diff --git a/Curation/Coagulation pathway/Coagulation-pathway2.xml b/Curation/Coagulation pathway/Coagulation-pathway2.xml
index 459adc22d8ceb5f6543c3aed69ac930bd3ab4c28..1ae280dfa632bfece74f95379d144c445a449c64 100644
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diff --git a/Curation/Coagulation pathway/Coagulation-pathway_stable.xml b/Curation/Coagulation pathway/Coagulation-pathway_stable.xml
index 459adc22d8ceb5f6543c3aed69ac930bd3ab4c28..1ae280dfa632bfece74f95379d144c445a449c64 100644
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index f6d3011fd893ea6ac54fd7065cfaa9ace27fd058..30d803c0c5c27dac9878c27c8f0c1642df66a585 100644
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diff --git a/Curation/Interferon pathway/Interferon1_v2.pdf b/Curation/Interferon pathway/Interferon1_v2.pdf
index 7a5c61d4398034f7362e7e493f2eeb96dfd929b2..1cf31e4fd7b009e20460cfc9c6838face81d1e6b 100644
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 <celldesigner:extension>
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 <reaction metaid="re98" id="re98" reversible="false">
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diff --git a/Curation/RTC-and-transcription/RTC-and-transcription-CD.pdf b/Curation/RTC-and-transcription/RTC-and-transcription-CD.pdf
index 2fb4fd96ff6bbb1afa293539e9666793f086606a..68f073637866700dd929a45342b684239ff5a1b0 100644
Binary files a/Curation/RTC-and-transcription/RTC-and-transcription-CD.pdf and b/Curation/RTC-and-transcription/RTC-and-transcription-CD.pdf differ
diff --git a/Curation/RTC-and-transcription/RTC-and-transcription-CD.xml b/Curation/RTC-and-transcription/RTC-and-transcription-CD.xml
index 605942dbdd14706fffdeb1825a33830a4e6f07bc..6165c3264e70ccd38589c249b43d808bb18e74cd 100644
--- a/Curation/RTC-and-transcription/RTC-and-transcription-CD.xml
+++ b/Curation/RTC-and-transcription/RTC-and-transcription-CD.xml
@@ -6,16 +6,30 @@
 <head>
 <title/>
 </head>
-<body>Pathway: Assembly of the Replication Transcription Complex and Transcription
+<body>
+[-:-]	Given input is not a valid SBGN-ML file.
+[macromolecule multimer:glyph28]	1 Set the default value of 2.
+[macromolecule multimer:glyph30]	1 Set the default value of 2.
+[macromolecule multimer:glyph26]	1 Set the default value of 2.
+[macromolecule multimer:glyph22]	1 Set the default value of 2.
+[macromolecule multimer:glyph24]	1 Set the default value of 2.
+[macromolecule multimer:glyph31]	1 Set the default value of 2.
+[macromolecule multimer:glyph29]	1 Set the default value of 2.
+[macromolecule multimer:glyph27]	1 Set the default value of 2.
+[macromolecule multimer:glyph32]	1 Set the default value of 2.
+[macromolecule multimer:glyph21]	1 Set the default value of 2.
+[macromolecule multimer:glyph23]	1 Set the default value of 2.
+[macromolecule multimer:glyph25]	1 Set the default value of 2.
+[SquareCompartment:glyph1]	CellDesigner requires thickness to be at least: 2.5
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 </html>
 </notes>
 <annotation>
 <celldesigner:extension>
 <celldesigner:modelVersion>4.0</celldesigner:modelVersion>
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+<celldesigner:species id="s_id_glyph22" name="nsp8_space_(II)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -23,7 +37,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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 </rdf:Description>
 </rdf:RDF>
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 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
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 <celldesigner:class>PROTEIN</celldesigner:class>
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+<celldesigner:proteinReference>p_s_id_glyph22</celldesigner:proteinReference>
+<celldesigner:state>
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+<celldesigner:species id="s_id_glyph24" name="nsp7">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -46,7 +63,7 @@
 </head>
 <body>
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 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -54,14 +71,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
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+<celldesigner:complexSpecies>s_id_glyph9</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
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+<celldesigner:proteinReference>p_s_id_glyph24</celldesigner:proteinReference>
+<celldesigner:state>
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+<celldesigner:species id="s_id_glyph31" name="nsp8_space_(I)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -69,7 +89,7 @@
 </head>
 <body>
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 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
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@@ -77,14 +97,17 @@
 </html>
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 <celldesigner:class>PROTEIN</celldesigner:class>
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+<celldesigner:proteinReference>p_s_id_glyph31</celldesigner:proteinReference>
+<celldesigner:state>
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+<celldesigner:species id="s_id_glyph21" name="nsp7">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -92,7 +115,7 @@
 </head>
 <body>
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 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -100,14 +123,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
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+<celldesigner:complexSpecies>s_id_glyph7</celldesigner:complexSpecies>
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 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph25</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph21</celldesigner:proteinReference>
+<celldesigner:state>
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+<celldesigner:species id="s_id_glyph23" name="nsp8_space_(II)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -115,7 +141,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -123,14 +149,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
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+<celldesigner:complexSpecies>s_id_glyph7</celldesigner:complexSpecies>
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-<celldesigner:geneReference>g_s_id_glyph10</celldesigner:geneReference>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph23</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
+</celldesigner:state>
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+<celldesigner:species id="s_id_glyph25" name="nsp8_space_(I)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -138,7 +167,7 @@
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+<rdf:Description rdf:about="#s_id_glyph25">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -146,14 +175,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s43</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph7</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
-<celldesigner:class>GENE</celldesigner:class>
-<celldesigner:geneReference>g_s_id_glyph9</celldesigner:geneReference>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph25</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
