTTCTCACCTTATGGTTTGATTATGGTCACTGGCCAGATGTCAAT
-GAGGCCTTAGTGGAGGGGGTGAAAGCCATCCAGATTGATACCTGGCTACAGGTTATACCT
-CAGCTCATTGCAAGAATTGATACGCCCAGACCCTTGGTGGGACGTCTCATTCACCAGCTT
-CTCACAGACATTGGTCGGTACCACCCCCAGGCCCTCATCTACCCACTGACAGTGGCTTCT
-AAGTCTACCACGACAGCCCGGCACAATGCAGCCAACAAGATTCTGAAGAACATGTGTGAG
-CACAGCAACACCCTGGTCCAGCAGGCCATGATGGTGAGCGAGGAGCTGATCCGAGTGGCC
-ATCCTCTGGCATGAGATGTGGCATGAAGGCCTGGAAGAGGCATCTCGTTTGTACTTTGGG
-GAAAGGAACGTGAAAGGCATGTTTGAGGTGCTGGAGCCCTTGCATGCTATGATGGAACGG
-GGCCCCCAGACTCTGAAGGAAACATCCTTTAATCAGGCCTATGGTCGAGATTTAATGGAG
-GCCCAAGAGTGGTGCAGGAAGTACATGAAATCAGGGAATGTCAAGGACCTCACCCAAGCC
-TGGGACCTCTATTATCATGTGTTCCGACGAATCTCAAAGCAGCTGCCTCAGCTCACATCC
-TTAGAGCTGCAATATGTTTCCCCAAAACTTCTGATGTGCCGGGACCTTGAATTGGCTGTG
-CCAGGAACATATGACCCCAACCAGCCAATCATTCGCATTCAGTCCATAGCACCGTCTTTG
-CAAGTCATCACATCCAAGCAGAGGCCCCGGAAATTGACACTTATGGGCAGCAACGGACAT
-GAGTTTGTTTTCCTTCTAAAAGGCCATGAAGATCTGCGCCAGGATGAGCGTGTGATGCAG
-CTCTTCGGCCTGGTTAACACCCTTCTGGCCAATGACCCAACATCTCTTCGGAAAAACCTC
-AGCATCCAGAGATACGCTGTCATCCCTTTATCGACCAACTCGGGCCTCATTGGCTGGGTT
-CCCCACTGTGACACACTGCACGCCCTCATCCGGGACTACAGGGAGAAGAAGAAGATCCTT
-CTCAACATCGAGCATCGCATCATGTTGCGGATGGCTCCGGACTATGACCACTTGACTCTG
-ATGCAGAAGGTGGAGGTGTTTGAGCATGCCGTCAATAATACAGCTGGGGACGACCTGGCC
-AAGCTGCTGTGGCTGAAAAGCCCCAGCTCCGAGGTGTGGTTTGACCGAAGAACCAATTAT
-ACCCGTTCTTTAGCGGTCATGTCAATGGTTGGGTATATTTTAGGCCTGGGAGATAGACAC
-CCATCCAACCTGATGCTGGACCGTCTGAGTGGGAAGATCCTGCACATTGACTTTGGGGAC
-TGCTTTGAGGTTGCTATGACCCGAGAGAAGTTTCCAGAGAAGATTCCATTTAGACTAACA
-AGAATGTTGACCAATGCTATGGAGGTTACAGGCCTGGATGGCAACTACAGAATCACATGC
-CACACAGTGATGGAGGTGCTGCGAGAGCACAAGGACAGTGTCATGGCCGTGCTGGAAGCC
-TTTGTCTATGACCCCTTGCTGAACTGGAGGCTGATGGACACAAATACCAAAGGCAACAAG
-CGATCCCGAACGAGGACGGATTCCTACTCTGCTGGCCAGTCAGTCGAAATTTTGGACGGT
-GTGGAACTTGGAGAGCCAGCCCATAAGAAAACGGGGACCACAGTGCCAGAATCTATTCAT
-TCTTTCATTGGAGACGGTTTGGTGAAACCAGAGGCCCTAAATAAGAAAGCTATCCAGATT
-ATTAACAGGGTTCGAGATAAGCTCACTGGTCGGGACTTCTCTCATGATGACACTTTGGAT
-GTTCCAACGCAAGTTGAGCTGCTCATCAAACAAGCGACATCCCATGAAAACCTCTGCCAG
-TGCTATATTGGCTGGTGCCCTTTCTGGTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00454</identifier>
- <name>PI3_PI4_kinase</name>
- </pfam>
- <pfam>
- <identifier>PF02259</identifier>
- <name>FAT</name>
- </pfam>
- <pfam>
- <identifier>PF02260</identifier>
- <name>FATC</name>
- </pfam>
- <pfam>
- <identifier>PF08771</identifier>
- <name>Rapamycin_bind</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transferase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transferase activity, transferring phosphorus-containing groups</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>phosphotransferase activity, alcohol group as acceptor</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="2">
- <id>BE0000695</id>
- <name>Peptidyl-prolyl cis-trans isomerase FKBP1A</name>
- <organism>Human</organism>
- <actions>
- <action>other</action>
- </actions>
- <references># Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11752352
-# Sehgal SN: Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc. 2003 May;35(3 Suppl):7S-14S. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12742462</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P62942">
- <name>Peptidyl-prolyl cis-trans isomerase FKBP1A</name>
- <general-function>Posttranslational modification, protein turnover, chaperones</general-function>
- <specific-function>May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides</specific-function>
- <gene-name>FKBP1A</gene-name>
- <locus>20p13</locus>
- <cellular-location>Cytoplasm</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>8.48</theoretical-pi>
- <molecular-weight>11820.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:3711</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>FKBP1A</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>FKBP1A</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>M34539</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>182628</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P62942</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>12 kDa FKBP</synonym>
- <synonym>EC 5.2.1.8</synonym>
- <synonym>FKBP-12</synonym>
- <synonym>Immunophilin FKBP12</synonym>
- <synonym>Peptidyl-prolyl cis-trans isomerase</synonym>
- <synonym>PPIase</synonym>
- <synonym>Rotamase</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>FK506-binding protein 1A
-GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWE
-EGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>327 bp
-ATGGGAGTGCAGGTGGAAACCATCTCCCCAGGAGACGGGCGCACCTTCCCCAAGCGCGGC
-CAGACCTGCGTGGTGCACTACACCGGGATGCTTGAAGATGGAAAGAAATTTGATTCCTCC
-CGGGACAGAAACAAGCCCTTTAAGTTTATGCTAGGCAAGCAGGAGGTGATCCGAGGCTGG
-GAAGAAGGGGTTGCCCAGATGAGTGTGGGTCAGAGAGCCAAACTGACTATATCTCCAGAT
-TATGCCTATGGTGCCACTGGGCACCCAGGCATCATCCCACCACATGCCACTCTCGTCTTC
-GATGTGGAGCTTCTAAAACTGGAATGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00254</identifier>
- <name>FKBP_C</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>macromolecule metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular protein metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>protein folding</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="3">
- <id>BE0001015</id>
- <name>Fibroblast growth factor 2</name>
- <organism>Human</organism>
- <actions>
- <action>other/unknown</action>
- </actions>
- <references># Sehgal SN: Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc. 2003 May;35(3 Suppl):7S-14S. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12742462</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P09038">
- <name>Fibroblast growth factor 2</name>
- <general-function>Involved in growth factor activity</general-function>
- <specific-function>The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors</specific-function>
- <gene-name>FGF2</gene-name>
- <locus>4q26-q27</locus>
- <cellular-location/>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>10.01</theoretical-pi>
- <molecular-weight>17254.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:3676</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>FGF2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>FGF2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>X04431</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>31362</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P09038</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Basic fibroblast growth factor</synonym>
- <synonym>BFGF</synonym>
- <synonym>HBGF-2</synonym>
- <synonym>Heparin-binding growth factor 2 precursor</synonym>
- <synonym>Prostatropin</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Heparin-binding growth factor 2 precursor
-MAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHI
-KLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKY
-TSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>468 bp
-ATGGCAGCCGGGAGCATCACCACGCTGCCCGCCTTGCCCGAGGATGGCGGCAGCGGCGCC
-TTCCCGCCCGGCCACTTCAAGGACCCCAAGCGGCTGTACTGCAAAAACGGGGGCTTCTTC
-CTGCGCATCCACCCCGACGGCCGAGTTGACGGGGTCCGGGAGAAGAGCGACCCTCACATC
-AAGCTACAACTTCAAGCAGAAGAGAGAGGAGTTGTGTCTATCAAAGGAGTGTGTGCTAAC
-CGTTACCTGGCTATGAAGGAAGATGGAAGATTACTGGCTTCTAAATGTGTTACGGATGAG
-TGTTTCTTTTTTGAACGATTGGAATCTAATAACTACAATACTTACCGGTCAAGGAAATAC
-ACCAGTTGGTATGTGGCACTGAAACGAACTGGGCAGTATAAACTTGGATCCAAAACAGGA
-CCTGGGCAGAAAGCTATACTTTTTCTTCCAATGTCTGCTAAGAGCTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00167</identifier>
- <name>FGF</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>signal transducer activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>growth factor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>receptor binding</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- </targets>
- <enzymes>
- <enzyme position="1">
- <id>BE0002638</id>
- <name>Cytochrome P450 3A4</name>
- <organism>Human</organism>
- <actions>
- <action>substrate</action>
- <action>inhibitor</action>
- </actions>
- <references># Flockhart DA. "Drug Interactions: Cytochrome P450 Drug Interaction Table":http://medicine.iupui.edu/clinpharm/ddis/table.asp. Indiana University School of Medicine (2007). Accessed May 28, 2010.
-# Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19934256
-# Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10490933</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P08684">
- <name>Cytochrome P450 3A4</name>
- <general-function>Involved in monooxygenase activity</general-function>
- <specific-function>Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide</specific-function>
- <gene-name>CYP3A4</gene-name>
- <locus>7q21.1</locus>
- <cellular-location>Endoplasmic reticulum</cellular-location>
- <transmembrane-regions>2-22</transmembrane-regions>
- <theoretical-pi>8.25</theoretical-pi>
- <molecular-weight>57344.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:2637</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>CYP3A4</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>M18907</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P08684</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>CYPIIIA4</synonym>
- <synonym>EC 1.14.13.67</synonym>
- <synonym>EC 1.14.13.97</synonym>
- <synonym>NF-25</synonym>
- <synonym>Nifedipine oxidase</synonym>
- <synonym>P450-PCN1</synonym>
- <synonym>Quinine 3-monooxygenase</synonym>
- <synonym>Taurochenodeoxycholate 6-alpha- hydroxylase</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Cytochrome P450 3A4
-MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
-DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
-AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
-MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
-FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
-IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
-NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
-KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
-GLLQPEKPVVLKVESRDGTVSGA</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1512 bp
-ATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG
-CTCCTCTATCTATATGGAACCCATTCACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG
-CCCACACCTCTGCCTTTTTTGGGAAATATTTTGTCCTACCATAAGGGCTTTTGTATGTTT
-GACATGGAATGTCATAAAAAGTATGGAAAAGTGTGGGGCTTTTATGATGGTCAACAGCCT
-GTGCTGGCTATCACAGATCCTGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT
-GTCTTCACAAACCGGAGGCCTTTTGGTCCAGTGGGATTTATGAAAAGTGCCATCTCTATA
-GCTGAGGATGAAGAATGGAAGAGATTACGATCATTGCTGTCTCCAACCTTCACCAGTGGA
-AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG
-AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAAGACGTCTTTGGGGCCTACAGC
-ATGGATGTGATCACTAGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA
-GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTGATTTTTTGGATCCATTCTTT
-CTCTCAATAACAGTCTTTCCATTCCTCATCCCAATTCTTGAAGTATTAAATATCTGTGTG
-TTTCCAAGAGAAGTTACAAATTTTTTAAGAAAATCTGTAAAAAGGATGAAAGAAAGTCGC
-CTCGAAGATACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAAT
-TCAAAAGAAACTGAGTCCCACAAAGCTCTGTCCGATCTGGAGCTCGTGGCCCAATCAATT
-ATCTTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATGTATGAA
-CTGGCCACTCACCCTGATGTCCAGCAGAAACTGCAGGAGGAAATTGATGCAGTTTTACCC
-AATAAGGCACCACCCACCTATGATACTGTGCTACAGATGGAGTATCTTGACATGGTGGTG
-AATGAAACGCTCAGATTATTCCCAATTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGAT
-GTTGAGATCAATGGGATGTTCATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGCT
-CTTCACCGTGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGATTCAGC
-AAGAAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGA
-AACTGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTT
-CAGAACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTAAGCTTAGGA
-GGACTTCTTCAACCAGAAAAACCCGTTGTTCTAAAGGTTGAGTCAAGGGATGGCACCGTA
-AGTGGAGCCTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00067</identifier>
- <name>p450</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>tetrapyrrole binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>heme binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>monooxygenase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>oxidoreductase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transition metal ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>iron ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>electron transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>generation of precursor metabolites and energy</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </enzyme>
- <enzyme position="2">
- <id>BE0002362</id>
- <name>Cytochrome P450 3A5</name>
- <organism>Human</organism>
- <actions>
- <action>substrate</action>
- </actions>
- <references># Flockhart DA. "Drug Interactions: Cytochrome P450 Drug Interaction Table":http://medicine.iupui.edu/clinpharm/ddis/table.asp. Indiana University School of Medicine (2007). Accessed May 28, 2010.</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P20815">
- <name>Cytochrome P450 3A5</name>
- <general-function>Secondary metabolites biosynthesis, transport and catabolism</general-function>
- <specific-function>Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics</specific-function>
- <gene-name>CYP3A5</gene-name>
- <locus>7q21.1</locus>
- <cellular-location>Endoplasmic reticulum</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>9.09</theoretical-pi>
- <molecular-weight>57109.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:2638</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>CYP3A5</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>CYP3A5</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>J04813</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>181346</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P20815</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>CYPIIIA5</synonym>
- <synonym>EC 1.14.14.1</synonym>
- <synonym>HLp2</synonym>
- <synonym>P450-PCN3</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Cytochrome P450 3A5
-MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
-DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
-AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
-MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
-FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
-IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
-NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
-KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
-LLQPEKPIVLKVDSRDGTLSGE</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1509 bp
-ATGGACCTCATCCCAAATTTGGCGGTGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG
-CTCCTCTATCTATATGGGACCCGTACACATGGACTTTTTAAGAGACTGGGAATTCCAGGG
-CCCACACCTCTGCCTTTGTTGGGAAATGTTTTGTCCTATCGTCAGGGTCTCTGGAAATTT
-GACACAGAGTGCTATAAAAAGTATGGAAAAATGTGGGGAACGTATGAAGGTCAACTCCCT
-GTGCTGGCCATCACAGATCCCGACGTGATCAGAACAGTGCTAGTGAAAGAATGTTATTCT
-GTCTTCACAAATCGAAGGTCTTTAGGCCCAGTGGGATTTATGAAAAGTGCCATCTCTTTA
-GCTGAGGATGAAGAATGGAAGAGAATACGGTCATTGCTGTCTCCAACCTTCACCAGCGGA
-AAACTCAAGGAGATGTTCCCCATCATTGCCCAGTATGGAGATGTATTGGTGAGAAACTTG
-AGGCGGGAAGCAGAGAAAGGCAAGCCTGTCACCTTGAAAGACATCTTTGGGGCCTACAGC
-ATGGATGTGATTACTGGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA
-GACCCCTTTGTGGAGAGCACTAAGAAGTTCCTAAAATTTGGTTTCTTAGATCCATTATTT
-CTCTCAATAATACTCTTTCCATTCCTTACCCCAGTTTTTGAAGCATTAAATGTCTCTCTG
-TTTCCAAAAGATACCATAAATTTTTTAAGTAAATCTGTAAACAGAATGAAGAAAAGTCGC
-CTCAACGACAAACAAAAGCACCGACTAGATTTCCTTCAGCTGATGATTGACTCCCAGAAT
-TCGAAAGAAACTGAGTCCCACAAAGCTCTGTCTGATCTGGAGCTCGCAGCCCAGTCAATA
-ATCTTCATTTTTGCTGGCTATGAAACCACCAGCAGTGTTCTTTCCTTCACTTTATATGAA
-CTGGCCACTCACCCTGATGTCCAGCAGAAACTGCAAAAGGAGATTGATGCAGTTTTGCCC
-AATAAGGCACCACCTACCTATGATGCCGTGGTACAGATGGAGTACCTTGACATGGTGGTG
-AATGAAACACTCAGATTATTCCCAGTTGCTATTAGACTTGAGAGGACTTGCAAGAAAGAT
-GTTGAAATCAATGGGGTATTCATTCCCAAAGGGTCAATGGTGGTGATTCCAACTTATGCT
-CTTCACCATGACCCAAAGTACTGGACAGAGCCTGAGGAGTTCCGCCCTGAAAGGTTCAGT
-AAGAAGAAGGACAGCATAGATCCTTACATATACACACCCTTTGGAACTGGACCCAGAAAC
-TGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAG
-AACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCTTGAAATTAGACACGCAAGGA
-CTTCTTCAACCAGAAAAACCCATTGTTCTAAAGGTGGATTCAAGAGATGGAACCCTAAGT
-GGAGAATGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00067</identifier>
- <name>p450</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>tetrapyrrole binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>heme binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>monooxygenase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>oxidoreductase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transition metal ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>iron ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>electron transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>generation of precursor metabolites and energy</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </enzyme>
- <enzyme position="3">
- <id>BE0003612</id>
- <name>Cytochrome P450 3A7</name>
- <organism>Human</organism>
- <actions>
- <action>substrate</action>
- </actions>
- <references># Flockhart DA. "Drug Interactions: Cytochrome P450 Drug Interaction Table":http://medicine.iupui.edu/clinpharm/ddis/table.asp. Indiana University School of Medicine (2007). Accessed May 28, 2010.</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P24462">
- <name>Cytochrome P450 3A7</name>
- <general-function>Secondary metabolites biosynthesis, transport and catabolism</general-function>
- <specific-function>Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics</specific-function>
- <gene-name>CYP3A7</gene-name>
- <locus>7q21-q22.1</locus>
- <cellular-location>Endoplasmic reticulum membrane</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>9.59</theoretical-pi>
- <molecular-weight>57525.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>GNC:2640</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>CYP3A7</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>D00408</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>220149</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P24462</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>CYPIIIA7</synonym>
- <synonym>P450-HFLA</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Cytochrome P450 3A7
-MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF
-DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI
-AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS
-MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV
-FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI
-IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV
-NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWREPEKFLPERFS
-KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG
-GLLLTEKPIVLKAESRDETVSGA</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1512 bp
-ATGGATCTCATCCCAAACTTGGCCGTGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGATA
-CTCCTCTATCTATATGGAACCCGTACACATGGACTTTTTAAGAAGCTTGGAATTCCAGGG
-CCCACACCTCTGCCTTTTTTGGGAAATGCTTTGTCCTTCCGTAAGGGCTATTGGACGTTT
-GACATGGAATGTTATAAAAAGTATAGAAAAGTCTGGGGTATTTATGACTGTCAACAGCCT
-ATGCTGGCTATCACAGATCCCGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCT
-GTCTTCACAAACCGGAGGCCTTTCGGGCCAGTGGGATTTATGAAAAATGCCATCTCTATA
-GCTGAGGATGAAGAATGGAAGAGAATACGATCATTGCTGTCTCCAACATTCACCAGCGGA
-AAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTG
-AGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAACACGTCTTTGGGGCCTACAGC
-ATGGATGTGATCACTAGCACATCATTTGGAGTGAGCATCGACTCTCTCAACAATCCACAA
-GACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTAATCCATTAGATCCATTCGTT
-CTCTCAATAAAAGTCTTTCCATTCCTTACCCCAATTCTTGAAGCATTAAATATCACTGTG
-TTTCCAAGAAAAGTTATAAGTTTTCTAACAAAATCTGTAAAACAGATAAAAGAAGGTCGC
-CTCAAAGAGACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAAT
-TCAAAAGACTCTGAGACCCACAAAGCTCTGTCTGATCTGGAGCTCATGGCCCAATCAATT
-ATCTTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATATATGAA
-CTGGCCACTCACCCTGATGTCCAGCAGAAAGTGCAGAAGGAAATTGATACAGTTTTACCC
-AATAAGGCACCACCCACCTATGATACTGTGCTACAGTTGGAGTATCTTGACATGGTGGTG
-AATGAAACACTCAGATTATTCCCAGTTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGAT
-GTTGAAATCAATGGGATGTTTATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGTT
-CTTCATCATGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGGTTCAGT
-AAAAAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGA
-AACTGCATTGGCATGAGGTTTGCTCTCGTGAACATGAAACTTGCTCTAGTCAGAGTCCTT
-CAGAACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTACGCTTTGGA
-GGACTTCTTCTAACAGAAAAACCCATTGTTCTAAAGGCTGAGTCAAGGGATGAGACCGTA
-AGTGGAGCCTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00067</identifier>
