query=NADH&token=MOCK_TOKEN_ID& 238 KB
Newer Older
1
[{"bloodBrainBarrier":"YES","brandNames":[],"description":"NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed) ","id":"NADH","name":"NADH","references":[{"annotatorClassName":"","id":0,"link":"http://www.drugbank.ca/drugs/DB00157","resource":"DB00157","type":"DRUGBANK"}],"synonyms":[],"targets":[{"name":"D-beta-hydroxybutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A chemiluminescence-flow injection analysis of serum 3-hydroxybutyrate using a bioreactor consisting of 3-hydroxybutyrate dehydrogenase and NADH oxidase.","authors":["Tabata M"," Totani M."],"journal":"Analytical biochemistry","year":1995,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8533882","id":"8533882","citationCount":5,"stringAuthors":"Tabata M,  Totani M."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8533882","resource":"8533882","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coenzyme binding by 3-hydroxybutyrate dehydrogenase, a lipid-requiring enzyme: lecithin acts as an allosteric modulator to enhance the affinity for coenzyme.","authors":["Rudy B"," Dubois H"," Mink R"," Trommer WE"," McIntyre JO"," Fleischer S."],"journal":"Biochemistry","year":1989,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2550053","id":"2550053","citationCount":8,"stringAuthors":"Rudy B,  Dubois H,  Mink R,  Trommer WE,  McIntyre JO,  Fleischer S."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2550053","resource":"2550053","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate.","authors":["Smith CM"," Plaut GW."],"journal":"European journal of biochemistry","year":1979,"link":"https://www.ncbi.nlm.nih.gov/pubmed/38961","id":"38961","citationCount":21,"stringAuthors":"Smith CM,  Plaut GW."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/38961","resource":"38961","type":"PUBMED"}],"targetElements":[{"id":329170,"modelId":15781,"type":"ALIAS"}],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=BDH1","resource":"BDH1","type":"HGNC_SYMBOL"}]},{"name":"11-cis retinol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=RDH5","resource":"RDH5","type":"HGNC_SYMBOL"}]},{"name":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]","references":[{"annotatorClassName":"","article":{"title":"Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts.","authors":["Gao L"," He P"," Sha J"," Liu C"," Dai L"," Hui N"," Ni X."],"journal":"Endocrinology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17463062","id":"17463062","citationCount":12,"stringAuthors":"Gao L,  He P,  Sha J,  Liu C,  Dai L,  Hui N,  Ni X."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17463062","resource":"17463062","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HPGD","resource":"HPGD","type":"HGNC_SYMBOL"}]},{"name":"2-oxoglutarate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The tricarboxylic acid cycle, an ancient metabolic network with a novel twist.","authors":["Mailloux RJ"," Bériault R"," Lemire J"," Singh R"," Chénier DR"," Hamel RD"," Appanna VD."],"journal":"PloS one","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17668068","id":"17668068","citationCount":115,"stringAuthors":"Mailloux RJ,  Bériault R,  Lemire J,  Singh R,  Chénier DR,  Hamel RD,  Appanna VD."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17668068","resource":"17668068","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=OGDH","resource":"OGDH","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Affinity alkylation of human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase by 2 alpha-bromoacetoxyprogesterone: evidence for separate dehydrogenase and isomerase sites on one protein.","authors":["Thomas JL"," Myers RP"," Rosik LO"," Strickler RC."],"journal":"Journal of steroid biochemistry","year":1990,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2362440","id":"2362440","citationCount":8,"stringAuthors":"Thomas JL,  Myers RP,  Rosik LO,  Strickler RC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2362440","resource":"2362440","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Testicular and adrenal 3 beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase.","authors":["Ishii-Ohba H"," Inano H"," Tamaoki B."],"journal":"Journal of steroid biochemistry","year":1987,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2961942","id":"2961942","citationCount":10,"stringAuthors":"Ishii-Ohba H,  Inano H,  Tamaoki B."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2961942","resource":"2961942","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B1","resource":"HSD3B1","type":"HGNC_SYMBOL"}]},{"name":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testosterone biosynthesis by ethanol: multiple sites and mechanisms in dispersed Leydig cells.","authors":["Widenius TV"," Orava MM"," Vihko RK"," Ylikahri RH"," Eriksson CJ."],"journal":"Journal of steroid biochemistry","year":1987,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3476810","id":"3476810","citationCount":14,"stringAuthors":"Widenius TV,  Orava MM,  Vihko RK,  Ylikahri RH,  Eriksson CJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3476810","resource":"3476810","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Studies of the human testis. VII. Conversion of pregnenolone to progesterone.","authors":["Fan DF"," Troen P."],"journal":"The Journal of clinical endocrinology and metabolism","year":1975,"link":"https://www.ncbi.nlm.nih.gov/pubmed/239964","id":"239964","citationCount":19,"stringAuthors":"Fan DF,  Troen P."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/239964","resource":"239964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of coenzyme binding by human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase using 5'-[p-(fluorosulfonyl)benzoyl]adenosine, an affinity labeling cofactor analog.","authors":["Thomas JL"," Myers RP"," Strickler RC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1991,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1911436","id":"1911436","citationCount":3,"stringAuthors":"Thomas JL,  Myers RP,  Strickler RC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1911436","resource":"1911436","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD3B2","resource":"HSD3B2","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxy-3-methylglutaryl-coenzyme A reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Improved posthypoxic recovery in vitro on treatment with drugs used for secondary stroke prevention.","authors":["Huber R"," Riepe MW."],"journal":"Neuropharmacology","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15755483","id":"15755483","citationCount":1,"stringAuthors":"Huber R,  Riepe MW."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15755483","resource":"15755483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.","authors":["Hedl M"," Rodwell VW."],"journal":"Protein science : a publication of the Protein Society","year":2004,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15152097","id":"15152097","citationCount":10,"stringAuthors":"Hedl M,  Rodwell VW."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15152097","resource":"15152097","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"3-hydroxy-3-methylglutaryl-coenzyme A reductase in the lobster mandibular organ: regulation by the eyestalk.","authors":["Li S"," Wagner CA"," Friesen JA"," Borst DW."],"journal":"General and comparative endocrinology","year":2003,"link":"https://www.ncbi.nlm.nih.gov/pubmed/14511985","id":"14511985","citationCount":15,"stringAuthors":"Li S,  Wagner CA,  Friesen JA,  Borst DW."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/14511985","resource":"14511985","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HMGCR","resource":"HMGCR","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyacyl-CoA dehydrogenase type-2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B10","resource":"HSD17B10","type":"HGNC_SYMBOL"}]},{"name":"3-hydroxyisobutyrate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HIBADH","resource":"HIBADH","type":"HGNC_SYMBOL"}]},{"name":"3-keto-steroid reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B7","resource":"HSD17B7","type":"HGNC_SYMBOL"}]},{"name":"4-trimethylaminobutyraldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli.","authors":["Prieto MI"," Martin J"," Balaña-Fouce R"," Garrido-Pertierra A."],"journal":"Biochimie","year":1987,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3129020","id":"3129020","citationCount":7,"stringAuthors":"Prieto MI,  Martin J,  Balaña-Fouce R,  Garrido-Pertierra A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3129020","resource":"3129020","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and kinetic characterization of gamma-aminobutyraldehyde dehydrogenase from rat liver.","authors":["Testore G"," Colombatto S"," Silvagno F"," Bedino S."],"journal":"The international journal of biochemistry & cell biology","year":1995,"link":"https://www.ncbi.nlm.nih.gov/pubmed/7584606","id":"7584606","citationCount":4,"stringAuthors":"Testore G,  Colombatto S,  Silvagno F,  Bedino S."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/7584606","resource":"7584606","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH9A1","resource":"ALDH9A1","type":"HGNC_SYMBOL"}]},{"name":"7-dehydrocholesterol reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=DHCR7","resource":"DHCR7","type":"HGNC_SYMBOL"}]},{"name":"Acyl carrier protein, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFAB1","resource":"NDUFAB1","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1A","references":[{"annotatorClassName":"","article":{"title":"Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions.","authors":["Bieganowski P"," Seidle HF"," Wojcik M"," Brenner C."],"journal":"The Journal of biological chemistry","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16760478","id":"16760478","citationCount":30,"stringAuthors":"Bieganowski P,  Seidle HF,  Wojcik M,  Brenner C."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16760478","resource":"16760478","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1A","resource":"ADH1A","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1B","references":[{"annotatorClassName":"","article":{"title":"Two highly divergent alcohol dehydrogenases of melon exhibit fruit ripening-specific expression and distinct biochemical characteristics.","authors":["Manríquez D"," El-Sharkawy I"," Flores FB"," El-Yahyaoui F"," Regad F"," Bouzayen M"," Latché A"," Pech JC."],"journal":"Plant molecular biology","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16897483","id":"16897483","citationCount":34,"stringAuthors":"Manríquez D,  El-Sharkawy I,  Flores FB,  El-Yahyaoui F,  Regad F,  Bouzayen M,  Latché A,  Pech JC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16897483","resource":"16897483","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1B","resource":"ADH1B","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 1C","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism.","authors":["Plapp BV"," Berst KB."],"journal":"Chemico-biological interactions","year":2003,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12604203","id":"12604203","citationCount":3,"stringAuthors":"Plapp BV,  Berst KB."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12604203","resource":"12604203","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH1C","resource":"ADH1C","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical basis of mitochondrial acetaldehyde dismutation in Saccharomyces cerevisiae.","authors":["Thielen J"," Ciriacy M."],"journal":"Journal of bacteriology","year":1991,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1938903","id":"1938903","citationCount":3,"stringAuthors":"Thielen J,  Ciriacy M."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1938903","resource":"1938903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mouse alcohol dehydrogenase 4: kinetic mechanism, substrate specificity and simulation of effects of ethanol on retinoid metabolism.","authors":["Plapp BV"," Mitchell JL"," Berst KB."],"journal":"Chemico-biological interactions","year":2001,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11306066","id":"11306066","citationCount":8,"stringAuthors":"Plapp BV,  Mitchell JL,  Berst KB."