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-<celldesigner:species id="s_id_glyph22" name="nsp7">
+<celldesigner:species id="s_id_glyph28" name="nsp7">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -161,7 +193,7 @@
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 </rdf:Description>
 </rdf:RDF>
@@ -169,17 +201,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
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 <celldesigner:class>PROTEIN</celldesigner:class>
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+<celldesigner:species id="s_id_glyph30" name="nsp8_space_(I)">
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 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -187,7 +219,7 @@
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@@ -195,17 +227,17 @@
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-<celldesigner:complexSpecies>s46</celldesigner:complexSpecies>
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+<celldesigner:species id="s_id_glyph26" name="nsp8_space_(II)">
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@@ -213,7 +245,7 @@
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph16">
+<rdf:Description rdf:about="#s_id_glyph26">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -221,17 +253,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s46</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph8</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph16</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph26</celldesigner:proteinReference>
 <celldesigner:state>
 <celldesigner:homodimer>2</celldesigner:homodimer>
 </celldesigner:state>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph26" name="nsp9">
+<celldesigner:species id="s_id_glyph60" name="nsp10">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -239,7 +271,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph26">
+<rdf:Description rdf:about="#s_id_glyph60">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -247,14 +279,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph5</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph26</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph60</celldesigner:proteinReference>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph12" name="(_plus_)sRNA">
+<celldesigner:species id="s_id_glyph57" name="nsp12">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -262,7 +294,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph12">
+<rdf:Description rdf:about="#s_id_glyph57">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -270,14 +302,129 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph5</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph57</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph38" name="nsp14">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph38">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph5</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph38</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph10" name="CoV_space_poly_minus__br_merase_space_complex">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph10">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph3</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>COMPLEX</celldesigner:class>
+<celldesigner:name>CoV_space_poly_minus__br_merase_space_complex</celldesigner:name>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph48" name="nsp9">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph48">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph3</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph48</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph7" name="complex">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph7">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph3</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>COMPLEX</celldesigner:class>
+<celldesigner:name>complex</celldesigner:name>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph15" name="(_plus_)gRNA_space_(including_space_ORF1a_space_ORF1b)">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph15">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph3</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>GENE</celldesigner:class>
-<celldesigner:geneReference>g_s_id_glyph12</celldesigner:geneReference>
+<celldesigner:geneReference>g_s_id_glyph15</celldesigner:geneReference>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph20" name="nsp7">
+<celldesigner:species id="s_id_glyph43" name="nsp10">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -285,7 +432,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph20">
+<rdf:Description rdf:about="#s_id_glyph43">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -293,17 +440,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s41</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph10</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph20</celldesigner:proteinReference>
-<celldesigner:state>
-<celldesigner:homodimer>2</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph43</celldesigner:proteinReference>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph18" name="nsp8_space_(II)">
+<celldesigner:species id="s_id_glyph68" name="nsp12">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -311,7 +455,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph18">
+<rdf:Description rdf:about="#s_id_glyph68">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -319,17 +463,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s41</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph10</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph18</celldesigner:proteinReference>
-<celldesigner:state>
-<celldesigner:homodimer>2</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph68</celldesigner:proteinReference>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph14" name="nsp8_space_(I)">
+<celldesigner:species id="s_id_glyph35" name="nsp14">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -337,7 +478,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph14">
+<rdf:Description rdf:about="#s_id_glyph35">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -345,17 +486,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s41</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph10</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph14</celldesigner:proteinReference>
-<celldesigner:state>
-<celldesigner:homodimer>4</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph35</celldesigner:proteinReference>
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 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph21" name="nsp8_space_(II)">
+<celldesigner:species id="s_id_glyph58" name="nsp10">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -363,7 +501,7 @@
 </head>
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph21">
+<rdf:Description rdf:about="#s_id_glyph58">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -371,17 +509,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s45</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph4</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph21</celldesigner:proteinReference>
-<celldesigner:state>