- <name>p450</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>tetrapyrrole binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>heme binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>monooxygenase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>oxidoreductase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transition metal ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>iron ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>electron transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>generation of precursor metabolites and energy</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </enzyme>
- </enzymes>
- <carriers/>
- <transporters>
- <transporter position="4">
- <id>BE0001032</id>
- <name>Multidrug resistance protein 1</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- <action>inducer</action>
- </actions>
- <references># Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8632764
-# Wacher VJ, Silverman JA, Wong S, Tran-Tau P, Chan AO, Chai A, Yu XQ, O'Mahony D, Ramtoola Z: Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate. J Pharmacol Exp Ther. 2002 Oct;303(1):308-13. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12235265
-# Arceci RJ, Stieglitz K, Bierer BE: Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. Blood. 1992 Sep 15;80(6):1528-36. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1381629
-# Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14985103</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P08183">
- <name>Multidrug resistance protein 1</name>
- <general-function>Defense mechanisms and drug export</general-function>
- <specific-function>Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells</specific-function>
- <gene-name>ABCB1</gene-name>
- <locus>7q21.1</locus>
- <cellular-location>Membrane; multi-pass membrane protein</cellular-location>
- <transmembrane-regions>52-72
-120-140
-189-209
-216-236
-297-317
-326-346
-711-731
-757-777
-833-853
-854-874
-937-957
-974-994</transmembrane-regions>
- <theoretical-pi>9.44</theoretical-pi>
- <molecular-weight>141464.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:40</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>ABCB1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>ABCB1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>M14758</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>307180</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P08183</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>ATP-binding cassette sub-family B member 1</synonym>
- <synonym>CD243 antigen</synonym>
- <synonym>EC 3.6.3.44</synonym>
- <synonym>P-glycoprotein 1</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Multidrug resistance protein 1
-MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
-HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
-IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
-KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
-DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
-AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
-AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
-QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
-ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
-IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
-FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
-SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
-NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
-GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
-ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEA
-IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
-AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
-YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
-QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
-SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
-EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
-LAQKGIYFSMVSVQAGTKRQ</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>3843 bp
-ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAAC
-AATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTT
-CGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATC
-CATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCA
-AATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGAT
-ACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGA
-ATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCT
-GGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATA
-GGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCT
-AAGATTAATGAAGTTATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTT
-TTCACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCC
-ATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACT
-GATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCA
-ATTAGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAAT
-TTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGT
-GCTGCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTG
-GTCCTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATT
-GGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGA
-GCAGCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAG
-AGTGGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGT
-TACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGGCCTGAACCTGAAGGTGCAGAGTGGG
-CAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATG
-CAGAGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACC
-ATAAATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTT
-GCCACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATT
-GAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTT
-GACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCC
-ATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCC
-TTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGG
-ACCACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGT
-TTCGATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGC
-ATTTACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCA
-GCTGATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCC
-AGTCTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGA
-AAGCTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATT
-ATGAAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATA
-AATGGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACA
-AGAATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTA
-GCCCTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCT
-GGAGAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGAT
-GTGAGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAAT
-GATGCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATA
-GCAAATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTA
-CTCTTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCT
-GGACAAGCACTGAAAGATAAGAAAGAACTAGAAGGTGCTGGGAAGATCGCTACTGAAGCA
-ATAGAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTAT
-GCTCAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATT
-ACATTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGA
-GCCTACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCT
-GTTGTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAA
-GCCAAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGC
-TACAGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTT
-GTATTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTG
-AAGAAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTC
-CAGCTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAA
-ATAAAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCC
-ATCCTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTG
-TCACAGGAAGAGATCGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCA
-CTGCCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAG
-AAACAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGAT
-GAAGCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAA
-GCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCA
-GACTTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTG
-CTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAG
-TGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00005</identifier>
- <name>ABC_tran</name>
- </pfam>
- <pfam>
- <identifier>PF00664</identifier>
- <name>ABC_membrane</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>integral to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>intrinsic to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ATP binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity, acting on acid anhydrides</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>nucleotide binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>pyrophosphatase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>purine nucleotide binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>nucleoside-triphosphatase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>adenyl nucleotide binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ATPase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ATPase activity, coupled to transmembrane movement of substances</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </transporter>
- <transporter position="5">
- <id>BE0001004</id>
- <name>Solute carrier organic anion transporter family member 1B1</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references># Fehrenbach T, Cui Y, Faulstich H, Keppler D: Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):415-20. Epub 2003 Oct 3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14530907</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="Q9Y6L6">
- <name>Solute carrier organic anion transporter family member 1B1</name>
- <general-function>Carbohydrate transport and metabolism</general-function>
- <specific-function>Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver</specific-function>
- <gene-name>SLCO1B1</gene-name>
- <locus>12p</locus>
- <cellular-location>Cell membrane; basolateral cell membrane; multi-pass membrane protein. Note=Detected in basolateral </cellular-location>
- <transmembrane-regions>97-117
-207-227
-259-279
-336-356
-376-396
-410-430
-575-595</transmembrane-regions>
- <theoretical-pi>8.68</theoretical-pi>
- <molecular-weight>76450.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:10959</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>SLCO1B1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>SLCO1B1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>AF060500</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>5051630</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>Q9Y6L6</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Liver-specific organic anion transporter 1</synonym>
- <synonym>LST-1</synonym>
- <synonym>OATP 2</synonym>
- <synonym>OATP-C</synonym>
- <synonym>Sodium-independent organic anion- transporting polypeptide 2</synonym>
- <synonym>Solute carrier family 21 member 6</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Solute carrier organic anion transporter family member 1B1
-MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFE
-ISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGY
-YRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNML
-RGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYV
-DLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLE
-TNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVF
-KYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS
-FYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGIT
-YISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAI
-QVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCI
-KWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASE
-NGSVMDEANLESLNKNKHFVPSAGADSETHC</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>2076 bp
-ATGGACCAAAATCAACATTTGAATAAAACAGCAGAGGCACAACCTTCAGAGAATAAGAAA
-ACAAGATACTGCAATGGATTGAAGATGTTCTTGGCAGCTCTGTCACTCAGCTTTATTGCT
-AAGACACTAGGTGCAATTATTATGAAAAGTTCCATCATTCATATAGAACGGAGATTTGAG
-ATATCCTCTTCTCTTGTTGGTTTTATTGACGGAAGCTTTGAAATTGGAAATTTGCTTGTG
-ATTGTATTTGTGAGTTACTTTGGATCCAAACTACATAGACCAAAGTTAATTGGAATCGGT
-TGTTTCATTATGGGAATTGGAGGTGTTTTGACTGCTTTGCCACATTTCTTCATGGGATAT
-TACAGGTATTCTAAAGAAACTAATATCAATTCATCAGAAAATTCAACATCGACCTTATCC
-ACTTGTTTAATTAATCAAATTTTATCACTCAATAAAGCATCACCTGAGATAGTGGGAAAA
-GGTTGTTTAAAGGAATCTGGGTCATACATGTGGATATATGTGTTCATGGGTAATATGCTT
-CGTGGAATAGGGGAGACTCCCATAGTACCACTGGGGCTTTCTTACATTGATGATTTCGCT
-AAAGAAGGACATTCTTCTTTGTATTTAGGTATATTGAATGCAATAGCAATGATTGGTCCA
-ATCATTGGCTTTACCCTGGGATCTCTGTTTTCTAAAATGTACGTGGATATTGGATATGTT
-AATCTAAGCACTATCAGGATAACTCCTACTGATTCTCGATGGGTTGGAGCTTGGTGGCTT
-AATTTCCTTGTGTCTGGACTATTCTCCATTATTTCTTCCATACCATTCTTTTTCTTGCCC
-CAAACTCCAAATAAACCACAAAAAGAAAGAAAAGCTTCACTGTCTTTGCATGTGCTGGAA
-ACAAATGATGAAAAGGATCAAACAGCTAATTTGACCAATCAAGGAAAAAATATTACCAAA
-AATGTGACTGGTTTTTTCCAGTCTTTTAAAAGCATCCTTACTAATCCCCTGTATGTTATG
-TTTGTGCTTTTGACGTTGTTACAAGTAAGCAGCTATATTGGTGCTTTTACTTATGTCTTC
-AAATACGTAGAGCAACAGTATGGTCAGCCTTCATCTAAGGCTAACATCTTATTGGGAGTC
-ATAACCATACCTATTTTTGCAAGTGGAATGTTTTTAGGAGGATATATCATTAAAAAATTC
-AAACTGAACACCGTTGGAATTGCCAAATTCTCATGTTTTACTGCTGTGATGTCATTGTCC
-TTTTACCTATTATATTTTTTCATACTCTGTGAAAACAAATCAGTTGCCGGACTAACCATG
-ACCTATGATGGAAATAATCCAGTGACATCTCATAGAGATGTACCACTTTCTTATTGCAAC
-TCAGACTGCAATTGTGATGAAAGTCAATGGGAACCAGTCTGTGGAAACAATGGAATAACT
-TACATCTCACCCTGTCTAGCAGGTTGCAAATCTTCAAGTGGCAATAAAAAGCCTATAGTG
-TTTTACAACTGCAGTTGTTTGGAAGTAACTGGTCTCCAGAACAGAAATTACTCAGCCCAT
-TTGGGTGAATGCCCAAGAGATGATGCTTGTACAAGGAAATTTTACTTTTTTGTTGCAATA
-CAAGTCTTGAATTTATTTTTCTCTGCACTTGGAGGCACCTCACATGTCATGCTGATTGTT
-AAAATTGTTCAACCTGAATTGAAATCACTTGCACTGGGTTTCCACTCAATGGTTATACGA
-GCACTAGGAGGAATTCTAGCTCCTATATATTTTGGGGCTCTGATTGATACAACGTGTATA
-AAGTGGTCCACCAACAACTGTGGCACACGTGGGTCATGTAGGACATATAATTCCACATCA
-TTTTCAAGGGTCTACTTGGGCTTGTCTTCAATGTTAAGAGTCTCATCACTTGTTTTATAT
-ATTATATTAATTTATGCCATGAAGAAAAAATATCAAGAGAAAGATATCAATGCATCAGAA
-AATGGAAGTGTCATGGATGAAGCAAACTTAGAATCCTTAAATAAAAATAAACATTTTGTC
-CCTTCTGCTGGGGCAGATAGTGAAACACATTGTTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF07648</identifier>
- <name>Kazal_2</name>
- </pfam>
- <pfam>
- <identifier>PF03137</identifier>
- <name>OATP</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>intrinsic to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>integral to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </transporter>
- <transporter position="6">
- <id>BE0003657</id>
- <name>Multidrug and toxin extrusion protein 1</name>
- <organism>Human</organism>
- <actions/>
- <references># Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, Becquemont L, Kim RB: Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005. Epub 2010 Jan 6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20053795</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="Q96FL8">
- <name>Multidrug and toxin extrusion protein 1</name>
- <general-function>Defense mechanisms</general-function>
- <specific-function>Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes</specific-function>
- <gene-name>SLC47A1</gene-name>
- <locus>17p11.2</locus>
- <cellular-location>Cell membrane</cellular-location>
- <transmembrane-regions>38-58
-73-93
-124-144
-153-173
-177-197
-217-237
-257-276
-296-316
-337-357
-371-391
-409-429
-438-458
-547-567</transmembrane-regions>
- <theoretical-pi>7.62</theoretical-pi>
- <molecular-weight>61921.6</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>GNC:25588</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>SLC47A1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>AK001709</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>7023138</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>Q96FL8</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>hMATE-1</synonym>
- <synonym>MATE-1</synonym>
- <synonym>Solute carrier family 47 member 1</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Multidrug and toxin extrusion protein 1
-MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISS
-VFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSA
-LVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLN
-QGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKL
-HQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYE
-LAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDH
-VGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVG
-LPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNV
-PRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRK
-QLVLRRGLLLLGVFLILLVGILVRFYVRIQ</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1713 bp
-ATGGAAGCTCCTGAGGAGCCCGCGCCAGTGCGCGGAGGCCCGGAGGCCACCCTTGAGGTC
-CGTGGGTCGCGCTGCTTGCGGCTGTCCGCCTTCCGAGAAGAGCTGCGGGCGCTCTTGGTC
-CTGGCTGGCCCCGCGTTCTTGGTTCAGCTGATGGTGTTCCTGATCAGCTTCATAAGCTCC
-GTGTTCTGTGGCCACCTGGGCAAGCTGGAGCTGGATGCAGTCACGCTGGCAATCGCGGTT
-ATCAATGTCACTGGTGTCTCAGTGGGATTCGGCTTATCTTCTGCCTGTGACACCCTCATC
-TCCCAGACGTACGGGAGCCAGAACCTGAAGCACGTGGGCGTGATCCTGCAGCGGAGTGCG
-CTCGTCCTGCTCCTCTGCTGCTTCCCCTGCTGGGCGCTCTTTCTCAACACCCAGCACATC
-CTGCTGCTCTTCAGGCAGGACCCAGATGTGTCCAGGCTTACCCAGACCTATGTCACGATC
-TTCATTCCAGCTCTTCCTGCAACCTTTCTTTATATGTTACAAGTTAAATATTTGCTCAAC
-CAGGGAATTGTACTGCCCCAGATCGTAACTGGAGTTGCAGCCAACCTTGTCAATGCCCTC
-GCCAACTATCTGTTTCTCCATCAACTGCATCTTGGGGTGATAGGCTCTGCACTGGCAAAC
-TTGATTTCCCAGTACACCCTGGCTCTACTCCTCTTTCTCTACATCCTCGGGAAAAAACTG
-CATCAAGCTACATGGGGAGGCTGGTCCCTCGAGTGCCTGCAGGACTGGGCCTCCTTCCTC
-CGCCTGGCCATCCCCAGCATGCTCATGCTGTGCATGGAGTGGTGGGCCTATGAGGTCGGG
-AGCTTCCTCAGTGGCATCCTCGGCATGGTGGAGCTGGGCGCTCAGTCCATCGTGTATGAA
-CTGGCCATCATTGTGTACATGGTCCTTGCAGGCTTCAGTGTGGCTGCCAGTGTCCGGGTA
-GGAAACGCTCTGGGTGCTGGAGACATGGAGCAGGCACGGAAGTCCTCTACCGTTTCCCTG
-CTGATTACAGTGCTCTTTGCTGTAGCCTTCAGTGTCCTGCTGTTAAGCTGTAAGGATCAC
-GTGGGGTACATTTTTACTACCGACCGAGACATCATTAATCTGGTGGCTCAGGTGGTTCCA
-ATTTATGCTGTTTCCCACCTCTTTGAAGCTCTTGCTTGCACGAGTGGTGGTGTTCTGAGG
-GGGAGTGGAAATCAGAAGGTTGGAGCCATTGTGAATACCATTGGGTACTATGTGGTTGGC
-CTCCCCATCGGGATCGCGCTGATGTTTGCAACCACACTTGGAGTGATGGGTCTGTGGTCA
-GGGATCATCATCTGTACAGTCTTTCAAGCTGTGTGTTTTCTAGGCTTTATTATTCAGCTA
-AATTGGAAAAAAGCCTGTCAGCAGGCTCAGGTACACGCCAATTTGAAAGTAAACAACGTG
-CCTCGGAGTGGGAATTCTGCTCTCCCTCAGGATCCGCTTCACCCAGGGTGCCCTGAAAAC
-CTTGAAGGAATTTTAACGAACGATGTTGGAAAGACAGGCGAGCCTCAGTCAGATCAGCAG
-ATGCGCCAAGAAGAACCTTTGCCGGAACATCCACAGGACGGCGCTAAATTGTCCAGGAAA
-CAGCTGGTGCTGCGGCGAGGGCTTCTGCTCCTGGGGGTCTTCTTAATCTTGCTGGTGGGG
-ATTTTAGTGAGATTCTATGTCAGAATTCAGTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF01554</identifier>
- <name>MatE</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>carrier activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>electrochemical potential-driven transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>porter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>antiporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>drug transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>drug transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>multidrug transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </transporter>
- </transporters>
-</drug><drug type="small molecule" created="2005-06-13 07:24:05 -0600" updated="2013-09-16 17:12:26 -0600" version="4.0">
- <drugbank-id>DB00915</drugbank-id>
- <name>Amantadine</name>
- <description>An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. [PubChem]</description>
- <cas-number>768-94-5</cas-number>
- <general-references/>
- <synthesis-reference/>
- <indication>For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.</indication>
- <pharmacology>Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance). It is a derivate of adamantane, like a similar drug rimantadine. The mechanism of action of amantadine in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. It has been shown to cause an increase in dopamine release in the animal brain, and does not possess anticholinergic activity.</pharmacology>
- <mechanism-of-action>The mechanism of its antiparkinsonic effect is not fully understood, but it appears to be releasing dopamine from the nerve endings of the brain cells, together with stimulation of norepinephrine response. It also has NMDA receptor antagonistic effects. The antiviral mechanism seems to be unrelated. The drug interferes with a viral protein, M2 (an ion channel), which is needed for the viral particle to become "uncoated" once it is taken inside the cell by endocytosis.</mechanism-of-action>