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11306066","resource":"11306066","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ethanol-induced inhibition of testosterone biosynthesis in vitro: lack of acetaldehyde effect.","authors":["Widenius TV."],"journal":"Alcohol and alcoholism (Oxford, Oxfordshire)","year":1987,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3593480","id":"3593480","citationCount":5,"stringAuthors":"Widenius TV."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3593480","resource":"3593480","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH4","resource":"ADH4","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class 4 mu/sigma chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family.","authors":["Dalfó D"," Marqués N"," Albalat R."],"journal":"The FEBS journal","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17608724","id":"17608724","citationCount":10,"stringAuthors":"Dalfó D,  Marqués N,  Albalat R."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17608724","resource":"17608724","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification and immunohistochemistry of retinol dehydrogenase from bovine retinal pigment epithelium.","authors":["Suzuki Y"," Ishiguro S"," Tamai M."],"journal":"Biochimica et biophysica acta","year":1993,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8490052","id":"8490052","citationCount":12,"stringAuthors":"Suzuki Y,  Ishiguro S,  Tamai M."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8490052","resource":"8490052","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues.","authors":["Kim DS"," Lee CB"," Park YS"," Ahn YH"," Kim TW"," Kee CS"," Kang JS"," Om AS."],"journal":"Journal of Korean Medical Science","year":2001,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11410692","id":"11410692","citationCount":1,"stringAuthors":"Kim DS,  Lee CB,  Park YS,  Ahn YH,  Kim TW,  Kee CS,  Kang JS,  Om AS."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11410692","resource":"11410692","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH7","resource":"ADH7","type":"HGNC_SYMBOL"}]},{"name":"Alcohol dehydrogenase class-3","references":[{"annotatorClassName":"","article":{"title":"High-resolution structures of formate dehydrogenase from Candida boidinii.","authors":["Schirwitz K"," Schmidt A"," Lamzin VS."],"journal":"Protein science : a publication of the Protein Society","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17525463","id":"17525463","citationCount":24,"stringAuthors":"Schirwitz K,  Schmidt A,  Lamzin VS."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17525463","resource":"17525463","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Enhanced activity of 3alpha-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reductive production of steroids.","authors":["Okochi M"," Nakagawa I"," Kobayashi T"," Hayashi S"," Furusaki S"," Honda H."],"journal":"Journal of biotechnology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17092593","id":"17092593","citationCount":7,"stringAuthors":"Okochi M,  Nakagawa I,  Kobayashi T,  Hayashi S,  Furusaki S,  Honda H."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17092593","resource":"17092593","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Logic gates and elementary computing by enzymes.","authors":["Baron R"," Lioubashevski O"," Katz E"," Niazov T"," Willner I."],"journal":"The journal of physical chemistry. A","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16821840","id":"16821840","citationCount":43,"stringAuthors":"Baron R,  Lioubashevski O,  Katz E,  Niazov T,  Willner I."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16821840","resource":"16821840","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ADH5","resource":"ADH5","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase X, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1B1","resource":"ALDH1B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 1 member A3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of retinaldehyde dehydrogenase 3.","authors":["Graham CE"," Brocklehurst K"," Pickersgill RW"," Warren MJ."],"journal":"The Biochemical journal","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16241904","id":"16241904","citationCount":21,"stringAuthors":"Graham CE,  Brocklehurst K,  Pickersgill RW,  Warren MJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16241904","resource":"16241904","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A3","resource":"ALDH1A3","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B1","resource":"ALDH3B1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase family 3 member B2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3B2","resource":"ALDH3B2","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, dimeric NADP-preferring","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["Wroczyński P"," Nowak M"," Wierzchowski J"," Szubert A"," Polański J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"Wroczyński P,  Nowak M,  Wierzchowski J,  Szubert A,  Polański J."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A1","resource":"ALDH3A1","type":"HGNC_SYMBOL"}]},{"name":"Aldehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective.","authors":["Quintanilla ME"," Tampier L"," Sapag A"," Gerdtzen Z"," Israel Y."],"journal":"American journal of physiology. Endocrinology and metabolism","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17488809","id":"17488809","citationCount":18,"stringAuthors":"Quintanilla ME,  Tampier L,  Sapag A,  Gerdtzen Z,  Israel Y."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17488809","resource":"17488809","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake.","authors":["Quintanilla ME"," Israel Y"," Sapag A"," Tampier L."],"journal":"Addiction biology","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16961761","id":"16961761","citationCount":66,"stringAuthors":"Quintanilla ME,  Israel Y,  Sapag A,  Tampier L."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16961761","resource":"16961761","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH2","resource":"ALDH2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":2,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.","authors":["Burczynski ME"," Sridhar GR"," Palackal NT"," Penning TM."],"journal":"The Journal of biological chemistry","year":2001,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11060293","id":"11060293","citationCount":79,"stringAuthors":"Burczynski ME,  Sridhar GR,  Palackal NT,  Penning TM."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11060293","resource":"11060293","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C1","resource":"AKR1C1","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.","authors":["Rizner TL"," Lin HK"," Peehl DM"," Steckelbroeck S"," Bauman DR"," Penning TM."],"journal":"Endocrinology","year":2003,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12810547","id":"12810547","citationCount":65,"stringAuthors":"Rizner TL,  Lin HK,  Peehl DM,  Steckelbroeck S,  Bauman DR,  Penning TM."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12810547","resource":"12810547","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).","authors":["Trauger JW"," Jiang A"," Stearns BA"," LoGrasso PV."],"journal":"Biochemistry","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12416991","id":"12416991","citationCount":43,"stringAuthors":"Trauger JW,  Jiang A,  Stearns BA,  LoGrasso PV."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12416991","resource":"12416991","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C2","resource":"AKR1C2","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":2,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer between progesterone and cofactor by human placental estradiol-17 beta dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"The Journal of steroid biochemistry and molecular biology","year":1990,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2146972","id":"2146972","citationCount":0,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2146972","resource":"2146972","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Bioluminescent assay of femtomole levels of estrone and estradiol.","authors":["Nicolas JC"," Boussioux AM"," Boularan AM"," Descomps B"," Crastes de Paulet A."],"journal":"Analytical biochemistry","year":1983,"link":"https://www.ncbi.nlm.nih.gov/pubmed/6584048","id":"6584048","citationCount":10,"stringAuthors":"Nicolas JC,  Boussioux AM,  Boularan AM,  Descomps B,  Crastes de Paulet A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/6584048","resource":"6584048","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C3","resource":"AKR1C3","type":"HGNC_SYMBOL"}]},{"name":"Aldo-keto reductase family 1 member C4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol.","authors":["Atalla A"," Breyer-Pfaff U"," Maser E."],"journal":"Xenobiotica; the fate of foreign compounds in biological systems","year":2000,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11037109","id":"11037109","citationCount":37,"stringAuthors":"Atalla A,  Breyer-Pfaff U,  Maser E."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11037109","resource":"11037109","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1C4","resource":"AKR1C4","type":"HGNC_SYMBOL"}]},{"name":"Aldose reductase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":42,"stringAuthors":"Ido Y."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Vitamin C. Biosynthesis, recycling and degradation in mammals.","authors":["Linster CL"," Van Schaftingen E."],"journal":"The FEBS journal","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17222174","id":"17222174","citationCount":219,"stringAuthors":"Linster CL,  Van Schaftingen E."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17222174","resource":"17222174","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=AKR1B1","resource":"AKR1B1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.","authors":["de La Fuente JL"," Rumbero A"," Martín JF"," Liras P."],"journal":"The Biochemical journal","year":1997,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9355735","id":"9355735","citationCount":8,"stringAuthors":"de La Fuente JL,  Rumbero A,  Martín JF,  Liras P."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9355735","resource":"9355735","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH7A1","resource":"ALDH7A1","type":"HGNC_SYMBOL"}]},{"name":"Alpha-aminoadipic semialdehyde synthase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17542618","id":"17542618","citationCount":3,"stringAuthors":"Xu H,  West AH,  Cook PF."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17542618","resource":"17542618","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," West AH"," Cook PF."],"journal":"Biochemistry","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17002315","id":"17002315","citationCount":12,"stringAuthors":"Xu H,  West AH,  Cook PF."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17002315","resource":"17002315","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.","authors":["Xu H"," Alguindigue SS"," West AH"," Cook PF."],"journal":"Biochemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17223709","id":"17223709","citationCount":9,"stringAuthors":"Xu H,  Alguindigue SS,  West AH,  Cook PF."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17223709","resource":"17223709","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=AASS","resource":"AASS","type":"HGNC_SYMBOL"}]},{"name":"Aminomethyltransferase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=AMT","resource":"AMT","type":"HGNC_SYMBOL"}]},{"name":"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD2","resource":"MTHFD2","type":"HGNC_SYMBOL"}]},{"name":"Biliverdin reductase A","references":[{"annotatorClassName":"","article":{"title":"Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions.","authors":["Franklin E"," Browne S"," Hayes J"," Boland C"," Dunne A"," Elliot G"," Mantle TJ."],"journal":"The Biochemical journal","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17402939","id":"17402939","citationCount":4,"stringAuthors":"Franklin E,  Browne S,  Hayes J,  Boland C,  Dunne A,  Elliot G,  Mantle TJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17402939","resource":"17402939","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRA","resource":"BLVRA","type":"HGNC_SYMBOL"}]},{"name":"C-1-tetrahydrofolate synthase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MTHFD1","resource":"MTHFD1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11beta-reduction.","authors":["Diederich S"," Hanke B"," Oelkers W"," Bähr V."],"journal":"The Journal of clinical endocrinology and metabolism","year":1997,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9141556","id":"9141556","citationCount":15,"stringAuthors":"Diederich S,  Hanke B,  Oelkers W,  Bähr V."