-<celldesigner:homodimer>2</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph58</celldesigner:proteinReference>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph19" name="nsp7">
+<celldesigner:species id="s_id_glyph65" name="nsp14">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -389,7 +524,7 @@
 </head>
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph19">
+<rdf:Description rdf:about="#s_id_glyph65">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -397,17 +532,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s45</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph4</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph19</celldesigner:proteinReference>
-<celldesigner:state>
-<celldesigner:homodimer>2</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph65</celldesigner:proteinReference>
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 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph15" name="nsp8_space_(I)">
+<celldesigner:species id="s_id_glyph47" name="nsp12">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -415,7 +547,30 @@
 </head>
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph15">
+<rdf:Description rdf:about="#s_id_glyph47">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph4</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph47</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph29" name="nsp8_space_(II)">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph29">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -423,17 +578,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s45</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph6</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph15</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph29</celldesigner:proteinReference>
 <celldesigner:state>
-<celldesigner:homodimer>4</celldesigner:homodimer>
+<celldesigner:homodimer>2</celldesigner:homodimer>
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-<celldesigner:species id="s_id_glyph34" name="nsp10">
+<celldesigner:species id="s_id_glyph27" name="nsp7">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -441,7 +596,7 @@
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@@ -449,14 +604,17 @@
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 <celldesigner:annotation>
-<celldesigner:complexSpecies>s39</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph6</celldesigner:complexSpecies>
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+<celldesigner:proteinReference>p_s_id_glyph27</celldesigner:proteinReference>
+<celldesigner:state>
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+<celldesigner:species id="s_id_glyph32" name="nsp8_space_(I)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -464,7 +622,7 @@
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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+<rdf:Description rdf:about="#s_id_glyph32">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -472,14 +630,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s39</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph6</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph28</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph32</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
+</celldesigner:state>
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-<celldesigner:species id="s_id_glyph35" name="nsp14">
+<celldesigner:species id="s_id_glyph59" name="nsp10">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -487,7 +648,7 @@
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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+<rdf:Description rdf:about="#s_id_glyph59">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -495,14 +656,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s39</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph11</celldesigner:complexSpecies>
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-<celldesigner:proteinReference>p_s_id_glyph35</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph59</celldesigner:proteinReference>
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-<celldesigner:species id="s_id_glyph37" name="nsp10">
+<celldesigner:species id="s_id_glyph55" name="nsp14">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -510,7 +671,7 @@
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+<rdf:Description rdf:about="#s_id_glyph55">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -518,14 +679,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s40</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph11</celldesigner:complexSpecies>
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-<celldesigner:proteinReference>p_s_id_glyph37</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph55</celldesigner:proteinReference>
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-<celldesigner:species id="s_id_glyph24" name="nsp12">
+<celldesigner:species id="s_id_glyph64" name="nsp12">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -533,7 +694,7 @@
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-<rdf:Description rdf:about="#s_id_glyph24">
+<rdf:Description rdf:about="#s_id_glyph64">
 <dcterms:modified rdf:parseType="Resource"/>
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 </rdf:RDF>
@@ -541,14 +702,14 @@
 </html>
 </celldesigner:notes>
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-<celldesigner:complexSpecies>s40</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph11</celldesigner:complexSpecies>
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-<celldesigner:proteinReference>p_s_id_glyph24</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph64</celldesigner:proteinReference>
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-<celldesigner:species id="s_id_glyph31" name="nsp14">
+<celldesigner:species id="s_id_glyph44" name="nsp9">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -556,7 +717,7 @@
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+<rdf:Description rdf:about="#s_id_glyph44">
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@@ -564,14 +725,14 @@
 </html>
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 <celldesigner:annotation>
-<celldesigner:complexSpecies>s40</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
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+<celldesigner:proteinReference>p_s_id_glyph44</celldesigner:proteinReference>
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-<celldesigner:species id="s40" name="CoV_space_polymerase_br_complex">
+<celldesigner:species id="s_id_glyph9" name="complex">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -579,7 +740,7 @@
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+<rdf:Description rdf:about="#s_id_glyph9">
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@@ -590,11 +751,11 @@
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-<celldesigner:name>CoV_space_polymerase_br_complex</celldesigner:name>
+<celldesigner:name>complex</celldesigner:name>
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-<celldesigner:species id="s41" name="_space_">
+<celldesigner:species id="s_id_glyph11" name="CoV_space_poly_minus__br_merase_space_complex">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -602,7 +763,7 @@