- <toxicity>Deaths have been reported from overdose with amantadine. The lowest reported acute lethal dose was 2 grams. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Pulmonary edema and respiratory distress (including ARDS) have been reported. Renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur. Central nervous system effects that have been reported include insomnia, anxiety, aggressive behavior, hypertonia, hyperkinesia, tremor, confusion, disorientation, depersonalization, fear, delirium, hallucination, psychotic reactions, lethargy, somnolence and coma. Seizures may be exacerbated in patients with prior history of seizure disorders. Hyperthermia has also been observed in cases where a drug overdose has occurred.</toxicity>
- <biotransformation>No appreciable metabolism, although negligible amounts of an acetyl metabolite have been identified.</biotransformation>
- <absorption>Amantadine is well absorbed orally from the gastrointestinal tract.</absorption>
- <half-life>Mean half-lives ranged from 10 to 14 hours, however renal function impairment causes a severe increase in half life to 7 to 10 days.</half-life>
- <protein-binding>Approximately 67% bound to plasma proteins over a concentration range of 0.1 to 2.0 &micro;g/mL.</protein-binding>
- <route-of-elimination>It is primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.</route-of-elimination>
- <volume-of-distribution>* 3 to 8 L/kg [healthy subjects]</volume-of-distribution>
- <clearance>* 0.2 - 0.3 L/hr/kg
-* 0.10 +/- 0.04 L/hr/kg [healthy, elderly male]</clearance>
- <secondary-accession-numbers>
- <secondary-accession-number>APRD00787</secondary-accession-number>
- </secondary-accession-numbers>
- <groups>
- <group>approved</group>
- </groups>
- <taxonomy>
- <kingdom/>
- <substructures/>
- </taxonomy>
- <synonyms>
- <synonym>1-adamantanamine</synonym>
- <synonym>1-adamantylamine</synonym>
- <synonym>1-aminoadamantane</synonym>
- <synonym>Amantidine</synonym>
- <synonym>Aminoadamantane</synonym>
- </synonyms>
- <salts>
- <salt>Amantadine hydrochloride</salt>
- <salt>Amantadine sulfate</salt>
- </salts>
- <brands>
- <brand>Endantadine</brand>
- <brand>PK-Merz</brand>
- <brand>Symadine</brand>
- <brand>Symmetrel</brand>
- </brands>
- <mixtures/>
- <packagers>
- <packager>
- <name>Anip Acquisition Co.</name>
- <url/>
- </packager>
- <packager>
- <name>A-S Medication Solutions LLC</name>
- <url>http://orders.a-smeds.com</url>
- </packager>
- <packager>
- <name>Banner Pharmacaps Inc.</name>
- <url>http://www.banpharm.com</url>
- </packager>
- <packager>
- <name>Bristol-Myers Squibb Co.</name>
- <url>http://www.bms.com</url>
- </packager>
- <packager>
- <name>Carolina Medical Products Co.</name>
- <url>http://www.carolinamedical.com</url>
- </packager>
- <packager>
- <name>Direct Dispensing Inc.</name>
- <url/>
- </packager>
- <packager>
- <name>Dispensing Solutions</name>
- <url>http://www.drxdispensing.com</url>
- </packager>
- <packager>
- <name>Diversified Healthcare Services Inc.</name>
- <url>http://www.dhscorp.com</url>
- </packager>
- <packager>
- <name>Endo Pharmaceuticals Inc.</name>
- <url>http://www.endo.com</url>
- </packager>
- <packager>
- <name>H.J. Harkins Co. Inc.</name>
- <url>http://hjharkinscompanyinc.com</url>
- </packager>
- <packager>
- <name>Heartland Repack Services LLC</name>
- <url/>
- </packager>
- <packager>
- <name>Hi Tech Pharmacal Co. Inc.</name>
- <url>http://www.hitechpharm.com</url>
- </packager>
- <packager>
- <name>Lake Erie Medical and Surgical Supply</name>
- <url/>
- </packager>
- <packager>
- <name>Lannett Co. Inc.</name>
- <url>http://www.lannett.com</url>
- </packager>
- <packager>
- <name>Major Pharmaceuticals</name>
- <url>http://www.majorpharmaceuticals.com</url>
- </packager>
- <packager>
- <name>Mikart Inc.</name>
- <url>http://www.mikart.com</url>
- </packager>
- <packager>
- <name>Murfreesboro Pharmaceutical Nursing Supply</name>
- <url>http://www.unitdosesupply.com</url>
- </packager>
- <packager>
- <name>Nucare Pharmaceuticals Inc.</name>
- <url>http://www.nucarerx.com</url>
- </packager>
- <packager>
- <name>Palmetto Pharmaceuticals Inc.</name>
- <url>http://www.palmettopharm.com</url>
- </packager>
- <packager>
- <name>Patient First Corp.</name>
- <url>http://www.patientfirst.com</url>
- </packager>
- <packager>
- <name>PD-Rx Pharmaceuticals Inc.</name>
- <url>http://www.pdrx.com</url>
- </packager>
- <packager>
- <name>Pharmaceutical Association</name>
- <url/>
- </packager>
- <packager>
- <name>Pharmedix</name>
- <url>http://www.pharmedixrx.com</url>
- </packager>
- <packager>
- <name>Physicians Total Care Inc.</name>
- <url>http://www.physicianstotalcare.com</url>
- </packager>
- <packager>
- <name>Preferred Pharmaceuticals Inc.</name>
- <url>http://www.preferredpharmaceuticals.com</url>
- </packager>
- <packager>
- <name>Prepackage Specialists</name>
- <url/>
- </packager>
- <packager>
- <name>Qualitest</name>
- <url>http://www.worldoftest.com</url>
- </packager>
- <packager>
- <name>Rebel Distributors Corp.</name>
- <url>http://www.rebelrx.com</url>
- </packager>
- <packager>
- <name>Redpharm Drug</name>
- <url/>
- </packager>
- <packager>
- <name>Remedy Repack</name>
- <url>http://www.remedyrepack.com</url>
- </packager>
- <packager>
- <name>Sandoz</name>
- <url>http://www.sandoz.ca</url>
- </packager>
- <packager>
- <name>Southwood Pharmaceuticals</name>
- <url>http://www.southwoodhealthcare.com</url>
- </packager>
- <packager>
- <name>Spectrum Pharmaceuticals</name>
- <url>http://www.spectrumpharm.com</url>
- </packager>
- <packager>
- <name>Tya Pharmaceuticals</name>
- <url/>
- </packager>
- <packager>
- <name>UDL Laboratories</name>
- <url>http://www.udllabs.com</url>
- </packager>
- <packager>
- <name>United Research Laboratories Inc.</name>
- <url>http://www.urlpharma.com</url>
- </packager>
- <packager>
- <name>Upsher Smith Laboratories</name>
- <url>http://www.upsher-smith.com</url>
- </packager>
- <packager>
- <name>USL Pharma Inc.</name>
- <url/>
- </packager>
- <packager>
- <name>Vangard Labs Inc.</name>
- <url/>
- </packager>
- <packager>
- <name>Vintage Pharmaceuticals Inc.</name>
- <url/>
- </packager>
- <packager>
- <name>Wockhardt Ltd.</name>
- <url>http://www.wockhardtin.com</url>
- </packager>
- </packagers>
- <manufacturers>
- <manufacturer generic="true">Actavis totowa llc</manufacturer>
- <manufacturer generic="true">Banner pharmacaps inc</manufacturer>
- <manufacturer generic="true">Sandoz inc</manufacturer>
- <manufacturer generic="true">Usl pharma inc</manufacturer>
- <manufacturer generic="true">Watson laboratories inc</manufacturer>
- <manufacturer generic="false">Solvay pharmaceuticals</manufacturer>
- <manufacturer generic="false">Endo pharmaceuticals inc</manufacturer>
- <manufacturer generic="true">Actavis mid atlantic llc</manufacturer>
- <manufacturer generic="true">Carolina medical products co</manufacturer>
- <manufacturer generic="true">Hi tech pharmacal co inc</manufacturer>
- <manufacturer generic="true">Mikart inc</manufacturer>
- <manufacturer generic="true">Pharmaceutical assoc inc div beach products</manufacturer>
- <manufacturer generic="true">Silarx pharmaceuticals inc</manufacturer>
- <manufacturer generic="true">Teva pharmaceuticals usa</manufacturer>
- <manufacturer generic="true">Vintage pharmaceuticals llc</manufacturer>
- <manufacturer generic="true">Wockhardt eu operations (swiss) ag</manufacturer>
- </manufacturers>
- <prices>
- <price>
- <description>Amantadine 100 mg tablet</description>
- <cost currency="USD">1.32</cost>
- <unit>tablet</unit>
- </price>
- <price>
- <description>Amantadine HCl 100 mg tablet</description>
- <cost currency="USD">1.37</cost>
- <unit>tablet</unit>
- </price>
- <price>
- <description>Symmetrel 100 mg tablet</description>
- <cost currency="USD">1.45</cost>
- <unit>tablet</unit>
- </price>
- <price>
- <description>Amantadine hcl powder</description>
- <cost currency="USD">6.7</cost>
- <unit>g</unit>
- </price>
- <price>
- <description>Symmetrel 50 mg/5ml Syrup 480ml Bottle</description>
- <cost currency="USD">151.46</cost>
- <unit>bottle</unit>
- </price>
- <price>
- <description>Pms-Amantadine Hydrochloride 10 mg/ml Syrup</description>
- <cost currency="USD">0.09</cost>
- <unit>ml</unit>
- </price>
- <price>
- <description>Amantadine HCl 50 mg/5ml Syrup</description>
- <cost currency="USD">0.16</cost>
- <unit>ml</unit>
- </price>
- <price>
- <description>Mylan-Amantadine 100 mg Capsule</description>
- <cost currency="USD">0.54</cost>
- <unit>capsule</unit>
- </price>
- <price>
- <description>Pms-Amantadine Hydrochloride 100 mg Capsule</description>
- <cost currency="USD">0.54</cost>
- <unit>capsule</unit>
- </price>
- <price>
- <description>Amantadine HCl 100 mg capsule</description>
- <cost currency="USD">0.78</cost>
- <unit>capsule</unit>
- </price>
- </prices>
- <categories>
- <category>Antiviral Agents</category>
- <category>Dopamine Agents</category>
- <category>Antiparkinson Agents</category>
- <category>Analgesics, Non-Narcotic</category>
- </categories>
- <affected-organisms>
- <affected-organism>Humans and other mammals</affected-organism>
- <affected-organism>Various viruses</affected-organism>
- </affected-organisms>
- <dosages>
- <dosage>
- <form>Capsule</form>
- <route>Oral</route>
- <strength/>
- </dosage>
- <dosage>
- <form>Syrup</form>
- <route>Oral</route>
- <strength/>
- </dosage>
- </dosages>
- <atc-codes>
- <atc-code>N04BB01</atc-code>
- <category/>
- </atc-codes>
- <ahfs-codes>
- <ahfs-code>08:18.04</ahfs-code>
- </ahfs-codes>
- <patents/>
- <food-interactions>
- <food-interaction>Avoid alcohol.</food-interaction>
- <food-interaction>Take without regard to meals.</food-interaction>
- </food-interactions>
- <drug-interactions>
- <drug-interaction>
- <drug>DB00843</drug>
- <name>Donepezil</name>
- <description>Possible antagonism of action</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00674</drug>
- <name>Galantamine</name>
- <description>Possible antagonism of action</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01043</drug>
- <name>Memantine</name>
- <description>Increased risk of CNS adverse effects with this association</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01267</drug>
- <name>Paliperidone</name>
- <description>The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, amantadine. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00989</drug>
- <name>Rivastigmine</name>
- <description>Possible antagonism of action</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01623</drug>
- <name>Thiothixene</name>
- <description>Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Amantadine. Consider alternate therapy or monitor for decreased effects of both agents. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00246</drug>
- <name>Ziprasidone</name>
- <description>The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, amantadine. Consider alternate therapy or monitor for worsening of movement disorder. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01624</drug>
- <name>Zuclopenthixol</name>
- <description>Antagonism may occur between zuclopenthixol, a dopamine D2 receptor antagonist, and amantadine, a dopamine agonist. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concurrent therapy is initiated, discontinued or dose(s) changed. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB08919</drug>
- <name>Zuclopenthixol acetate</name>
- <description>Antagonism may occur between zuclopenthixol, a dopamine D2 receptor antagonist, and amantadine, a dopamine agonist. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concurrent therapy is initiated, discontinued or dose(s) changed. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB08920</drug>
- <name>Zuclopenthixol decanoate</name>
- <description>Antagonism may occur between zuclopenthixol, a dopamine D2 receptor antagonist, and amantadine, a dopamine agonist. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concurrent therapy is initiated, discontinued or dose(s) changed. </description>
- </drug-interaction>
- </drug-interactions>
- <calculated-properties>
- <property>
- <kind>logP</kind>
- <value>2.53</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>logS</kind>
- <value>-3.2</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>Water Solubility</kind>
- <value>8.46e-02 g/l</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>logP</kind>
- <value>1.47</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>IUPAC Name</kind>
- <value>adamantan-1-amine</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Traditional IUPAC Name</kind>
- <value>amantadine</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Weight</kind>
- <value>151.2487</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Monoisotopic Weight</kind>
- <value>151.136099549</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>SMILES</kind>
- <value>NC12CC3CC(CC(C3)C1)C2</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Formula</kind>
- <value>C10H17N</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChI</kind>
- <value>InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChIKey</kind>
- <value>InChIKey=DKNWSYNQZKUICI-UHFFFAOYSA-N</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polar Surface Area (PSA)</kind>
- <value>26.02</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Refractivity</kind>
- <value>45.54</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polarizability</kind>
- <value>17.92</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Rotatable Bond Count</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Acceptor Count</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Donor Count</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>pKa (strongest basic)</kind>
- <value>10.71</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Physiological Charge</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Number of Rings</kind>
- <value>3</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Bioavailability</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Rule of Five</kind>
- <value>true</value>
- <source>ChemAxon</source>
- </property>
- </calculated-properties>
- <experimental-properties>
- <property>
- <kind>Water Solubility</kind>
- <value>6290 mg/L (freely soluble)</value>
- <source/>
- </property>
- <property>
- <kind>Melting Point</kind>
- <value>180 °C</value>
- <source>PhysProp</source>
- </property>
- <property>
- <kind>logP</kind>
- <value>2.44</value>
- <source>HANSCH,C ET AL. (1995)</source>
- </property>
- </experimental-properties>
- <external-identifiers>
- <external-identifier>
- <resource>ChEBI</resource>
- <identifier>2618</identifier>
- </external-identifier>
- <external-identifier>
- <resource>Drugs Product Database (DPD)</resource>
- <identifier>2262649</identifier>
- </external-identifier>
- <external-identifier>
- <resource>KEGG Compound</resource>
- <identifier>C06818</identifier>
- </external-identifier>
- <external-identifier>
- <resource>National Drug Code Directory</resource>
- <identifier>0832-1015-00</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PharmGKB</resource>
- <identifier>PA448360</identifier>
- </external-identifier>
- <external-identifier>
- <resource>Wikipedia</resource>
- <identifier>Amantadine</identifier>
- </external-identifier>
- </external-identifiers>
- <external-links>
- <external-link>
- <resource>RxList</resource>
- <url>http://www.rxlist.com/cgi/generic3/amantadine.htm</url>
- </external-link>
- <external-link>
- <resource>Drugs.com</resource>
- <url>http://www.drugs.com/cdi/amantadine.html</url>
- </external-link>
- </external-links>
- <targets>
- <target position="1">
- <id>BE0000630</id>
- <name>Matrix protein 2</name>
- <organism>Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references># Wang C, Takeuchi K, Pinto LH, Lamb RA: Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. J Virol. 1993 Sep;67(9):5585-94. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7688826
-# Jing X, Ma C, Ohigashi Y, Oliveira FA, Jardetzky TS, Pinto LH, Lamb RA: Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10967-72. Epub 2008 Jul 31. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18669647
-# Wang J, Cady SD, Balannik V, Pinto LH, DeGrado WF, Hong M: Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc. 2009 Jun 17;131(23):8066-76. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19469531
-# Beigel J, Bray M: Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102. Epub 2008 Feb 4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18328578
-# Lear JD: Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data. FEBS Lett. 2003 Sep 18;552(1):17-22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12972146
-# Salom D, Hill BR, Lear JD, DeGrado WF: pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry. 2000 Nov 21;39(46):14160-70. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11087364</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P21430">
- <name>Matrix protein 2</name>
- <general-function/>
- <specific-function>Forms a highly low-pH gated proton-selective channel. When the environmental pH is lower than a threshold, the M2 channel is activated and selectively transports protons across the membrane from the extracellular side to the cytoplasmic side. Crucial for the uncoating process. When the virion is internalized into the endosome, the channel acidifies the virion's interior, promoting the dissociation of matrix protein 1 (M1) from the ribonucleoprotein (RNP) thus allowing the transport of the RNP from the virion into the cell's nucleus. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation</specific-function>
- <gene-name>M</gene-name>
- <locus/>
- <cellular-location>Virion; virion membrane. Cell membrane; apical cell membrane; single-pass type III membrane protein </cellular-location>
- <transmembrane-regions>23-43</transmembrane-regions>
- <theoretical-pi>4.87</theoretical-pi>
- <molecular-weight>11166.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>M23978</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>324265</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P21430</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Proton channel protein M2</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Matrix protein 2
-MSLLTEVETPIRNEWGCRCNDSSDPLVVAASIIGILHLILWILDHLFFKCIYRFFKHGLK
-RGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIELE</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>294 bp
-ATGAGTCTTCTAACCGAGGTCGAAACGCCTATCAGAAACGAATGGGGGTGCAGATGCAAC
-GATTCAAGTGACCCTCTTGTTGTTGCCGCGAGTATCATTGGGATCTTGCACTTGATATTG
-TGGATTCTTGATCATCTTTTTTTCAAATGCATTTATCGCTTCTTTAAACACGGTCTGAAA
-AGAGGGCCTTCTACGGAAGGAGTACCAGAGTCTATGAGGGAAGAATATCGAAAGGAACAG
-CAGAGTGCTGTGGATGCTGACGATAGTCATTTTGTCAGCATAGAGCTGGAGTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00599</identifier>
- <name>Flu_M2</name>
- </pfam>
- </pfams>
- <go-classifiers/>
- </polypeptide>
- </components>
- </target>
- <target position="2">
- <id>BE0000641</id>
- <name>Glutamate receptor ionotropic, NMDA 3A</name>
- <organism>Human</organism>
- <actions>
- <action>antagonist</action>
- </actions>
- <references># Blanpied TA, Clarke RJ, Johnson JW: Amantadine inhibits NMDA receptors by accelerating channel closure during channel block. J Neurosci. 2005 Mar 30;25(13):3312-22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15800186
-# Hesselink MB, De Boer AG, Breimer DD, Danysz W: Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists. J Neural Transm. 1999;106(5-6):409-21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10443547</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="Q8TCU5">
- <name>Glutamate receptor ionotropic, NMDA 3A</name>
- <general-function>Involved in ionotropic glutamate receptor activity</general-function>
- <specific-function>NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism</specific-function>
- <gene-name>GRIN3A</gene-name>
- <locus>9q31.1</locus>
- <cellular-location>Cell membrane; multi-pass membrane protein. Enriched in post-synaptic plasma membrane and post-synap</cellular-location>
- <transmembrane-regions>675-695
-749-769
-931-951</transmembrane-regions>
- <theoretical-pi>7.81</theoretical-pi>
- <molecular-weight>125597.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:16767</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>GRIN3A</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>GRIN3A</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>AJ416950</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>20372905</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>Q8TCU5</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Glutamate receptor subunit 3A precursor</synonym>
