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minerva
core
Commits
1bdd52fc
Commit
1bdd52fc
authored
Sep 24, 2018
by
Piotr Gawron
Browse files
Merge branch '500-gene-variants-in-molart' into 'master'
Resolve "gene variants in molart" Closes
#500
See merge request
!420
parents
b7c2d52b
728cbe10
Pipeline
#6556
passed with stage
in 7 minutes and 26 seconds
Changes
8
Pipelines
4
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annotation/src/test/java/lcsb/mapviewer/annotation/cache/PermanentDatabaseLevelCacheTest.java
View file @
1bdd52fc
This diff is collapsed.
Click to expand it.
frontend-js/src/main/js/map/data/GeneVariant.js
View file @
1bdd52fc
...
...
@@ -9,7 +9,8 @@
* @param {string} javaObject.referenceGenomeType
* @param {string} javaObject.referenceGenomeVersion
* @param {string} javaObject.contig
* @param {null|number} [javaObject.allelFrequency]
* @param {string} [javaObject.aminoAcidChange]
* @param {null|string} [javaObject.allelFrequency]
* @param {null|string} [javaObject.variantIdentifier]
*
* @constructor
...
...
@@ -23,8 +24,25 @@ function GeneVariant(javaObject) {
this
.
setContig
(
javaObject
.
contig
);
this
.
setAllelFrequency
(
javaObject
.
allelFrequency
);
this
.
setVariantIdentifier
(
javaObject
.
variantIdentifier
);
this
.
setAminoAcidChange
(
javaObject
.
aminoAcidChange
);
}
/**
*
* @param {string} aminoAcidChange
*/
GeneVariant
.
prototype
.
setAminoAcidChange
=
function
(
aminoAcidChange
)
{
this
.
_aminoAcidChange
=
aminoAcidChange
;
};
/**
*
* @returns {string}
*/
GeneVariant
.
prototype
.
getAminoAcidChange
=
function
()
{
return
this
.
_aminoAcidChange
;
};
/**
*
* @param {number} position
...
...
@@ -91,13 +109,13 @@ GeneVariant.prototype.getContig = function () {
/**
*
* @param {
number
} allelFrequency
* @param {
string
} allelFrequency
*/
GeneVariant
.
prototype
.
setAllelFrequency
=
function
(
allelFrequency
)
{
if
(
allelFrequency
===
null
)
{
this
.
_allelFrequency
=
undefined
;
}
else
{
this
.
_allelFrequency
=
allelFrequency
;
this
.
_allelFrequency
=
parseFloat
(
allelFrequency
)
;
}
};
...
...
frontend-js/src/test/js/map/data/GeneVariant-test.js
View file @
1bdd52fc
...
...
@@ -5,6 +5,7 @@ var assert = require('assert');
describe
(
'
GeneVariant
'
,
function
()
{
it
(
"
constructor
"
,
function
()
{
// noinspection SpellCheckingInspection
var
data
=
{
position
:
12
,
originalDna
:
"
A
"
,
...
...
@@ -13,7 +14,8 @@ describe('GeneVariant', function () {
referenceGenomeVersion
:
"
v1
"
,
contig
:
"
1
"
,
allelFrequency
:
"
0.2
"
,
variantIdentifier
:
"
id
"
variantIdentifier
:
"
id
"
,
aminoAcidChange
:
"
LRRK2:NM_198578:exon1:c.T45C:p.T15T
"
};
var
variant
=
new
GeneVariant
(
data
);
assert
.
equal
(
variant
.
getPosition
(),
data
.
position
);
...
...
@@ -24,5 +26,6 @@ describe('GeneVariant', function () {
assert
.
equal
(
variant
.
getAllelFrequency
(),
data
.
allelFrequency
);
assert
.
equal
(
variant
.
getVariantIdentifier
(),
data
.
variantIdentifier
);
assert
.
equal
(
variant
.
getReferenceGenomeVersion
(),
data
.
referenceGenomeVersion
);
assert
.
equal
(
variant
.
getAminoAcidChange
(),
data
.
aminoAcidChange
);
});
});
model/src/main/java/lcsb/mapviewer/model/map/layout/GeneVariation.java
View file @
1bdd52fc
...