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+<rdf:Description rdf:about="#s_id_glyph11">
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-<celldesigner:species id="s44" name="CoV_space_polymerase_br_complex">
+<celldesigner:species id="s_id_glyph14" name="(_plus_)gRNA_space_(including_space_ORF1a_space_ORF1b)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -625,7 +786,7 @@
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@@ -633,14 +794,14 @@
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 <celldesigner:annotation>
-<celldesigner:complexSpecies>s43</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
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-<celldesigner:name>CoV_space_polymerase_br_complex</celldesigner:name>
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 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -648,7 +809,7 @@
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@@ -656,1010 +817,2630 @@
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+<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
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+<celldesigner:class>SQUARE</celldesigner:class>
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+<celldesigner:listOfLayers/>
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 <listOfUnits>
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 <listOfUnits>
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 </unitDefinition>
 </listOfUnitDefinitions>
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+</celldesigner:extension>
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 <compartment metaid="default" id="default" size="1" units="volume"/>
 </listOfCompartments>
 <listOfSpecies>
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diff --git a/Curation/RTC-and-transcription/RTC-and-transcription_stable.xml b/Curation/RTC-and-transcription/RTC-and-transcription_stable.xml
index 605942dbdd14706fffdeb1825a33830a4e6f07bc..6165c3264e70ccd38589c249b43d808bb18e74cd 100644
--- a/Curation/RTC-and-transcription/RTC-and-transcription_stable.xml
+++ b/Curation/RTC-and-transcription/RTC-and-transcription_stable.xml
@@ -6,16 +6,30 @@
 <head>
 <title/>
 </head>
-<body>Pathway: Assembly of the Replication Transcription Complex and Transcription
+<body>
+[-:-]	Given input is not a valid SBGN-ML file.
+[macromolecule multimer:glyph28]	1 Set the default value of 2.
+[macromolecule multimer:glyph30]	1 Set the default value of 2.
+[macromolecule multimer:glyph26]	1 Set the default value of 2.
+[macromolecule multimer:glyph22]	1 Set the default value of 2.
+[macromolecule multimer:glyph24]	1 Set the default value of 2.
+[macromolecule multimer:glyph31]	1 Set the default value of 2.
+[macromolecule multimer:glyph29]	1 Set the default value of 2.
+[macromolecule multimer:glyph27]	1 Set the default value of 2.
+[macromolecule multimer:glyph32]	1 Set the default value of 2.
+[macromolecule multimer:glyph21]	1 Set the default value of 2.
+[macromolecule multimer:glyph23]	1 Set the default value of 2.
+[macromolecule multimer:glyph25]	1 Set the default value of 2.
+[SquareCompartment:glyph1]	CellDesigner requires thickness to be at least: 2.5
 </body>
 </html>
 </notes>
 <annotation>
 <celldesigner:extension>
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 <celldesigner:listOfIncludedSpecies>
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+<celldesigner:species id="s_id_glyph22" name="nsp8_space_(II)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -23,7 +37,7 @@
 </head>
 <body>
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 <celldesigner:class>PROTEIN</celldesigner:class>
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+<celldesigner:proteinReference>p_s_id_glyph22</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
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+<celldesigner:species id="s_id_glyph24" name="nsp7">
 <celldesigner:notes>
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 <head>
@@ -46,7 +63,7 @@
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+<rdf:Description rdf:about="#s_id_glyph24">
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+<celldesigner:complexSpecies>s_id_glyph9</celldesigner:complexSpecies>
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 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph33</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph24</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
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+<celldesigner:complexSpecies>s_id_glyph9</celldesigner:complexSpecies>
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+<celldesigner:proteinReference>p_s_id_glyph31</celldesigner:proteinReference>
+<celldesigner:state>
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@@ -92,7 +115,7 @@
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph25">
+<rdf:Description rdf:about="#s_id_glyph21">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -100,14 +123,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s43</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph7</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph25</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph21</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
+</celldesigner:state>
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-<celldesigner:species id="s_id_glyph10" name="(_minus_)sRNA">
+<celldesigner:species id="s_id_glyph23" name="nsp8_space_(II)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -115,7 +141,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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+<rdf:Description rdf:about="#s_id_glyph23">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -123,14 +149,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s43</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph7</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
-<celldesigner:class>GENE</celldesigner:class>
-<celldesigner:geneReference>g_s_id_glyph10</celldesigner:geneReference>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph23</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
+</celldesigner:state>
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-<celldesigner:species id="s_id_glyph9" name="(_plus_)sRNA">
+<celldesigner:species id="s_id_glyph25" name="nsp8_space_(I)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -138,7 +167,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph9">
+<rdf:Description rdf:about="#s_id_glyph25">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -146,14 +175,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s43</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph7</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
-<celldesigner:class>GENE</celldesigner:class>
-<celldesigner:geneReference>g_s_id_glyph9</celldesigner:geneReference>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph25</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
+</celldesigner:state>
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 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph22" name="nsp7">