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9141556","resource":"9141556","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B1","resource":"HSD11B1","type":"HGNC_SYMBOL"}]},{"name":"Corticosteroid 11-beta-dehydrogenase isozyme 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney.","authors":["Mercer WR"," Krozowski ZS."],"journal":"Endocrinology","year":1992,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1727721","id":"1727721","citationCount":62,"stringAuthors":"Mercer WR,  Krozowski ZS."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1727721","resource":"1727721","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Comparison of 11 beta-hydroxysteroid dehydrogenase in spontaneously hypertensive and Wistar-Kyoto rats.","authors":["Hermans JJ"," Steckel B"," Thijssen HH"," Janssen BJ"," Netter KJ"," Maser E."],"journal":"Steroids","year":1995,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8585102","id":"8585102","citationCount":3,"stringAuthors":"Hermans JJ,  Steckel B,  Thijssen HH,  Janssen BJ,  Netter KJ,  Maser E."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8585102","resource":"8585102","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD11B2","resource":"HSD11B2","type":"HGNC_SYMBOL"}]},{"name":"Cysteine dioxygenase type 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=CDO1","resource":"CDO1","type":"HGNC_SYMBOL"}]},{"name":"Cytochrome P450 4A11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cytochrome P450 4A, peroxisomal enzymes and nicotinamide cofactors in koala liver.","authors":["Ngo S"," Kong S"," Kirlich A"," McKinnon RA"," Stupans I."],"journal":"Comparative biochemistry and physiology. Toxicology & pharmacology : CBP","year":2000,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11246504","id":"11246504","citationCount":6,"stringAuthors":"Ngo S,  Kong S,  Kirlich A,  McKinnon RA,  Stupans I."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11246504","resource":"11246504","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP4A11","resource":"CYP4A11","type":"HGNC_SYMBOL"}]},{"name":"D-3-phosphoglycerate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A new family of 2-hydroxyacid dehydrogenases.","authors":["Grant GA."],"journal":"Biochemical and biophysical research communications","year":1989,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2692566","id":"2692566","citationCount":45,"stringAuthors":"Grant GA."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2692566","resource":"2692566","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Serine biosynthesis in human hair follicles by the phosphorylated pathway: follicular 3-phosphoglycerate dehydrogenase.","authors":["Goldsmith LA"," O'Barr T."],"journal":"The Journal of investigative dermatology","year":1976,"link":"https://www.ncbi.nlm.nih.gov/pubmed/945314","id":"945314","citationCount":4,"stringAuthors":"Goldsmith LA,  O'Barr T."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/945314","resource":"945314","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cofactor binding to Escherichia coli D-3-phosphoglycerate dehydrogenase induces multiple conformations which alter effector binding.","authors":["Grant GA"," Hu Z"," Xu XL."],"journal":"The Journal of biological chemistry","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12183470","id":"12183470","citationCount":9,"stringAuthors":"Grant GA,  Hu Z,  Xu XL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12183470","resource":"12183470","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=PHGDH","resource":"PHGDH","type":"HGNC_SYMBOL"}]},{"name":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase.","authors":["Inagaki E"," Ohshima N"," Takahashi H"," Kuroishi C"," Yokoyama S"," Tahirov TH."],"journal":"Journal of molecular biology","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16934832","id":"16934832","citationCount":39,"stringAuthors":"Inagaki E,  Ohshima N,  Takahashi H,  Kuroishi C,  Yokoyama S,  Tahirov TH."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16934832","resource":"16934832","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH4A1","resource":"ALDH4A1","type":"HGNC_SYMBOL"}]},{"name":"Dihydrofolate reductase","references":[{"annotatorClassName":"","article":{"title":"Proteome-wide profiling of isoniazid targets in Mycobacterium tuberculosis.","authors":["Argyrou A"," Jin L"," Siconilfi-Baez L"," Angeletti RH"," Blanchard JS."],"journal":"Biochemistry","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17115689","id":"17115689","citationCount":38,"stringAuthors":"Argyrou A,  Jin L,  Siconilfi-Baez L,  Angeletti RH,  Blanchard JS."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17115689","resource":"17115689","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.","authors":["Vickers TJ"," Orsomando G"," de la Garza RD"," Scott DA"," Kang SO"," Hanson AD"," Beverley SM."],"journal":"The Journal of biological chemistry","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17032644","id":"17032644","citationCount":14,"stringAuthors":"Vickers TJ,  Orsomando G,  de la Garza RD,  Scott DA,  Kang SO,  Hanson AD,  Beverley SM."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17032644","resource":"17032644","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=DHFR","resource":"DHFR","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyl dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE.","authors":["Yan LJ"," Yang SH"," Shu H"," Prokai L"," Forster MJ."],"journal":"Electrophoresis","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17315258","id":"17315258","citationCount":27,"stringAuthors":"Yan LJ,  Yang SH,  Shu H,  Prokai L,  Forster MJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17315258","resource":"17315258","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants.","authors":["Gutiérrez-Correa J."],"journal":"Current drug targets","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17017892","id":"17017892","citationCount":3,"stringAuthors":"Gutiérrez-Correa J."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17017892","resource":"17017892","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex.","authors":["Islam MM"," Wallin R"," Wynn RM"," Conway M"," Fujii H"," Mobley JA"," Chuang DT"," Hutson SM."],"journal":"The Journal of biological chemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17314104","id":"17314104","citationCount":36,"stringAuthors":"Islam MM,  Wallin R,  Wynn RM,  Conway M,  Fujii H,  Mobley JA,  Chuang DT,  Hutson SM."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17314104","resource":"17314104","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=DLD","resource":"DLD","type":"HGNC_SYMBOL"}]},{"name":"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.","authors":["Shi S"," Ehrt S."],"journal":"Infection and immunity","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16368957","id":"16368957","citationCount":40,"stringAuthors":"Shi S,  Ehrt S."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16368957","resource":"16368957","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=DLAT","resource":"DLAT","type":"HGNC_SYMBOL"}]},{"name":"Dihydropteridine reductase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Determination of NADPH-specific dihydropteridine reductase in extract from human, monkey, and bovine livers by single radial immunodiffusion: selective assay differentiating NADPH- and NADH-specific enzymes.","authors":["Nakanishi N"," Ozawa K"," Yamada S."],"journal":"Journal of biochemistry","year":1986,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3086306","id":"3086306","citationCount":1,"stringAuthors":"Nakanishi N,  Ozawa K,  Yamada S."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3086306","resource":"3086306","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectral studies of the interaction of the substrate 'quinonoid' 6-methyl dihydropterine and the coenzyme NADH used as marker in the dihydropteridine reductase assay.","authors":["van der Heiden C"," Brink W."],"journal":"Journal of inherited metabolic disease","year":1982,"link":"https://www.ncbi.nlm.nih.gov/pubmed/6820434","id":"6820434","citationCount":1,"stringAuthors":"van der Heiden C,  Brink W."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/6820434","resource":"6820434","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-ferric reductase activity associated with dihydropteridine reductase.","authors":["Lee PL"," Halloran C"," Cross AR"," Beutler E."],"journal":"Biochemical and biophysical research communications","year":2000,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10814540","id":"10814540","citationCount":5,"stringAuthors":"Lee PL,  Halloran C,  Cross AR,  Beutler E."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10814540","resource":"10814540","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=QDPR","resource":"QDPR","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":2,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The 20 alpha-hydroxysteroid dehydrogenase of Streptomyces hydrogenans.","authors":["Rimsay RL"," Murphy GW"," Martin CJ"," Orr JC."],"journal":"European journal of biochemistry","year":1988,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3164265","id":"3164265","citationCount":3,"stringAuthors":"Rimsay RL,  Murphy GW,  Martin CJ,  Orr JC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3164265","resource":"3164265","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B1","resource":"HSD17B1","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Microsomal 20 alpha-hydroxysteroid dehydrogenase activity for progesterone in human placenta.","authors":["Fukuda T"," Hirato K"," Yanaihara T"," Nakayama T."],"journal":"Endocrinologia japonica","year":1986,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3463506","id":"3463506","citationCount":2,"stringAuthors":"Fukuda T,  Hirato K,  Yanaihara T,  Nakayama T."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3463506","resource":"3463506","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stereospecificity of hydrogen transfer by bovine testicular 20 alpha-hydroxysteroid dehydrogenase.","authors":["Pineda JA"," Murdock GL"," Watson RJ"," Warren JC."],"journal":"Journal of steroid biochemistry","year":1989,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2615366","id":"2615366","citationCount":2,"stringAuthors":"Pineda JA,  Murdock GL,  Watson RJ,  Warren JC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2615366","resource":"2615366","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity.","authors":["Wintergalen N"," Thole HH"," Galla HJ"," Schlegel W."],"journal":"European journal of biochemistry","year":1995,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8529651","id":"8529651","citationCount":27,"stringAuthors":"Wintergalen N,  Thole HH,  Galla HJ,  Schlegel W."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8529651","resource":"8529651","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B2","resource":"HSD17B2","type":"HGNC_SYMBOL"}]},{"name":"Estradiol 17-beta-dehydrogenase 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B8","resource":"HSD17B8","type":"HGNC_SYMBOL"}]},{"name":"Fatty aldehyde dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of a long-chain fatty aldehyde dehydrogenase induced during the development of bioluminescence in Beneckea harveyi.","authors":["Bognar A"," Meighen E."],"journal":"Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire","year":1983,"link":"https://www.ncbi.nlm.nih.gov/pubmed/6603890","id":"6603890","citationCount":0,"stringAuthors":"Bognar A,  Meighen E."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/6603890","resource":"6603890","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH3A2","resource":"ALDH3A2","type":"HGNC_SYMBOL"}]},{"name":"Flavin reductase (NADPH)","references":[{"annotatorClassName":"","article":{"title":"Characterization of two components of the 2-naphthoate monooxygenase system from Burkholderia sp. strain JT1500.","authors":["Deng D"," Li X"," Fang X"," Sun G."],"journal":"FEMS microbiology letters","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17559398","id":"17559398","citationCount":2,"stringAuthors":"Deng D,  Li X,  Fang X,  Sun G."