</head> <body>Authors: <br/> Jan Hasenauer, ICB Helmholtz Center Munich, Munich, Germany <br/> <br/> Leonard Schmiester, Helmholtz Zentrum München, Munich, Germany </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:modelVersion>4.0</celldesigner:modelVersion> <celldesigner:modelDisplay sizeX="4010" sizeY="4010"/> <celldesigner:listOfIncludedSpecies> <celldesigner:species id="s44" name="ELOB"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>EloBC</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr2</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> <celldesigner:species id="s45" name="ELOC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> 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xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s22"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc:HGNC%3A2552"/> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s30" id="Cul2_mRNA" name="CUL2" compartment="c3" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn9</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s30"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc:HGNC%3A2552"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s41" id="DUB" name="DUB" compartment="c3" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr9</celldesigner:proteinReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="deubiquit_subs_ub"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s41"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:DUB"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s25" id="DUB_gene" name="DUB" compartment="c2" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn16</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s25"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:DUB"/> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s33" id="DUB_mRNA" name="DUB" compartment="c3" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn12</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s33"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:DUB"/> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s60" id="E1" name="E1" compartment="c3" initialAmount="0" charge="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ubiquitin activating enzymes (UBA) Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. The gene group contains several members, inclusing UBA1 (HGNC:12469) and UBA1 (HGNC:30661). </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:proteinReference>pr7</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s60"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:UBA"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s23" id="E1_gene" name="E1" compartment="c2" initialAmount="0" charge="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ubiquitin activating enzymes (UBA) Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. The gene group contains several members, inclusing UBA1 (HGNC:12469) and UBA1 (HGNC:30661). </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:geneReference>gn14</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s23"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:UBA"/> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s31" id="E1_mRNA" name="E1" compartment="c3" initialAmount="0" charge="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ubiquitin activating enzymes (UBA) Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. The gene group contains several members, inclusing UBA1 (HGNC:12469) and UBA1 (HGNC:30661). </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:rnaReference>rn10</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s31"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:UBA"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s39" id="E1_ub" name="E1" compartment="c3" initialAmount="0" charge="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ubiquitin activating enzymes (UBA) Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. The gene group contains several members, inclusing UBA1 (HGNC:12469) and UBA1 (HGNC:30661). </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:proteinReference>pr7</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> <celldesigner:modification residue="rs1" state="ubiquitinated"/> </celldesigner:listOfModifications> </celldesigner:state> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s39"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:UBA"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s40" id="E2" name="E2" compartment="c3" initialAmount="0" charge="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ubiquitin conjugating enzymes E2 (UBE2) Ubiquitin-conjugating enzymes: Ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome. The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. The gene group defined on HCNG contains several members, inclusing UBE2A (HGNC:12472) and UBE2B (HGNC:12473). </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:proteinReference>pr8</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s40"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:UBE2"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s24" id="E2_gene" name="E2" compartment="c2" initialAmount="0" charge="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ubiquitin conjugating enzymes E2 (UBE2) Ubiquitin-conjugating enzymes: Ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome. The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. The gene group defined on HCNG contains several members, inclusing UBE2A (HGNC:12472) and UBE2B (HGNC:12473). </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:geneReference>gn15</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s24"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:UBE2"/> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s32" id="E2_mRNA" name="E2" compartment="c3" initialAmount="0" charge="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ubiquitin conjugating enzymes E2 (UBE2) Ubiquitin-conjugating enzymes: Ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome. The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. The gene group defined on HCNG contains several members, inclusing UBE2A (HGNC:12472) and UBE2B (HGNC:12473). </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:rnaReference>rn11</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s32"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:UBE2"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s119" id="E2_ub" name="E2" compartment="c3" initialAmount="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ubiquitin conjugating enzymes E2 (UBE2) Ubiquitin-conjugating enzymes: Ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome.The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. The gene group defined on HCNG contains several members, inclusing UBE2A (HGNC:12472) and UBE2B (HGNC:12473). </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:proteinReference>pr8</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> <celldesigner:modification residue="rs1" state="ubiquitinated"/> </celldesigner:listOfModifications> </celldesigner:state> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s119"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:UBE2"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s201" id="E3" name="Cul2 ubiquitin ligase" compartment="c3" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>Cul2 ubiquitin