+<celldesigner:species id="s_id_glyph28" name="nsp7">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -161,7 +193,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph22">
+<rdf:Description rdf:about="#s_id_glyph28">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -169,17 +201,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s46</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph8</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph22</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph28</celldesigner:proteinReference>
 <celldesigner:state>
 <celldesigner:homodimer>2</celldesigner:homodimer>
 </celldesigner:state>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph17" name="nsp8_space_(I)">
+<celldesigner:species id="s_id_glyph30" name="nsp8_space_(I)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -187,7 +219,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph17">
+<rdf:Description rdf:about="#s_id_glyph30">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -195,17 +227,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s46</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph8</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph17</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph30</celldesigner:proteinReference>
 <celldesigner:state>
-<celldesigner:homodimer>4</celldesigner:homodimer>
+<celldesigner:homodimer>2</celldesigner:homodimer>
 </celldesigner:state>
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 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph16" name="nsp8_space_(II)">
+<celldesigner:species id="s_id_glyph26" name="nsp8_space_(II)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -213,7 +245,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph16">
+<rdf:Description rdf:about="#s_id_glyph26">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -221,17 +253,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s46</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph8</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph16</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph26</celldesigner:proteinReference>
 <celldesigner:state>
 <celldesigner:homodimer>2</celldesigner:homodimer>
 </celldesigner:state>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph26" name="nsp9">
+<celldesigner:species id="s_id_glyph60" name="nsp10">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -239,7 +271,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph26">
+<rdf:Description rdf:about="#s_id_glyph60">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -247,14 +279,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph5</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph26</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph60</celldesigner:proteinReference>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph12" name="(_plus_)sRNA">
+<celldesigner:species id="s_id_glyph57" name="nsp12">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -262,7 +294,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph12">
+<rdf:Description rdf:about="#s_id_glyph57">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -270,14 +302,129 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph5</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph57</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph38" name="nsp14">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph38">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph5</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph38</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph10" name="CoV_space_poly_minus__br_merase_space_complex">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph10">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph3</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>COMPLEX</celldesigner:class>
+<celldesigner:name>CoV_space_poly_minus__br_merase_space_complex</celldesigner:name>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph48" name="nsp9">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph48">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph3</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph48</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph7" name="complex">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph7">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph3</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>COMPLEX</celldesigner:class>
+<celldesigner:name>complex</celldesigner:name>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph15" name="(_plus_)gRNA_space_(including_space_ORF1a_space_ORF1b)">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph15">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph3</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>GENE</celldesigner:class>
-<celldesigner:geneReference>g_s_id_glyph12</celldesigner:geneReference>
+<celldesigner:geneReference>g_s_id_glyph15</celldesigner:geneReference>
 </celldesigner:speciesIdentity>
 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph20" name="nsp7">
+<celldesigner:species id="s_id_glyph43" name="nsp10">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -285,7 +432,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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+<rdf:Description rdf:about="#s_id_glyph43">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -293,17 +440,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s41</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph10</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
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-<celldesigner:state>
-<celldesigner:homodimer>2</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph43</celldesigner:proteinReference>
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 </celldesigner:annotation>
 </celldesigner:species>
-<celldesigner:species id="s_id_glyph18" name="nsp8_space_(II)">
+<celldesigner:species id="s_id_glyph68" name="nsp12">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -311,7 +455,7 @@
 </head>
 <body>
 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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+<rdf:Description rdf:about="#s_id_glyph68">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -319,17 +463,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s41</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph10</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph18</celldesigner:proteinReference>
-<celldesigner:state>
-<celldesigner:homodimer>2</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph68</celldesigner:proteinReference>
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-<celldesigner:species id="s_id_glyph14" name="nsp8_space_(I)">
+<celldesigner:species id="s_id_glyph35" name="nsp14">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -337,7 +478,7 @@
 </head>
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+<rdf:Description rdf:about="#s_id_glyph35">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -345,17 +486,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s41</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph10</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
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-<celldesigner:state>