- <synonym>N-methyl-D-aspartate receptor subtype NR3A</synonym>
- <synonym>NMDAR-L</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Glutamate [NMDA] receptor subunit 3A precursor
-MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTT
-APRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAE
-ALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSF
-LQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQL
-SLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITAN
-LPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQ
-NMEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM
-EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTR
-LGSWQGRKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAG
-QLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIV
-GDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTR
-DTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSAL
-NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGI
-HDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNNPEKLD
-AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFM
-DMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLL
-PRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLS
-HDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELS
-ELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>3348 bp
-ATGAGGAGACTGAGTTTGTGGTGGCTGCTGAGCAGGGTCTGTCTGCTGTTGCCGCCGCCC
-TGCGCACTGGTGCTGGCCGGGGTGCCCAGCTCCTCCTCGCACCCGCAGCCCTGCCAGATC
-CTCAAGCGCATCGGGCACGCGGTGAGGGTGGGCGCGGTGCACTTGCAGCCCTGGACCACC
-GCCCCCCGCGCGGCCAGCCGCGCTCCGGACGACAGCCGAGCAGGAGCCCAGAGGGATGAG
-CCGGAGCCAGGGACTAGGCGGTCCCCGGCGCCCTCGCCGGGCGCACGCTGGTTGGGGAGC
-ACCCTGCATGGCCGGGGGCCGCCGGGCTCCCGTAAGCCCGGGGAGGGCGCCAGGGCGGAG
-GCCCTGTGGCCACGGGACGCCCTCCTATTTGCCGTGGACAACCTGAACCGCGTGGAAGGG
-CTGCTACCCTACAACCTGTCTTTGGAAGTAGTGATGGCCATCGAGGCAGGCCTGGGCGAT
-CTGCCACTTTTGCCCTTCTCCTCCCCTAGTTCGCCATGGAGCAGTGACCCTTTCTCCTTC
-CTGCAAAGTGTGTGCCATACCGTGGTGGTGCAAGGGGTGTCGGCGCTGCTCGCCTTCCCC
-CAGAGCCAGGGCGAAATGATGGAGCTCGACTTGGTCAGCTTAGTCCTGCACATTCCAGTG
-ATCAGCATCGTGCGCCACGAGTTTCCGCGGGAGAGTCAGAATCCCCTTCACCTACAACTG
-AGTTTAGAAAATTCATTAAGTTCTGATGCTGATGTCACTGTCTCAATCCTGACCATGAAC
-AACTGGTACAATTTTAGCTTGTTGCTGTGCCAGGAAGACTGGAACATCACCGACTTCCTC
-CTCCTTACCCAGAATAATTCCAAGTTCCACCTTGGTTCTATCATCAACATCACCGCTAAC
-CTCCCCTCCACCCAGGACCTCTTGAGCTTCCTACAGATCCAGCTTGAGAGTATTAAGAAC
-AGCACACCCACAGTGGTGATGTTTGGCTGCGACATGGAAAGTATCCGGCGGATTTTCGAA
-ATTACAACCCAGTTTGGGGTCATGCCCCCTGAACTTCGTTGGGTGCTGGGAGATTCCCAG
-AATATGGAGGAACTGAGGACAGAGGGTCTGCCCTTAGGACTCATTGCTCATGGAAAAACA
-ACACAGTCTGTCTTTGAGCACTACGTACAAGATGCTATGGAGCTGGTCGCAAGAGCTGTA
-GCCACAGCCACCATGATCCAACCAGAACTTGCTCTCATTCCCAGCACGATGAACTGCATG
-GAGGTGGAAACTACAAATCTCACTTCAGGACAATATTTATCAAGGTTTCTAGCCAATACC
-ACTTTCAGAGGCCTCAGTGGTTCCATCAGAGTAAAAGGTTCCACCATCGTCAGCTCAGAA
-AACAACTTTTTCATCTGGAATCTTCAACATGACCCCATGGGAAAGCCAATGTGGACCCGC
-TTGGGCAGCTGGCAGGGGAGAAAGATTGTCATGGACTATGGAATATGGCCAGAGCAGGCC
-CAGAGACACAAAACCCACTTCCAACATCCAAGTAAGCTACACTTGAGAGTGGTTACCCTG
-ATTGAGCATCCTTTTGTCTTCACAAGGGAGGTAGATGATGAAGGCTTGTGCCCTGCTGGC
-CAACTCTGTCTAGACCCCATGACTAATGACTCTTCCACACTGGACAGCCTTTTTAGCAGC
-CTCCATAGCAGTAATGATACAGTGCCCATTAAATTCAAGAAGTGCTGCTATGGATATTGC
-ATTGATCTGCTGGAAAAGATAGCAGAAGACATGAACTTTGACTTCGACCTCTATATTGTA
-GGGGATGGAAAGTATGGAGCCTGGAAAAATGGGCACTGGACTGGGCTAGTGGGTGATCTC
-CTGAGAGGGACTGCCCACATGGCAGTCACTTCCTTTAGCATCAATACTGCACGGAGCCAG
-GTGATAGATTTCACCAGCCCTTTCTTCTCCACCAGCTTGGGCATCTTAGTGAGGACCCGA
-GATACAGCAGCTCCCATTGGAGCCTTCATGTGGCCACTCCACTGGACAATGTGGCTGGGG
-ATTTTTGTGGCTCTGCACATCACTGCCGTCTTCCTCACTCTGTATGAATGGAAGAGTCCA
-TTTGGTTTGACTCCCAAGGGGCGAAATAGAAGTAAAGTCTTCTCCTTTTCTTCAGCCTTG
-AACATCTGTTATGCCCTCTTGTTTGGCAGAACAGTGGCCATCAAACCTCCAAAATGTTGG
-ACTGGAAGGTTTCTAATGAACCTTTGGGCCATTTTCTGTATGTTTTGCCTTTCCACATAC
-ACGGCAAACTTGGCTGCTGTCATGGTAGGTGAGAAGATCTATGAAGAGCTTTCTGGAATA
-CATGACCCCAAGTTACATCATCCTTCCCAAGGATTCCGCTTTGGAACTGTCCGAGAAAGC
-AGTGCTGAAGATTATGTGAGACAAAGTTTCCCAGAGATGCATGAATATATGAGAAGGTAC
-AATGTTCCAGCCACCCCTGATGGAGTGGAGTATCTGAAGAACAATCCAGAGAAACTAGAC
-GCCTTCATCATGGACAAAGCCCTTCTGGATTATGAAGTGTCAATAGATGCTGACTGCAAA
-CTTCTCACTGTGGGGAAGCCATTTGCCATAGAAGGATACGGCATTGGCCTCCCACCCAAC
-TCTCCATTGACCGCCAACATATCCGAGCTAATCAGTCAATACAAGTCACATGGGTTTATG
-GATATGCTCCATGACAAGTGGTACAGGGTGGTTCCCTGTGGCAAGAGAAGTTTTGCTGTC
-ACGGAGACTTTGCAAATGGGCATCAAACACTTCTCTGGGCTCTTTGTGCTGCTGTGCATT
-GGATTTGGTCTGTCCATTTTGACCACCATTGGTGAGCACATAGTATACAGGCTGCTGCTA
-CCACGAATCAAAAACAAATCCAAGCTGCAATACTGGCTCCACACCAGCCAGAGATTACAC
-AGAGCAATAAATACATCATTTATAGAGGAAAAGCAGCAGCATTTCAAGACCAAACGTGTG
-GAAAAGAGGTCTAATGTGGGACCCCGTCAGCTTACCGTATGGAATACTTCCAATCTGAGT
-CATGACAACCGACGGAAATACATCTTTAGTGATGAGGAAGGACAAAACCAGCTGGGCATC
-CGGATCCACCAGGACATCCCCCTCCCTCCAAGGAGAAGAGAGCTCCCTGCCTTGCGGACC
-ACCAATGGGAAAGCAGACTCCCTAAATGTATCTCGGAACTCAGTGATGCAGGAACTCTCA
-GAGCTCGAGAAGCAGATTCAGGTGATCCGTCAGGAGCTGCAGCTGGCTGTGAGCAGGAAA
-ACGGAGCTGGAGGAGTATCAAAGGACAAGTCGGACTTGTGAGTCCTAG</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00060</identifier>
- <name>Lig_chan</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transmembrane receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ligand-gated ion channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>extracellular ligand-gated ion channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>excitatory extracellular ligand-gated ion channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>glutamate-gated ion channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>glutamate receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ionotropic glutamate receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>signal transducer activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>ion transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="3">
- <id>BE0000756</id>
- <name>D(2) dopamine receptor</name>
- <organism>Human</organism>
- <actions>
- <action>agonist</action>
- </actions>
- <references># Tomitaka S, Hashimoto K, Narita N, Minabe Y, Tamura A: Amantadine induces c-fos in rat striatum: reversal with dopamine D1 and NMDA receptor antagonists. Eur J Pharmacol. 1995 Oct 16;285(2):207-11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8566141
-# Ameri A: Effects of the Aconitum alkaloid songorine on synaptic transmission and paired-pulse facilitation of CA1 pyramidal cells in rat hippocampal slices. Br J Pharmacol. 1998 Oct;125(3):461-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9806328
-# Hirose G: Drug induced parkinsonism: A review. J Neurol. 2006 Aug;253 Suppl 3:iii22-iii24. "doi:10.1007/s00415-006-3004-8":http://dx.doi.org/10.1007/s00415-006-3004-8
-# Hesselink MB, De Boer AG, Breimer DD, Danysz W: Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists. J Neural Transm. 1999;106(5-6):409-21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10443547
-# Cousins MS, Carriero DL, Salamone JD: Tremulous jaw movements induced by the acetylcholinesterase inhibitor tacrine: effects of antiparkinsonian drugs. Eur J Pharmacol. 1997 Mar 19;322(2-3):137-45. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9098680</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P14416">
- <name>D(2) dopamine receptor</name>
- <general-function>Involved in dopamine receptor activity</general-function>
- <specific-function>This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase</specific-function>
- <gene-name>DRD2</gene-name>
- <locus>11q23</locus>
- <cellular-location>Membrane; multi-pass membrane protein</cellular-location>
- <transmembrane-regions>38-60
-72-97
-109-130
-152-174
-187-210
-374-397
-406-429</transmembrane-regions>
- <theoretical-pi>9.85</theoretical-pi>
- <molecular-weight>50620.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:3023</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>DRD2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>DRD2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>M30625</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>181432</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P14416</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Dopamine D2 receptor</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>D(2) dopamine receptor
-MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
-REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
-SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
-ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
-KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
-SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
-RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
-VNPIIYTTFNIEFRKAFLKILHC</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1332 bp
-ATGGATCCACTGAATCTGTCCTGGTATGATGATGATCTGGAGAGGCAGAACTGGAGCCGG
-CCCTTCAACGGGTCAGACGGGAAGGCGGACAGACCCCACTACAACTACTATGCCACACTG
-CTCACCCTGCTCATCGCTGTCATCGTCTTCGGCAACGTGCTGGTGTGCATGGCTGTGTCC
-CGCGAGAAGGCGCTGCAGACCACCACCAACTACCTGATCGTCAGCCTCGCAGTGGCCGAC
-CTCCTCGTCGCCACACTGGTCATGCCATGGGTTGTCTACCTGGAGGTGGTAGGTGAGTGG
-AAATTCAGCAGGATTCACTGTGACATCTTCGTCACTCTGGACGTCATGATGTGCACGGCG
-AGCATCCTGAACTTGTGTGCCATCAGCATCGACAGGTACACAGCTGTGGCCATGCCCATG
-CTGTACAATACGCGCTACAGCTCCAAGCGCCGGGTCACCGTCATGATCTCCATCGTCTGG
-GTCCTGTCCTTCACCATCTCCTGCCCACTCCTCTTCGGACTCAATAACGCAGACCAGAAC
-GAGTGCATCATTGCCAACCCGGCCTTCGTGGTCTACTCCTCCATCGTCTCCTTCTACGTG
-CCCTTCATTGTCACCCTGCTGGTCTACATCAAGATCTACATTGTCCTCCGCAGACGCCGC
-AAGCGAGTCAACACCAAACGCAGCAGCCGAGCTTTCAGGGCCCACCTGAGGGCTCCACTA
-AAGGGCAACTGTACTCACCCCGAGGACATGAAACTCTGCACCGTTATCATGAAGTCTAAT
-GGGAGTTTCCCAGTGAACAGGCGGAGAGTGGAGGCTGCCCGGCGAGCCCAGGAGCTGGAG
-ATGGAGATGCTCTCCAGCACCAGCCCACCCGAGAGGACCCGGTACAGCCCCATCCCACCC
-AGCCACCACCAGCTGACTCTCCCCGACCCGTCCCACCACGGTCTCCACAGCACTCCTGAC
-AGCCCCGCCAAACCAGAGAAGAATGGGCATGCCAAAGACCACCCCAAGATTGCCAAGATC
-TTTGAGATCCAGACCATGCCCAATGGCAAAACCCGGACCTCCCTCAAGACCATGAGCCGT
-AGAAAGCTCTCCCAGCAGAAGGAGAAGAAAGCCACTCAGATGCTCGCCATTGTTCTCGGC
-GTGTTCATCATCTGCTGGCTGCCCTTCTTCATCACACACATCCTGAACATACACTGTGAC
-TGCAACATCCCGCCTGTCCTGTACAGCGCCTTCACGTGGCTGGGCTATGTCAACAGCGCC
-GTGAACCCCATCATCTACACCACCTTCAACATTGAGTTCCGCAAGGCCTTCCTGAAGATC
-CTTCACTGCTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00001</identifier>
- <name>7tm_1</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>intrinsic to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>integral to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>amine receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>signal transducer activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>dopamine receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transmembrane receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>G-protein coupled receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>rhodopsin-like receptor activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>signal transduction</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cell surface receptor linked signal transduction</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>G-protein coupled receptor protein signaling pathway</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cell communication</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- </targets>
- <enzymes>
- <enzyme>
- <id>BE0002151</id>
- <name>Aromatic-L-amino-acid decarboxylase</name>
- <organism>Human</organism>
- <actions>
- <action>inducer</action>
- </actions>
- <references>
-# Li XM, Juorio AV, Qi J, Boulton AA: Amantadine increases aromatic L-amino acid decarboxylase mRNA in PC12 cells. J Neurosci Res. 1998 Aug 15;53(4):490-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9710269
-# Fisher A, Biggs CS, Starr MS: Effects of glutamate antagonists on the activity of aromatic L-amino acid decarboxylase. Amino Acids. 1998;14(1-3):43-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9871440</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P20711">
- <name>Aromatic-L-amino-acid decarboxylase</name>
- <general-function>Amino acid transport and metabolism</general-function>
- <specific-function>Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine</specific-function>
- <gene-name>DDC</gene-name>
- <locus>7p11</locus>
- <cellular-location/>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>7.21</theoretical-pi>
- <molecular-weight>53895.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:2719</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>DDC</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>DDC</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>M76180</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>181521</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P20711</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>AADC</synonym>
- <synonym>DDC</synonym>
- <synonym>DOPA decarboxylase</synonym>
- <synonym>EC 4.1.1.28</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Aromatic-L-amino-acid decarboxylase
-MNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV
-EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD
-WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM
-EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV
-ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
-PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL
-KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN
-EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
-</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1443 bp
-ATGAACGCAAGTGAATTCCGAAGGAGAGGGAAGGAGATGGTGGATTACGTGGCCAACTAC
-ATGGAAGGCATTGAGGGACGCCAGGTCTACCCTGACGTGGAGCCCGGGTACCTGCGGCCG
-CTGATCCCTGCCGCTGCCCCTCAGGAGCCAGACACGTTTGAGGACATCATCAACGACGTT
-GAGAAGATAATCATGCCTGGGGTGACGCACTGGCACAGCCCCTACTTCTTCGCCTACTTC
-CCCACTGCCAGCTCGTACCCGGCCATGCTTGCGGACATGCTGTGCGGGGCCATTGGCTGC
-ATCGGCTTCTCCTGGGCGGCAAGCCCAGCATGCACAGAGCTGGAGACTGTGATGATGGAC
-TGGCTCGGGAAGATGCTGGAACTACCAAAGGCATTTTTGAATGAGAAAGCTGGAGAAGGG
-GGAGGAGTGATCCAGGGAAGTGCCAGTGAAGCCACCCTGGTGGCCCTGCTGGCCGCTCGG
-ACCAAAGTGATCCATCGGCTGCAGGCAGCGTCCCCAGAGCTCACACAGGCCGCTATCATG
-GAGAAGCTGGTGGCTTACTCATCCGATCAGGCACACTCCTCAGTGGAAAGAGCTGGGTTA
-ATTGGTGGAGTGAAATTAAAAGCCATCCCCTCAGATGGCAACTTCGCCATGCGTGCGTCT
-GCCCTGCAGGAAGCCCTGGAGAGAGACAAAGCGGCTGGCCTGATTCCTTTCTTTATGGTT
-GCCACCCTGGGGACCACAACATGCTGCTCCTTTGACAATCTCTTAGAAGTCGGTCCTATC
-TGCAACAAGGAAGACATATGGCTGCACGTTGATGCAGCCTACGCAGGCAGTGCATTCATC
-TGCCCTGAGTTCCGGCACCTTCTGAATGGAGTGGAGTTTGCAGATTCATTCAACTTTAAT
-CCCCACAAATGGCTATTGGTGAATTTTGACTGTTCTGCCATGTGGGTGAAAAAGAGAACA
-GACTTAACGGGAGCCTTTAGACTGGACCCCACTTACCTGAAGCACAGCCATCAGGATTCA
-GGGCTTATCACTGACTACCGGCATTGGCAGATACCACTGGGCAGAAGATTTCGCTCTTTG
-AAAATGTGGTTTGTATTTAGGATGTATGGAGTCAAAGGACTGCAGGCTTATATCCGCAAG
-CATGTCCAGCTGTCCCATGAGTTTGAGTCACTGGTGCGCCAGGATCCCCGCTTTGAAATC
-TGTGTGGAAGTCATTCTGGGGCTTGTCTGCTTTCGGCTAAAGGGTTCCAACAAAGTGAAT
-GAAGCTCTTCTGCAAAGAATAAACAGTGCCAAAAAAATCCACTTGGTTCCATGTCACCTC
-AGGGACAAGTTTGTCCTGCGCTTTGCCATCTGTTCTCGCACGGTGGAATCTGCCCATGTG
-CAGCGGGCCTGGGAACACATCAAAGAGCTGGCGGCCGACGTGCTGCGAGCAGAGAGGGAG
-TAG</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00282</identifier>
- <name>Pyridoxal_deC</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>lyase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>carbon-carbon lyase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>carboxy-lyase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>amino acid metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>amino acid and derivative metabolism</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </enzyme>
- <enzyme>
- <id>BE0002196</id>
- <name>Amine oxidase [flavin-containing] B</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references>
-# Wesemann W, Ekenna O: Effect of 1-aminoadamantanes on the MAO activity in brain, liver, and kidney of the rat. Arzneimittelforschung. 1982;32(10):1241-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6891223</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P27338">
- <name>Amine oxidase [flavin-containing] B</name>
- <general-function>Amino acid transport and metabolism</general-function>
- <specific-function>Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine</specific-function>
- <gene-name>MAOB</gene-name>
- <locus>Xp11.23</locus>
- <cellular-location>Mitochondrion</cellular-location>
- <transmembrane-regions>490-516</transmembrane-regions>
- <theoretical-pi>7.55</theoretical-pi>
- <molecular-weight>58764.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:6834</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>MAOB</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>MAOB</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>S62734</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>398415</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P27338</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>EC 1.4.3.4</synonym>
- <synonym>MAO-B</synonym>
- <synonym>Monoamine oxidase type B</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Amine oxidase [flavin-containing] B
-MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
-VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
-TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
-SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
-TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
-YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
-LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
-IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
-FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1560 bp
-ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
-AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
-GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
-GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
-AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
-GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
-ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
-GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
-GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
-TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
-ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
-ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
-ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
-ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
-ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
-TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
-GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
-ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
-TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
-GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
-TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
-ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
-GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
-GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
-TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
-ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC
-</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF01593</identifier>
- <name>Amino_oxidase</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>oxidoreductase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>generation of precursor metabolites and energy</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>electron transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </enzyme>
- </enzymes>
- <carriers/>
- <transporters>
- <transporter position="1">
- <id>BE0003647</id>
- <name>Solute carrier family 22 member 2</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references># Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12089365
-# Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C, Arndt P, Ulzheimer JC, Sonders MS, Baumann C, Waldegger S, Lang F, Koepsell H: Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9687576
-# Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12438515
-# Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15640376</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="O15244">
- <name>Solute carrier family 22 member 2</name>
- <general-function>Carbohydrate transport and metabolism</general-function>
- <specific-function>Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity</specific-function>
- <gene-name>SLC22A2</gene-name>
- <locus>6q26</locus>
- <cellular-location>Membrane</cellular-location>
- <transmembrane-regions>23-43
-151-171
-178-198
-209-229
-239-259
-264-284
-349-369
-376-396
-415-435
-442-462
-465-485
-495-515</transmembrane-regions>
- <theoretical-pi>8.45</theoretical-pi>