ligase</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> 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xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s280"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc:HGNC%3A12491"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s36" id="Zyg11B" name="ZYG11B" compartment="c3" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr4</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s36"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc:HGNC%3A25820"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s46" id="Zyg11B_EloBC" name="Zyg11B:EloBC" compartment="c3" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>Zyg11B:EloBC</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s46"> <bqbiol:hasPart> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:ZYG11B"/> </rdf:Bag> </bqbiol:hasPart> <bqbiol:hasPart> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:ELOB"/> </rdf:Bag> </bqbiol:hasPart> <bqbiol:hasPart> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:ELOC"/> </rdf:Bag> </bqbiol:hasPart> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s20" id="Zyg11B_gene" name="ZYG11B" compartment="c2" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn11</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s20"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc:HGNC%3A25820"/> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s28" id="Zyg11B_mRNA" name="ZYG11B" compartment="c3" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn7</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s28"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc:HGNC%3A25820"/> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s89" id="Zyg11B_ubit_target_ub" name="ubit_traget" compartment="c3" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:proteinReference>pr11</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> <celldesigner:modification residue="rs2" state="ubiquitinated"/> </celldesigner:listOfModifications> </celldesigner:state> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s91" id="proteasom_26S" name="26S-proteasom" compartment="c3" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>26S-proteasom</celldesigner:name> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="deg_substrate_ub"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s91"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0000502"/> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s337" id="s337" name="degradation" compartment="c3" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>DEGRADED</celldesigner:class> <celldesigner:name>degradation</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="CDMT00005" id="s338" name="ubit_traget" compartment="c3" initialAmount="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Note: The usual substrates bound by Zyb11B are proteins with exposed N-terminal glycines (10.1126/science.aaw4912). For the complex including Orf10 this is unclear. </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:hypothetical>true</celldesigner:hypothetical> <celldesigner:proteinReference>pr11</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> </listOfSpecies> <listOfParameters> <parameter metaid="k1" id="k1" name="k_transcr_EloB" value="0.1" units="substance"/> <parameter metaid="k2" id="k2" name="k_transl_EloB" value="0.1" units="substance"/> <parameter metaid="k3" id="k3" name="k_transcr_EloC" value="0.1" units="substance"/> <parameter metaid="k4" id="k4" name="k_transcr_Zyg11B" value="0.1" units="substance"/> <parameter metaid="k5" id="k5" name="k_transcr_Rbx1" value="0.1" units="substance"/> <parameter metaid="k6" id="k6" name="k_transcr_Cul2" value="0.1" units="substance"/> <parameter metaid="k9" id="k9" name="k_transl_EloC" value="0.1" units="substance"/> <parameter metaid="k10" id="k10" name="k_transl_Zyg11B" value="0.1" units="substance"/> <parameter metaid="k11" id="k11" name="k_transl_Rbx1" value="0.1" units="substance"/> <parameter metaid="k12" id="k12" name="k_transl_Cul2" value="0.1" units="substance"/> <parameter metaid="k128" id="k128" name="k_transcr_Orf10" value="0.1" units="substance"/> <parameter metaid="k125" id="k125" name="k_transl_Orf10" value="0.1" units="substance"/> <parameter metaid="k7" id="k7" name="k_transcr_E1" value="0.1" units="substance"/> <parameter metaid="k13" id="k13" name="k_transl_E1" value="0.1" units="substance"/> <parameter metaid="k8" id="k8" name="k_transcr_E2" value="0.1" units="substance"/> <parameter metaid="k14" id="k14" name="k_transl_E2" value="0" units="substance"/> <parameter metaid="k15" id="k15" name="k_transcr_DUB" value="0.1" units="substance"/> <parameter metaid="k16" id="k16" name="k_transl_DUB" value="0.1" units="substance"/> <parameter metaid="k115" id="k115" name="k_transcr_Ubc12" value="0.1" units="substance"/> <parameter metaid="k116" id="k116" name="k_transl_Ubc" value="0.1" units="substance"/> <parameter metaid="k85" id="k85" name="k_transcr_NEDD8" value="0.1" units="substance"/> <parameter metaid="k90" id="k90" name="k_transl_NEDD8" value="0.1" units="substance"/> <parameter metaid="k86" id="k86" name="k_transcr_NAE1" value="0.1" units="substance"/> <parameter metaid="k89" id="k89" name="k_transl_NAE1" value="0" units="substance"/> <parameter metaid="k87" id="k87" name="k_transcr_UBA3" value="0.1" units="substance"/> <parameter metaid="k88" id="k88" name="k_transl_UBA3" value="0.1" units="substance"/> <parameter metaid="k17" id="k17" name="k_deg_EloB_mRNA" value="0.1" units="substance"/> <parameter metaid="k18" id="k18" name="k_deg_EloB" value="0.1" units="substance"/> <parameter metaid="k19" id="k19" name="k_deg_EloC_mRNA" value="0.1" units="substance"/> <parameter metaid="k20" id="k20" name="k_deg_EloC" value="0.1" units="substance"/> <parameter metaid="k21" id="k21" name="k_deg_Zyg11B_mRNA" value="0.1" units="substance"/> <parameter metaid="k22" id="k22" name="k_deg_Zyg11B" value="0.1" units="substance"/> <parameter metaid="k23" id="k23" name="k_deg_Rbx1_mRNA" value="0.1" units="substance"/> <parameter metaid="k24" id="k24" name="k_deg_Rbx1" value="0.1" units="substance"/> <parameter metaid="k25" id="k25" name="k_deg_Cul2_mRNA" value="0.1" units="substance"/> <parameter metaid="k26" id="k26" name="k_deg_Cul2" value="0.1" units="substance"/> <parameter metaid="k126" id="k126" name="k_deg_Orf10_mRNA" value="0.1" units="substance"/> <parameter metaid="k127" id="k127" name="k_deg_Orf10" value="0.1" units="substance"/> <parameter metaid="k91" id="k91" name="k_deg_NEDD8_mRNA" value="0.1" units="substance"/> <parameter metaid="k92" id="k92" name="k_deg_NEDD8" value="0.1" units="substance"/> <parameter metaid="k93" id="k93" name="k_deg_NAE1_mRNA" value="0.1" units="substance"/> <parameter metaid="k94" id="k94" name="k_deg_NAE1" value="0.1" units="substance"/> <parameter metaid="k95" id="k95" name="k_deg_UBA3_mRNA" value="0.1" units="substance"/> <parameter metaid="k96" id="k96" name="k_deg_UBA3" value="0.1" units="substance"/> <parameter metaid="k118" id="k118" name="k_deg_Ubc12_mRNA" value="0.1" units="substance"/> <parameter metaid="k117" id="k117" name="k_deg_Ubc12" value="0.1" units="substance"/> <parameter metaid="k31" id="k32" name="k_deg_DUB" value="0.1" units="substance"/> <parameter metaid="k32" id="k31" name="k_deg_DUB_mRNA" value="0.1" units="substance"/> <parameter metaid="k29" id="k29" name="k_deg_E2_mRNA" value="0.1" units="substance"/> <parameter