</head> <body>Authors: <br/> Marius Rameil, University of Bonn, Bonn, Germany <br/> <br/> Vanessa Nakonecnij, University of Bonn, Bonn, Germany <br/> <br/> Marta Conti, University of Bonn, Bonn, Germany </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:modelVersion>4.0</celldesigner:modelVersion> <celldesigner:modelDisplay sizeX="2600" sizeY="2700"/> <celldesigner:listOfIncludedSpecies> <celldesigner:species id="s152" name="dsRNA"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body/> </html> </celldesigner:notes> <celldesigner:annotation> <celldesigner:complexSpecies>s244</celldesigner:complexSpecies> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn8</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:annotation> </celldesigner:species> <celldesigner:species id="s241" name="TRIM25"> <celldesigner:notes> <html 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scheme="Color"/> </celldesigner:briefView> <celldesigner:info state="empty" angle="-1.5707963267948966"/> </celldesigner:speciesAlias> </celldesigner:listOfSpeciesAliases> <celldesigner:listOfGroups/> <celldesigner:listOfProteins> <celldesigner:protein id="pr8" name="STAT1" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> UniProt: P42224 </body> </html> </celldesigner:notes> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="2.4" id="rs1" name="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr9" name="STAT2" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> UniProt: P52630 </body> </html> </celldesigner:notes> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="2.4" id="rs1" name="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr10" name="IRF9" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> UniProt: Q00978 </body> </html> </celldesigner:notes> </celldesigner:protein> <celldesigner:protein id="pr17" name="STAT3" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> UniProt: P40763 </body> </html> </celldesigner:notes> </celldesigner:protein> <celldesigner:protein id="pr4" name="TYK2" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> UniProt: P29597 </body> </html> </celldesigner:notes> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="0.7853981633974483" id="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr5" name="JAK1" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> UniProt: P23458 </body> </html> </celldesigner:notes> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="0.7853981633974483" id="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr6" name="IFNLR1" type="RECEPTOR"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> Uniprot: Q8IU57 </body> </html> </celldesigner:notes> </celldesigner:protein> <celldesigner:protein id="pr7" name="SOCS1" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> UniProt: O15524 </body> </html> </celldesigner:notes> </celldesigner:protein> <celldesigner:protein id="pr11" name="SOCS3" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> UniProt: O14543 </body> </html> </celldesigner:notes> </celldesigner:protein> <celldesigner:protein id="pr25" name="Nsp1" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> Uniprot: P0C6X7 for REP-1-ab </body> </html> </celldesigner:notes> </celldesigner:protein> <celldesigner:protein id="pr26" name="IFIH1" type="GENERIC"/> <celldesigner:protein id="pr27" name="nsp14" type="GENERIC"/> <celldesigner:protein id="pr28" name="nsp16" type="GENERIC"/> <celldesigner:protein id="pr29" name="RIG-I" type="RECEPTOR"> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="3.141592653589793" id="rs2" side="outside"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr3" name="IKK" type="GENERIC"> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="0.7853981633974483" id="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr30" name="TBK1" type="GENERIC"> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="0.7853981633974483" id="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr31" name="IRF3" type="GENERIC"> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="0.7853981633974483" id="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr32" name="IRF1" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> UniProt: P10914 </body> </html> </celldesigner:notes> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="0.7853981633974483" id="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr33" name="IFN-III" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> either: IFNL-1, IFNL-2, IFNL-3 or IFNL-4 Uniprot: Q8IU54, Q8IZJ0, Q8IZI9, K9M1U5 </body> </html> </celldesigner:notes> </celldesigner:protein> <celldesigner:protein id="pr2" name="MAVS" type="GENERIC"> <celldesigner:listOfModificationResidues> <celldesigner:modificationResidue angle="0.7853981633974483" id="rs1" side="none"/> </celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="pr13" name="PLPro" type="GENERIC"> <celldesigner:notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body> Uniprot: K4LC41 </body> </html> </celldesigner:notes> </celldesigner:protein> <celldesigner:protein id="pr34" name="M" type="GENERIC"/> <celldesigner:protein id="pr38" name="TRIM25" type="GENERIC"/> <celldesigner:protein id="pr39" name="RNF135" type="GENERIC"/> <celldesigner:protein id="pr40" name="MAPK11" type="GENERIC"/> <celldesigner:protein id="pr41" name="MAPK12" type="GENERIC"/> <celldesigner:protein id="pr42" name="MAPK13" type="GENERIC"/> <celldesigner:protein id="pr43" name="MAPK14" type="GENERIC"/> <celldesigner:protein id="pr44" name="NFKB2" type="GENERIC"/> <celldesigner:protein id="pr45" name="NFKB1" type="GENERIC"/> <celldesigner:protein id="pr46" name="IFNL1" type="GENERIC"/> <celldesigner:protein