- <molecular-weight>62564.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>GNC:10966</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>SLC22A2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>X98333</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>2281942</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>O15244</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>hOCT2</synonym>
- <synonym>Organic cation transporter 2</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Solute carrier family 22 member 2
-MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
-LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
-PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
-LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
-YQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAM
-RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
-LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
-SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
-TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
-KMIYLQVQKLDIPLN</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1668 bp
-ATGCCCACCACCGTGGACGATGTCCTGGAGCATGGAGGGGAGTTTCACTTTTTCCAGAAG
-CAAATGTTTTTCCTCTTGGCTCTGCTCTCGGCTACCTTCGCGCCCATCTACGTGGGCATC
-GTCTTCCTGGGCTTCACCCCTGACCACCGCTGCCGGAGCCCCGGAGTGGCCGAGCTGAGT
-CTGCGCTGCGGCTGGAGTCCTGCAGAGGAACTGAACTACACGGTGCCGGGCCCAGGACCT
-GCGGGCGAAGCCTCCCCAAGACAGTGTAGGCGCTACGAGGTGGACTGGAACCAGAGCACC
-TTTGACTGCGTGGACCCCCTGGCCAGCCTGGACACCAACAGGAGCCGCCTGCCACTGGGC
-CCCTGCCGGGACGGCTGGGTGTACGAGACGCCTGGCTCGTCCATCGTCACCGAGTTTAAC
-CTGGTATGTGCCAACTCCTGGATGTTGGACCTATTCCAGTCATCAGTGAATGTAGGATTC
-TTTATTGGCTCTATGAGTATCGGCTACATAGCAGACAGGTTTGGCCGTAAGCTCTGCCTC
-CTAACTACAGTCCTCATAAATGCTGCAGCTGGAGTTCTCATGGCCATTTCCCCAACCTAT
-ACGTGGATGTTAATTTTTCGCTTAATCCAAGGACTGGTCAGCAAAGCAGGCTGGTTAATA
-GGCTACATCCTGATTACAGAATTTGTTGGGCGGAGATATCGGAGAACAGTGGGGATTTTT
-TACCAAGTTGCCTATACAGTTGGGCTCCTGGTGCTAGCTGGGGTGGCTTACGCACTTCCT
-CACTGGAGGTGGTTGCAGTTCACAGTTGCTCTGCCCAACTTCTTCTTCTTGCTCTATTAC
-TGGTGCATACCTGAGTCTCCCAGGTGGCTGATCTCCCAGAATAAGAATGCTGAAGCCATG
-AGAATCATTAAGCACATCGCAAAGAAAAATGGAAAATCTCTACCCGCCTCCCTTCAGCGC
-CTGAGACTTGAAGAGGAAACTGGCAAGAAATTGAACCCTTCATTTCTTGACTTGGTCAGA
-ACTCCTCAGATAAGGAAACATACTATGATATTGATGTACAACTGGTTCACGAGCTCTGTG
-CTCTACCAGGGCCTCATCATGCACATGGGCCTTGCAGGTGACAATATCTACCTGGATTTC
-TTCTACTCTGCCCTGGTTGAATTCCCAGCTGCCTTCATGATCATCCTCACCATCGACCGC
-ATCGGACGCCGTTACCCTTGGGCTGCATCAAATATGGTTGCAGGGGCAGCCTGTCTGGCC
-TCAGTTTTTATACCTGGTGATCTACAATGGCTAAAAATTATTATCTCATGCTTGGGAAGA
-ATGGGGATCACAATGGCCTATGAGATAGTCTGCCTGGTCAATGCTGAGCTGTACCCCACA
-TTCATTAGGAATCTTGGCGTCCACATCTGTTCCTCAATGTGTGACATTGGTGGCATCATC
-ACGCCATTCCTGGTCTACCGGCTCACTAACATCTGGCTTGAGCTCCCGCTGATGGTTTTC
-GGCGTACTTGGCTTGGTTGCTGGAGGTCTGGTGCTGTTGCTTCCAGAAACTAAAGGGAAA
-GCTTTGCCTGAGACCATCGAGGAAGCCGAAAATATGCAAAGACCAAGAAAAAATAAAGAA
-AAGATGATTTACCTCCAAGTTCAGAAACTAGACATTCCATTGAACTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00083</identifier>
- <name>Sugar_tr</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>intrinsic to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>integral to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>ion transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </transporter>
- <transporter position="2">
- <id>BE0003648</id>
- <name>Solute carrier family 22 member 1</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references># Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12606755
-# Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9655880
-# Goralski KB, Lou G, Prowse MT, Gorboulev V, Volk C, Koepsell H, Sitar DS: The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther. 2002 Dec;303(3):959-68. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12438515
-# Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15640376</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="O15245">
- <name>Solute carrier family 22 member 1</name>
- <general-function>Carbohydrate transport and metabolism</general-function>
- <specific-function>Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase</specific-function>
- <gene-name>SLC22A1</gene-name>
- <locus>6q26</locus>
- <cellular-location>Basolateral cell membrane</cellular-location>
- <transmembrane-regions>22-42
-150-170
-177-197
-207-229
-236-256
-263-283
-348-368
-377-397
-403-423
-432-452
-465-485
-493-513</transmembrane-regions>
- <theoretical-pi>6.81</theoretical-pi>
- <molecular-weight>61187.4</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>GNC:10963</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>SLC22A1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>X98332</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>2511670</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>O15245</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>hOCT1</synonym>
- <synonym>Organic cation transporter 1</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Solute carrier family 22 member 1
-MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ
-RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP
-CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFFFGSLGVGYFADRFGRKLCLL
-GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY
-QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK
-IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL
-YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM
-IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT
-PFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKEN
-TIYLKVQTSEPSGT</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1665 bp
-ATGCCCACCGTGGATGACATTCTGGAGCAGGTTGGGGAGTCTGGCTGGTTCCAGAAGCAA
-GCCTTCCTCATCTTATGCCTGCTGTCGGCTGCCTTTGCGCCCATCTGTGTGGGCATCGTC
-TTCCTGGGTTTCACACCTGACCACCACTGCCAGAGCCCTGGGGTGGCTGAGCTGAGCCAG
-CGCTGTGGCTGGAGCCCTGCGGAGGAGCTGAACTATACAGTGCCAGGCCTGGGGCCCGCG
-GGCGAGGCCTTCCTTGGCCAGTGCAGGCGCTATGAAGTGGACTGGAACCAGAGCGCCCTC
-AGCTGTGTAGACCCCCTGGCTAGCCTGGCCACCAACAGGAGCCACCTGCCGCTGGGTCCC
-TGCCAGGATGGCTGGGTGTATGACACGCCCGGCTCTTCCATCGTCACTGAGTTCAACCTG
-GTGTGTGCTGACTCCTGGAAGCTGGACCTCTTTCAGTCCTGTTTGAATGCGGGCTTCTTC
-TTTGGCTCTCTCGGTGTTGGCTACTTTGCAGACAGGTTTGGCCGTAAGCTGTGTCTCCTG
-GGAACTGTGCTGGTCAACGCGGTGTCGGGCGTGCTCATGGCCTTCTCGCCCAACTACATG
-TCCATGCTGCTCTTCCGCCTGCTGCAGGGCCTGGTCAGCAAGGGCAACTGGATGGCTGGC
-TACACCCTAATCACAGAATTTGTTGGCTCGGGCTCCAGAAGAACGGTGGCGATCATGTAC
-CAGATGGCCTTCACGGTGGGGCTGGTGGCGCTTACCGGGCTGGCCTACGCCCTGCCTCAC
-TGGCGCTGGCTGCAGCTGGCAGTCTCCCTGCCCACCTTCCTCTTCCTGCTCTACTACTGG
-TGTGTGCCGGAGTCCCCTCGGTGGCTGTTATCACAAAAAAGAAACACTGAAGCAATAAAG
-ATAATGGACCACATCGCTCAAAAGAATGGGAAGTTGCCTCCTGCTGATTTAAAGATGCTT
-TCCCTCGAAGAGGATGTCACCGAAAAGCTGAGCCCTTCATTTGCAGACCTGTTCCGCACG
-CCGCGCCTGAGGAAGCGCACCTTCATCCTGATGTACCTGTGGTTCACGGACTCTGTGCTC
-TATCAGGGGCTCATCCTGCACATGGGCGCCACCAGCGGGAACCTCTACCTGGATTTCCTT
-TACTCCGCTCTGGTCGAAATCCCGGGGGCCTTCATAGCCCTCATCACCATTGACCGCGTG
-GGCCGCATCTACCCCATGGCCATGTCAAATTTGTTGGCGGGGGCAGCCTGCCTCGTCATG
-ATTTTTATCTCACCTGACCTGCACTGGTTAAACATCATAATCATGTGTGTTGGCCGAATG
-GGAATCACCATTGCAATACAAATGATCTGCCTGGTGAATGCTGAGCTGTACCCCACATTC
-GTCAGGAACCTCGGAGTGATGGTGTGTTCCTCCCTGTGTGACATAGGTGGGATAATCACC
-CCCTTCATAGTCTTCAGGCTGAGGGAGGTCTGGCAAGCCTTGCCCCTCATTTTGTTTGCG
-GTGTTGGGCCTGCTTGCCGCGGGAGTGACGCTACTTCTTCCAGAGACCAAGGGGGTCGCT
-TTGCCAGAGACCATGAAGGACGCCGAGAACCTTGGGAGAAAAGCAAAGCCCAAAGAAAAC
-ACGATTTACCTTAAGGTCCAAACCTCAGAACCCTCGGGCACCTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF07690</identifier>
- <name>MFS_1</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>intrinsic to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>integral to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>ion transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </transporter>
- <transporter position="3">
- <id>BE0001032</id>
- <name>Multidrug resistance protein 1</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references># Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12438524</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P08183">
- <name>Multidrug resistance protein 1</name>
- <general-function>Defense mechanisms and drug export</general-function>
- <specific-function>Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells</specific-function>
- <gene-name>ABCB1</gene-name>
- <locus>7q21.1</locus>
- <cellular-location>Membrane; multi-pass membrane protein</cellular-location>
- <transmembrane-regions>52-72
-120-140
-189-209
-216-236
-297-317
-326-346
-711-731
-757-777
-833-853
-854-874
-937-957
-974-994</transmembrane-regions>
- <theoretical-pi>9.44</theoretical-pi>
- <molecular-weight>141464.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:40</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>ABCB1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>ABCB1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>M14758</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>307180</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P08183</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>ATP-binding cassette sub-family B member 1</synonym>
- <synonym>CD243 antigen</synonym>
- <synonym>EC 3.6.3.44</synonym>
- <synonym>P-glycoprotein 1</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Multidrug resistance protein 1
-MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
-HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
-IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
-KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
-DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
-AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
-AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
-QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
-ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
-IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
-FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
-SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
-NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
-GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
-ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEA
-IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
-AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
-YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
-QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
-SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
-EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
-LAQKGIYFSMVSVQAGTKRQ</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>3843 bp
-ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAAC
-AATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTT
-CGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATC
-CATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCA
-AATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGAT
-ACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGA
-ATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCT
-GGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATA
-GGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCT
-AAGATTAATGAAGTTATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTT
-TTCACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCC
-ATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACT
-GATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCA
-ATTAGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAAT
-TTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGT
-GCTGCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTG
-GTCCTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATT
-GGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGA
-GCAGCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAG
-AGTGGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGT
-TACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGGCCTGAACCTGAAGGTGCAGAGTGGG
-CAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATG
-CAGAGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACC
-ATAAATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTT
-GCCACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATT
-GAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTT
-GACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCC
-ATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCC
-TTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGG
-ACCACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGT
-TTCGATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGC
-ATTTACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCA
-GCTGATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCC
-AGTCTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGA
-AAGCTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATT
-ATGAAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATA
-AATGGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACA
-AGAATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTA
-GCCCTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCT
-GGAGAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGAT
-GTGAGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAAT
-GATGCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATA
-GCAAATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTA
-CTCTTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCT
-GGACAAGCACTGAAAGATAAGAAAGAACTAGAAGGTGCTGGGAAGATCGCTACTGAAGCA
-ATAGAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTAT
-GCTCAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATT
-ACATTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGA
-GCCTACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCT
-GTTGTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAA
-GCCAAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGC
-TACAGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTT
-GTATTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTG
-AAGAAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTC
-CAGCTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAA
-ATAAAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCC
-ATCCTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTG
-TCACAGGAAGAGATCGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCA
-CTGCCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAG
-AAACAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGAT
-GAAGCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAA
-GCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCA
-GACTTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTG
-CTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAG
-TGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00005</identifier>
- <name>ABC_tran</name>
- </pfam>
- <pfam>
- <identifier>PF00664</identifier>
- <name>ABC_membrane</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>integral to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>intrinsic to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ATP binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity, acting on acid anhydrides</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>nucleotide binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>pyrophosphatase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>purine nucleotide binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>nucleoside-triphosphatase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>adenyl nucleotide binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ATPase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ATPase activity, coupled to transmembrane movement of substances</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </transporter>
- </transporters>
-</drug><drug type="small molecule" created="2005-06-13 07:24:05 -0600" updated="2013-09-16 17:13:27 -0600" version="4.0">
- <drugbank-id>DB01119</drugbank-id>
- <name>Diazoxide</name>
- <description>A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. [PubChem]</description>
- <cas-number>364-98-7</cas-number>
- <general-references/>
- <synthesis-reference/>
- <indication>Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.</indication>
- <pharmacology>Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.</pharmacology>
- <mechanism-of-action>As a diuretic, diazoxide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like diazoxide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of diazoxide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. As a antihypoglycemic, diazoxide inhibits insulin release from the pancreas, probably by opening potassium channels in the beta cell membrane.</mechanism-of-action>
- <toxicity>Oral LD<sub>50</sub> in rat and mouse: 980 mg/kg and 444 mg/kg, respectively.</toxicity>
- <biotransformation>Hepatic.</biotransformation>
- <absorption>Readily absorbed following oral administration.</absorption>
- <half-life>28 &plusmn;8.3 hours in normal adults.</half-life>
- <protein-binding>Very high (more than 90%) to serum proteins.</protein-binding>
- <route-of-elimination>Proglycem is extensively bound (more than 90%) to serum proteins, and is excreted in the kidneys.</route-of-elimination>
- <volume-of-distribution/>
- <clearance/>
- <secondary-accession-numbers>
- <secondary-accession-number>APRD00914</secondary-accession-number>
- </secondary-accession-numbers>
- <groups>
- <group>approved</group>
- </groups>
- <taxonomy>
- <kingdom>Organic</kingdom>
- <substructures>
- <substructure class="false">Sulfonyls</substructure>
- <substructure class="false">Benzene and Derivatives</substructure>
- <substructure class="false">Aryl Halides</substructure>
- <substructure class="true">Benzenesulfonamides</substructure>
- <substructure class="false">Halobenzenes</substructure>
- <substructure class="false">Heterocyclic compounds</substructure>
- <substructure class="false">Aromatic compounds</substructure>
- <substructure class="false">Carboxamidines</substructure>
- <substructure class="false">Thiadiazines</substructure>
- <substructure class="false">Sulfonamides</substructure>
- <substructure class="false">Imines</substructure>
- <substructure class="false">Anilines</substructure>
- </substructures>
- </taxonomy>
- <synonyms/>
- <salts/>
- <brands>
- <brand>Dizoxide</brand>
- <brand>Eudemine</brand>
- <brand>Hyperstat</brand>
- <brand>Hypertonalum</brand>
- <brand>Mutabase</brand>
- <brand>Proglicem</brand>
- <brand>Proglycem</brand>
- </brands>
- <mixtures/>
- <packagers>
- <packager>
- <name>Ivax Pharmaceuticals</name>
- <url/>
- </packager>
- <packager>
- <name>Medisca Inc.</name>
- <url>http://www.medisca.com</url>
- </packager>
- <packager>
- <name>Teva Pharmaceutical Industries Ltd.</name>
- <url>http://www.tevapharm.com</url>
- </packager>
- </packagers>
- <manufacturers>
- <manufacturer generic="false">Teva branded pharmaceutical products r&d inc</manufacturer>
- <manufacturer generic="true">Abraxis pharmaceutical products</manufacturer>
- <manufacturer generic="false">Schering corp sub schering plough corp</manufacturer>
- <manufacturer generic="false">Teva global respiratory research llc</manufacturer>
- </manufacturers>
- <prices>
- <price>
- <description>Proglycem 100 mg Capsule</description>
- <cost currency="USD">1.65</cost>
- <unit>capsule</unit>
- </price>
- <price>
- <description>Diazoxide powder</description>
- <cost currency="USD">85.07</cost>
- <unit>g</unit>
- </price>
- <price>
- <description>Proglycem 50 mg/ml Suspension 30ml Bottle</description>
- <cost currency="USD">197.05</cost>
- <unit>bottle</unit>
- </price>
- </prices>
- <categories/>
- <affected-organisms>
- <affected-organism>Humans and other mammals</affected-organism>
- </affected-organisms>
- <dosages>
- <dosage>
- <form>Capsule</form>
- <route>Oral</route>
- <strength/>
- </dosage>
- </dosages>
- <atc-codes>
- <atc-code>C02DA01</atc-code>
- <category/>
- <atc-code>V03AH01</atc-code>
- <category/>
- </atc-codes>
- <ahfs-codes>
- <ahfs-code>24:08.20</ahfs-code>
- </ahfs-codes>
- <patents/>
- <food-interactions/>
- <drug-interactions>
- <drug-interaction>
- <drug>DB00436</drug>
- <name>Bendroflumethiazide</name>
- <description>Significant hyperglycemic effect</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00672</drug>
- <name>Chlorpropamide</name>
- <description>Antagonism. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00310</drug>
- <name>Chlorthalidone</name>
- <description>Significant hyperglycemic effect</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01320</drug>
- <name>Fosphenytoin</name>
- <description>Diazoxide decreases the hydantoin effect</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB01016</drug>