metaid="k30" id="k30" name="k_deg_E2" value="0.1" units="substance"/> <parameter metaid="k27" id="k27" name="k_deg_E1_mRNA" value="0.1" units="substance"/> <parameter metaid="k28" id="k28" name="k_deg_E1" value="0.1" units="substance"/> <parameter metaid="k133" id="k133" name="k_deg_CSN5" value="0.1" units="substance"/> <parameter metaid="k131" id="k131" name="k_syn_CSN5" value="0.1" units="substance"/> <parameter metaid="k130" id="k130" name="k_deg_26S_proteasom" value="0.1" units="substance"/> <parameter metaid="k129" id="k129" name="k_syn_26S_proteasom" value="0.1" units="substance"/> <parameter metaid="k83" id="k83" name="k_deg_substrate:ub" value="0.1" units="substance"/> <parameter metaid="k33" id="k33" name="k_bind_EloB_EloC" value="0.1" units="substance"/> <parameter metaid="k35" id="k35" name="k_bind_Elo_Zyg11B" value="0.1" units="substance"/> <parameter metaid="k37" id="k37" name="k_bind_Cul2_Rbx1" value="0.1" units="substance"/> <parameter metaid="k39" id="k39" name="k_bind_Elo:Zyg11B_Cul2:Rbx1" value="0.1" units="substance"/> <parameter metaid="k43" id="k43" name="k_bind_E3_subs" value="0.1" units="substance"/> <parameter metaid="k63" id="k63" name="k_bind_NEDD8_NAE" value="0.1" units="substance"/> <parameter metaid="k67" id="k67" name="k_bind_NAE_Pevonedistat" value="0.1" units="substance"/> <parameter metaid="k69" id="k69" name="k_bind_Ubc12_NAE:NEDD8" value="0.1" units="substance"/> <parameter metaid="k71" id="k71" name="k_bind_E3:subs_NEDD8" value="0.1" units="substance"/> <parameter metaid="k72" id="k72" name="k_ubiquit:E2_E3:subs" value="0.1" units="substance"/> <parameter metaid="k75" id="k75" name="k_bind_E2_E3:subs" value="0.1" units="substance"/> <parameter metaid="k97" id="k97" name="k_bind_NAE1_UBA3" value="0.1" units="substance"/> <parameter metaid="k110" id="k110" name="k_bind_Orf10_E3" value="0.1" units="substance"/> <parameter metaid="k112" id="k112" name="k_bind_E3:Orf10_subs" value="0.1" units="substance"/> <parameter metaid="k114" id="k114" name="k_bind_E3:Orf10:subs_NEDD8" value="0.1" units="substance"/> <parameter metaid="k119" id="k119" name="k_ubiquit:E2_E3:Orf10:subs" value="0.1" units="substance"/> <parameter metaid="k41" id="k41" name="k_ubiquit_E1" value="0.1" units="substance"/> <parameter metaid="k42" id="k42" name="k_ubiquit_E2" value="0.1" units="substance"/> <parameter metaid="k77" id="k77" name="k_ubiquit_subs:E3" value="0.1" units="substance"/> <parameter metaid="k82" id="k82" name="k_diss_E3:NEDD8_E3:subs" value="0.1" units="substance"/> <parameter metaid="k84" id="k84" name="k_deubiquit_subs:ub" value="0.1" units="substance"/> <parameter metaid="k105" id="k105" name="k_ubiquit_subs:E3:Orf10" value="0.1" units="substance"/> <parameter metaid="k107" id="k107" name="k_diss_E3:Orf10:NEDD8_E3:Orf10:subs" value="0.1" units="substance"/> <parameter metaid="k34" id="k34" name="diss_EloB:EloC" value="0.1" units="substance"/> <parameter metaid="k36" id="k36" name="diss_Elo:Zyg11B" value="0.1" units="substance"/> <parameter metaid="k38" id="k38" name="diss_Cul2:Rbx1" value="0.1" units="substance"/> <parameter metaid="k40" id="k40" name="diss_E3" value="0.1" units="substance"/> <parameter metaid="k44" id="k44" name="diss_E3:subs" value="0.1" units="substance"/> <parameter metaid="k68" id="k68" name="diss:NAE:Pevonedistat" value="0.1" units="substance"/> <parameter metaid="k74" id="k74" name="deubiquit_E2:E3:subs" value="0.1" units="substance"/> <parameter metaid="k76" id="k76" name="diss_E2:E3:subs" value="0.1" units="substance"/> <parameter metaid="k79" id="k79" name="diss_E2:E3:subs:ub" value="0.1" units="substance"/> <parameter metaid="k81" id="k81" name="diss_E3:subs" value="0.1" units="substance"/> <parameter metaid="k98" id="k98" name="diss_NAE" value="0.1" units="substance"/> <parameter metaid="k106" id="k106" name="diss_E3:Orf10:subs:ub" value="0.1" units="substance"/> <parameter metaid="k111" id="k111" name="diss_E3:Orf10" value="0.1" units="substance"/> <parameter metaid="k113" id="k113" name="diss_E3:Orf10:subs" value="0.1" units="substance"/> <parameter metaid="k120" id="k120" name="deubiquit_E2:E3:Orf10:subs" value="0.1" units="substance"/> <parameter metaid="k134" id="k134" name="bind_E2_E3:Orf10:subs" value="0.1" units="substance"/> <parameter metaid="k123" id="k123" name="diss_E2:E3:Orf10:subs" value="0.1" units="substance"/> </listOfParameters> <listOfReactions> <reaction metaid="re105" id="ubiquit_subs_E3_Orf10" name="ubiquit_subs:E3:Orf10" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>ubiquit_subs:E3:Orf10</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E3_NEDD8_Orf10_E2_ub_Substrate" alias="csa32"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="E3_NEDD8_Orf10_E2_Substrate_ub" alias="csa31"> <celldesigner:linkAnchor position="WNW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00240" species="E3_NEDD8_Orf10_E2_ub_Substrate"> <annotation> <celldesigner:extension> <celldesigner:alias>csa32</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00253" species="E3_NEDD8_Orf10_E2_Substrate_ub"> <annotation> <celldesigner:extension> <celldesigner:alias>csa31</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00333"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> E3_NEDD8_Orf10_E2_ub_Substrate </ci> <ci> k105 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re77" id="ubiquit_subs_E3" name="ubiquit_subs:E3" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>ubiquit_subs:E3</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E3_NEDD8_E2_ub_Substrate" alias="csa17"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="E3_NEDD8_E2_Substrate_ub" alias="csa18"> <celldesigner:linkAnchor position="WNW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> 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</annotation> <listOfReactants> <speciesReference metaid="CDMT00344" species="Orf10_pss_sgmRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa278</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00345" species="Orf10"> <annotation> <celldesigner:extension> <celldesigner:alias>sa55</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00139"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Orf10_pss_sgmRNA </ci> <ci> k125 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re90" id="transl_NEDD8" name="transl_NEDD8" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transl_NEDD8</celldesigner:name> <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NEDD8_mRNA" alias="sa173"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="NEDD8" alias="sa118"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00234" species="NEDD8_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa173</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00250" species="NEDD8"> <annotation> <celldesigner:extension> <celldesigner:alias>sa118</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00136"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NEDD8_mRNA </ci> <ci> k90 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re89" id="transl_NAE1" name="transl_NAE1" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transl_NAE1</celldesigner:name> <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NAE1_mRNA" alias="sa174"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="NAE1" alias="sa176"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00232" species="NAE1_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa174</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00233" species="NAE1"> <annotation> <celldesigner:extension> <celldesigner:alias>sa176</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00132"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NAE1_mRNA </ci> <ci> k89 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re19" id="transl_EloC" name="transl_EloC" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transl_EloC</celldesigner:name> <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="EloC_mRNA" alias="sa10"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="EloC" alias="sa18"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00028" species="EloC_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa10</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00029" species="EloC"> <annotation> <celldesigner:extension> <celldesigner:alias>sa18</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00030"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> EloC_mRNA </ci> <ci> k9 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re11" id="transl_EloB" name="transl_EloB" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transl_EloB</celldesigner:name> <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="EloB_mRNA" alias="sa9"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="EloB" alias="sa17"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00026" species="EloB_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa9</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00027" species="EloB"> <annotation> <celldesigner:extension> <celldesigner:alias>sa17</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00107"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> EloB_mRNA </ci> <ci> k2 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re24" id="transl_E2" name="transl_E2" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transl_E2</celldesigner:name> <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E2_mRNA" alias="sa15"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="E2" alias="sa23"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00039" species="E2_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa15</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00040" species="E2"> <annotation> <celldesigner:extension> <celldesigner:alias>sa23</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00041"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> E2_mRNA </ci> <ci> k14 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re23" id="transl_E1" name="transl_E1" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transl_E1</celldesigner:name> <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E1_mRNA" alias="sa14"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="E1" alias="sa22"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00036" species="E1_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa14</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00037" species="E1"> <annotation> <celldesigner:extension> <celldesigner:alias>sa22</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00038"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> E1_mRNA </ci> <ci> k13 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re26" id="transl_DUB" name="transl_DUB" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transl_DUB</celldesigner:name> <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="DUB_mRNA" alias="sa16"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="DUB" alias="sa24"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00045" species="DUB_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa16</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00046" species="DUB"> <annotation> <celldesigner:extension> <celldesigner:alias>sa24</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00047"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> DUB_mRNA </ci> <ci> k16 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re22" id="transl_Cul2" name="transl_Cul2" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transl_Cul2</celldesigner:name> <celldesigner:reactionType>TRANSLATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Cul2_mRNA" alias="sa13"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="CUL2" alias="sa21"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00033" species="Cul2_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa13</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00034" species="CUL2"> <annotation> <celldesigner:extension> <celldesigner:alias>sa21</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00035"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Cul2_mRNA </ci> <ci> k12 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re13" id="transcr_Zyg11B" name="transcr_Zyg11B" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_Zyg11B</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Zyg11B_gene" alias="sa3"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="Zyg11B_mRNA" alias="sa11"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00011" species="Zyg11B_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa3</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00024" species="Zyg11B_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa11</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00025"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Zyg11B_gene </ci> <ci> k4 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re115" id="transcr_Ubc12" name="transcr_Ubc12" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_Ubc12</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Ubc12_gene" alias="sa256"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="Ubc12_mRNA" alias="sa255"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00270" species="Ubc12_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa256</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00271" species="Ubc12_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa255</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00137"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Ubc12_gene </ci> <ci> k115 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re87" id="transcr_UBA3" name="transcr_UBA3" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_UBA3</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="UBA3_gene" alias="sa180"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="UBA3_mRNA" alias="sa175"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00248" species="UBA3_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa180</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00249" species="UBA3_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa175</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00130"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> UBA3_gene </ci> <ci> k87 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re15" id="transcr_Rbx1" name="transcr_Rbx1" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_Rbx1</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Rbx1_gene" alias="sa4"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="Rbx1_mRNA" alias="sa12"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00012" species="Rbx1_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa4</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00013" species="Rbx1_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa12</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00014"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Rbx1_gene </ci> <ci> k5 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re85" id="transcr_NEDD8" name="transcr_NEDD8" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_NEDD8</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NEDD8_gene" alias="sa178"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="NEDD8_mRNA" alias="sa173"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00237" species="NEDD8_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa178</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00238" species="NEDD8_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa173</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00126"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NEDD8_gene </ci> <ci> k85 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re86" id="transcr_NAE1" name="transcr_NAE1" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_NAE1</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NAE1_gene" alias="sa179"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="NAE1_mRNA" alias="sa174"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00235" species="NAE1_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa179</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00236" species="NAE1_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa174</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00128"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NAE1_gene </ci> <ci> k86 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re12" id="transcr_EloC" name="transcr_EloC" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_EloC</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="EloC_gene" alias="sa2"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="EloC_mRNA" alias="sa10"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00008" species="EloC_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa2</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00009" species="EloC_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa10</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00010"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> EloC_gene </ci> <ci> k3 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re10" id="transcr_EloB" name="transcr_EloB" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_EloB</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="EloB_gene" alias="sa1"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="EloB_mRNA" alias="sa9"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00006" species="EloB_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa1</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00007" species="EloB_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa9</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00015"> <annotation> <celldesigner:extension> <celldesigner:selectedFunction>NonPredefinedFunction</celldesigner:selectedFunction> </celldesigner:extension> </annotation> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> EloB_gene </ci> <ci> k1 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re18" id="transcr_E2" name="transcr_E2" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_E2</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E2_gene" alias="sa7"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="E2_mRNA" alias="sa15"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00021" species="E2_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa7</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00022" species="E2_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa15</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00023"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> E2_gene </ci> <ci> k8 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re17" id="transcr_E1" name="transcr_E1" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_E1</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E1_gene" alias="sa6"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="E1_mRNA" alias="sa14"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00018" species="E1_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa6</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00019" species="E1_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa14</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00020"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> E1_gene </ci> <ci> k7 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re25" id="transcr_DUB" name="transcr_DUB" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_DUB</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="DUB_gene" alias="sa8"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="DUB_mRNA" alias="sa16"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00042" species="DUB_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa8</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00043" species="DUB_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa16</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00044"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> DUB_gene </ci> <ci> k15 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re16" id="transcr_Cul2" name="transcr_Cul2" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>transcr_Cul2</celldesigner:name> <celldesigner:reactionType>TRANSCRIPTION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Cul2_gene" alias="sa5"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="Cul2_mRNA" alias="sa13"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00016" species="Cul2_gene"> <annotation> <celldesigner:extension> <celldesigner:alias>sa5</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00017" species="Cul2_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa13</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00048"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Cul2_gene </ci> <ci> k6 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re131" id="syn_CSN5" name="syn_CSN5" reversible="false" fast="false"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Note: As the signalosome is a mult-protein complex, this is a complex synthesis process. </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:name>syn_CSN5</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s337" alias="sa269"> <celldesigner:linkAnchor position="NW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="CSN5" alias="csa23"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00338" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa269</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00339" species="CSN5"> <annotation> <celldesigner:extension> <celldesigner:alias>csa23</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00212"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <ci> k131 </ci> </math> </kineticLaw> </reaction> <reaction metaid="re129" id="syn_26S_proteasom" name="syn_26S_proteasom" reversible="false" fast="false"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Note: As the proteasome is a mult-protein complex, this is a complex synthesis process. </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:name>syn_26S_proteasom</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="s337" alias="sa268"> <celldesigner:linkAnchor