diff --git a/Curation/Apoptosis/Apoptosis_stable.xml b/Curation/Apoptosis/Apoptosis_stable.xml
new file mode 100644
index 0000000000000000000000000000000000000000..169a472be9ddeac3f8d6059569bb88e8a159dc79
--- /dev/null
+++ b/Curation/Apoptosis/Apoptosis_stable.xml
@@ -0,0 +1,4315 @@
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+Vidisha Singh, Genhotel laboratory, University of Evry-paris saclay, Evry, France
+Apoptosis pathway for Covid-19 maps project is constructed by using the review paper of Fung&Liu,2019,Annu rev micro (PMID=31226023).
+KEGG pathway database is used to add reactions between the elements.
+Map is constructed in the form of a cell including plasma membrane, cytoplasm in addition to extracellular space.
+Ligands are present in the extracellular space which interacts with receptors in the plasma membrane to initiate signaling cascade in the cytoplasm.
+All the map elements are named according to HGNC naming scheme.
+All map reactions are annotated with PubMed Ids, KEGG pathway Ids using MIRIAM add relation'bqbiol:isDescribedby'.
+MESH Id is provided for the phenotype 'Apoptosis'.
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diff --git a/Curation/Coagulation pathway/Coagulation-pathway1.xml b/Curation/Coagulation pathway/Coagulation-pathway1.xml
new file mode 100644
index 0000000000000000000000000000000000000000..2b8087bf4feb2e8f2e0bed4315005e5651a761e4
--- /dev/null
+++ b/Curation/Coagulation pathway/Coagulation-pathway1.xml
@@ -0,0 +1,13872 @@
+
+
+
+
+
+
+
+
+Authors: Goar Frishman
+Description: Thrombosis model of COVID-19
+
+
+
+
+
+4.0
+
+
+
+
+
+
+
+
+
+
+
+
+s435
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+PROTEIN
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+
+
+
+
+
+
+
+Ang I can be cleaved by NEP to Ang (1–7).
+ACE and NEP hydrolysed Ang I efficiently, whereas ACE2 hydrolysed Ang I only very slowly.
+PMID:15283675
+
+
+
+
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+PROTEIN
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+
+Long Name: FibrinogenSynonym: Factor IAccession: P00406
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+
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+Long Name: FibrinogenSynonym: Factor IAccession: P00406
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+Long Name: FibrinogenSynonym: Factor IAccession: P00406
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+
+
+
+Long Name: High molecular weight kininogenSynonym: Fitzgerald, Flaujeac Williams factor,HMWK,contact activation cofactor,plasma thromboplastin antecedentAccession: P00413
+
+
+
+
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+
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+
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+Institute of Experimental Genetics (IEG), Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany
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+
+
+
+inside
+
+PROTEIN
+pr58
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr62
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+transmembrane
+
+COMPLEX
+ITGA2:ITGAB1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr78
+
+
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+
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+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+Long Name: High molecular weight kininogenSynonym: Fitzgerald, Flaujeac Williams factor,HMWK,contact activation cofactor,plasma thromboplastin antecedentAccession: P00413
+
+
+
+
+
+inside
+
+PROTEIN
+pr77
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+COMPLEX
+KNG1:KLKB1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+Long Name: kallikreinSynonym: Fletcher factorAccession: P00437
+
+
+
+
+
+inside
+
+PROTEIN
+p25
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+Long Name: KininogenSynonym: Alpha-2-thiol proteinase inhibitor,KNGAccession: P00451
+
+
+
+
+
+inside
+
+PROTEIN
+p93
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
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+inside
+
+PROTEIN
+pr80
+
+
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+
+
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+
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+
+
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+
+
+
+
+inside
+
+PROTEIN
+pr81
+
+
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+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PHENOTYPE
+MASP2 deposition
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr82
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr51
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr51
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+COMPLEX
+PLAT:SERPINE1
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr55
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr55