...
@@ -5,6 +5,8 @@ import java.util.ArrayList;
import
java.util.Collection
;
import
java.util.List
;
import
org.apache.log4j.Logger
;
import
lcsb.mapviewer.common.exception.NotImplementedException
;
import
lcsb.mapviewer.model.map.MiriamData
;
...
...
@@ -16,262 +18,289 @@ import lcsb.mapviewer.model.map.MiriamData;
*/
public
class
GeneVariation
implements
Serializable
{
/**
*
*/
private
static
final
long
serialVersionUID
=
1L
;
/**
* Variation position in the genome.
*/
private
Long
position
;
/**
* Original dna (from the reference genome).
*/
private
String
originalDna
;
/**
* Alternative dna (suggested by the variant).
*/
private
String
modifiedDna
;
/**
* Contig where variant was observed.
*/
private
String
contig
;
private
String
allelFrequency
;
private
String
variantIdentifier
;
/**
* Reference genome type.
*/
private
ReferenceGenomeType
referenceGenomeType
;
/**
* Version of the reference genome.
*/
private
String
referenceGenomeVersion
;
/**
* List of references connected to this variant.
*/
private
List
<
MiriamData
>
references
=
new
ArrayList
<>();
/**
* Constructor that creates copy of the {@link GeneVariation}.
*
* @param original
* original {@link GeneVariation}
*/
protected
GeneVariation
(
GeneVariation
original
)
{
this
.
setPosition
(
original
.
getPosition
());
this
.
setOriginalDna
(
original
.
getOriginalDna
());
this
.
setModifiedDna
(
original
.
getModifiedDna
());
this
.
setReferenceGenomeType
(
original
.
getReferenceGenomeType
());
this
.
setReferenceGenomeVersion
(
original
.
getReferenceGenomeVersion
());
this
.
addReferences
(
original
.
getReferences
());
this
.
setContig
(
original
.
getContig
());
this
.
setAllelFrequency
(
original
.
getAllelFrequency
());
this
.
setVariantIdentifier
(
original
.
getVariantIdentifier
());
}
/**
* Default constructor.
*/
public
GeneVariation
()
{
}
/**
* Adds references.
*
* @param references
* references to add
* @see #references
*/
private
void
addReferences
(
Collection
<
MiriamData
>
references
)
{
for
(
MiriamData
reference
:
references
)
{
addReference
(
reference
);
}
}
/**
* @return the position
* @see #position
*/
public
Long
getPosition
()
{
return
position
;
}
/**
* @param position
* the position to set
* @see #position
*/
public
void
setPosition
(
Long
position
)
{
this
.
position
=
position
;
}
/**
* @return the originalDna
* @see #originalDna
*/
public
String
getOriginalDna
()
{
return
originalDna
;
}
/**
* @param originalDna
* the originalDna to set
* @see #originalDna
*/
public
void
setOriginalDna
(
String
originalDna
)
{
this
.
originalDna
=
originalDna
;
}
/**
* @return the modifiedDna
* @see #modifiedDna
*/
public
String
getModifiedDna
()
{
return
modifiedDna
;
}
/**
* @param modifiedDna
* the modifiedDna to set
* @see #modifiedDna
*/
public
void
setModifiedDna
(
String
modifiedDna
)
{
this
.
modifiedDna
=
modifiedDna
;
}
/**
* @return the referenceGenomeType
* @see #referenceGenomeType
*/
public
ReferenceGenomeType
getReferenceGenomeType
()
{
return
referenceGenomeType
;
}
/**
* @param referenceGenomeType
* the referenceGenomeType to set
* @see #referenceGenomeType
*/
public
void
setReferenceGenomeType
(
ReferenceGenomeType
referenceGenomeType
)
{
this
.