-<celldesigner:homodimer>4</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph35</celldesigner:proteinReference>
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 </celldesigner:annotation>
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-<celldesigner:species id="s_id_glyph21" name="nsp8_space_(II)">
+<celldesigner:species id="s_id_glyph58" name="nsp10">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -363,7 +501,7 @@
 </head>
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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+<rdf:Description rdf:about="#s_id_glyph58">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -371,17 +509,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s45</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph4</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
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-<celldesigner:state>
-<celldesigner:homodimer>2</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph58</celldesigner:proteinReference>
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 </celldesigner:species>
-<celldesigner:species id="s_id_glyph19" name="nsp7">
+<celldesigner:species id="s_id_glyph65" name="nsp14">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -389,7 +524,7 @@
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+<rdf:Description rdf:about="#s_id_glyph65">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -397,17 +532,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s45</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph4</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
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-<celldesigner:state>
-<celldesigner:homodimer>2</celldesigner:homodimer>
-</celldesigner:state>
+<celldesigner:proteinReference>p_s_id_glyph65</celldesigner:proteinReference>
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-<celldesigner:species id="s_id_glyph15" name="nsp8_space_(I)">
+<celldesigner:species id="s_id_glyph47" name="nsp12">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -415,7 +547,30 @@
 </head>
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
-<rdf:Description rdf:about="#s_id_glyph15">
+<rdf:Description rdf:about="#s_id_glyph47">
+<dcterms:modified rdf:parseType="Resource"/>
+</rdf:Description>
+</rdf:RDF>
+</body>
+</html>
+</celldesigner:notes>
+<celldesigner:annotation>
+<celldesigner:complexSpecies>s_id_glyph4</celldesigner:complexSpecies>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>p_s_id_glyph47</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+</celldesigner:annotation>
+</celldesigner:species>
+<celldesigner:species id="s_id_glyph29" name="nsp8_space_(II)">
+<celldesigner:notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>
+<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
+<rdf:Description rdf:about="#s_id_glyph29">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -423,17 +578,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s45</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph6</celldesigner:complexSpecies>
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 <celldesigner:class>PROTEIN</celldesigner:class>
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+<celldesigner:proteinReference>p_s_id_glyph29</celldesigner:proteinReference>
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+<celldesigner:homodimer>2</celldesigner:homodimer>
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+<celldesigner:species id="s_id_glyph27" name="nsp7">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -441,7 +596,7 @@
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+<rdf:Description rdf:about="#s_id_glyph27">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -449,14 +604,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s39</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph6</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph34</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph27</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
+</celldesigner:state>
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-<celldesigner:species id="s_id_glyph28" name="nsp12">
+<celldesigner:species id="s_id_glyph32" name="nsp8_space_(I)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -464,7 +622,7 @@
 </head>
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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+<rdf:Description rdf:about="#s_id_glyph32">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -472,14 +630,17 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s39</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph6</celldesigner:complexSpecies>
 <celldesigner:speciesIdentity>
 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph28</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph32</celldesigner:proteinReference>
+<celldesigner:state>
+<celldesigner:homodimer>2</celldesigner:homodimer>
+</celldesigner:state>
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+<celldesigner:species id="s_id_glyph59" name="nsp10">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -487,7 +648,7 @@
 </head>
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+<rdf:Description rdf:about="#s_id_glyph59">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -495,14 +656,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s39</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph11</celldesigner:complexSpecies>
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 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph35</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph59</celldesigner:proteinReference>
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-<celldesigner:species id="s_id_glyph37" name="nsp10">
+<celldesigner:species id="s_id_glyph55" name="nsp14">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -510,7 +671,7 @@
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+<rdf:Description rdf:about="#s_id_glyph55">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -518,14 +679,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s40</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph11</celldesigner:complexSpecies>
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 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph37</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph55</celldesigner:proteinReference>
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-<celldesigner:species id="s_id_glyph24" name="nsp12">
+<celldesigner:species id="s_id_glyph64" name="nsp12">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -533,7 +694,7 @@
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 <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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+<rdf:Description rdf:about="#s_id_glyph64">
 <dcterms:modified rdf:parseType="Resource"/>
 </rdf:Description>
 </rdf:RDF>
@@ -541,14 +702,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
-<celldesigner:complexSpecies>s40</celldesigner:complexSpecies>
+<celldesigner:complexSpecies>s_id_glyph11</celldesigner:complexSpecies>
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 <celldesigner:class>PROTEIN</celldesigner:class>