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17559398","resource":"17559398","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=BLVRB","resource":"BLVRB","type":"HGNC_SYMBOL"}]},{"name":"GDH/6PGL endoplasmic bifunctional protein","references":[{"annotatorClassName":"","article":{"title":"Electrochemical regeneration of NADH using conductive vanadia-silica xerogels.","authors":["Siu E"," Won K"," Park CB."],"journal":"Biotechnology progress","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17269701","id":"17269701","citationCount":10,"stringAuthors":"Siu E,  Won K,  Park CB."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17269701","resource":"17269701","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Co-expression of P450 BM3 and glucose dehydrogenase by recombinant Escherichia coli and its application in an NADPH-dependent indigo production system.","authors":["Lu Y"," Mei L."],"journal":"Journal of industrial microbiology & biotechnology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17171348","id":"17171348","citationCount":13,"stringAuthors":"Lu Y,  Mei L."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17171348","resource":"17171348","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"In vitro RNA editing in plant mitochondria does not require added energy.","authors":["Takenaka M"," Verbitskiy D"," van der Merwe JA"," Zehrmann A"," Plessmann U"," Urlaub H"," Brennicke A."],"journal":"FEBS letters","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17531229","id":"17531229","citationCount":3,"stringAuthors":"Takenaka M,  Verbitskiy D,  van der Merwe JA,  Zehrmann A,  Plessmann U,  Urlaub H,  Brennicke A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17531229","resource":"17531229","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Coimmobilization of dehydrogenases and their cofactors in electrochemical biosensors.","authors":["Zhang M"," Mullens C"," Gorski W."],"journal":"Analytical chemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17298031","id":"17298031","citationCount":23,"stringAuthors":"Zhang M,  Mullens C,  Gorski W."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17298031","resource":"17298031","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=H6PD","resource":"H6PD","type":"HGNC_SYMBOL"}]},{"name":"GDP-L-fucose synthase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=TSTA3","resource":"TSTA3","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD1","resource":"GLUD1","type":"HGNC_SYMBOL"}]},{"name":"Glutamate dehydrogenase 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=GLUD2","resource":"GLUD2","type":"HGNC_SYMBOL"}]},{"name":"Glutathione reductase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Evidence for an additional disulfide reduction pathway in Escherichia coli.","authors":["Knapp KG"," Swartz JR."],"journal":"Journal of bioscience and bioengineering","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17502280","id":"17502280","citationCount":3,"stringAuthors":"Knapp KG,  Swartz JR."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17502280","resource":"17502280","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.","authors":["Aon MA"," Cortassa S"," Maack C"," O'Rourke B."],"journal":"The Journal of biological chemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17540766","id":"17540766","citationCount":101,"stringAuthors":"Aon MA,  Cortassa S,  Maack C,  O'Rourke B."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17540766","resource":"17540766","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Damage of oxidative stress on mitochondria during microspores development in Honglian CMS line of rice.","authors":["Wan C"," Li S"," Wen L"," Kong J"," Wang K"," Zhu Y."],"journal":"Plant cell reports","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17053903","id":"17053903","citationCount":24,"stringAuthors":"Wan C,  Li S,  Wen L,  Kong J,  Wang K,  Zhu Y."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17053903","resource":"17053903","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila.","authors":["Cheng Z"," Arscott LD"," Ballou DP"," Williams CH."],"journal":"Biochemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17550271","id":"17550271","citationCount":27,"stringAuthors":"Cheng Z,  Arscott LD,  Ballou DP,  Williams CH."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17550271","resource":"17550271","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition.","authors":["Gazaryan IG"," Krasinskaya IP"," Kristal BS"," Brown AM."],"journal":"The Journal of biological chemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17565998","id":"17565998","citationCount":59,"stringAuthors":"Gazaryan IG,  Krasinskaya IP,  Kristal BS,  Brown AM."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17565998","resource":"17565998","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=GSR","resource":"GSR","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":42,"stringAuthors":"Ido Y."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Thioredoxin-dependent regulation of photosynthetic glyceraldehyde-3-phosphate dehydrogenase: autonomous vs. CP12-dependent mechanisms.","authors":["Trost P"," Fermani S"," Marri L"," Zaffagnini M"," Falini G"," Scagliarini S"," Pupillo P"," Sparla F."],"journal":"Photosynthesis research","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17031544","id":"17031544","citationCount":35,"stringAuthors":"Trost P,  Fermani S,  Marri L,  Zaffagnini M,  Falini G,  Scagliarini S,  Pupillo P,  Sparla F."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17031544","resource":"17031544","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Sevoflurane modulates the activity of glyceraldehyde 3-phosphate dehydrogenase.","authors":["Swearengin TA"," Fibuch EE"," Seidler NW."],"journal":"Journal of enzyme inhibition and medicinal chemistry","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17194030","id":"17194030","citationCount":4,"stringAuthors":"Swearengin TA,  Fibuch EE,  Seidler NW."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17194030","resource":"17194030","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDH","resource":"GAPDH","type":"HGNC_SYMBOL"}]},{"name":"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oral streptococcal glyceraldehyde-3-phosphate dehydrogenase mediates interaction with Porphyromonas gingivalis fimbriae.","authors":["Maeda K"," Nagata H"," Nonaka A"," Kataoka K"," Tanaka M"," Shizukuishi S."],"journal":"Microbes and infection","year":2004,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15488735","id":"15488735","citationCount":25,"stringAuthors":"Maeda K,  Nagata H,  Nonaka A,  Kataoka K,  Tanaka M,  Shizukuishi S."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15488735","resource":"15488735","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12.","authors":["Graciet E"," Lebreton S"," Camadro JM"," Gontero B."],"journal":"European journal of biochemistry","year":2003,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12492483","id":"12492483","citationCount":28,"stringAuthors":"Graciet E,  Lebreton S,  Camadro JM,  Gontero B."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12492483","resource":"12492483","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase.","authors":["Ismail SA"," Park HW."],"journal":"Acta crystallographica. Section D, Biological crystallography","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16239728","id":"16239728","citationCount":18,"stringAuthors":"Ismail SA,  Park HW."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16239728","resource":"16239728","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=GAPDHS","resource":"GAPDHS","type":"HGNC_SYMBOL"}]},{"name":"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase.","authors":["Fonvielle M"," Therisod H"," Hemery M"," Therisod M."],"journal":"Bioorganic & medicinal chemistry letters","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17088060","id":"17088060","citationCount":0,"stringAuthors":"Fonvielle M,  Therisod H,  Hemery M,  Therisod M."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17088060","resource":"17088060","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=GPD1","resource":"GPD1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress-related factors in Bartter's and Gitelman's syndromes: relevance for angiotensin II signalling.","authors":["Calò LA"," Pagnin E"," Davis PA"," Sartori M"," Semplicini A."],"journal":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","year":2003,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12897089","id":"12897089","citationCount":29,"stringAuthors":"Calò LA,  Pagnin E,  Davis PA,  Sartori M,  Semplicini A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12897089","resource":"12897089","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae.","authors":["Auclair K"," Huang HW"," Moënne-Loccoz P"," Ortiz de Montellano PR."],"journal":"Protein expression and purification","year":2003,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12699699","id":"12699699","citationCount":5,"stringAuthors":"Auclair K,  Huang HW,  Moënne-Loccoz P,  Ortiz de Montellano PR."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12699699","resource":"12699699","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX1","resource":"HMOX1","type":"HGNC_SYMBOL"}]},{"name":"Heme oxygenase 2","references":[{"annotatorClassName":"","article":{"title":"DNA cleavage by UVA irradiation of NADH with dioxygen via radical chain processes.","authors":["Tanaka M"," Ohkubo K"," Fukuzumi S."],"journal":"The journal of physical chemistry. A","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16986858","id":"16986858","citationCount":20,"stringAuthors":"Tanaka M,  Ohkubo K,  Fukuzumi S."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16986858","resource":"16986858","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inactivation of copper, zinc superoxide dismutase by H2O2 : mechanism of protection.","authors":["Goldstone AB"," Liochev SI"," Fridovich I."],"journal":"Free radical biology & medicine","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17157188","id":"17157188","citationCount":9,"stringAuthors":"Goldstone AB,  Liochev SI,  Fridovich I."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17157188","resource":"17157188","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HMOX2","resource":"HMOX2","type":"HGNC_SYMBOL"}]},{"name":"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons.","authors":["Norman JP"," Perry SW"," Kasischke KA"," Volsky DJ"," Gelbard HA."],"journal":"Journal of immunology (Baltimore, Md. : 1950)","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17202348","id":"17202348","citationCount":34,"stringAuthors":"Norman JP,  Perry SW,  Kasischke KA,  Volsky DJ,  Gelbard HA."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17202348","resource":"17202348","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HADH","resource":"HADH","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.","authors":["Bowne SJ"," Sullivan LS"," Mortimer SE"," Hedstrom L"," Zhu J"," Spellicy CJ"," Gire AI"," Hughbanks-Wheaton D"," Birch DG"," Lewis RA"," Heckenlively JR"," Daiger SP."],"journal":"Investigative ophthalmology & visual science","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16384941","id":"16384941","citationCount":69,"stringAuthors":"Bowne SJ,  Sullivan LS,  Mortimer SE,  Hedstrom L,  Zhu J,  Spellicy CJ,  Gire AI,  Hughbanks-Wheaton D,  Birch DG,  Lewis RA,  Heckenlively JR,  Daiger SP."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16384941","resource":"16384941","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH1","resource":"IMPDH1","type":"HGNC_SYMBOL"}]},{"name":"Inosine-5'-monophosphate dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity.","authors":["Wang J"," Zeevi A"," Webber S"," Girnita DM"," Addonizio L"," Selby R"," Hutchinson IV"," Burckart GJ."],"journal":"Pharmacogenetics and genomics","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17496727","id":"17496727","citationCount":31,"stringAuthors":"Wang J,  Zeevi A,  Webber S,  Girnita DM,  Addonizio L,  Selby R,  Hutchinson IV,  Burckart GJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17496727","resource":"17496727","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=IMPDH2","resource":"IMPDH2","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues.","authors":["PLAUT GW"," SUNG SC."],"journal":"The Journal of biological chemistry","year":1954,"link":"https://www.ncbi.nlm.nih.gov/pubmed/13152105","id":"13152105","citationCount":36,"stringAuthors":"PLAUT GW,  SUNG SC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/13152105","resource":"13152105","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":27,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":3,"stringAuthors":"Rose ZB."