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+Long Name: Activated Protein CSynonym: FXIV,anticoagulant protein C,autoprothrombin IIA,vitamin K-dependent protein CAccession: P00423
+
+
+
+
+
+inside
+
+PROTEIN
+pr41
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr50
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+Long Name: FibrinogenSynonym: Factor IAccession: P00406
+
+
+
+
+
+inside
+
+PROTEIN
+pr49
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr102
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr33
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr4
+
+
+
+
+
+
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+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr7
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+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PHENOTYPE
+SARS-CoV-2 infection
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr42
+
+
+
+
+
+
+
+
+
+
+
+
+
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+
+
+
+
+
+
+inside
+
+PROTEIN
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+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+COMPLEX
+SERPINF2:Plasmin
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr43
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr43
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+COMPLEX
+TAT complex
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+Long Name: FibrinogenSynonym: Factor IAccession: P00406
+
+
+
+
+
+inside
+
+PROTEIN
+pr56
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr32
+
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+
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+
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+
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+
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+
+
+inside
+
+PROTEIN
+pr32
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+COMPLEX
+Thrombin:Thrombomodulin
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+p36
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PHENOTYPE
+Thrombosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PROTEIN
+pr100
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+SIMPLE_MOLECULE
+angiotensin I
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+SIMPLE_MOLECULE
+angiotensin I-7
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+SIMPLE_MOLECULE
+angiotensin II
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PHENOTYPE
+apoptosis
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+IL-6 (19.23%), IL-10 (50%), TNF-alpha (11.54%) and IFN-gamma (19.23%) were elevated 6 infants with SARS-CoV-2 infection in Wuhan. PMID:32504360
+
+
+
+
+
+inside
+
+PHENOTYPE
+cytokine storm
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PHENOTYPE
+platelet activation
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+PHENOTYPE
+platelet aggregation
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+inside
+
+DEGRADED
+s521
+
+
+
+
+
+
+
+inside
+
+DEGRADED
+s86
+
+
+
+
+
+
+
+inside
+
+PHENOTYPE
+septal capillary necrosis
+
+
+
+
+
+
+
+outerSurface
+
+PHENOTYPE
+thrombus formation
+
+
+
+
+
+
+
+
+
+
+
+
+The classical pathway is activated by antibodies [one IgM molecule, multiple (preferably 6) IgG molecules] leading to the formation of the classical C3 convertase (C2aC4b) by the activation C2 and C4 by C1s/C1r. PMID: 26521297
+
+
+
+
+
+PMID:26521297
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.11696969696970028,0.33757575757575786
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa365
+
+
+
+
+
+
+sa367
+
+
+
+
+
+
+
+
+csa35
+
+
+
+
+
+
+
+
+
+
+
+C3-activation by the classical, lectin or alternative C3 convertase results in the formation of the C5 (C3bBbC3b) convertase. PMID: 26521297
+
+
+
+
+
+PMID:26521297
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.2784503631961268,0.0024213075060544043
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa310
+
+
+
+
+
+
+csa26
+
+
+
+
+
+
+
+
+csa27
+
+
+
+
+
+
+
+
+
+
+
+C4 is activated by enzymatic cleavage into C4a and C4b that can bind covalently to proteins or carbohydrates through a thioester bond. C4b is cleaved successively by factor I (CFB) leaving first iC4b and then C4d bound to the membrane. PMID: 19362461
+
+
+
+
+
+PMID:19362461
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa365
+
+
+
+
+
+
+
+
+sa387
+
+
+
+
+
+
+
+
+sa385
+
+
+
+
+
+
+
+
+
+
+
+Extensive C4d deposition localized to the interalveolar septal capillaries and in microvasculature was then demonstrated in covid-19 patients. PMID: 32299776
+
+
+
+
+
+PMID: 32299776
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa387
+
+
+
+
+
+
+
+
+sa388
+
+
+
+
+
+
+
+
+
+
+
+The C4d deposits in lung transplants were associated with septal capillary necrosis and deposition of IgG, C1q, C3, and or C5b-9. PMID: 19362461
+
+
+
+
+
+PMID:19362461