- <name>Glyburide</name>
- <description>Antagonism. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00999</drug>
- <name>Hydrochlorothiazide</name>
- <description>Significant hyperglycemic effect</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00808</drug>
- <name>Indapamide</name>
- <description>Significant hyperglycemic effect</description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00252</drug>
- <name>Phenytoin</name>
- <description>Diazoxide decreases the efficacy of phenytoin. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00519</drug>
- <name>Trandolapril</name>
- <description>Diazoxide may increase the hypotensive effect of Trandolapril. Monitor for changes in blood pressure.</description>
- </drug-interaction>
- </drug-interactions>
- <calculated-properties>
- <property>
- <kind>logP</kind>
- <value>1.09</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>logS</kind>
- <value>-2.6</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>Water Solubility</kind>
- <value>5.52e-01 g/l</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>logP</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>IUPAC Name</kind>
- <value>7-chloro-3-methyl-4H-1$l^{6},2,4-benzothiadiazine-1,1-dione</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Traditional IUPAC Name</kind>
- <value>diazoxide</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Weight</kind>
- <value>230.671</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Monoisotopic Weight</kind>
- <value>229.991675875</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>SMILES</kind>
- <value>CC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Formula</kind>
- <value>C8H7ClN2O2S</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChI</kind>
- <value>InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChIKey</kind>
- <value>InChIKey=GDLBFKVLRPITMI-UHFFFAOYSA-N</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polar Surface Area (PSA)</kind>
- <value>58.53</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Refractivity</kind>
- <value>54.84</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polarizability</kind>
- <value>20.98</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Rotatable Bond Count</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Acceptor Count</kind>
- <value>4</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Donor Count</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>pKa (strongest acidic)</kind>
- <value>10.48</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>pKa (strongest basic)</kind>
- <value>1.33</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Physiological Charge</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Number of Rings</kind>
- <value>2</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Bioavailability</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Rule of Five</kind>
- <value>true</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Ghose Filter</kind>
- <value>true</value>
- <source>ChemAxon</source>
- </property>
- </calculated-properties>
- <experimental-properties>
- <property>
- <kind>Water Solubility</kind>
- <value>2850 mg/L</value>
- <source/>
- </property>
- <property>
- <kind>Melting Point</kind>
- <value>330.5 °C</value>
- <source>PhysProp</source>
- </property>
- <property>
- <kind>logP</kind>
- <value>1.20</value>
- <source>HANSCH,C ET AL. (1995)</source>
- </property>
- <property>
- <kind>pKa</kind>
- <value>8.74</value>
- <source>SANGSTER (1994)</source>
- </property>
- </experimental-properties>
- <external-identifiers>
- <external-identifier>
- <resource>ChEBI</resource>
- <identifier>4495</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PubChem Compound</resource>
- <identifier>3019</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PubChem Substance</resource>
- <identifier>46508027</identifier>
- </external-identifier>
- <external-identifier>
- <resource>Drugs Product Database (DPD)</resource>
- <identifier>503347</identifier>
- </external-identifier>
- <external-identifier>
- <resource>KEGG Compound</resource>
- <identifier>C06949</identifier>
- </external-identifier>
- <external-identifier>
- <resource>KEGG Drug</resource>
- <identifier>D00294</identifier>
- </external-identifier>
- <external-identifier>
- <resource>ChemSpider</resource>
- <identifier>2911</identifier>
- </external-identifier>
- <external-identifier>
- <resource>National Drug Code Directory</resource>
- <identifier>0575-6000-01</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PharmGKB</resource>
- <identifier>PA449285</identifier>
- </external-identifier>
- <external-identifier>
- <resource>IUPHAR</resource>
- <identifier>2409</identifier>
- </external-identifier>
- <external-identifier>
- <resource>Guide to Pharmacology</resource>
- <identifier>2409</identifier>
- </external-identifier>
- <external-identifier>
- <resource>Wikipedia</resource>
- <identifier>Diazoxide</identifier>
- </external-identifier>
- </external-identifiers>
- <external-links>
- <external-link>
- <resource>Drugs.com</resource>
- <url>http://www.drugs.com/cdi/diazoxide-suspension.html</url>
- </external-link>
- </external-links>
- <targets>
- <target position="1">
- <id>BE0000708</id>
- <name>ATP-sensitive inward rectifier potassium channel 11</name>
- <organism>Human</organism>
- <actions>
- <action>inducer</action>
- </actions>
- <references># D'hahan N, Moreau C, Prost AL, Jacquet H, Alekseev AE, Terzic A, Vivaudou M: Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12162-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10518593
-# Sakura H, Trapp S, Liss B, Ashcroft FM: Altered functional properties of KATP channel conferred by a novel splice variant of SUR1. J Physiol. 1999 Dec 1;521 Pt 2:337-50. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10581306
-# Shindo T, Katayama Y, Horio Y, Kurachi Y: MCC-134, a novel vascular relaxing agent, is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel. J Pharmacol Exp Ther. 2000 Jan;292(1):131-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10604939
-# de Lonlay P, Fournet JC, Touati G, Groos MS, Martin D, Sevin C, Delagne V, Mayaud C, Chigot V, Sempoux C, Brusset MC, Laborde K, Bellane-Chantelot C, Vassault A, Rahier J, Junien C, Brunelle F, Nihoul-Fekete C, Saudubray JM, Robert JJ: Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases. Eur J Pediatr. 2002 Jan;161(1):37-48. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11808879
-# Russ U, Lange U, Loffler-Walz C, Hambrock A, Quast U: Binding and effect of K ATP channel openers in the absence of Mg2+. Br J Pharmacol. 2003 May;139(2):368-80. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12770942</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="Q14654">
- <name>ATP-sensitive inward rectifier potassium channel 11</name>
- <general-function>Involved in inward rectifier potassium channel activity</general-function>
- <specific-function>This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium</specific-function>
- <gene-name>KCNJ11</gene-name>
- <locus>11p15.1</locus>
- <cellular-location>Membrane; multi-pass membrane protein</cellular-location>
- <transmembrane-regions>69-93
-145-166</transmembrane-regions>
- <theoretical-pi>8.1</theoretical-pi>
- <molecular-weight>43541.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:6257</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>KCNJ11</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>KCNJ11</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>D50582</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>1088445</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>Q14654</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>IKATP</synonym>
- <synonym>Inward rectifier K(+) channel Kir6.2</synonym>
- <synonym>Potassium channel, inwardly rectifying subfamily J member 11</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>ATP-sensitive inward rectifier potassium channel 11
-MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF
-TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA
-FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
-LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
-ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
-RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT
-LASARGPLRKRSVPMAKAKPKFSISPDSLS</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1173 bp
-ATGCTGTCCCGCAAGGGCATCATCCCCGAGGAATACGTGCTGACACGCCTGGCAGAGGAC
-CCTGCCGAGCCCAGGTACCGTGCCCGCCAGCGGAGGGCCCGCTTTGTGTCCAAGAAAGGC
-AACTGCAACGTGGCCCACAAGAACATCCGGGAGCAGGGCCGCTTCCTGCAGGACGTGTTC
-ACCACGCTGGTGGACCTCAAGTGGCCACACACATTGCTCATCTTCACCATGTCCTTCCTG
-TGCAGCTGGCTGCTCTTCGCCATGGCCTGGTGGCTCATCGCCTTCGCCCACGGTGACCTG
-GCCCCCAGCGAGGGCACTGCTGAGCCCTGTGTCACCAGCATCCACTCCTTCTCGTCTGCC
-TTCCTTTTCTCCATTGAGGTCCAAGTGACTATTGGCTTTGGGGGGCGCATGGTGACTGAG
-GAGTGCCCACTGGCCATCCTGAGCCTCATCGTGCAGAACATCGTGGGGCTCATGATCAAC
-GCCATCATGCTTGGCTGCATCTTCATGAAGACTGCCCAAGCCCACCGCAGGGCTGAGACC
-CTCATCTTCAGCAAGCATGCGGTGATCGCTCTGCGCCACGGCCGCCTCTGCTTCATGCTA
-CGTGTGGGTGACCTCCGCAAGAGCATGATCATCAGCGCCACCATCCACATGCAGGTGGTA
-CGCAAGACCACCAGCCCCGAGGGCGAGGTGGTGCCCCTCCACCAGGTGGACATCCCCATG
-GAGAACGGCGTGGGTGGCAACAGCATCTTCCTGGTGGCCCCGCTGATCATCTACCATGTC
-ATTGATGCCAACAGCCCACTCTACGACCTGGCACCCAGCGACCTGCACCACCACCAGGAC
-CTCGAGATCATCGTCATCCTGGAAGGCGTGGTGGAAACCACGGGCATCACCACCCAGGCC
-CGCACCTCCTACCTGGCCGATGAGATCCTGTGGGGCCAGCGCTTTGTGCCCATTGTAGCT
-GAGGAGGACGGACGTTACTCTGTGGACTACTCCAAGTTTGGCAACACCATCAAAGTGCCC
-ACACCACTCTGCACGGCCCGCCAGCTTGATGAGGACCACAGCCTACTGGAAGCTCTGACC
-CTCGCCTCAGCCCGCGGGCCCCTGCGCAAGCGCAGCGTGCCCATGGCCAAGGCCAAGCCC
-AAGTTCAGCATCTCTCCAGATTCCCTGTCCTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF01007</identifier>
- <name>IRK</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>voltage-gated potassium channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>inward rectifier potassium channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ATP-activated inward rectifier potassium channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>voltage-gated ion channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>monovalent inorganic cation transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>potassium ion transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>ion transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cation transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="2">
- <id>BE0000267</id>
- <name>Carbonic anhydrase 1</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references># Domoki F, Bari F, Nagy K, Busija DW, Siklos L: Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs. Brain Res. 2004 Sep 3;1019(1-2):97-104. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15306243
-# Erdemli G, Krnjevic K: Diazoxide suppresses slowly-inactivating outward and inward currents in CA1 hippocampal neurones. Neuroreport. 1993 Dec 13;5(3):249-51. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8298083
-# Erdemli G, Krnjevic K: Actions of diazoxide on CA1 neurons in hippocampal slices from rats. Can J Physiol Pharmacol. 1995 May;73(5):608-18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7585327
-# Scuvee-Moreau J, Seutin V, Vrijens B, Pirotte B, De Tullio P, Massotte L, Albert A, Delarge J, Dresse A: Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro. Arch Physiol Biochem. 1997 Sep;105(5):421-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9439778
-# Crepel V, Rovira C, Ben-Ari Y: The K+ channel opener diazoxide enhances glutamatergic currents and reduces GABAergic currents in hippocampal neurons. J Neurophysiol. 1993 Feb;69(2):494-503. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7681475</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P00915">
- <name>Carbonic anhydrase 1</name>
- <general-function>Inorganic ion transport and metabolism</general-function>
- <specific-function>Reversible hydration of carbon dioxide</specific-function>
- <gene-name>CA1</gene-name>
- <locus>8q13-q22.1</locus>
- <cellular-location>Cytoplasm</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>7.14</theoretical-pi>
- <molecular-weight>28739.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:1368</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>CA1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>CA1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>X05014</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>29600</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P00915</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>CA-I</synonym>
- <synonym>Carbonate dehydratase I</synonym>
- <synonym>Carbonic anhydrase I</synonym>
- <synonym>EC 4.2.1.1</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Carbonic anhydrase 1
-ASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEII
-NVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHV
-AHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFD
-PSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVP
-MQHNNRPTQPLKGRTVRASF</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>786 bp
-ATGGCAAGTCCAGACTGGGGATATGATGACAAAAATGGTCCTGAACAATGGAGCAAGCTG
-TATCCCATTGCCAATGGAAATAACCAATCCCCTGTTGATATTAAAACCAGTGAAACCAAA
-CATGACACCTCTCTGAAACCTATTAGTGTCTCCTACAACCCAGCCACAGCCAAAGAAATT
-ATCAATGTGGGGCATTCTTTCCATGTAAATTTTGAGGACAACGATAACCGATCAGTGCTG
-AAAGGTGGTCCTTTCTCTGACAGCTACAGGCTCTTTCAGTTTCATTTTCACTGGGGCAGT
-ACAAATGAGCATGGTTCAGAACATACAGTGGATGGAGTCAAATATTCTGCCGAGCTTCAC
-GTAGCTCACTGGAATTCTGCAAAGTACTCCAGCCTTGCTGAAGCTGCCTCAAAGGCTGAT
-GGTTTGGCAGTTATTGGTGTTTTGATGAAGGTTGGTGAGGCCAACCCAAAGCTGCAGAAA
-GTACTTGATGCCCTCCAAGCAATTAAAACCAAGGGCAAACGAGCCCCATTCACAAATTTT
-GACCCCTCTACTCTCCTTCCTTCATCCCTGGATTTCTGGACCTACCCTGGCTCTCTGACT
-CATCCTCCTCTTTATGAGAGTGTAACTTGGATCATCTGTAAGGAGAGCATCAGTGTCAGC
-TCAGAGCAGCTGGCACAATTCCGCAGCCTTCTATCAAATGTTGAAGGTGATAACGCTGTC
-CCCATGCAGCACAACAACCGCCCAACCCAACCTCTGAAGGGCAGAACAGTGAGAGCTTCA
-TTTTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00194</identifier>
- <name>Carb_anhydrase</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydro-lyase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>carbonate dehydratase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>lyase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transition metal ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>zinc ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>carbon-oxygen lyase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>one-carbon compound metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular metabolism</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="3">
- <id>BE0000322</id>
- <name>Carbonic anhydrase 2</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references># Munoz A, Nakazaki M, Goodman JC, Barrios R, Onetti CG, Bryan J, Aguilar-Bryan L: Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels. Stroke. 2003 Jan;34(1):164-70. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12511769
-# Sekine N, Ullrich S, Regazzi R, Pralong WF, Wollheim CB: Postreceptor signalling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1. Endocrinology. 1996 May;137(5):1841-50. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8612523</references>
- <known-action>yes</known-action>
- <components>
- <polypeptide id="P00918">
- <name>Carbonic anhydrase 2</name>
- <general-function>Inorganic ion transport and metabolism</general-function>
- <specific-function>Reversible hydration of carbon dioxide</specific-function>
- <gene-name>CA2</gene-name>
- <locus>8q22</locus>
- <cellular-location>Cytoplasm</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>7.47</theoretical-pi>
- <molecular-weight>29115.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:1373</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>CA2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>CA2</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>M77181</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>179780</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P00918</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>CA-II</synonym>
- <synonym>Carbonate dehydratase II</synonym>
- <synonym>Carbonic anhydrase C</synonym>
- <synonym>Carbonic anhydrase II</synonym>
- <synonym>EC 4.2.1.1</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Carbonic anhydrase 2
-SHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILN
-NGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLV
-HWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPR
-GLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMV
-DNWRPAQPLKNRQIKASFK</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>783 bp
-ATGTCCCATCACTGGGGGTACGGCAAACACAACGGACCTGAGCACTGGCATAAGGACTTC
-CCCATTGCCAAGGGAGAGCGCCAGTCCCCTGTTGACATCGACACTCATACAGCCAAGTAT
-GACCCTTCCCTGAAGCCCCTGTCTGTTTCCTATGATCAAGCAACTTCCCTGAGGATCCTC
-AACAATGGTCATGCTTTCAACGTGGAGTTTGATGACTCTCAGGACAAAGCAGTGCTCAAG
-GGAGGACCCCTGGATGGCACTTACAGATTGATTCAGTTTCACTTTCACTGGGGTTCACTT
-GATGGACAAGGTTCAGAGCATACTGTGGATAAAAAGAAATATGCTGCAGAACTTCACTTG
-GTTCACTGGAACACCAAATATGGGGATTTTGGGAAAGCTGTGCAGCAACCTGATGGACTG
-GCCGTTCTAGGTATTTTTTTGAAGGTTGGCAGCGCTAAACCGGGCCTTCAGAAAGTTGTT
-GATGTGCTGGATTCCATTAAAACAAAGGGCAAGAGTGCTGACTTCACTAACTTCGATCCT
-CGTGGCCTCCTTCCTGAATCCTTGGATTACTGGACCTACCCAGGCTCACTGACCACCCCT
-CCTCTTCTGGAATGTGTGACCTGGATTGTGCTCAAGGAACCCATCAGCGTCAGCAGCGAG
-CAGGTGTTGAAATTCCGTAAACTTAACTTCAATGGGGAGGGTGAACCCGAAGAACTGATG
-GTGGACAACTGGCGCCCAGCTCAGCCACTGAAGAACAGGCAAATCAAAGCTTCCTTCAAA
-TAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00194</identifier>
- <name>Carb_anhydrase</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydro-lyase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>carbonate dehydratase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>lyase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transition metal ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>zinc ion binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>carbon-oxygen lyase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>one-carbon compound metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular metabolism</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="4">
- <id>BE0000732</id>
- <name>Sodium/potassium-transporting ATPase subunit alpha-1</name>
- <organism>Human</organism>
- <actions>
- <action>other</action>
- </actions>
- <references># Lawrence CL, Rainbow RD, Davies NW, Standen NB: Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels. Br J Pharmacol. 2002 Jul;136(5):746-52. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12086984
-# Guo W, Chen N, Chen Y, Xia Q, Shen Y: Activation of Mitochondrial ATP-Sensitive Potassium Channel Contributes to Protective Effect in Prolonged Myocardial Preservation. Conf Proc IEEE Eng Med Biol Soc. 2005;4:4027-30. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17281115
-# Comelli M, Metelli G, Mavelli I: Downmodulation of mitochondrial F0F1 ATP synthase by diazoxide in cardiac myoblasts: a dual effect of the drug. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H820-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17287451</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P05023">
- <name>Sodium/potassium-transporting ATPase subunit alpha-1</name>
- <general-function>Inorganic ion transport and metabolism</general-function>
- <specific-function>This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients</specific-function>
- <gene-name>ATP1A1</gene-name>
- <locus>1p21</locus>
- <cellular-location>Membrane; multi-pass membrane protein</cellular-location>
- <transmembrane-regions>88-108
-132-152
-289-308
-321-338
-773-792
-803-823
-844-866
-919-938
-952-970
-986-1006</transmembrane-regions>
- <theoretical-pi>5.15</theoretical-pi>
- <molecular-weight>112897.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:799</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>ATP1A1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>ATP1A1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>D00099</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>219942</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P05023</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>EC 3.6.3.9</synonym>
- <synonym>Na(+)/K(+) ATPase alpha-1 subunit</synonym>
- <synonym>Sodium pump subunit alpha 1</synonym>
- <synonym>Sodium/potassium-transporting ATPase alpha-1 chain precursor</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Sodium/potassium-transporting ATPase alpha-1 chain precursor
-MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLS
-RGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAA
-TEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSI
-NAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETR
-NIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAV
-FLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKN
-LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLA
-LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEI
-PFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQN
-AYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVP
-DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDA
-KACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVN
-DSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL
-TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPK
-TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVED
-SYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE
-ETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKE
-TYY</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>3072 bp
-ATGGGGAAGGGGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGAT
-AAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCT
-ATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGC
-CGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTC
-ACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTC
-TCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCT
-ACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTA
-ATCATAACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCC
-TTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATA
-AATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCT
-GCTGACCTCAGAATCATATCTGCAAATGGCTGCAAGGTGGATAACTCCTCGCTCACTGGT
-GAATCAGAACCCCAGACTAGGTCTCCAGATTTCACAAATGAAAACCCCCTGGAGACGAGG
-AACATTGCCTTCTTTTCAACAAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTAC
-ACTGGGGATCGCACTGTGATGGGAAGAATTGCCACACTTGCTTCTGGGCTGGAAGGAGGC
-CAGACCCCCATTGCTGCAGAAATTGAACATTTTATCCACATCATCACGGGTGTGGCTGTG
-TTCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCT
-GTCATCTTCCTCATCGGTATCATCGTAGCCAATGTGCCGGAAGGTTTGCTGGCCACTGTC
-ACGGTCTGTCTGACACTTACTGCCAAACGCATGGCAAGGAAAAACTGCTTAGTGAAGAAC
-TTAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACT
-CTGACTCAGAACCGGATGACAGTGGCCCACATGTGGTTTGACAATCAAATCCATGAAGCT
-GATACGACAGAGAATCAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCT
-CTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTA
-CCTATTCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATA
-GAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATA
-CCCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAG
-CCCCAACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCT
-ATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAAC
-GCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTG
-CCAGATGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATC
-GATAATCTGTGCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCT
-GATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCAT
-CCAATCACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACC
-GTGGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCC
-AAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGAC
-ATTTTGAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATC
-ATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAAT
-GACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGAT
-GTGTCCAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACT
-GGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTA
-ACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTA
-CCACTGGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGTTCCTGCCATC
-TCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAA
-ACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATC
-CAGGCCCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCA
-ATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGAC
-AGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACA
-GCCTTCTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGG
-AGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAA
-GAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATG
-TATCCCCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTA
-TATGACGAAGTCAGAAAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAA
-ACCTACTATTAG</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00689</identifier>
- <name>Cation_ATPase_C</name>
- </pfam>
- <pfam>
- <identifier>PF00690</identifier>
- <name>Cation_ATPase_N</name>
- </pfam>
- <pfam>
- <identifier>PF00122</identifier>
- <name>E1-E2_ATPase</name>
- </pfam>
- <pfam>
- <identifier>PF00702</identifier>
- <name>Hydrolase</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>intrinsic to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>integral to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>monovalent inorganic cation transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>nucleotide binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ATP binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>purine nucleotide binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>adenyl nucleotide binding</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>hydrolase activity, acting on acid anhydrides</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>ion transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cation transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>monovalent inorganic cation transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="5">
- <id>BE0000553</id>
- <name>Calcium-activated potassium channel subunit alpha-1</name>
- <organism>Human</organism>
- <actions>
- <action>other</action>
- </actions>
- <references># Klockner U, Trieschmann U, Isenberg G: Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells. Arzneimittelforschung. 1989 Jan;39(1A):120-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2541731
-# O'Malley D, Shanley LJ, Harvey J: Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels. Neuropharmacology. 2003 Jun;44(7):855-63. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12726817
-# Zhang L, Li X, Zhou R, Xing G: Possible role of potassium channel, big K in etiology of schizophrenia. Med Hypotheses. 2006;67(1):41-3. Epub 2006 Jan 30. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16446048</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="Q12791">
- <name>Calcium-activated potassium channel subunit alpha-1</name>
- <general-function>Inorganic ion transport and metabolism</general-function>
- <specific-function>Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)</specific-function>
- <gene-name>KCNMA1</gene-name>
- <locus>10q22.3</locus>
- <cellular-location>Membrane; multi-pass membrane protein</cellular-location>
- <transmembrane-regions>87-107
-179-199
-215-235
-240-260
-265-285
-301-321
-368-388</transmembrane-regions>
- <theoretical-pi>7.07</theoretical-pi>
- <molecular-weight>137561.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:6284</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>KCNMA1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>KCNMA1</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>U13913</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>537439</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>Q12791</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>BK channel</synonym>
- <synonym>BKCA alpha</synonym>
- <synonym>Calcium-activated potassium channel, subfamily M subunit alpha 1</synonym>
- <synonym>hSlo</synonym>
- <synonym>K(VCA)alpha</synonym>
- <synonym>KCa1.1</synonym>
- <synonym>Maxi K channel</synonym>
- <synonym>MaxiK</synonym>
- <synonym>Slo homolog</synonym>
- <synonym>Slo-alpha</synonym>
- <synonym>Slo1</synonym>
- <synonym>Slowpoke homolog</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Calcium-activated potassium channel subunit alpha 1
-MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS
-VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH
-CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
-VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL
-WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL
-VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
-KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES
-VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK
-IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW
-NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE
-MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG
-FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERD
-CSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPN
-TSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSG
-HVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVS
-ILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIG
-VLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDD
-DPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEEN
-ALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRL
-RDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSS
-KKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>3639 bp
-ATGAGTAGCAATATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCCTCC
-TCCTCTTCCTCTTCTTCTTCTTCCTCCTCCTCTTCCTCCTCGTCCTCGGTCCACGAGCCC
-AAGATGGATGCGCTCATCATCCCGGTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAA
-CGCATGTGGTGGGCTTTCCTGGCCTCCTCCATGGTGACTTTCTTCGGGGGCCTCTTCATC
-ATCTTGCTCTGGCGGACGCTCAAGTACCTGTGGACCGTGTGCTGCCACTGCGGGGGCAAG
-ACGAAGGAGGCCCAGAAGATTAACAATGGCTCAAGCCAGGCGGATGGCACTCTCAAACCA
-GTGGATGAAAAAGAGGAGGCAGTGGCCGCCGAGGTCGGCTGGATGACCTCCGTGAAGGAC
-TGGGCGGGGGTGATGATATCCGCCCAGACACTGACTGGCAGAGTCCTGGTTGTCTTAGTC
-TTTGCTCTCAGCATCGGTGCACTTGTAATATACTTCATAGATTCATCAAACCCAATAGAA
-TCCTGCCAGAATTTCTACAAAGATTTCACATTACAGATCGACATGGCTTTCAACGTGTTC
-TTCCTTCTCTACTTCGGCTTGCGGTTTATTGCAGCCAACGATAAATTGTGGTTCTGGCTG
-GAAGTGAACTCTGTAGTGGATTTCTTCACGGTGCCCCCCGTGTTTGTGTCTGTGTACTTA
-AACAGAAGTTGGCTTGGTTTGAGATTTTTAAGAGCTCTGAGACTGATACAGTTTTCAGAA
-ATTTTGCAGTTTCTGAATATTCTTAAAACAAGTAATTCCATCAAGCTGGTGAATCTGCTC
-TCCATATTTATCAGCACGTGGCTGACTGCAGCCGGGTTCATCCATTTGGTGGAGAATTCA
-GGGGACCCATGGGAAAATTTCCAAAACAACCAGGCTCTCACCTACTGGGAATGTGTCTAT
-TTACTCATGGTCACAATGTCCACCGTTGGTTATGGGGATGTTTATGCAAAAACCACACTT
-GGGCGCCTCTTCATGGTCTTCTTCATCCTCGGGGGACTGGCCATGTTTGCCAGCTACGTC
-CCTGAAATCATAGAGTTAATAGGAAACCGCAAGAAATACGGGGGCTCCTATAGTGCGGTT
-AGTGGAAGAAAGCACATTGTGGTCTGCGGACACATCACTCTGGAGAGTGTTTCCAACTTC
-CTGAAGGACTTTCTGCACAAGGACCGGGATGACGTCAATGTGGAGATCGTTTTTCTTCAC
-AACATCTCCCCCAACCTGGAGCTTGAAGCTCTGTTCAAACGACATTTTACTCAGGTGGAA
-TTTTATCAGGGTTCCGTCCTCAATCCACATGATCTTGCAAGAGTCAAGATAGAGTCAGCA
-GATGCATGCCTGATCCTTGCCAACAAGTACTGCGCTGACCCGGATGCGGAGGATGCCTCG
-AATATCATGAGAGTAATCTCCATAAAGAACTACCATCCGAAGATAAGAATCATCACTCAA
-ATGCTGCAGTATCACAACAAGGCCCATCTGCTAAACATCCCGAGCTGGAATTGGAAAGAA
-GGTGATGACGCAATCTGCCTCGCAGAGTTGAAGTTGGGCTTCATAGCCCAGAGCTGCCTG
-GCTCAAGGCCTCTCCACCATGCTTGCCAACCTCTTCTCCATGAGGTCATTCATAAAGATT
-GAGGAAGACACATGGCAGAAATACTACTTGGAAGGAGTCTCAAATGAAATGTACACAGAA
-TATCTCTCCAGTGCCTTCGTGGGTCTGTCCTTCCCTACTGTTTGTGAGCTGTGTTTTGTG
-AAGCTCAAGCTCCTAATGATAGCCATTGAGTACAAGTCTGCCAACCGAGAGAGCCGTATA
-TTAATTAATCCTGGAAACCATCTTAAGATCCAAGAAGGTACTTTAGGATTTTTCATCGCA
-AGTGATGCCAAAGAAGTTAAAAGGGCATTTTTTTACTGCAAGGCCTGTCATGATGACATC
-ACAGATCCCAAAAGAATAAAAAAATGTGGCTGCAAACGGCCCAAGATGTCCATCTACAAG
-AGAATGAGACGGGCATGTTGTTTTGATTGCGGACGTTCTGAGCGTGACTGCTCATGCATG
-TCAGGCCGTGTGCGTGGTAACGTGGACACCCTTGAGAGAGCCTTCCCACTTTCTTCTGTC
-TCTGTTAATGATTGCTCCACCAGTTTCCGTGCCTTTGAAGATGAGCAGCCGTCAACACTA
-TCACCAAAAAAAAAGCAACGGAATGGAGGCATGCGGAACTCACCCAACACCTCGCCTAAG
-CTGATGAGGCATGACCCCTTGTTAATTCCTGGCAATGATCAGATTGACAACATGGACTCC
-AATGTGAAGAAGTACGACTCTACTGGGATGTTTCACTGGTGTGCACCCAAGGAGATAGAG
-AAAGTCATCCTGACTCGAAGTGAAGCTGCCATGACCGTCCTGAGTGGCCATGTCGTGGTC
-TGCATCTTTGGCGACGTCAGCTCAGCCCTGATCGGCCTCCGGAACCTGGTGATGCCGCTC
-CGTGCCAGCAACTTTCATTACCATGAGCTCAAGCACATTGTGTTTGTGGGCTCTATTGAG
-TACCTCAAGCGGGAATGGGAGACGCTTCATAACTTCCCCAAAGTGTCCATATTGCCTGGT
-ACGCCATTAAGTCGGGCTGATTTAAGGGCTGTCAACATCAACCTCTGTGACATGTGCGTT
-ATCCTGTCAGCCAATCAGAATAATATTGATGATACTTCGCTGCAGGACAAGGAATGCATC
-TTGGCGTCACTCAACATCAAATCTATGCAGTTTGATGACAGCATCGGAGTCTTGCAGGCT
-AATTCCCAAGGGTTCACACCTCCAGGAATGGATAGATCCTCTCCAGATAACAGCCCAGTG
-CACGGGATGTTACGTCAACCATCCATCACAACTGGGGTCAACATCCCCATCATCACTGAA
-CTAGTGAACGATACTAATGTTCAGTTTTTGGACCAAGACGATGATGATGACCCTGATACA
-GAACTGTACCTCACGCAGCCCTTTGCCTGTGGGACAGCATTTGCCGTCAGTGTCCTGGAC
-TCACTCATGAGCGCGACGTACTTCAATGACAATATCCTCACCCTGATACGGACCCTGGTG
-ACCGGAGGAGCCACGCCGGAGCTGGAGGCTCTGATTGCTGAGGAAAACGCCCTTAGAGGT
-GGCTACAGCACCCCGCAGACACTGGCCAATAGGGACCGCTGCCGCGTGGCCCAGTTAGCT
-CTGCTCGATGGGCCATTTGCGGACTTAGGGGATGGTGGTTGTTATGGTGATCTGTTCTGC
-AAAGCTCTGAAAACATATAATATGCTTTGTTTTGGAATTTACCGGCTGAGAGATGCTCAC
-CTCAGCACCCCCAGTCAGTGCACAAAGAGGTATGTCATCACCAACCCGCCCTATGAGTTT
-GAGCTCGTGCCGACGGACCTGATCTTCTGCTTAATGCAGTTTGACCACAATGCCGGCCAG
-TCCCGGGCCAGCCTGTCCCATTCCTCCCACTCGTCGCAGTCCTCCAGCAAGAAGAGCTCC
-TCTGTTCACTCCATCCCATCCACAGCAAACCGACAGAACCGGCCCAAGTCCAGGGAGTCC
-CGGGACAAACAGAAGTACGTGCAGGAAGAGCGGCTTTGA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00520</identifier>
- <name>Ion_trans</name>
- </pfam>
- <pfam>
- <identifier>PF03493</identifier>
- <name>BK_channel_a</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>protein complex</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>voltage-gated potassium channel complex</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>voltage-gated potassium channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>potassium channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>calcium-activated potassium channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>voltage-gated ion channel activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>monovalent inorganic cation transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>potassium ion transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>ion transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cation transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- <target position="6">
- <id>BE0000419</id>
- <name>Solute carrier family 12 member 3</name>
- <organism>Human</organism>
- <actions>
- <action>unknown</action>
- </actions>
- <references># Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
-# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P55017">
- <name>Solute carrier family 12 member 3</name>
- <general-function>Involved in transporter activity</general-function>
- <specific-function>Electrically silent transporter system. Mediates sodium and chloride reabsorption</specific-function>
- <gene-name>SLC12A3</gene-name>
- <locus>16q13</locus>
- <cellular-location>Membrane; multi-pass membrane protein</cellular-location>
- <transmembrane-regions>136-156
-159-179
-219-239
-262-282
-287-307
-340-360
-378-398
-453-473
-512-532
-535-555
-578-598
-661-681</transmembrane-regions>
- <theoretical-pi>7.94</theoretical-pi>
- <molecular-weight>113140.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:10912</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>SLC12A3</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>SLC12A3</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>U44128</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>1172161</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P55017</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Na-Cl symporter</synonym>
- <synonym>Thiazide-sensitive sodium-chloride cotransporter</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Solute carrier family 12 member 3
-MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT
-IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG
-EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
-VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE
-TVRDLLQEYGAPIVDPINDIRIIGVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY
-LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI
-SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA
-CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
-QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY
-ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL
-LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD
-FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG
-VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFEFNYGVCVMRMREGL
-NVSKMMQAHINPVFDPAEDGKEASARVDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDG
-GLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHILPDIN
-QNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKSLRQVRLN
-EIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYC
-Q</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>3093 bp
-ATGGCAGAACTGCCCACAACAGAGACGCCTGGGGACGCCACTTTGTGCAGCGGGCGCTTC
-ACCATCAGCACACTGCTGAGCAGTGATGAGCCCTCTCCACCAGCTGCCTATGACAGCAGC
-CACCCCAGCCACCTGACCCACAGCAGCACCTTCTGCATGCGCACCTTTGGCTACAACACG
-ATCGATGTGGTGCCCACATATGAGCACTATGCCAACAGCACCCAGCCTGGTGAGCCCCGG
-AAGGTCCGGCCCACACTGGCTGACCTGCACTCCTTCCTCAAGCAGGAAGGCAGACACCTG
-CATGCCCTGGCCTTTGACAGCCGGCCCAGCCACGAGATGACTGATGGGCTGGTGGAGGGC
-GAGGCAGGCACCAGCAGCGAGAAGAACCCCGAGGAGCCAGTGCGCTTCGGCTGGGTCAAG
-GGGGTGATGATTCGTTGCATGCTCAACATTTGGGGCGTGATCCTCTACCTGCGGCTGCCC
-TGGATTACGGCCCAGGCAGGCATCGTCCTGACCTGGATCATCATCCTGCTGTCGGTCACG
-GTGACCTCCATCACAGGCCTCTCCATCTCAGCCATCTCCACCAATGGCAAGGTCAAGTCA
-GGTGGCACCTACTTCCTCATCTCCCGGAGTCTGGGCCCAGAGCTTGGGGGCTCCATCGGC
-CTCATTTTCGCTTTCGCCAATGCCGTGGGTGTGGCCATGCACACGGTGGGCTTTGCAGAG
-ACCGTGCGGGACCTGCTCCAGGAGTATGGGGCACCCATCGTGGACCCCATTAACGACATC
-CGCATCATTGGCGTGGTCTCGGTCACTGTGCTGCTGGCCATCTCCCTGGCTGGCATGGAG
-TGGGAGTCCAAGGCCCAGGTGCTGTTCTTCCTTGTCATCATGGTCTCCTTTGCCAACTAT
-TTAGTGGGGACGCTGATCCCCCCATCTGAGGACAAGGCCTCCAAGGGCTTCTTCAGCTAC
-CGGGCGGACATTTTTGTCCAGAACTTGGTGCCTGACTGGCGGGGTCCAGATGGCACCTTC
-TTCGGAATGTTCTCCATCTTCTTCCCCTCGGCCACAGGCATCCTGGCAGGGGCCAACATA
-TCTGGTGACCTCAAGGACCCTGCTATAGCCATCCCCAAGGGGACCCTCATGGCCATTTTC
-TGGACGACCATTTCCTACCTGGCCATCTCAGCCACCATTGGCTCCTGCGTGGTGCGTGAT
-GCCTCTGGGGTCCTGAATGACACAGTGACCCCTGGCTGGGGTGCCTGCGAGGGGCTGGCC
-TGCAGCTATGGCTGGAACTTCACCGAGTGCACCCAGCAGCACAGCTGCCACTACGGCCTC
-ATCAACTATTACCAGACCATGAGCATGGTGTCAGGCTTCGCGCCCCTGATCACGGCTGGC
-ATCTTCGGGGCCACCCTCTCCTCTGCCCTGGCCTGCCTTGTCTCTGCTGCCAAAGTCTTC
-CAGTGCCTTTGCGAGGACCAGCTGTACCCACTGATCGGCTTCTTCGGCAAAGGCTATGGC
-AAGAACAAGGAGCCCGTGCGTGGCTACCTGCTGGCCTACGCCATCGCTGTGGCCTTCATC
-ATCATCGCTGAGCTCAACACCATAGCCCCCATCATTTCCAACTTCTTCCTCTGCTCCTAT
-GCCCTCATCAACTTCAGCTGCTTCCACGCCTCCATCACCAACTCGCCTGGGTGGAGACCT
-TCATTCCAATACTACAACAAGTGGGCGGCGCTGTTTGGGGCTATCATCTCCGTGGTCATC
-ATGTTCCTCCTCACCTGGTGGGCGGCCCTCATCGCCATTGGCGTGGTGCTCTTCCTCCTG
-CTCTATGTCATCTACAAGAAGCCAGAGGTAAATTGGGGCTCCTCGGTACAGGCTGGCTCC
-TACAACCTGGCCCTCAGCTACTCGGTGGGCCTCAATGAGGTGGAAGACCACATCAAGAAC
-TACCGCCCCCAGTGCCTGGTGCTCACGGGGCCCCCCAACTTCCGCCCGGCCCTGGTGGAC
-TTTGTGGGCACCTTCACCCGGAACCTCAGCCTGATGATCTGTGGCCACGTGCTCATCGGA
-CCCCACAAGCAGAGGATGCCTGAGCTCCAGCTCATCGCCAACGGGCACACCAAGTGGCTG
-AACAAGAGGAAGATCAAGGCCTTCTACTCGGATGTCATTGCCGAGGACCTCCGCAGAGGC
-GTCCAGATCCTCATGCAGGCCGCAGGTCTCGGGAGAATGAAGCCCAACATTCTGGTGGTT
-GGGTTCAAGAAGAACTGGCAGTCGGCTCACCCGGCCACAGTGGAAGACTACATTGGCATC
-CTCCATGATGCCTTTGAGTTCAACTATGGCGTGTGTGTCATGAGGATGCGGGAGGGACTC
-AACGTGTCCAAGATGATGCAGGCGCACATTAACCCCGTGTTTGACCCAGCGGAGGACGGG
-AAGGAAGCCAGCGCCAGAGGTGCCAGGCCATCAGTCTCTGGCGCTTTGGACCCCAAGGCC
-CTGGTGAAGGAGGAGCAGGCCACCACCATCTTCCAGTCGGAGCAGGGCAAGAAGACCATA
-GACATCTACTGGCTCTTTGACGATGGAGGCCTCACCCTCCTCATTCCCTATCTCCTTGGC
-CGCAAGAGGAGGTGGAGCAAATGCAAGATCCGTGTGTTCGTAGGCGGCCAGATTAACAGG
-ATGGACCAGGAGAGAAAGGCGATCATTTCTCTGCTGAGCAAGTTCCGACTGGGATTCCAT
-GAAGTCCACATCCTCCCTGACATCAACCAGAACCCTCGGGCTGAGCACACCAAGAGGTTT
-GAGGACATGATTGCACCCTTCCGTCTGAATGATGGCTTCAAGGATGAGGCCACTGTCAAC
-GAGATGCGGCGGGACTGCCCCTGGAAGATCTCAGATGAGGAGATTACGAAGAACAGAGTC
-AAGTCCCTTCGGCAGGTGAGGCTGAATGAGATTGTGCTGGATTACTCCCGAGACGCTGCT
-CTCATCGTCATCACTTTGCCCATAGGGAGGAAGGGGAAGTGCCCCAGCTCGCTGTACATG
-GCCTGGCTGGAGACCCTGTCCCAGGACCTCAGACCTCCAGTCATCCTGATCCGAGGAAAC
-CAGGAAAACGTGCTCACCTTTTACTGCCAGTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00324</identifier>
- <name>AA_permease</name>
- </pfam>
- <pfam>
- <identifier>PF08403</identifier>
- <name>AA_permease_N</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>intrinsic to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>integral to membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>anion:cation symporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation:chloride symporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>monovalent inorganic cation transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>sodium ion transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>anion transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>inorganic anion transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>ion transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cation transport</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>chloride transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- </targets>