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3A","resource":"IDH3A","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":27,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"https://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":29,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":3,"stringAuthors":"Rose ZB."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3B","resource":"IDH3B","type":"HGNC_SYMBOL"}]},{"name":"Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.","authors":["Stein AM"," Stein JH"," Kirkman SK."],"journal":"Biochemistry","year":1967,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4292141","id":"4292141","citationCount":27,"stringAuthors":"Stein AM,  Stein JH,  Kirkman SK."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4292141","resource":"4292141","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NICOTINAMIDE ADENINE DINUCLEOTIDE-SPECIFIC ISOCITRIC DEHYDROGENASE. A POSSIBLE REGULATORY PROTEIN.","authors":["SANWAL BD"," ZINK MW"," STACHOW CS."],"journal":"The Journal of biological chemistry","year":1964,"link":"https://www.ncbi.nlm.nih.gov/pubmed/14189899","id":"14189899","citationCount":29,"stringAuthors":"SANWAL BD,  ZINK MW,  STACHOW CS."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/14189899","resource":"14189899","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The stereochemistry of the nicotinamide adenine dinucleotide-specific isocitric dehydrogenase reaction.","authors":["Rose ZB."],"journal":"The Journal of biological chemistry","year":1966,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4380379","id":"4380379","citationCount":3,"stringAuthors":"Rose ZB."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4380379","resource":"4380379","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=IDH3G","resource":"IDH3G","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A chain","references":[{"annotatorClassName":"","article":{"title":"Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.","authors":["Semenza GL."],"journal":"The Biochemical journal","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17555402","id":"17555402","citationCount":250,"stringAuthors":"Semenza GL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17555402","resource":"17555402","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Histochemical and histopathological study of the gastric mucosa in the portal hypertensive gastropathy.","authors":["Drăghia AC."],"journal":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17308685","id":"17308685","citationCount":4,"stringAuthors":"Drăghia AC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17308685","resource":"17308685","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons.","authors":["O'Brien J"," Kla KM"," Hopkins IB"," Malecki EA"," McKenna MC."],"journal":"Neurochemical research","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17006762","id":"17006762","citationCount":30,"stringAuthors":"O'Brien J,  Kla KM,  Hopkins IB,  Malecki EA,  McKenna MC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17006762","resource":"17006762","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHA","resource":"LDHA","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6A","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6A","resource":"LDHAL6A","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase A-like 6B","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHAL6B","resource":"LDHAL6B","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase B chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus.","authors":["Razeto A"," Kochhar S"," Hottinger H"," Dauter M"," Wilson KS"," Lamzin VS."],"journal":"Journal of molecular biology","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12054772","id":"12054772","citationCount":34,"stringAuthors":"Razeto A,  Kochhar S,  Hottinger H,  Dauter M,  Wilson KS,  Lamzin VS."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12054772","resource":"12054772","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism.","authors":["Mdluli K"," Booth MP"," Brady RL"," Rumsby G."],"journal":"Biochimica et biophysica acta","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16198644","id":"16198644","citationCount":18,"stringAuthors":"Mdluli K,  Booth MP,  Brady RL,  Rumsby G."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16198644","resource":"16198644","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Lactate dehydrogenase isoenzymes of sperm cells and tests.","authors":["Clausen J."],"journal":"The Biochemical journal","year":1969,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4303363","id":"4303363","citationCount":12,"stringAuthors":"Clausen J."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/4303363","resource":"4303363","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHB","resource":"LDHB","type":"HGNC_SYMBOL"}]},{"name":"L-lactate dehydrogenase C chain","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Rapid purification of lactate dehydrogenase X from mouse testes by two steps of affinity chromatography on oxamate-sepharose.","authors":["Spielmann H"," Eibs HG"," Mentzel C."],"journal":"Experientia","year":1976,"link":"https://www.ncbi.nlm.nih.gov/pubmed/182529","id":"182529","citationCount":1,"stringAuthors":"Spielmann H,  Eibs HG,  Mentzel C."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/182529","resource":"182529","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers.","authors":["Morris ID"," Higgins C"," Matlin SA."],"journal":"Journal of reproduction and fertility","year":1986,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3735252","id":"3735252","citationCount":3,"stringAuthors":"Morris ID,  Higgins C,  Matlin SA."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3735252","resource":"3735252","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Developmental changes in lactate dehydrogenase-X activity in young jaundiced male rats.","authors":["Gu Y"," Davis DR"," Lin YC."],"journal":"Archives of andrology","year":1989,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2751392","id":"2751392","citationCount":10,"stringAuthors":"Gu Y,  Davis DR,  Lin YC."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/2751392","resource":"2751392","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=LDHC","resource":"LDHC","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, cytoplasmic","references":[{"annotatorClassName":"","article":{"title":"Heterologous expression of cDNAs encoding monodehydroascorbate reductases from the moss, Physcomitrella patens and characterization of the expressed enzymes.","authors":["Drew DP"," Lunde C"," Lahnstein J"," Fincher GB."],"journal":"Planta","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16983536","id":"16983536","citationCount":10,"stringAuthors":"Drew DP,  Lunde C,  Lahnstein J,  Fincher GB."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16983536","resource":"16983536","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH1","resource":"MDH1","type":"HGNC_SYMBOL"}]},{"name":"Malate dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"D-mannitol production by resting state whole cell biotrans-formation of D-fructose by heterologous mannitol and formate dehydrogenase gene expression in Bacillus megaterium.","authors":["Bäumchen C"," Roth AH"," Biedendieck R"," Malten M"," Follmann M"," Sahm H"," Bringer-Meyer S"," Jahn D."],"journal":"Biotechnology journal","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17619232","id":"17619232","citationCount":11,"stringAuthors":"Bäumchen C,  Roth AH,  Biedendieck R,  Malten M,  Follmann M,  Sahm H,  Bringer-Meyer S,  Jahn D."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17619232","resource":"17619232","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Fluorescent sensing layer for the determination of L-malic acid in wine.","authors":["Gallarta F"," Sáinz FJ"," Sáenz C."],"journal":"Analytical and bioanalytical chemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17203264","id":"17203264","citationCount":3,"stringAuthors":"Gallarta F,  Sáinz FJ,  Sáenz C."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17203264","resource":"17203264","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[Lymphocyte metabolism in patients with acute pancreatitis with different genotypes of GSTM1 and GSTT1 genes].","authors":["Markova EV"," Zotova NV"," Savchenko AA"," Titova NM"," Slepov EV"," Cherdantsev DV"," Konovalenko AN."],"journal":"Biomeditsinskaia khimiia","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16898590","id":"16898590","citationCount":1,"stringAuthors":"Markova EV,  Zotova NV,  Savchenko AA,  Titova NM,  Slepov EV,  Cherdantsev DV,  Konovalenko AN."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16898590","resource":"16898590","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Characterization of malate dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum.","authors":["Yennaco LJ"," Hu Y"," Holden JF."],"journal":"Extremophiles : life under extreme conditions","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17487443","id":"17487443","citationCount":5,"stringAuthors":"Yennaco LJ,  Hu Y,  Holden JF."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17487443","resource":"17487443","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":65,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MDH2","resource":"MDH2","type":"HGNC_SYMBOL"}]},{"name":"Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The effect of ligand binding on the proteolytic pattern of methylmalonate semialdehyde dehydrogenase.","authors":["Kedishvili NY"," Popov KM"," Harris RA."],"journal":"Archives of biochemistry and biophysics","year":1991,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1898092","id":"1898092","citationCount":1,"stringAuthors":"Kedishvili NY,  Popov KM,  Harris RA."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1898092","resource":"1898092","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH6A1","resource":"ALDH6A1","type":"HGNC_SYMBOL"}]},{"name":"Methylsterol monooxygenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MSMO1","resource":"MSMO1","type":"HGNC_SYMBOL"}]},{"name":"NAD(P) transhydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation.","authors":["Kabus A"," Georgi T"," Wendisch VF"," Bott M."],"journal":"Applied microbiology and biotechnology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17216441","id":"17216441","citationCount":58,"stringAuthors":"Kabus A,  Georgi T,  Wendisch VF,  Bott M."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17216441","resource":"17216441","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NNT","resource":"NNT","type":"HGNC_SYMBOL"}]},{"name":"NAD-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ME2","resource":"ME2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria.","authors":["Au HC"," Seo BB"," Matsuno-Yagi A"," Yagi T"," Scheffler IE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10200266","id":"10200266","citationCount":40,"stringAuthors":"Au HC,  Seo BB,  Matsuno-Yagi A,  Yagi T,  Scheffler IE."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10200266","resource":"10200266","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":54,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA1","resource":"NDUFA1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA10","resource":"NDUFA10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA11","resource":"NDUFA11","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA12","resource":"NDUFA12","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA13","resource":"NDUFA13","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA2","resource":"NDUFA2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA3","resource":"NDUFA3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4","resource":"NDUFA4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA4L2","resource":"NDUFA4L2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5","references":[{"annotatorClassName":"","article":{"title":"Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase.","authors":["Chen CL"," Zhang L"," Yeh A"," Chen CA"," Green-Church KB"," Zweier JL"," Chen YR."],"journal":"Biochemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17444656","id":"17444656","citationCount":44,"stringAuthors":"Chen CL,  Zhang L,  Yeh A,  Chen CA,  Green-Church KB,  Zweier JL,  Chen YR."