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa388
+
+
+
+
+
+
+
+
+sa389
+
+
+
+
+
+
+
+
+
+
+
+The pulmonary findings of covid-19 cases were accompanied by significant deposits of terminal complement components C5b-9 (membrane attack complex), C4d, and mannose binding lectin (MBL)-associated serine protease (MASP)2, in the microvasculature, consistent with sustained, systemic activation of the complement pathways in covid-19 patients with microvascular injury and thrombosis. PMID: 32299776
+
+
+
+
+
+PMID:32299776
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa32
+
+
+
+
+
+
+
+
+sa390
+
+
+
+
+
+
+
+
+
+
+
+The values of D-dimer, fibrin/fibrinogen degradation products (FDP), and fibrinogen (FIB) in all SARS-CoV-2 cases were substantially higher than those in healthy controls. PMID:2117226
+
+
+
+
+
+PMID:2117226
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.40346892803123513,0.03284406891039593
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa395
+
+
+
+
+
+
+
+
+
+
+
+Von Willebrand (vWF) activity, vWF antigen and FVIII were considerably increased, and 50/57 tested patients (87.7%) had positive lupus anticoagulant. PMID: 32367170
+
+
+
+
+
+PMID:32367170
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa179
+
+
+
+
+
+
+
+
+
+
+
+
+Whole blood from 24 patients admitted at the intensive care unit because of Covid-19 was collected and evaluated. Fibrinogen was increased and D-dimer was dramatically increased. C-reactive protein was increased. Factor VIII and von Willebrand factor (n=11) were increased. Antithrombin (n=11) was marginally decreased and protein C (n=11) was increased. The results of this cohort of patients with Covid-19 are not consistent with acute disseminated intravascular coagulation (DIC), rather they support hypercoagulability together with a severe inflammatory state. PMID: 32302438
+
+
+
+
+
+PMID:32367170
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa202
+
+
+
+
+
+
+
+
+
+
+
+SARS-2-S exploits ACE2 for entry. SARS-CoV-2 can use TMPRSS2 for S protein priming and camostat mesylate, an inhibitor of TMPRSS2, blocks SARS-CoV-2 infection of lung cells. PMID:32142651
+
+
+
+
+
+PMID:32142651
+KNOWN_TRANSITION_OMITTED
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa391
+
+
+
+
+
+
+
+
+csa37
+
+
+
+
+
+
+
+
+
+
+
+Bradykinin concentrations and the ratio of bradykinin to its stable metabolite BK1–5 (RPPGF) were significantly increased in patients presenting with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema compared to ACE inhibitor-treated controls. PMID: 30036596
+ACE catalyses degradation of Bradykinin in human plasma. PMID: 10749699
+
+
+
+
+
+PMID:30036596
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.6799999999999926,0.02666666666666906
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa402
+
+
+
+
+
+
+
+
+sa407
+
+
+
+
+
+
+sa397
+
+
+
+
+
+
+
+
+sa198
+
+
+
+
+
+
+
+
+PMID: 30036596
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa398
+
+
+
+
+
+
+
+
+sa394
+
+
+
+
+
+
+
+
+
+
+
+Recently, ACE2 was reported as an entry receptor for SARS-CoV-2. In this study, we present the crystal structure of the C-terminal domain of SARS-CoV-2 (SARS-CoV-2-CTD) spike (S) protein in complex with human ACE2 (hACE2), which reveals a hACE2-binding mode similar overall to that observed for SARS-CoV. PMID:32275855
+
+
+
+
+
+PMID:32275855
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.4344827586206852,-0.05517241379310356
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa398
+
+
+
+
+
+
+sa391
+
+
+
+
+
+
+
+
+csa37
+
+
+
+
+
+
+
+
+
+
+
+In Renal cortex, protein expression of ACE was increased in old SD rats vs. young. ACE-2 protein expression was decreased in old rats vs. young. PMID:20689271
+
+
+
+
+
+PMID:20689271
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa399
+
+
+
+
+
+
+
+
+sa398
+
+
+
+
+
+
+
+
+
+
+
+he main role of ACE2 is the degradation of Ang II resulting in the formation of angiotensin 1-7 (Ang 1-7) which opposes the actions of Ang II. PMID:22536270
+ACE2 metabolizes ANG II to Ang 1-7 in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH. PMID:23392115
+
+
+
+
+
+PMID:23392115
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa195
+
+
+
+
+
+
+
+
+sa400
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+
+
+
+There was co-localization of COVID-19 spike glycoproteins with C4d and C5b-9 in the interalveolar septa and the cutaneous microvasculature of 2 cases examined. PMID: 32299776
+
+
+
+
+
+PMID:32299776
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa391
+
+
+
+
+
+
+
+
+sa387
+
+
+
+
+
+
+
+
+
+
+
+There was co-localization of COVID-19 spike glycoproteins with C4d and C5b-9 in the interalveolar septa and the cutaneous microvasculature of 2 cases examined. PMID: 32299776
+
+
+
+
+
+PMID:32299776