id="pr47" name="IFNL2" type="GENERIC"/> <celldesigner:protein id="pr48" name="IFNL3" type="GENERIC"/> <celldesigner:protein id="pr49" name="IFNL4" type="GENERIC"/> <celldesigner:protein id="pr50" name="IFNA1" type="GENERIC"/> <celldesigner:protein id="pr51" name="IFNA2" type="GENERIC"/> <celldesigner:protein id="pr52" name="IFNA4" type="GENERIC"/> <celldesigner:protein id="pr53" name="IFNA5" type="GENERIC"/> <celldesigner:protein id="pr54" name="IFNA6" type="GENERIC"/> <celldesigner:protein id="pr55" name="IFNA7" type="GENERIC"/> <celldesigner:protein id="pr56" name="IFNA8" type="GENERIC"/> <celldesigner:protein id="pr57" name="IFNA10" type="GENERIC"/> <celldesigner:protein id="pr58" name="IFNA14" type="GENERIC"/> <celldesigner:protein id="pr59" name="IFNA16" type="GENERIC"/> <celldesigner:protein id="pr60" name="IFNA17" type="GENERIC"/> <celldesigner:protein id="pr61" name="IFNA21" type="GENERIC"/> <celldesigner:protein id="pr62" name="IFNB1" type="GENERIC"/> <celldesigner:protein id="pr63" name="IL6" type="GENERIC"/> <celldesigner:protein id="pr64" name="IFI6" type="GENERIC"/> <celldesigner:protein id="pr65" name="OAS1" type="GENERIC"/> <celldesigner:protein id="pr66" name="OAS2" type="GENERIC"/> <celldesigner:protein id="pr67" name="OAS3" type="GENERIC"/> <celldesigner:protein id="pr68" name="RSAD2" type="GENERIC"/> <celldesigner:protein id="pr69" name="IFIT1" type="GENERIC"/> <celldesigner:protein id="pr70" name="IRF7" type="GENERIC"/> <celldesigner:protein id="pr71" name="EIF2AK2" type="GENERIC"/> </celldesigner:listOfProteins> <celldesigner:listOfGenes> <celldesigner:gene id="gn5" name="IFN-sensitive-response-element" type="GENE"/> <celldesigner:gene id="gn1" name="IFN-III" type="GENE"/> </celldesigner:listOfGenes> <celldesigner:listOfRNAs> <celldesigner:RNA id="rn1" name="ISGs" type="RNA"/> <celldesigner:RNA id="rn5" name="viral RNA" type="RNA"/> <celldesigner:RNA id="rn6" name="viral RNA+N-methyl-Guanine" type="RNA"/> <celldesigner:RNA id="rn7" name="5'cap-viral-RNA" type="RNA"/> <celldesigner:RNA id="rn8" name="dsRNA" type="RNA"/> <celldesigner:RNA id="rn3" name="IFN-III" type="RNA"/> <celldesigner:RNA id="rn9" name="dsRNA_vesicle" type="RNA"/> <celldesigner:RNA id="rn10" name="RNA" type="RNA"/> </celldesigner:listOfRNAs> <celldesigner:listOfAntisenseRNAs/> <celldesigner:listOfLayers> <celldesigner:layer id="1" name="Layer0001" locked="false" visible="true"/> </celldesigner:listOfLayers> <celldesigner:listOfBlockDiagrams/> </celldesigner:extension> </annotation> <listOfUnitDefinitions> <unitDefinition metaid="substance" id="substance" name="substance"> <listOfUnits> <unit metaid="CDMT00127" kind="mole"/> </listOfUnits> </unitDefinition> <unitDefinition metaid="volume" id="volume" name="volume"> <listOfUnits> <unit metaid="CDMT00128" kind="litre"/> </listOfUnits> </unitDefinition> <unitDefinition metaid="area" id="area" name="area"> <listOfUnits> <unit metaid="CDMT00129" kind="metre" exponent="2"/> </listOfUnits> </unitDefinition> <unitDefinition metaid="length" id="length" name="length"> <listOfUnits> <unit metaid="CDMT00139" kind="metre"/> </listOfUnits> </unitDefinition> <unitDefinition metaid="time" id="time" name="time"> <listOfUnits> <unit metaid="CDMT00140" kind="second"/> </listOfUnits> </unitDefinition> </listOfUnitDefinitions> <listOfCompartments> <compartment metaid="default" id="default" size="1" units="volume"/> <compartment metaid="c1" id="c1" name="cell" size="1" units="volume" outside="default"> <annotation> <celldesigner:extension> <celldesigner:name>cell</celldesigner:name> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#c1"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005737"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </compartment> <compartment metaid="c3" id="c3" name="nucleus" size="1" units="volume" outside="c5"> <annotation> <celldesigner:extension> <celldesigner:name>nucleus</celldesigner:name> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#c3"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005634"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </compartment> <compartment metaid="c5" id="c5" name="innate immune cell" size="100" units="volume" outside="default"> <annotation> <celldesigner:extension> <celldesigner:name>innate immune cell</celldesigner:name> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#c5"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:mesh:D007962"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </compartment> <compartment metaid="c11" id="c11" name="peroxisome" size="1" units="volume" outside="c5"> <annotation> <celldesigner:extension> <celldesigner:name>peroxisome</celldesigner:name> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#c11"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005777"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </compartment> <compartment metaid="c10" id="c10" name="mitochondrion" size="1" units="volume" outside="c5"> <annotation> <celldesigner:extension> <celldesigner:name>mitochondrion</celldesigner:name> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#c10"> <bqbiol:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005739"/> </rdf:Bag> </bqbiol:is> </rdf:Description> </rdf:RDF> </annotation> </compartment> </listOfCompartments> <listOfSpecies> <species metaid="s12" id="s12" name="STAT1" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr8</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> <celldesigner:modification residue="rs1" state="empty"/> </celldesigner:listOfModifications> </celldesigner:state> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s13" id="s13" name="STAT1" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr8</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> <celldesigner:modification