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17444656","resource":"17444656","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli.","authors":["Belevich G"," Euro L"," Wikström M"," Verkhovskaya M."],"journal":"Biochemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17209562","id":"17209562","citationCount":15,"stringAuthors":"Belevich G,  Euro L,  Wikström M,  Verkhovskaya M."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17209562","resource":"17209562","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA5","resource":"NDUFA5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA6","resource":"NDUFA6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA7","resource":"NDUFA7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients.","authors":["Triepels R"," van den Heuvel L"," Loeffen J"," Smeets R"," Trijbels F"," Smeitink J."],"journal":"Human genetics","year":1998,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9860297","id":"9860297","citationCount":10,"stringAuthors":"Triepels R,  van den Heuvel L,  Loeffen J,  Smeets R,  Trijbels F,  Smeitink J."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9860297","resource":"9860297","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA8","resource":"NDUFA8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"The flavoprotein subcomplex of complex I (NADH:ubiquinone oxidoreductase) from bovine heart mitochondria: insights into the mechanisms of NADH oxidation and NAD+ reduction from protein film voltammetry.","authors":["Barker CD"," Reda T"," Hirst J."],"journal":"Biochemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17323923","id":"17323923","citationCount":14,"stringAuthors":"Barker CD,  Reda T,  Hirst J."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17323923","resource":"17323923","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Maintenance of the metabolic homeostasis of the heart: developing a systems analysis approach.","authors":["Balaban RS."],"journal":"Annals of the New York Academy of Sciences","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17132781","id":"17132781","citationCount":17,"stringAuthors":"Balaban RS."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17132781","resource":"17132781","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Inhibition of complex I by Ca2+ reduces electron transport activity and the rate of superoxide anion production in cardiac submitochondrial particles.","authors":["Matsuzaki S"," Szweda LI."],"journal":"Biochemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17260964","id":"17260964","citationCount":12,"stringAuthors":"Matsuzaki S,  Szweda LI."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17260964","resource":"17260964","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle.","authors":["Fisher N"," Bray PG"," Ward SA"," Biagini GA."],"journal":"Trends in parasitology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17499024","id":"17499024","citationCount":32,"stringAuthors":"Fisher N,  Bray PG,  Ward SA,  Biagini GA."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17499024","resource":"17499024","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning and sequence analysis of the gene encoding 19-kD subunit of Complex I from Dunaliella salina.","authors":["Liu Y"," Qiao DR"," Zheng HB"," Dai XL"," Bai LH"," Zeng J"," Cao Y."],"journal":"Molecular biology reports","year":2008,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17530440","id":"17530440","citationCount":3,"stringAuthors":"Liu Y,  Qiao DR,  Zheng HB,  Dai XL,  Bai LH,  Zeng J,  Cao Y."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17530440","resource":"17530440","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFA9","resource":"NDUFA9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB1","resource":"NDUFB1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB10","resource":"NDUFB10","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB2","resource":"NDUFB2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB3","resource":"NDUFB3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB4","resource":"NDUFB4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB5","resource":"NDUFB5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB6","resource":"NDUFB6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":54,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB7","resource":"NDUFB7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB8","resource":"NDUFB8","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFB9","resource":"NDUFB9","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC1","resource":"NDUFC1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] 1 subunit C2","references":[{"annotatorClassName":"","article":{"title":"Regulatory loop between redox sensing of the NADH/NAD(+) ratio by Rex (YdiH) and oxidation of NADH by NADH dehydrogenase Ndh in Bacillus subtilis.","authors":["Gyan S"," Shiohira Y"," Sato I"," Takeuchi M"," Sato T."],"journal":"Journal of bacteriology","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17015645","id":"17015645","citationCount":59,"stringAuthors":"Gyan S,  Shiohira Y,  Sato I,  Takeuchi M,  Sato T."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17015645","resource":"17015645","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Stimulation of chlororespiration by heat and high light intensity in oat plants.","authors":["Quiles MJ."],"journal":"Plant, cell & environment","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16898010","id":"16898010","citationCount":40,"stringAuthors":"Quiles MJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16898010","resource":"16898010","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Generation of a membrane potential by Lactococcus lactis through aerobic electron transport.","authors":["Brooijmans RJ"," Poolman B"," Schuurman-Wolters GK"," de Vos WM"," Hugenholtz J."],"journal":"Journal of bacteriology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17496098","id":"17496098","citationCount":36,"stringAuthors":"Brooijmans RJ,  Poolman B,  Schuurman-Wolters GK,  de Vos WM,  Hugenholtz J."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17496098","resource":"17496098","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption.","authors":["Zhu X"," Liu B"," Zhou S"," Chen YR"," Deng Y"," Zweier JL"," He G."],"journal":"American journal of physiology. Heart and circulatory physiology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17513495","id":"17513495","citationCount":25,"stringAuthors":"Zhu X,  Liu B,  Zhou S,  Chen YR,  Deng Y,  Zweier JL,  He G."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17513495","resource":"17513495","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFC2","resource":"NDUFC2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation?","authors":["Schuelke M"," Loeffen J"," Mariman E"," Smeitink J"," van den Heuvel L."],"journal":"Biochemical and biophysical research communications","year":1998,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9571201","id":"9571201","citationCount":11,"stringAuthors":"Schuelke M,  Loeffen J,  Mariman E,  Smeitink J,  van den Heuvel L."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9571201","resource":"9571201","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13.","authors":["Ali ST"," Duncan AM"," Schappert K"," Heng HH"," Tsui LC"," Chow W"," Robinson BH."],"journal":"Genomics","year":1993,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8288251","id":"8288251","citationCount":16,"stringAuthors":"Ali ST,  Duncan AM,  Schappert K,  Heng HH,  Tsui LC,  Chow W,  Robinson BH."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8288251","resource":"8288251","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis.","authors":["Grad LI"," Lemire BD."],"journal":"Human molecular genetics","year":2004,"link":"https://www.ncbi.nlm.nih.gov/pubmed/14662656","id":"14662656","citationCount":59,"stringAuthors":"Grad LI,  Lemire BD."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/14662656","resource":"14662656","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV1","resource":"NDUFV1","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of genes regulated by UV/salicylic acid.","authors":["Paunesku T"," Chang-Liu CM"," Shearin-Jones P"," Watson C"," Milton J"," Oryhon J"," Salbego D"," Milosavljevic A"," Woloschak GE."],"journal":"International journal of radiation biology","year":2000,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10716640","id":"10716640","citationCount":3,"stringAuthors":"Paunesku T,  Chang-Liu CM,  Shearin-Jones P,  Watson C,  Milton J,  Oryhon J,  Salbego D,  Milosavljevic A,  Woloschak GE."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10716640","resource":"10716640","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV2","resource":"NDUFV2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFV3","resource":"NDUFV3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS2","resource":"NDUFS2","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS3","resource":"NDUFS3","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The NADH: ubiquinone oxidoreductase (complex I) of the mammalian respiratory chain and the cAMP cascade.","authors":["Papa S"," Sardanelli AM"," Scacco S"," Petruzzella V"," Technikova-Dobrova Z"," Vergari R"," Signorile A."],"journal":"Journal of bioenergetics and biomembranes","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11860175","id":"11860175","citationCount":34,"stringAuthors":"Papa S,  Sardanelli AM,  Scacco S,  Petruzzella V,  Technikova-Dobrova Z,  Vergari R,  Signorile A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11860175","resource":"11860175","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A nonsense mutation in the NDUFS4 gene encoding the 18 kDa (AQDQ) subunit of complex I abolishes assembly and activity of the complex in a patient with Leigh-like syndrome.","authors":["Petruzzella V"," Vergari R"," Puzziferri I"," Boffoli D"," Lamantea E"," Zeviani M"," Papa S."],"journal":"Human molecular genetics","year":2001,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11181577","id":"11181577","citationCount":70,"stringAuthors":"Petruzzella V,  Vergari R,  Puzziferri I,  Boffoli D,  Lamantea E,  Zeviani M,  Papa S."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11181577","resource":"11181577","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase.","authors":["Raha S"," Myint AT"," Johnstone L"," Robinson BH."],"journal":"Free radical biology & medicine","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11864782","id":"11864782","citationCount":54,"stringAuthors":"Raha S,  Myint AT,  Johnstone L,  Robinson BH."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11864782","resource":"11864782","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS4","resource":"NDUFS4","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients.","authors":["Loeffen J"," Smeets R"," Smeitink J"," Triepels R"," Sengers R"," Trijbels F"," van den Heuvel L."],"journal":"Journal of inherited metabolic disease","year":1999,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10070614","id":"10070614","citationCount":7,"stringAuthors":"Loeffen J,  Smeets R,  Smeitink J,  Triepels R,  Sengers R,  Trijbels F,  van den Heuvel L."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10070614","resource":"10070614","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS5","resource":"NDUFS5","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS6","resource":"NDUFS6","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone.","authors":["Schuler F"," Yano T"," Di Bernardo S"," Yagi T"," Yankovskaya V"," Singer TP"," Casida JE."],"journal":"Proceedings of the National Academy of Sciences of the United States of America","year":1999,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10097178","id":"10097178","citationCount":58,"stringAuthors":"Schuler F,  Yano T,  Di Bernardo S,  Yagi T,  Yankovskaya V,  Singer TP,  Casida JE."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10097178","resource":"10097178","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13.","authors":["Hyslop SJ"," Duncan AM"," Pitkänen S"," Robinson BH."],"journal":"Genomics","year":1996,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8938450","id":"8938450","citationCount":11,"stringAuthors":"Hyslop SJ,  Duncan AM,  Pitkänen S,  Robinson BH."