-<celldesigner:proteinReference>p_s_id_glyph24</celldesigner:proteinReference>
+<celldesigner:proteinReference>p_s_id_glyph64</celldesigner:proteinReference>
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-<celldesigner:species id="s_id_glyph31" name="nsp14">
+<celldesigner:species id="s_id_glyph44" name="nsp9">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -556,7 +717,7 @@
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+<rdf:Description rdf:about="#s_id_glyph44">
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 </rdf:Description>
 </rdf:RDF>
@@ -564,14 +725,14 @@
 </html>
 </celldesigner:notes>
 <celldesigner:annotation>
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+<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
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 <celldesigner:class>PROTEIN</celldesigner:class>
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+<celldesigner:proteinReference>p_s_id_glyph44</celldesigner:proteinReference>
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-<celldesigner:species id="s40" name="CoV_space_polymerase_br_complex">
+<celldesigner:species id="s_id_glyph9" name="complex">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -579,7 +740,7 @@
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+<rdf:Description rdf:about="#s_id_glyph9">
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 <celldesigner:class>COMPLEX</celldesigner:class>
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+<celldesigner:name>complex</celldesigner:name>
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-<celldesigner:species id="s41" name="_space_">
+<celldesigner:species id="s_id_glyph11" name="CoV_space_poly_minus__br_merase_space_complex">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -602,7 +763,7 @@
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+<celldesigner:name>CoV_space_poly_minus__br_merase_space_complex</celldesigner:name>
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-<celldesigner:species id="s44" name="CoV_space_polymerase_br_complex">
+<celldesigner:species id="s_id_glyph14" name="(_plus_)gRNA_space_(including_space_ORF1a_space_ORF1b)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -625,7 +786,7 @@
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@@ -633,14 +794,14 @@
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+<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
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-<celldesigner:name>CoV_space_polymerase_br_complex</celldesigner:name>
+<celldesigner:class>GENE</celldesigner:class>
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+<celldesigner:species id="s_id_glyph12" name="(_minus_)gRNA_space_(including_space_ORF1a_space_ORF1b)">
 <celldesigner:notes>
 <html xmlns="http://www.w3.org/1999/xhtml">
 <head>
@@ -648,7 +809,7 @@
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@@ -656,1010 +817,2630 @@
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+<celldesigner:complexSpecies>s_id_glyph2</celldesigner:complexSpecies>
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-<celldesigner:name>_space_</celldesigner:name>
+<celldesigner:class>GENE</celldesigner:class>
+<celldesigner:geneReference>g_s_id_glyph12</celldesigner:geneReference>
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+<celldesigner:listOfCompartmentAliases>
+<celldesigner:compartmentAlias id="glyph1" compartment="s_id_glyph1">
+<celldesigner:class>SQUARE</celldesigner:class>
+<celldesigner:bounds x="1085.0" y="355.0" w="1340.0" h="1070.0"/>
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+<celldesigner:paint color="ff8080ff" scheme="Color"/>
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+<celldesigner:speciesIdentity>
+<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
+<celldesigner:name>angiotensin II</celldesigner:name>
+</celldesigner:speciesIdentity>
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+<rdf:Description rdf:about="#s4">
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+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
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+<annotation>
+<celldesigner:extension>
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+<celldesigner:proteinReference>pr8</celldesigner:proteinReference>
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+<rdf:Description rdf:about="#s15">
+<bqbiol:isEncodedBy>
+<rdf:Bag>
+<rdf:li rdf:resource="urn:miriam:hgnc:HGNC%3A336"/>
+</rdf:Bag>
+</bqbiol:isEncodedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s7" id="s7" name="angiotensin 1-5" compartment="c1" initialAmount="0" charge="0">
+<annotation>
+<celldesigner:extension>
+<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
+<celldesigner:speciesIdentity>
+<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
+<celldesigner:name>angiotensin 1-5</celldesigner:name>
+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
+<celldesigner:catalyzed reaction="re42"/>
+</celldesigner:listOfCatalyzedReactions>
+</celldesigner:extension>
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+<rdf:Description rdf:about="#s7">
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+<rdf:li rdf:resource="urn:miriam:obo.chebi:CHEBI%3A80129"/>
+</rdf:Bag>
+</bqbiol:isEncodedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s1" id="s1" name="AGT" compartment="default" initialAmount="0" charge="0">
+<annotation>
+<celldesigner:extension>
+<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>pr2</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
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+<rdf:Description rdf:about="#s1">
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+</bqbiol:isEncodedBy>
+</rdf:Description>
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+</annotation>
+</species>
+<species metaid="s19" id="s19" name="REN" compartment="c7" initialAmount="0" charge="0">
+<annotation>
+<celldesigner:extension>
+<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
+<celldesigner:speciesIdentity>
+<celldesigner:class>GENE</celldesigner:class>
+<celldesigner:geneReference>gn1</celldesigner:geneReference>
+</celldesigner:speciesIdentity>
+</celldesigner:extension>
+<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
+<rdf:Description rdf:about="#s19">
+<bqbiol:isEncodedBy>
+<rdf:Bag>
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+</rdf:Bag>
+</bqbiol:isEncodedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s13" id="s13" name="Calcitriol" compartment="c6" initialAmount="0" charge="0">
+<annotation>
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+<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
+<celldesigner:name>Calcitriol</celldesigner:name>
+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
+<celldesigner:catalyzed reaction="re27"/>
+</celldesigner:listOfCatalyzedReactions>
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+<rdf:Description rdf:about="#s13">
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+<species metaid="s18" id="s18" name="MME" compartment="c1" initialAmount="0" charge="0">
+<notes>
+<html xmlns="http://www.w3.org/1999/xhtml">
+<head>
+<title/>
+</head>
+<body>Ang I can be cleaved by NEP to Ang (1–7).