residue="rs1" state="phosphorylated"/> </celldesigner:listOfModifications> </celldesigner:state> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s25" id="s25" name="STAT2" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr9</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> <celldesigner:modification residue="rs1" state="empty"/> </celldesigner:listOfModifications> </celldesigner:state> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s24" id="s24" name="STAT2" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr9</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> <celldesigner:modification residue="rs1" state="phosphorylated"/> </celldesigner:listOfModifications> </celldesigner:state> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s23" id="s23" name="IRF9" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr10</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s69" id="s69" name="STAT3" compartment="c1" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr17</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s14" id="s14" name="IFN-sensitive-response-element" compartment="c3" initialAmount="0" charge="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>GENE</celldesigner:class> <celldesigner:geneReference>gn5</celldesigner:geneReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s8" id="s8" name="ISGs" compartment="c1" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn1</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s21" id="s21" name="ISGs" compartment="c3" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn1</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s29" id="s29" name="receptor complex" compartment="c1" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>transmembrane</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>receptor complex</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s46" id="s46" name="SOCS1" compartment="c1" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr7</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s47" id="s47" name="SOCS3" compartment="c1" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr11</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s56" id="s56" name="ISGF3 precursor" compartment="c1" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>ISGF3 precursor</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s81" id="s81" name="inhibited ribosomal 40S SU" compartment="c1" initialAmount="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>described in: 10.1101/2020.05.18.102467 (not yet peer-reviewed!!) </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>inhibited ribosomal 40S SU</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s81"> <bqbiol:occursIn> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:doi:10.1101%2F2020.05.18.102467"/> </rdf:Bag> </bqbiol:occursIn> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s82" id="s82" name="Nsp1" compartment="c1" initialAmount="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>NCBI: YP_009725297 </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr25</celldesigner:proteinReference> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s82"> <bqmodel:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:ncbiprotein:YP_009725297"/> </rdf:Bag> </bqmodel:is> <bqmodel:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:uniprot:P0C6X7"/> </rdf:Bag> </bqmodel:is> </rdf:Description> </rdf:RDF> </annotation> </species> <species metaid="s83" id="s83" name="inhibited 80S ribosome" compartment="c1" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>COMPLEX</celldesigner:class> <celldesigner:name>inhibited 80S ribosome</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s93" id="s93" name="viral RNA" compartment="c5" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn5</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s94" id="s94" name="viral RNA+N-methyl-Guanine" compartment="c5" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn6</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s95" id="s95" name="5'cap-viral-RNA" compartment="c5" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>RNA</celldesigner:class> <celldesigner:rnaReference>rn7</celldesigner:rnaReference> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s96" id="s96" name="IFIH1" compartment="c5" initialAmount="0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <title/> </head> <body>UniProt Q9BYX4 </body> </html> </notes> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr26</celldesigner:proteinReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re24"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> </annotation> </species> <species metaid="s97" id="s97" name="sa75_degraded" compartment="c5" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>DEGRADED</celldesigner:class> <celldesigner:name>sa75_degraded</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> </annotation> </species> <species metaid="s98" id="s98" name="nsp14" compartment="c5" initialAmount="0"> <annotation> <celldesigner:extension> <celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment> <celldesigner:speciesIdentity> <celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>pr27</celldesigner:proteinReference> </celldesigner:speciesIdentity> <celldesigner:listOfCatalyzedReactions> <celldesigner:catalyzed reaction="re25"/> </celldesigner:listOfCatalyzedReactions> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description 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