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8938450","resource":"8938450","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase.","authors":["Albracht SP."],"journal":"Biochimica et biophysica acta","year":1993,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8369340","id":"8369340","citationCount":27,"stringAuthors":"Albracht SP."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/8369340","resource":"8369340","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS7","resource":"NDUFS7","type":"HGNC_SYMBOL"}]},{"name":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Learning from hydrogenases: location of a proton pump and of a second FMN in bovine NADH--ubiquinone oxidoreductase (Complex I).","authors":["Albracht SP"," Hedderich R."],"journal":"FEBS letters","year":2000,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11086155","id":"11086155","citationCount":39,"stringAuthors":"Albracht SP,  Hedderich R."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11086155","resource":"11086155","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The first nuclear-encoded complex I mutation in a patient with Leigh syndrome.","authors":["Loeffen J"," Smeitink J"," Triepels R"," Smeets R"," Schuelke M"," Sengers R"," Trijbels F"," Hamel B"," Mullaart R"," van den Heuvel L."],"journal":"American journal of human genetics","year":1998,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9837812","id":"9837812","citationCount":114,"stringAuthors":"Loeffen J,  Smeitink J,  Triepels R,  Smeets R,  Schuelke M,  Sengers R,  Trijbels F,  Hamel B,  Mullaart R,  van den Heuvel L."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9837812","resource":"9837812","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of ferredoxin-NADP oxidoreductase with the chloroplastic pyridine nucleotide dehydrogenase complex in barley leaves","authors":["Jose Quiles M"," Cuello J."],"journal":"Plant physiology","year":1998,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9576793","id":"9576793","citationCount":27,"stringAuthors":"Jose Quiles M,  Cuello J."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9576793","resource":"9576793","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS8","resource":"NDUFS8","type":"HGNC_SYMBOL"}]},{"name":"NADH-cytochrome b5 reductase 3","references":[{"annotatorClassName":"","article":{"title":"Expression and characterization of a functional canine variant of cytochrome b5 reductase.","authors":["Roma GW"," Crowley LJ"," Barber MJ."],"journal":"Archives of biochemistry and biophysics","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16814740","id":"16814740","citationCount":7,"stringAuthors":"Roma GW,  Crowley LJ,  Barber MJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16814740","resource":"16814740","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.","authors":["Nussenzveig RH"," Lingam HB"," Gaikwad A"," Zhu Q"," Jing N"," Prchal JT."],"journal":"Haematologica","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17082011","id":"17082011","citationCount":9,"stringAuthors":"Nussenzveig RH,  Lingam HB,  Gaikwad A,  Zhu Q,  Jing N,  Prchal JT."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17082011","resource":"17082011","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure of Physarum polycephalum cytochrome b5 reductase at 1.56 A resolution.","authors":["Kim S"," Suga M"," Ogasahara K"," Ikegami T"," Minami Y"," Yubisui T"," Tsukihara T."],"journal":"Acta crystallographica. Section F, Structural biology and crystallization communications","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17401193","id":"17401193","citationCount":4,"stringAuthors":"Kim S,  Suga M,  Ogasahara K,  Ikegami T,  Minami Y,  Yubisui T,  Tsukihara T."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17401193","resource":"17401193","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Reductive detoxification of arylhydroxylamine carcinogens by human NADH cytochrome b5 reductase and cytochrome b5.","authors":["Kurian JR"," Chin NA"," Longlais BJ"," Hayes KL"," Trepanier LA."],"journal":"Chemical research in toxicology","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17040106","id":"17040106","citationCount":14,"stringAuthors":"Kurian JR,  Chin NA,  Longlais BJ,  Hayes KL,  Trepanier LA."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17040106","resource":"17040106","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Structure and properties of the recombinant NADH-cytochrome b5 reductase of Physarum polycephalum.","authors":["Ikegami T"," Kameyama E"," Yamamoto SY"," Minami Y"," Yubisui T."],"journal":"Bioscience, biotechnology, and biochemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17341833","id":"17341833","citationCount":1,"stringAuthors":"Ikegami T,  Kameyama E,  Yamamoto SY,  Minami Y,  Yubisui T."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17341833","resource":"17341833","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=CYB5R3","resource":"CYB5R3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NDUFS1","resource":"NDUFS1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":131,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND1","resource":"MT-ND1","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness.","authors":["Nikonova EV"," Vijayasarathy C"," Zhang L"," Cater JR"," Galante RJ"," Ward SE"," Avadhani NG"," Pack AI."],"journal":"Sleep","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15700717","id":"15700717","citationCount":18,"stringAuthors":"Nikonova EV,  Vijayasarathy C,  Zhang L,  Cater JR,  Galante RJ,  Ward SE,  Avadhani NG,  Pack AI."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15700717","resource":"15700717","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"[The changes of gene expression in multiple myeloma treated with thalidomide].","authors":["Zhang HB"," Chen SL"," Liu JZ"," Xiao B"," Chen ZB"," Wang HJ."],"journal":"Zhonghua nei ke za zhi","year":2003,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12882707","id":"12882707","citationCount":0,"stringAuthors":"Zhang HB,  Chen SL,  Liu JZ,  Xiao B,  Chen ZB,  Wang HJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12882707","resource":"12882707","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":131,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND2","resource":"MT-ND2","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"TTD: Therapeutic Target Database.","authors":["Chen X"," Ji ZL"," Chen YZ."],"journal":"Nucleic acids research","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11752352","id":"11752352","citationCount":131,"stringAuthors":"Chen X,  Ji ZL,  Chen YZ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11752352","resource":"11752352","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND3","resource":"MT-ND3","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells.","authors":["Shen XY"," Zacal N"," Singh G"," Rainbow AJ."],"journal":"Photochemistry and photobiology","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15560738","id":"15560738","citationCount":19,"stringAuthors":"Shen XY,  Zacal N,  Singh G,  Rainbow AJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15560738","resource":"15560738","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Oxidative stress induces differential gene expression in a human lens epithelial cell line.","authors":["Carper DA"," Sun JK"," Iwata T"," Zigler JS"," Ibaraki N"," Lin LR"," Reddy V."],"journal":"Investigative ophthalmology & visual science","year":1999,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9950599","id":"9950599","citationCount":21,"stringAuthors":"Carper DA,  Sun JK,  Iwata T,  Zigler JS,  Ibaraki N,  Lin LR,  Reddy V."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9950599","resource":"9950599","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Deletion of the structural gene for the NADH-dehydrogenase subunit 4 of Synechocystis 6803 alters respiratory properties.","authors":["Dzelzkalns VA"," Obinger C"," Regelsberger G"," Niederhauser H"," Kamensek M"," Peschek GA"," Bogorad L."],"journal":"Plant physiology","year":1994,"link":"https://www.ncbi.nlm.nih.gov/pubmed/7846157","id":"7846157","citationCount":7,"stringAuthors":"Dzelzkalns VA,  Obinger C,  Regelsberger G,  Niederhauser H,  Kamensek M,  Peschek GA,  Bogorad L."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/7846157","resource":"7846157","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4","resource":"MT-ND4","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 4L","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND4L","resource":"MT-ND4L","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 5","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Phylogenetic reconstruction of the Felidae using 16S rRNA and NADH-5 mitochondrial genes.","authors":["Johnson WE"," O'Brien SJ."],"journal":"Journal of molecular evolution","year":1997,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9071018","id":"9071018","citationCount":52,"stringAuthors":"Johnson WE,  O'Brien SJ."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/9071018","resource":"9071018","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos.","authors":["Bao HG"," Zhao CJ"," Li JY"," Wu Ch."],"journal":"Animal genetics","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17614984","id":"17614984","citationCount":3,"stringAuthors":"Bao HG,  Zhao CJ,  Li JY,  Wu Ch."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17614984","resource":"17614984","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND5","resource":"MT-ND5","type":"HGNC_SYMBOL"}]},{"name":"NADH-ubiquinone oxidoreductase chain 6","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=MT-ND6","resource":"MT-ND6","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme","references":[{"annotatorClassName":"","article":{"title":"Determining Actinobacillus succinogenes metabolic pathways and fluxes by NMR and GC-MS analyses of 13C-labeled metabolic product isotopomers.","authors":["McKinlay JB"," Shachar-Hill Y"," Zeikus JG"," Vieille C."],"journal":"Metabolic engineering","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17197218","id":"17197218","citationCount":58,"stringAuthors":"McKinlay JB,  Shachar-Hill Y,  Zeikus JG,  Vieille C."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17197218","resource":"17197218","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ME1","resource":"ME1","type":"HGNC_SYMBOL"}]},{"name":"NADP-dependent malic enzyme, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates.","authors":["Luo C"," Wang X"," Long J"," Liu J."],"journal":"Journal of biochemical and biophysical methods","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16740313","id":"16740313","citationCount":9,"stringAuthors":"Luo C,  Wang X,  Long J,  Liu J."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16740313","resource":"16740313","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Identification of cold acclimation-responsive Rhododendron genes for lipid metabolism, membrane transport and lignin biosynthesis: importance of moderately abundant ESTs in genomic studies.","authors":["Wei H"," Dhanaraj AL"," Arora R"," Rowland LJ"," Fu Y"," Sun L."],"journal":"Plant, cell & environment","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17080607","id":"17080607","citationCount":25,"stringAuthors":"Wei H,  Dhanaraj AL,  Arora R,  Rowland LJ,  Fu Y,  Sun L."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17080607","resource":"17080607","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"L-2-hydroxyglutaric aciduria, a defect of metabolite repair.","authors":["Rzem R"," Vincent MF"," Van Schaftingen E"," Veiga-da-Cunha M."],"journal":"Journal of inherited metabolic disease","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17603759","id":"17603759","citationCount":65,"stringAuthors":"Rzem R,  Vincent MF,  Van Schaftingen E,  Veiga-da-Cunha M."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17603759","resource":"17603759","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ME3","resource":"ME3","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal bifunctional enzyme","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=EHHADH","resource":"EHHADH","type":"HGNC_SYMBOL"}]},{"name":"Peroxisomal multifunctional enzyme type 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution.","authors":["Haapalainen AM"," Koski MK"," Qin YM"," Hiltunen JK"," Glumoff T."],"journal":"Structure (London, England : 1993)","year":2003,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12517343","id":"12517343","citationCount":21,"stringAuthors":"Haapalainen AM,  Koski MK,  Qin YM,  Hiltunen JK,  Glumoff T."