position="NW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="proteasom_26S" alias="csa25"> <celldesigner:linkAnchor position="ENE"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00308" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa268</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00335" species="proteasom_26S"> <annotation> <celldesigner:extension> <celldesigner:alias>csa25</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00210"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <ci> k129 </ci> </math> </kineticLaw> </reaction> <reaction metaid="CDMT00173" id="diss_NAE_Pevonedistat" name="diss_NAE:Pevonedistat" reversible="false" fast="false"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ref: https://doi.org/10.1182/blood-2018-02-829051 </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:name>diss_NAE:Pevonedistat</celldesigner:name> <celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NAE_Pevonedistat" alias="csa12"> <celldesigner:linkAnchor position="W"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="Pevonedistat" alias="sa54"> <celldesigner:linkAnchor position="E"/> </celldesigner:baseProduct> <celldesigner:baseProduct species="NAE" alias="csa9"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="unknown"/> <celldesigner:lineDirection arm="1" index="0" value="unknown"/> <celldesigner:lineDirection arm="2" index="0" value="unknown"/> </celldesigner:listOfLineDirection> 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xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NAE_Pevonedistat </ci> <ci> k68 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re98" id="diss_NAE" name="diss_NAE" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>diss_NAE</celldesigner:name> <celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NAE" alias="csa9"> <celldesigner:linkAnchor position="WSW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="NAE1" alias="sa176"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseProduct> <celldesigner:baseProduct species="UBA3" alias="sa177"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection arm="0" index="0" value="unknown"/> <celldesigner:lineDirection arm="1" index="0" value="unknown"/> <celldesigner:lineDirection arm="2" index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.3056518541863671,0.28117449311902476</celldesigner:editPoints> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00228" species="NAE"> <annotation> <celldesigner:extension> <celldesigner:alias>csa9</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00229" species="NAE1"> <annotation> <celldesigner:extension> <celldesigner:alias>sa176</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00230" species="UBA3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa177</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00295"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NAE </ci> <ci> k98 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re45" id="diss_EloB_EloC" name="diss_EloB:EloC" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>diss_EloB:EloC</celldesigner:name> <celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="EloBC" alias="csa1"> <celldesigner:linkAnchor position="WSW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="EloB" alias="sa17"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseProduct> <celldesigner:baseProduct species="EloC" alias="sa18"> <celldesigner:linkAnchor position="ESE"/> 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<celldesigner:alias>sa17</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> <speciesReference metaid="CDMT00085" species="EloC"> <annotation> <celldesigner:extension> <celldesigner:alias>sa18</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00285"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> EloBC </ci> <ci> k34 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re47" id="diss_Elo_Zyg11B" name="diss_Elo:Zyg11B" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>diss_Elo:Zyg11B</celldesigner:name> <celldesigner:reactionType>DISSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Zyg11B_EloBC" alias="csa2"> <celldesigner:linkAnchor position="WNW"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> 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<celldesigner:alias>sa102</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00275" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa257</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00206"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Ubc12 </ci> <ci> k117 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re95" id="deg_UBA3_mRNA" name="deg_UBA3_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_UBA3_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="UBA3_mRNA" alias="sa175"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa185"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00221" species="UBA3_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa175</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00222" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa185</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00204"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> UBA3_mRNA </ci> <ci> k95 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re96" id="deg_UBA3" name="deg_UBA3" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_UBA3</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="UBA3" alias="sa177"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa187"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00223" species="UBA3"> <annotation> <celldesigner:extension> <celldesigner:alias>sa177</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00224" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa187</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00205"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> UBA3 </ci> <ci> k96 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re33" id="deg_Rbx1_mRNA" name="deg_Rbx1_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_Rbx1_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Rbx1_mRNA" alias="sa12"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa31"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00060" species="Rbx1_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa12</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00061" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa31</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00147"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Rbx1_mRNA </ci> <ci> k23 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re34" id="deg_Rbx1" name="deg_Rbx1" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_Rbx1</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Rbx1" alias="sa20"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa32"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00062" species="Rbx1"> <annotation> <celldesigner:extension> <celldesigner:alias>sa20</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00063" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa32</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00148"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Rbx1 </ci> <ci> k24 