+ACE and NEP hydrolysed Ang I efficiently, whereas ACE2 hydrolysed Ang I only very slowly.
+PMID:15283675
+</body>
+</html>
+</notes>
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+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s6" id="s6" name="ACE" compartment="c1" initialAmount="0">
+<annotation>
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+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>pr3</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
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+<celldesigner:catalyzed reaction="re119"/>
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+</rdf:Bag>
+</bqbiol:isEncodedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s29" id="s29" name="ADAM17" compartment="c1" initialAmount="0">
+<annotation>
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+<celldesigner:speciesIdentity>
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+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
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+</celldesigner:listOfCatalyzedReactions>
+</celldesigner:extension>
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+<rdf:Description rdf:about="#s29">
+<bqbiol:isEncodedBy>
+<rdf:Bag>
+<rdf:li rdf:resource="urn:miriam:hgnc:HGNC%3A195"/>
+</rdf:Bag>
+</bqbiol:isEncodedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s14" id="s14" name="S" compartment="default" charge="0">
+<annotation>
+<celldesigner:extension>
+<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
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+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
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+<celldesigner:catalyzed reaction="re153"/>
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+</celldesigner:extension>
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+<rdf:Description rdf:about="#s14">
+<bqbiol:isEncodedBy>
+<rdf:Bag>
+<rdf:li rdf:resource="urn:miriam:uniprot:P0DTC2"/>
+</rdf:Bag>
+</bqbiol:isEncodedBy>
+<bqbiol:isEncodedBy>
+<rdf:Bag>
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+</rdf:Bag>
+</bqbiol:isEncodedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s30" id="s30" name="sex, male" compartment="default" initialAmount="0">
+<annotation>
+<celldesigner:extension>
+<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
+<celldesigner:speciesIdentity>
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+<celldesigner:name>sex, male</celldesigner:name>
+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
+<celldesigner:catalyzed reaction="re93"/>
+<celldesigner:catalyzed reaction="re95"/>
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+<rdf:Description rdf:about="#s30">
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+<rdf:li rdf:resource="urn:miriam:mesh:D008297"/>
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+</bqbiol:isDescribedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s31" id="s31" name="Camostat mesilate" compartment="default" initialAmount="0">
+<annotation>
+<celldesigner:extension>
+<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
+<celldesigner:speciesIdentity>
+<celldesigner:class>DRUG</celldesigner:class>
+<celldesigner:name>Camostat mesilate</celldesigner:name>
+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
+<celldesigner:catalyzed reaction="re150"/>
+</celldesigner:listOfCatalyzedReactions>
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+<rdf:Description rdf:about="#s31">
+<bqbiol:isDescribedBy>
+<rdf:Bag>
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+</rdf:Bag>
+</bqbiol:isDescribedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s33" id="s33" name="PRCP" compartment="c3" initialAmount="0">
+<annotation>
+<celldesigner:extension>
+<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>pr15</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
+<celldesigner:catalyzed reaction="re19"/>
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+</celldesigner:extension>
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+<rdf:Description rdf:about="#s33">
+<bqbiol:isEncodedBy>
+<rdf:Bag>
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+</rdf:Bag>
+</bqbiol:isEncodedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s34" id="s34" name="THOP1" compartment="c1" initialAmount="0">
+<annotation>
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+<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
+<celldesigner:speciesIdentity>
+<celldesigner:class>PROTEIN</celldesigner:class>
+<celldesigner:proteinReference>pr16</celldesigner:proteinReference>
+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
+<celldesigner:catalyzed reaction="re133"/>
+</celldesigner:listOfCatalyzedReactions>
+</celldesigner:extension>
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+<rdf:Description rdf:about="#s34">
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+<rdf:Bag>
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+</bqbiol:isEncodedBy>
+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s36" id="s36" name="alamandine" compartment="c1" initialAmount="0">
+<annotation>
+<celldesigner:extension>
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+<celldesigner:speciesIdentity>
+<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
+<celldesigner:name>alamandine</celldesigner:name>
+</celldesigner:speciesIdentity>
+<celldesigner:listOfCatalyzedReactions>
+<celldesigner:catalyzed reaction="re90"/>
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+</celldesigner:extension>
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+<rdf:Description rdf:about="#s36">
+<bqbiol:isDescribedBy>
+<rdf:Bag>
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+</rdf:Description>
+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s38" id="s38" name="angiotensin A" compartment="c1" initialAmount="0">
+<annotation>
+<celldesigner:extension>
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+<rdf:Description rdf:about="#s38">
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+</rdf:RDF>
+</annotation>
+</species>
+<species metaid="s41" id="s41" name="aging" compartment="default" initialAmount="0">
+<annotation>
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+<celldesigner:name>aging</celldesigner:name>
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+<rdf:Description rdf:about="#s41">
+<bqbiol:isDescribedBy>
+<rdf:Bag>
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