- <enzymes>
- <enzyme position="7">
- <id>BE0002240</id>
- <name>Glutamine synthetase</name>
- <organism>Human</organism>
- <actions>
- <action>inhibitor</action>
- </actions>
- <references># Velloso LA, Bjork E, Ballagi AE, Funa K, Andersson A, Kampe O, Karlsson FA, Eizirik DL: Regulation of GAD expression in islets of Langerhans occurs both at the mRNA and protein level. Mol Cell Endocrinol. 1994 Jun;102(1-2):31-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7926271:1</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P15104">
- <name>Glutamine synthetase</name>
- <general-function>Amino acid transport and metabolism</general-function>
- <specific-function>ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine</specific-function>
- <gene-name>GLUL</gene-name>
- <locus>1q31</locus>
- <cellular-location>Cytoplasm</cellular-location>
- <transmembrane-regions>None</transmembrane-regions>
- <theoretical-pi>6.88</theoretical-pi>
- <molecular-weight>42065.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>HUGO Gene Nomenclature Committee (HGNC)</resource>
- <identifier>HGNC:4341</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenAtlas</resource>
- <identifier>GLUL</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GeneCards</resource>
- <identifier>GLUL</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>Y00387</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>31833</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P15104</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>EC 6.3.1.2</synonym>
- <synonym>Glutamate--ammonia ligase</synonym>
- <synonym>GS</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Glutamine synthetase
-MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEW
-NFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRI
-MDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHY
-RACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDP
-KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
-TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL
-LNETGDEPFQYKN</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1122 bp
-ATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTG
-CCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTG
-CGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGG
-AATTTCGATGGCTCCAGTACTTTACAGTCTGAGGGTTCCAACAGTGACATGTATCTCGTG
-CCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCTAACAAGCTGGTGTTATGTGAA
-GTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATA
-ATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAGTATACCCTCATG
-GGGACAGATGGGCACCCCTTTGGTTGGCCTTCCAACGGCTTCCCAGGGCCCCAGGGTCCA
-TATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTAC
-CGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCC
-CAGTGGGAATTTCAGATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTG
-GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCT
-AAGCCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCC
-ATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGG
-CACCAGTACCACATCCGTGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGTCTA
-ACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGGTGGTGTAGCCAATCGTAGC
-GCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGATCGT
-CGCCCCTCTGCCAACTGCGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTT
-CTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAATTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00120</identifier>
- <name>Gln-synt_C</name>
- </pfam>
- <pfam>
- <identifier>PF03951</identifier>
- <name>Gln-synt_N</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ammonia ligase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>catalytic activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>glutamate-ammonia ligase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ligase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ligase activity, forming carbon-nitrogen bonds</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>acid-ammonia (or amide) ligase activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>nitrogen compound metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>glutamine biosynthesis</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>amino acid metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>amino acid and derivative metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>glutamine family amino acid metabolism</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>glutamine metabolism</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </enzyme>
- </enzymes>
- <carriers/>
- <transporters/>
-</drug><drug type="small molecule" created="2005-06-13 07:24:05 -0600" updated="2013-09-16 17:16:06 -0600" version="4.0">
- <drugbank-id>DB01828</drugbank-id>
- <name>Methylamine</name>
- <description/>
- <cas-number>74-89-5</cas-number>
- <general-references/>
- <synthesis-reference>Charles Pigerol, Pierre Eymard, Jean-Claude Vernieres, Jean-Pierre Werbenec, "Active derivatives of methylamine, therapeutic compositions containing the same and processes for preparing the said derivatives and compositions." U.S. Patent US4026925, issued March, 1956.</synthesis-reference>
- <indication/>
- <pharmacology/>
- <mechanism-of-action/>
- <toxicity/>
- <biotransformation/>
- <absorption/>
- <half-life/>
- <protein-binding/>
- <route-of-elimination/>
- <volume-of-distribution/>
- <clearance/>
- <secondary-accession-numbers>
- <secondary-accession-number>EXPT02363</secondary-accession-number>
- </secondary-accession-numbers>
- <groups>
- <group>experimental</group>
- </groups>
- <taxonomy>
- <kingdom/>
- <substructures/>
- </taxonomy>
- <synonyms/>
- <salts/>
- <brands/>
- <mixtures/>
- <packagers/>
- <manufacturers/>
- <prices/>
- <categories/>
- <affected-organisms/>
- <dosages/>
- <atc-codes/>
- <ahfs-codes/>
- <patents/>
- <food-interactions/>
- <drug-interactions/>
- <calculated-properties>
- <property>
- <kind>logP</kind>
- <value>-1.1</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>logS</kind>
- <value>1.07</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>Water Solubility</kind>
- <value>3.67e+02 g/l</value>
- <source>ALOGPS</source>
- </property>
- <property>
- <kind>logP</kind>
- <value>-0.63</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>IUPAC Name</kind>
- <value>methanamine</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Traditional IUPAC Name</kind>
- <value>methylamine</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Weight</kind>
- <value>31.0571</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Monoisotopic Weight</kind>
- <value>31.042199165</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>SMILES</kind>
- <value>CN</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Formula</kind>
- <value>CH5N</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChI</kind>
- <value>InChI=1S/CH5N/c1-2/h2H2,1H3</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChIKey</kind>
- <value>InChIKey=BAVYZALUXZFZLV-UHFFFAOYSA-N</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polar Surface Area (PSA)</kind>
- <value>26.02</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Refractivity</kind>
- <value>9.92</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polarizability</kind>
- <value>3.86</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Rotatable Bond Count</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Acceptor Count</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Donor Count</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>pKa (strongest basic)</kind>
- <value>10.08</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Physiological Charge</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Number of Rings</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Bioavailability</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Rule of Five</kind>
- <value>true</value>
- <source>ChemAxon</source>
- </property>
- </calculated-properties>
- <experimental-properties>
- <property>
- <kind>Water Solubility</kind>
- <value>1.08E+006 mg/L (at 25 °C)</value>
- <source>SCHWEIZER,AE ET AL. (1978)</source>
- </property>
- <property>
- <kind>Melting Point</kind>
- <value>-93.4 °C</value>
- <source>PhysProp</source>
- </property>
- <property>
- <kind>Boiling Point</kind>
- <value>-6.3 °C</value>
- <source>PhysProp</source>
- </property>
- <property>
- <kind>logP</kind>
- <value>-0.57</value>
- <source>HANSCH,C ET AL. (1995)</source>
- </property>
- <property>
- <kind>pKa</kind>
- <value>10.6</value>
- <source>DEAN,JA (1987)</source>
- </property>
- </experimental-properties>
- <external-identifiers>
- <external-identifier>
- <resource>ChEBI</resource>
- <identifier>16830</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PubChem Compound</resource>
- <identifier>6329</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PubChem Substance</resource>
- <identifier>46507449</identifier>
- </external-identifier>
- <external-identifier>
- <resource>KEGG Compound</resource>
- <identifier>C00218</identifier>
- </external-identifier>
- <external-identifier>
- <resource>ChemSpider</resource>
- <identifier>6089</identifier>
- </external-identifier>
- <external-identifier>
- <resource>PDB</resource>
- <identifier>NME</identifier>
- </external-identifier>
- <external-identifier>
- <resource>Wikipedia</resource>
- <identifier>Methylamine</identifier>
- </external-identifier>
- </external-identifiers>
- <external-links/>
- <targets>
- <target>
- <id>BE0001338</id>
- <name>Ammonia channel</name>
- <organism>Escherichia coli (strain K12)</organism>
- <actions/>
- <references># Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17139284
-# Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17016423</references>
- <known-action>unknown</known-action>
- <components>
- <polypeptide id="P69681">
- <name>Ammonia channel</name>
- <general-function>Inorganic ion transport and metabolism</general-function>
- <specific-function>Involved in the uptake of ammonia</specific-function>
- <gene-name>amtB</gene-name>
- <locus/>
- <cellular-location>Cell inner membrane; multi-pass membrane protein</cellular-location>
- <transmembrane-regions>29-55
-60-90
-119-141
-147-170
-185-203
-216-242
-246-275
-280-294
-303-328
-333-354
-370-402</transmembrane-regions>
- <theoretical-pi>7.17</theoretical-pi>
- <molecular-weight>44515.0</molecular-weight>
- <chromosome-location/>
- <external-identifiers>
- <external-identifier>
- <resource>GenBank Gene Database</resource>
- <identifier>U40429</identifier>
- </external-identifier>
- <external-identifier>
- <resource>GenBank Protein Database</resource>
- <identifier>1103924</identifier>
- </external-identifier>
- <external-identifier>
- <resource>UniProtKB</resource>
- <identifier>P69681</identifier>
- </external-identifier>
- </external-identifiers>
- <synonyms>
- <synonym>Ammonia channel precursor</synonym>
- <synonym>Ammonia transporter</synonym>
- </synonyms>
- <amino-acid-sequence>
- <fasta>>Ammonia channel precursor
-MKIATIKTGLASLAMLPGLVMAAPAVADKADNAFMMICTALVLFMTIPGIALFYGGLIRG
-KNVLSMLTQVTVTFALVCILWVVYGYSLAFGEGNNFFGNINWLMLKNIELTAVMGSIYQY
-IHVAFQGSFACITVGLIVGALAERIRFSAVLIFVVVWLTLSYIPIAHMVWGGGLLASHGA
-LDFAGGTVVHINAAIAGLVGAYLIGKRVGFGKEAFKPHNLPMVFTGTAILYIGWFGFNAG
-SAGTANEIAALAFVNTVVATAAAILGWIFGEWALRGKPSLLGACSGAIAGLVGVTPACGY
-IGVGGALIIGVVAGLAGLWGVTMLKRLLRVDDPCDVFGVHGVCGIVGCIMTGIFAASSLG
-GVGFAEGVTMGHQLLVQLESIAITIVWSGVVAFIGYKLADLTVGLRVPEEQEREGLDVNS
-HGENAYNA</fasta>
- </amino-acid-sequence>
- <gene-sequence>
- <fasta>>1287 bp
-ATGAAGATAGCGACGATAAAAACTGGGCTTGCTTCACTGGCGATGCTTCCGGGACTGGTA
-ATGGCTGCACCTGCGGTGGCCGATAAAGCCGACAATGCGTTTATGATGATTTGTACTGCG
-CTGGTGCTGTTTATGACTATTCCGGGGATTGCCCTGTTTTACGGTGGGTTGATTCGCGGC
-AAAAACGTGCTGTCGATGCTGACGCAGGTGACGGTGACATTTGCACTGGTCTGTATTCTC
-TGGGTGGTTTACGGTTACTCGCTGGCGTTTGGTGAGGGCAACAACTTCTTCGGCAACATT
-AACTGGTTGATGCTGAAAAACATCGAACTGACGGCGGTGATGGGCAGCATTTATCAGTAT
-ATCCACGTGGCGTTTCAGGGATCGTTTGCCTGCATTACCGTCGGCTTGATAGTTGGGGCG
-CTGGCGGAACGAATCCGCTTCTCAGCTGTGTTGATTTTCGTGGTGGTATGGCTGACGCTC
-TCTTACATTCCGATTGCGCATATGGTGTGGGGCGGTGGTTTGCTGGCTTCTCACGGTGCG
-CTGGATTTCGCGGGTGGCACCGTGGTGCACATTAACGCCGCAATCGCCGGTCTGGTGGGC
-GCGTATCTGATAGGAAAACGCGTGGGCTTCGGTAAAGAGGCGTTTAAACCGCACAACCTG
-CCGATGGTCTTCACCGGGACTGCCATTCTCTATATCGGTTGGTTTGGCTTTAACGCCGGG
-TCAGCGGGCACGGCGAATGAAATCGCGGCACTGGCATTTGTGAATACTGTGGTCGCAACG
-GCGGCGGCAATTCTTGGCTGGATCTTCGGTGAATGGGCGCTGCGTGGTAAGCCTTCACTG
-CTGGGGGCGTGTTCTGGCGCGATTGCCGGTCTGGTCGGCGTGACGCCAGCCTGCGGCTAC
-ATTGGGGTTGGCGGCGCGTTGATTATCGGCGTGGTAGCTGGTCTGGCGGGCTTGTGGGGC
-GTTACCATGCTCAAACGCTTGCTGCGGGTGGATGATCCCTGCGATGTCTTCGGTGTGCAC
-GGCGTTTGTGGCATTGTCGGCTGTATCATGACCGGGATTTTTGCCGCCAGCTCGCTGGGC
-GGCGTGGGCTTCGCTGAAGGTGTGACGATGGGCCATCAGTTGCTGGTACAGCTGGAAAGC
-ATCGCCATTACGATCGTCTGGTCCGGTGTTGTGGCATTTATCGGCTACAAATTGGCGGAT
-CTGACGGTTGGTCTGCGTGTACCGGAAGAGCAGGAGCGAGAAGGGCTGGATGTCAACAGC
-CACGGCGAGAATGCCTATAACGCGTAA</fasta>
- </gene-sequence>
- <pfams>
- <pfam>
- <identifier>PF00909</identifier>
- <name>Ammonium_transp</name>
- </pfam>
- </pfams>
- <go-classifiers>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>cell</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>component</category>
- <description>membrane</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ion transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>cation transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>organic cation transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>function</category>
- <description>ammonium transporter activity</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>cellular physiological process</description>
- </go-classifier>
- <go-classifier>
- <id/>
- <category>process</category>
- <description>transport</description>
- </go-classifier>
- </go-classifiers>
- </polypeptide>
- </components>
- </target>
- </targets>
- <enzymes/>
- <carriers/>
- <transporters/>
-</drug><drug type="small molecule" created="2010-08-09 11:11:30 -0600" updated="2013-09-16 18:04:21 -0600" version="4.0">
- <drugbank-id>DB06723</drugbank-id>
- <name>Aluminum hydroxide</name>
- <description>Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. </description>
- <cas-number/>
- <general-references/>
- <synthesis-reference>Richard H. Goheen, William A. Nigro, Paul J. The, "Process for producing aluminum hydroxide of improved whiteness." U.S. Patent US4915930, issued November, 1933.</synthesis-reference>
- <indication>For relief of heartburn and acid indigestion. </indication>
- <pharmacology>Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. </pharmacology>
- <mechanism-of-action>Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO<sub>3</sub><sup>-</sup>) and prostaglandins.</mechanism-of-action>
- <toxicity/>
- <biotransformation>Not metabolized. </biotransformation>
- <absorption>Approximately 17-30% of the aluminum chloride formed is absorbed. </absorption>
- <half-life/>
- <protein-binding/>
- <route-of-elimination>Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function. </route-of-elimination>
- <volume-of-distribution/>
- <clearance/>
- <secondary-accession-numbers/>
- <groups>
- <group>approved</group>
- </groups>
- <taxonomy>
- <kingdom/>
- <substructures/>
- </taxonomy>
- <synonyms/>
- <salts/>
- <brands>
- <brand>AlternaGel</brand>
- <brand>Alu-Cap</brand>
- <brand>Amphojel</brand>
- </brands>
- <mixtures/>
- <packagers/>
- <manufacturers>
- <manufacturer generic="false">3m pharmaceuticals inc</manufacturer>
- <manufacturer generic="false">Wyeth</manufacturer>
- </manufacturers>
- <prices/>
- <categories/>
- <affected-organisms/>
- <dosages>
- <dosage>
- <form>Capsule</form>
- <route>Oral</route>
- <strength>475 mg</strength>
- </dosage>
- <dosage>
- <form>Suspension</form>
- <route>Oral</route>
- <strength>320 mg/5 ml</strength>
- </dosage>
- <dosage>
- <form>Suspension</form>
- <route>Oral</route>
- <strength>600 mg/5 ml</strength>
- </dosage>
- <dosage>
- <form>Tablet</form>
- <route>Oral</route>
- <strength>300 mg</strength>
- </dosage>
- <dosage>
- <form>Tablet, film coated</form>
- <route>Oral</route>
- <strength>600 mg</strength>
- </dosage>
- </dosages>
- <atc-codes/>
- <ahfs-codes>
- <ahfs-code>56:04</ahfs-code>
- </ahfs-codes>
- <patents/>
- <food-interactions/>
- <drug-interactions>
- <drug-interaction>
- <drug>DB02300</drug>
- <name>Calcipotriol</name>
- <description>Vitamin D Analogs may increase the serum concentration of Aluminum Hydroxide. Specifically, the absorption of aluminum may be increased, leading to increased serum aluminum concentrations. Avoid chronic and/or excessive use of aluminum and aluminum-containing products in patients who are also taking vitamin D analogs. Any patients consuming such a combination should be monitored closely for aluminum status and signs/symptoms of aluminum-related toxicities. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB00169</drug>
- <name>Cholecalciferol</name>
- <description>Vitamin D analogs such as cholecalciferol may increase the serum concentration of aluminum hydroxide. Specifically, the absorption of aluminum may be increased, leading to increased serum aluminum concentrations. Avoid chronic and/or excessive use of aluminum and aluminum-containing products in patients who are also taking vitamin D analogs. Any patients consuming such a combination should be monitored closely for aluminum status and signs/symptoms of aluminum-related toxicities. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB08826</drug>
- <name>Deferiprone</name>
- <description>Deferiprone may decrease gastrointestinal absorption by chelating to other ions. Interaction is significant so monitor closely. </description>
- </drug-interaction>
- <drug-interaction>
- <drug>DB06210</drug>
- <name>Eltrombopag</name>
- <description>Decreases levels of eltrombopag by GI absorption inhibition. </description>
- </drug-interaction>
- </drug-interactions>
- <calculated-properties>
- <property>
- <kind>logP</kind>
- <value>1.45</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>IUPAC Name</kind>
- <value>aluminium(3+) ion trioxidanide</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Traditional IUPAC Name</kind>
- <value>aluminium(3+) trihydroxide</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Weight</kind>
- <value>78.0036</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Monoisotopic Weight</kind>
- <value>77.989757403</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>SMILES</kind>
- <value>[OH-].[OH-].[OH-].[Al+3]</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Molecular Formula</kind>
- <value>AlH3O3</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChI</kind>
- <value>InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>InChIKey</kind>
- <value>InChIKey=WNROFYMDJYEPJX-UHFFFAOYSA-K</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polar Surface Area (PSA)</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Refractivity</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Polarizability</kind>
- <value>1.78</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Rotatable Bond Count</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Acceptor Count</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>H Bond Donor Count</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>pKa (strongest acidic)</kind>
- <value>15.7</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>pKa (strongest basic)</kind>
- <value>-1.8</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Physiological Charge</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Number of Rings</kind>
- <value>0</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Bioavailability</kind>
- <value>1</value>
- <source>ChemAxon</source>
- </property>
- <property>
- <kind>Rule of Five</kind>
- <value>true</value>
- <source>ChemAxon</source>
- </property>
- </calculated-properties>
- <experimental-properties/>
- <external-identifiers/>
- <external-links/>
- <targets/>
- <enzymes/>
- <carriers/>
- <transporters/>
-</drug>
-</drugs>