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re126" id="deg_Orf10_mRNA" name="deg_Orf10_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_Orf10_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Orf10_pss_sgmRNA" alias="sa278"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa266"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00355" species="Orf10_pss_sgmRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa278</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00356" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa266</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00208"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Orf10_pss_sgmRNA </ci> <ci> k126 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re127" id="deg_Orf10" name="deg_Orf10" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_Orf10</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Orf10" alias="sa55"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa265"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00306" species="Orf10"> <annotation> <celldesigner:extension> <celldesigner:alias>sa55</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00307" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa265</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00209"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Orf10 </ci> <ci> k127 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re91" id="deg_NEDD8_mRNA" name="deg_NEDD8_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_NEDD8_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NEDD8_mRNA" alias="sa173"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa181"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00213" species="NEDD8_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa173</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00214" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa181</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00189"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NEDD8_mRNA </ci> <ci> k91 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re92" id="deg_NEDD8" name="deg_NEDD8" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_NEDD8</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NEDD8" alias="sa118"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa182"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00215" species="NEDD8"> <annotation> <celldesigner:extension> <celldesigner:alias>sa118</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00216" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa182</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00201"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NEDD8 </ci> <ci> k92 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re93" id="deg_NAE1_mRNA" name="deg_NAE1_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_NAE1_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NAE1_mRNA" alias="sa174"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa183"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00217" species="NAE1_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa174</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00218" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa183</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00202"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NAE1_mRNA </ci> <ci> k93 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re94" id="deg_NAE1" name="deg_NAE1" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_NAE1</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NAE1" alias="sa176"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa184"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00219" species="NAE1"> <annotation> <celldesigner:extension> <celldesigner:alias>sa176</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00220" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa184</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00203"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> NAE1 </ci> <ci> k94 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re29" id="deg_EloC_mRNA" name="deg_EloC_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_EloC_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="EloC_mRNA" alias="sa10"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa27"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00052" species="EloC_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa10</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00053" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa27</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00143"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> EloC_mRNA </ci> <ci> k19 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re30" id="deg_EloC" name="deg_EloC" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_EloC</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="EloC" alias="sa18"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa28"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00054" species="EloC"> <annotation> <celldesigner:extension> <celldesigner:alias>sa18</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00055" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa28</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00144"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> EloC </ci> <ci> k20 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re27" id="deg_EloB_mRNA" name="deg_EloB_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_EloB_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="EloB_mRNA" alias="sa9"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa25"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00064" species="EloB_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa9</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00065" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa25</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00141"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> EloB_mRNA </ci> <ci> k17 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re28" id="deg_EloB" name="deg_EloB" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_EloB</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="EloB" alias="sa17"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa26"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00066" species="EloB"> <annotation> <celldesigner:extension> <celldesigner:alias>sa17</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00067" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa26</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00142"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> EloB </ci> <ci> k18 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re39" id="deg_E2_mRNA" name="deg_E2_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_E2_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E2_mRNA" alias="sa15"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa37"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00072" species="E2_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa15</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00073" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa37</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00153"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> E2_mRNA </ci> <ci> k29 