referenceGenomeType
=
referenceGenomeType
;
}
/**
* @return the references
* @see #references
*/
public
List
<
MiriamData
>
getReferences
()
{
return
references
;
}
/**
* @return the referenceGenomeVersion
* @see #referenceGenomeVersion
*/
public
String
getReferenceGenomeVersion
()
{
return
referenceGenomeVersion
;
}
/**
* @param referenceGenomeVersion
* the referenceGenomeVersion to set
* @see #referenceGenomeVersion
*/
public
void
setReferenceGenomeVersion
(
String
referenceGenomeVersion
)
{
this
.
referenceGenomeVersion
=
referenceGenomeVersion
;
}
/**
* Adds reference.
*
* @param reference
* reference to add
* @see #references
*/
public
void
addReference
(
MiriamData
reference
)
{
this
.
references
.
add
(
reference
);
}
/**
* Creates copy of the object.
*
* @return copy of the object
*/
public
GeneVariation
copy
()
{
if
(
this
.
getClass
().
equals
(
GeneVariation
.
class
))
{
return
new
GeneVariation
(
this
);
}
else
{
throw
new
NotImplementedException
(
"Copy method not implemented for class: "
+
this
.
getClass
());
}
}
/**
* @return the contig
* @see #contig
*/
public
String
getContig
()
{
return
contig
;
}
/**
* @param contig
* the contig to set
* @see #contig
*/
public
void
setContig
(
String
contig
)
{
this
.
contig
=
contig
;
}
/**
* Sets {@link #position}.
*
* @param position
* new position value
*/
public
void
setPosition
(
int
position
)
{
this
.
position
=
(
long
)
position
;
}
/**
* @return the allelFrequency
* @see #allelFrequency
*/
public
String
getAllelFrequency
()
{
return
allelFrequency
;
}
/**
* @param allelFrequency
* the allelFrequency to set
* @see #allelFrequency
*/
public
void
setAllelFrequency
(
String
allelFrequency
)
{
this
.
allelFrequency
=
allelFrequency
;
}
/**
* @return the variantIdentifier
* @see #variantIdentifier
*/
public
String
getVariantIdentifier
()
{
return
variantIdentifier
;
}
/**
* @param variantIdentifier
* the variantIdentifier to set
* @see #variantIdentifier
*/
public
void
setVariantIdentifier
(
String
variantIdentifier
)
{
this
.
variantIdentifier
=
variantIdentifier
;
}
/**
* Default class logger.
*/
@SuppressWarnings
(
"unused"
)
private
static
Logger
logger
=
Logger
.
getLogger
(
GeneVariation
.
class
);
/**
*
*/
private
static
final
long
serialVersionUID
=
1L
;
/**
* Variation position in the genome.
*/
private
Long
position
;
/**
* Original DNA (from the reference genome).
*/
private
String
originalDna
;
/**
* Alternative DNA (suggested by the variant).
*/
private
String
modifiedDna
;
/**
* Contig where variant was observed.
*/
private
String
contig
;
/**
* Allel frequency of the variant.
*/
private
String
allelFrequency
;
/**
* Amino acid change for corresponding protein.
*/
private
String
aminoAcidChange
;
/**
* Gene variant id.
*/
private
String
variantIdentifier
;
/**
* Reference genome type.
*/
private
ReferenceGenomeType
referenceGenomeType
;
/**
* Version of the reference genome.
*/
private
String
referenceGenomeVersion
;
/**
* List of references connected to this variant.
*/
private
List
<
MiriamData
>
references
=
new
ArrayList
<>();
/**
* Constructor that creates copy of the {@link GeneVariation}.