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.9888297553357447,-0.10509743240629535
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa391
+
+
+
+
+
+
+
+
+csa32
+
+
+
+
+
+
+
+
+
+
+
+C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis. PMID: 10807586
+
+
+
+
+
+PMID:10807586
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa390
+
+
+
+
+
+
+
+
+sa408
+
+
+
+
+
+
+
+
+
+
+
+The involvement of MAC in the intravascular release of vWf and aggregation of platelets in organ allografts has been demonstrated by experiments in C6 deficient rats. PMID: 19362461
+
+
+
+
+
+PMID:19362461
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa390
+
+
+
+
+
+
+
+
+sa409
+
+
+
+
+
+
+
+
+
+
+
+Patients with COVID-19 commonly show higher concentration of CRP. PMID;32278764
+
+
+
+
+
+PMID;32278764
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.4882904576981377,0.0752781122284627 0.5115060455493592,-0.07530948464447396
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa410
+
+
+
+
+
+
+
+
+
+
+
+These pulmonary findings were accompanied by significant deposits of terminal complement components C5b-9 (membrane attack complex), C4d, and mannose binding lectin (MBL)-associated serine protease (MASP)2, in the microvasculature, consistent with sustained, systemic activation of the alternative and lectin-based complement pathways. PMID: 32299776
+
+
+
+
+
+PMID:32299776
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.22851346553735352,-0.04525753700577484 0.26625754425115367,0.14531912272947922
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa357
+
+
+
+
+
+
+
+
+
+
+
+Von Willebrand (vWF) activity, vWF antigen and FVIII were considerably increased, and 50/57 tested patients (87.7%) had positive lupus anticoagulant.PMID: 32367170
+
+
+
+
+
+PMID:32367170
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa411
+
+
+
+
+
+
+
+
+
+
+
+Plasma concentration of C-reactive protein was correlated with a risk of developing peripheral vascular disease. PMID: 9490235
+
+
+
+
+
+PMID:9490235
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.5838361007402466,-0.4929214016581861
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa410
+
+
+
+
+
+
+
+
+sa271
+
+
+
+
+
+
+
+
+
+
+
+VWF-mediated process is involved in platelet aggregation in stenotic arteries leading to acute thrombotic occlusion. PMID: 3500650
+
+
+
+
+
+PMID:3500650
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa411
+
+
+
+
+
+
+
+
+sa271
+
+
+
+
+
+
+
+
+
+
+
+Fibrinogen was increased and D-dimer was dramatically increased. C-reactive protein was increased in covid-19 patients.actor VIII and von Willebrand factor (n=11) were increased. Antithrombin (n=11) was marginally decreased and protein C (n=11) was increased. PMID: 32302438
+
+
+
+
+
+PMID:32302438
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.9572898873630855,0.20220276683432514
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa205
+
+
+
+
+
+
+
+
+
+
+
+Acute respiratory failure and a systemic coagulopathy are critical aspects of the morbidity and mortality characterizing infection with severe acute respiratory distress syndrome-associated coronavirus-2, the etiologic agent of Coronavirus disease 2019 (COVID-19). Skin and lung tissues from 5 patients with severe COVID-19 characterized by respiratory failure (n= 5) and purpuric skin rash (n = 3) were examined. The pattern of COVID-19 pneumonitis was predominantly a pauci-inflammatory septal capillary injury with significant septal capillary mural and luminal fibrin deposition and permeation of the interalveolar septa by neutrophils. No viral cytopathic changes were observed and the diffuse alveolar damage (DAD) with hyaline membranes, inflammation, and type II pneumocyte hyperplasia, hallmarks of classic acute respiratory distress syndrome, were not prominent. These pulmonary findings were accompanied by significant deposits of terminal complement components C5b-9 (membrane attack complex), C4d, and mannose binding lectin (MBL)-associated serine protease (MASP)2, in the microvasculature, consistent with sustained, systemic activation of the alternative and lectin-based complement pathways. PMID: 32299776
+
+
+
+
+
+PMID:32299776
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa387
+
+
+
+
+
+
+
+
+
+
+
+Human alpha 2-antiplasmin rapidly forms a stable, equimolar complex with either its target enzyme, plasmin, or with trypsin. PMID: 2437112
+
+
+
+
+
+PMID:2437112
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.464864864864861,0.12837837837839317
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa212
+
+
+
+
+
+
+sa412
+
+
+
+
+
+
+
+
+csa38
+
+
+
+
+
+
+
+
+
+
+
+The level of SERPINF2-Plasmin Complex (PIC) was higher in COVID-19 patients were higher than health controls, and also higher in the patients with thrombotic disease than without thrombotic disease in whole blood. DOI:10.1101/2020.04.25.20077842