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re40" id="deg_E2" name="deg_E2" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_E2</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E2" alias="sa23"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa36"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00074" species="E2"> <annotation> <celldesigner:extension> <celldesigner:alias>sa23</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00075" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa36</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00154"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> E2 </ci> <ci> k30 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re37" id="deg_E1_mRNA" name="deg_E1_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_E1_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E1_mRNA" alias="sa14"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa35"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00068" species="E1_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa14</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00069" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa35</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00151"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> E1_mRNA </ci> <ci> k27 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re38" id="deg_E1" name="deg_E1" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_E1</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="E1" alias="sa22"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa36"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00070" species="E1"> <annotation> <celldesigner:extension> <celldesigner:alias>sa22</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00071" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa36</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00152"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> E1 </ci> <ci> k28 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re41" id="deg_DUB_mRNA" name="deg_DUB_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_DUB_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="DUB_mRNA" alias="sa16"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa39"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00076" species="DUB_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa16</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00077" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa39</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00158"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> DUB_mRNA </ci> <ci> k31 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re42" id="deg_DUB" name="deg_DUB" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_DUB</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="DUB" alias="sa24"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa40"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00078" species="DUB"> <annotation> <celldesigner:extension> <celldesigner:alias>sa24</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00079" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa40</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00177"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> DUB </ci> <ci> k32 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re35" id="deg_Cul2_mRNA" name="deg_Cul2_mRNA" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_Cul2_mRNA</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="Cul2_mRNA" alias="sa13"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa33"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00080" species="Cul2_mRNA"> <annotation> <celldesigner:extension> <celldesigner:alias>sa13</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00081" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa33</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00149"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> Cul2_mRNA </ci> <ci> k25 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re36" id="deg_Cul2" name="deg_Cul2" reversible="false" fast="false"> <annotation> <celldesigner:extension> <celldesigner:name>deg_Cul2</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="CUL2" alias="sa21"> <celldesigner:linkAnchor position="S"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa34"> <celldesigner:linkAnchor position="N"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00082" species="CUL2"> <annotation> <celldesigner:extension> <celldesigner:alias>sa21</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00086" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa34</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00150"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> CUL2 </ci> <ci> k26 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re133" id="deg_CSN5" name="deg_CSN5" reversible="false" fast="false"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Note: As the signalosome is a mult-protein complex, this is a complex 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<celldesigner:alias>csa23</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00341" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa269</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00231"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> CSN5 </ci> <ci> k133 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="re130" id="deg_26S_proteasom" name="deg_26S_proteasom" reversible="false" fast="false"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Note: As the proteasome is a mult-protein complex, this is a complex degradation process. </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:name>deg_26S_proteasom</celldesigner:name> <celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="proteasom_26S" alias="csa25"> <celldesigner:linkAnchor position="ESE"/> </celldesigner:baseReactant> </celldesigner:baseReactants> <celldesigner:baseProducts> <celldesigner:baseProduct species="s337" alias="sa268"> <celldesigner:linkAnchor position="SW"/> </celldesigner:baseProduct> </celldesigner:baseProducts> <celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0"> <celldesigner:listOfLineDirection> <celldesigner:lineDirection index="0" value="unknown"/> </celldesigner:listOfLineDirection> </celldesigner:connectScheme> <celldesigner:line width="1.0" color="ff000000"/> </celldesigner:extension> </annotation> <listOfReactants> <speciesReference metaid="CDMT00336" species="proteasom_26S"> <annotation> <celldesigner:extension> <celldesigner:alias>csa25</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfReactants> <listOfProducts> <speciesReference metaid="CDMT00337" species="s337"> <annotation> <celldesigner:extension> <celldesigner:alias>sa268</celldesigner:alias> </celldesigner:extension> </annotation> </speciesReference> </listOfProducts> <kineticLaw metaid="CDMT00211"> <math xmlns="http://www.w3.org/1998/Math/MathML"> <apply> <times/> <ci> proteasom_26S </ci> <ci> k130 </ci> </apply> </math> </kineticLaw> </reaction> <reaction metaid="CDMT00182" id="bind_Ubc12_NAE_NEDD8" name="bind_Ubc12_NAE:NEDD8" reversible="false" fast="false"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>Ref: https://doi.org/10.1182/blood-2018-02-829051 </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:name>bind_Ubc12_NAE:NEDD8</celldesigner:name> <celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType> <celldesigner:baseReactants> <celldesigner:baseReactant species="NAE_NEDD8" alias="csa11"> <celldesigner:linkAnchor 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