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/12517343","resource":"12517343","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B4","resource":"HSD17B4","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 1, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"Glutamine synthetase and glutamate dehydrogenase contribute differentially to proline accumulation in leaves of wheat (Triticum aestivum) seedlings exposed to different salinity.","authors":["Wang ZQ"," Yuan YZ"," Ou JQ"," Lin QH"," Zhang CF."],"journal":"Journal of plant physiology","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16777263","id":"16777263","citationCount":33,"stringAuthors":"Wang ZQ,  Yuan YZ,  Ou JQ,  Lin QH,  Zhang CF."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16777263","resource":"16777263","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Plant P5C reductase as a new target for aminomethylenebisphosphonates.","authors":["Forlani G"," Giberti S"," Berlicki L"," Petrollino D"," Kafarski P."],"journal":"Journal of agricultural and food chemistry","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17474756","id":"17474756","citationCount":13,"stringAuthors":"Forlani G,  Giberti S,  Berlicki L,  Petrollino D,  Kafarski P."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17474756","resource":"17474756","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR1","resource":"PYCR1","type":"HGNC_SYMBOL"}]},{"name":"Pyrroline-5-carboxylate reductase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Purification and characterization of Delta(1)-pyrroline-5-carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves.","authors":["Murahama M"," Yoshida T"," Hayashi F"," Ichino T"," Sanada Y"," Wada K."],"journal":"Plant & cell physiology","year":2001,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11479381","id":"11479381","citationCount":15,"stringAuthors":"Murahama M,  Yoshida T,  Hayashi F,  Ichino T,  Sanada Y,  Wada K."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11479381","resource":"11479381","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=PYCR2","resource":"PYCR2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA1","resource":"PDHA1","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHA2","resource":"PDHA2","type":"HGNC_SYMBOL"}]},{"name":"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulation of pyruvate dehydrogenase in isolated rat liver mitochondria. Effects of octanoate, oxidation-reduction state, and adenosine triphosphate to adenosine diphosphate ratio.","authors":["Taylor SI"," Mukherjee C"," Jungas RL."],"journal":"The Journal of biological chemistry","year":1975,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1116996","id":"1116996","citationCount":44,"stringAuthors":"Taylor SI,  Mukherjee C,  Jungas RL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1116996","resource":"1116996","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=PDHB","resource":"PDHB","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 1","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Activities of cytosolic aldehyde dehydrogenase isozymes in colon cancer: determination using selective, fluorimetric assays.","authors":["Wroczyński P"," Nowak M"," Wierzchowski J"," Szubert A"," Polański J."],"journal":"Acta poloniae pharmaceutica","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16583981","id":"16583981","citationCount":3,"stringAuthors":"Wroczyński P,  Nowak M,  Wierzchowski J,  Szubert A,  Polański J."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16583981","resource":"16583981","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":11,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A1","resource":"ALDH1A1","type":"HGNC_SYMBOL"}]},{"name":"Retinal dehydrogenase 2","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity.","authors":["Lamb AL"," Newcomer ME."],"journal":"Biochemistry","year":1999,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10320326","id":"10320326","citationCount":54,"stringAuthors":"Lamb AL,  Newcomer ME."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/10320326","resource":"10320326","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.","authors":["Russo J"," Barnes A"," Berger K"," Desgrosellier J"," Henderson J"," Kanters A"," Merkov L."],"journal":"BMC pharmacology","year":2002,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11872149","id":"11872149","citationCount":11,"stringAuthors":"Russo J,  Barnes A,  Berger K,  Desgrosellier J,  Henderson J,  Kanters A,  Merkov L."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/11872149","resource":"11872149","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH1A2","resource":"ALDH1A2","type":"HGNC_SYMBOL"}]},{"name":"Ribosyldihydronicotinamide dehydrogenase [quinone]","references":[{"annotatorClassName":"","article":{"title":"Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor.","authors":["Jamieson D"," Tung AT"," Knox RJ"," Boddy AV."],"journal":"British journal of cancer","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17031400","id":"17031400","citationCount":14,"stringAuthors":"Jamieson D,  Tung AT,  Knox RJ,  Boddy AV."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17031400","resource":"17031400","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"NQO1 and NQO2 regulation of humoral immunity and autoimmunity.","authors":["Iskander K"," Li J"," Han S"," Zheng B"," Jaiswal AK."],"journal":"The Journal of biological chemistry","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16905546","id":"16905546","citationCount":33,"stringAuthors":"Iskander K,  Li J,  Han S,  Zheng B,  Jaiswal AK."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16905546","resource":"16905546","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NQO2","resource":"NQO2","type":"HGNC_SYMBOL"}]},{"name":"Short-chain specific acyl-CoA dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ACADS","resource":"ACADS","type":"HGNC_SYMBOL"}]},{"name":"Sorbitol dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"Pyridine nucleotide redox abnormalities in diabetes.","authors":["Ido Y."],"journal":"Antioxidants & redox signaling","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17508915","id":"17508915","citationCount":42,"stringAuthors":"Ido Y."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17508915","resource":"17508915","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase.","authors":["Klimacek M"," Hellmer H"," Nidetzky B."],"journal":"The Biochemical journal","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17343568","id":"17343568","citationCount":8,"stringAuthors":"Klimacek M,  Hellmer H,  Nidetzky B."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17343568","resource":"17343568","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=SORD","resource":"SORD","type":"HGNC_SYMBOL"}]},{"name":"Steroid 17-alpha-hydroxylase/17,20 lyase","references":[{"annotatorClassName":"","article":{"title":"Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase.","authors":["Pandey AV"," Kempná P"," Hofer G"," Mullis PE"," Flück CE."],"journal":"Molecular endocrinology (Baltimore, Md.)","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17595315","id":"17595315","citationCount":49,"stringAuthors":"Pandey AV,  Kempná P,  Hofer G,  Mullis PE,  Flück CE."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17595315","resource":"17595315","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=CYP17A1","resource":"CYP17A1","type":"HGNC_SYMBOL"}]},{"name":"Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Changes in gene expression associated with loss of function of the NSDHL sterol dehydrogenase in mouse embryonic fibroblasts.","authors":["Cunningham D"," Swartzlander D"," Liyanarachchi S"," Davuluri RV"," Herman GE."],"journal":"Journal of lipid research","year":2005,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15805545","id":"15805545","citationCount":9,"stringAuthors":"Cunningham D,  Swartzlander D,  Liyanarachchi S,  Davuluri RV,  Herman GE."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/15805545","resource":"15805545","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=NSDHL","resource":"NSDHL","type":"HGNC_SYMBOL"}]},{"name":"Succinate-semialdehyde dehydrogenase, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=ALDH5A1","resource":"ALDH5A1","type":"HGNC_SYMBOL"}]},{"name":"Testosterone 17-beta-dehydrogenase 3","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17 beta-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction.","authors":["Inano H"," Tamaoki B."],"journal":"European journal of biochemistry","year":1975,"link":"https://www.ncbi.nlm.nih.gov/pubmed/237755","id":"237755","citationCount":9,"stringAuthors":"Inano H,  Tamaoki B."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/237755","resource":"237755","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HSD17B3","resource":"HSD17B3","type":"HGNC_SYMBOL"}]},{"name":"Trifunctional enzyme subunit alpha, mitochondrial","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=HADHA","resource":"HADHA","type":"HGNC_SYMBOL"}]},{"name":"Tyrosinase","references":[{"annotatorClassName":"","article":{"title":"Decolourization of azo dye methyl red by Saccharomyces cerevisiae MTCC 463.","authors":["Jadhav JP"," Parshetti GK"," Kalme SD"," Govindwar SP."],"journal":"Chemosphere","year":2007,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17292452","id":"17292452","citationCount":47,"stringAuthors":"Jadhav JP,  Parshetti GK,  Kalme SD,  Govindwar SP."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17292452","resource":"17292452","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition.","authors":["Zafar KS"," Siegel D"," Ross D."],"journal":"Molecular pharmacology","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16790533","id":"16790533","citationCount":48,"stringAuthors":"Zafar KS,  Siegel D,  Ross D."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/16790533","resource":"16790533","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=TYR","resource":"TYR","type":"HGNC_SYMBOL"}]},{"name":"UDP-glucose 6-dehydrogenase","references":[{"annotatorClassName":"","article":{"title":"How many drug targets are there?","authors":["Overington JP"," Al-Lazikani B"," Hopkins AL."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","id":"17139284","citationCount":1191,"stringAuthors":"Overington JP,  Al-Lazikani B,  Hopkins AL."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17139284","resource":"17139284","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Drugs, their targets and the nature and number of drug targets.","authors":["Imming P"," Sinning C"," Meyer A."],"journal":"Nature reviews. Drug discovery","year":2006,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","id":"17016423","citationCount":230,"stringAuthors":"Imming P,  Sinning C,  Meyer A."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/17016423","resource":"17016423","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Regulatory mechanisms of UDP-glucuronic acid biosynthesis in cultured human skin fibroblasts.","authors":["Castellani AA"," De Luca G"," Rindi S"," Salvini R"," Tira ME."],"journal":"The Italian journal of biochemistry","year":1986,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3804697","id":"3804697","citationCount":4,"stringAuthors":"Castellani AA,  De Luca G,  Rindi S,  Salvini R,  Tira ME."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/3804697","resource":"3804697","type":"PUBMED"},{"annotatorClassName":"","article":{"title":"Mechanism of cadmium-decreased glucuronidation in the rat.","authors":["Alary J"," Cravedi JP"," Baradat M"," Carrera G."],"journal":"Biochemical pharmacology","year":1992,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1472079","id":"1472079","citationCount":3,"stringAuthors":"Alary J,  Cravedi JP,  Baradat M,  Carrera G."},"id":0,"link":"https://www.ncbi.nlm.nih.gov/pubmed/1472079","resource":"1472079","type":"PUBMED"}],"targetElements":[],"targetParticipants":[{"annotatorClassName":"","id":0,"link":"https://www.genenames.org/cgi-bin/gene_symbol_report?match=UGDH","resource":"UGDH","type":"HGNC_SYMBOL"}]}]}]