*
* @param original
* original {@link GeneVariation}
*/
protected
GeneVariation
(
GeneVariation
original
)
{
this
.
setPosition
(
original
.
getPosition
());
this
.
setOriginalDna
(
original
.
getOriginalDna
());
this
.
setModifiedDna
(
original
.
getModifiedDna
());
this
.
setReferenceGenomeType
(
original
.
getReferenceGenomeType
());
this
.
setReferenceGenomeVersion
(
original
.
getReferenceGenomeVersion
());
this
.
addReferences
(
original
.
getReferences
());
this
.
setContig
(
original
.
getContig
());
this
.
setAllelFrequency
(
original
.
getAllelFrequency
());
this
.
setVariantIdentifier
(
original
.
getVariantIdentifier
());
this
.
setAminoAcidChange
(
original
.
getAminoAcidChange
());
}
/**
* Default constructor.
*/
public
GeneVariation
()
{
}
/**
* Adds references.
*
* @param references
* references to add
* @see #references
*/
private
void
addReferences
(
Collection
<
MiriamData
>
references
)
{
for
(
MiriamData
reference
:
references
)
{
addReference
(
reference
);
}
}
/**
* @return the position
* @see #position
*/
public
Long
getPosition
()
{
return
position
;
}
/**
* @param position
* the position to set
* @see #position
*/
public
void
setPosition
(
Long
position
)
{
this
.
position
=
position
;
}
/**
* @return the originalDna
* @see #originalDna
*/
public
String
getOriginalDna
()
{
return
originalDna
;
}
/**
* @param originalDna
* the originalDna to set
* @see #originalDna
*/
public
void
setOriginalDna
(
String
originalDna
)
{
this
.
originalDna
=
originalDna
;
}
/**
* @return the modifiedDna
* @see #modifiedDna
*/
public
String
getModifiedDna
()
{
return
modifiedDna
;
}
/**
* @param modifiedDna
* the modifiedDna to set
* @see #modifiedDna
*/
public
void
setModifiedDna
(
String
modifiedDna
)
{
this
.
modifiedDna
=
modifiedDna
;
}
/**
* @return the referenceGenomeType
* @see #referenceGenomeType
*/
public
ReferenceGenomeType
getReferenceGenomeType
()
{
return
referenceGenomeType
;
}
/**
* @param referenceGenomeType
* the referenceGenomeType to set
* @see #referenceGenomeType
*/
public
void
setReferenceGenomeType
(
ReferenceGenomeType
referenceGenomeType
)
{
this
.
referenceGenomeType
=
referenceGenomeType
;
}
/**
* @return the references
* @see #references
*/
public
List
<
MiriamData
>
getReferences
()
{
return
references
;
}
/**
* @return the referenceGenomeVersion
* @see #referenceGenomeVersion
*/
public
String
getReferenceGenomeVersion
()
{
return
referenceGenomeVersion
;
}
/**
* @param referenceGenomeVersion
* the referenceGenomeVersion to set
* @see #referenceGenomeVersion
*/
public
void
setReferenceGenomeVersion
(
String
referenceGenomeVersion
)
{
this
.
referenceGenomeVersion
=
referenceGenomeVersion
;
}
/**
* Adds reference.
*
* @param reference
* reference to add
* @see #references
*/
public
void
addReference
(
MiriamData
reference
)
{
this
.
references
.
add
(
reference
);
}
/**
* Creates copy of the object.
*
* @return copy of the object
*/
public
GeneVariation
copy
()
{
if
(
this
.
getClass
().
equals
(
GeneVariation
.
class
))
{
return
new
GeneVariation
(
this
);
}
else
{
throw
new
NotImplementedException
(
"Copy method not implemented for class: "
+
this
.
getClass
());
}
}
/**
* @return the contig
* @see #contig
*/
public
String
getContig
()
{
return
contig
;
}
/**
* @param contig
* the contig to set
* @see #contig
*/
public
void
setContig
(
String
contig
)
{
this
.
contig
=
contig
;
}
/**
* Sets {@link #position}.
*
* @param position
* new position value
*/
public
void
setPosition
(
int
position
)
{
this
.
position
=
(
long
)
position
;
}
/**
* @return the allelFrequency
* @see #allelFrequency
*/
public
String
getAllelFrequency
()
{
return
allelFrequency
;
}
/**