+
+
+
+
+
+DOI:10.1101/2020.04.25.20077842
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.35232206427909935,-0.2277416817486484 0.6470216387989278,0.22816591338183478
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+csa38
+
+
+
+
+
+
+
+
+
+
+
+The level of Thrombomodulin was higher in COVID-19 patients were higher than health controls, and also higher in the patients with thrombotic disease than without thrombotic disease in whole blood samples. DOI:10.1101/2020.04.25.20077842
+
+
+
+
+
+DOI:10.1101/2020.04.25.20077842
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa301
+
+
+
+
+
+
+
+
+
+
+
+Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. PMID:21304106
+
+
+
+
+
+PMID:21304106
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa167
+
+
+
+
+
+
+
+
+sa251
+
+
+
+
+
+
+
+
+sa165
+
+
+
+
+
+
+
+
+
+
+
+The level of TAT Complex was higher in COVID-19 patients were higher than health controls, and also higher in the patients with thrombotic disease than without thrombotic disease in whole blood samples. DOI:10.1101/2020.04.25.20077842
+
+
+
+
+
+DOI:10.1101/2020.04.25.20077842
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+csa14
+
+
+
+
+
+
+
+
+
+
+
+The level of t-PA/PAI-1 Complex (t-PAIC) was higher in COVID-19 patients were higher than health controls, and also higher in the patients with thrombotic disease than without thrombotic disease in whole blood samples. DOI:10.1101/2020.04.25.20077842
+
+
+
+
+
+DOI:10.1101/2020.04.25.20077842
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+csa16
+
+
+
+
+
+
+
+
+
+
+
+Once factor VII is activated to factor XIIa it converts prekallikrein to kallikrein and kallikrein digests KNG1 to liberate
+bradykinin. ISBN:9781482204049
+
+
+
+
+
+ISBN:9781482204049
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.15662650602409123,0.6265060240963827
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa11
+
+
+
+
+
+
+
+
+sa250
+
+
+
+
+
+
+sa402
+
+
+
+
+
+
+sa251
+
+
+
+
+
+
+
+
+csa11
+
+
+
+
+
+
+
+
+
+
+
+The elevated circulatory levels of C5b-9 were also reported in severe cases of COVID-19. PMCID: PMC7260598
+
+
+
+
+
+PMC7260598
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.3427939481347567,0.20281312476650348 0.6080231444645727,-0.24547622275565617 1.0059443877679346,-0.010047180894038332
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+csa32
+
+
+
+
+
+
+
+
+
+
+
+The elevated circulatory levels of C5a were also reported in severe cases of COVID-19. PMCID: PMC7260598
+
+
+
+
+
+PMC7260598
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa253
+
+
+
+
+
+
+
+
+
+
+
+Bradykinin stimulates tissue plasminogen activator release in human vasculature. PMID: 10373228
+Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily, is the principal inhibitor of tPA and uPA in the fibrinolytic system. PMID: 12769655
+
+
+
+
+
+PMID:10373228, PMID:2769655
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa225
+
+
+
+
+
+
+
+
+sa213
+
+
+
+
+
+
+
+
+sa224
+
+
+
+
+
+
+sa402
+
+
+
+
+
+
+
+
+
+
+
+
+Renin provides only one known function, to cleave the 10-amino acid precursor peptide angiotensin I (Ang-I),1 from the N terminus of mature angiotensinogen (AGT). PMID:10585461
+
+
+
+
+
+PMID:10585461, PMID:30934934, PMID:6172448
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa196
+
+
+
+
+
+
+
+
+sa195
+
+
+
+
+
+
+
+
+sa197
+
+
+
+
+
+
+
+
+
+
+
+C2 complement component was activated by MASP1. PMID: 10946292
+
+
+
+
+
+PMID:10946292
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.4745762711864394,0.06779661016948957
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa366
+
+
+
+
+
+
+
+
+sa367
+
+
+
+
+
+
+sa368
+
+
+
+
+
+
+
+
+sa358
+
+
+
+
+
+
+
+
+
+
+
+MBL2 interacts with MASP2. PMID: 11290788
+
+
+
+
+
+PMID:11290788
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa362
+
+
+
+
+
+
+
+
+sa357
+
+
+
+
+
+
+
+
+
+
+
+MBL2 interacts with MASP1. PMID: 11290788
+
+
+
+
+
+PMID:11290788
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa362
+
+
+
+
+
+
+
+
+sa358
+
+
+
+
+
+
+
+
+
+
+
+Factor F9a increases hydrolysis of F10. PMID:11551226
+AT-III inhibits thrombin,factors IXa, Xa and XIa. PMID: 15853774
+
+
+
+
+
+PMID:11551226
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.7500000000000071,-1.4210854715202004E-14
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa177
+
+
+
+
+
+
+
+
+sa176
+
+
+
+
+
+
+sa178
+
+
+
+
+
+
+
+
+sa175
+
+
+
+
+
+
+sa202
+
+
+
+
+
+
+
+
+
+
+
+C3 converting enzyme activity digests C3 into C3a and C3b fragments. PMID; 12440962
+
+
+
+
+
+PMID:12440962
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.28143939393939377,0.28143939393939554
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa252
+
+
+
+
+
+
+
+
+sa308
+
+
+
+
+
+
+sa310
+
+
+
+
+
+
+
+
+csa26
+
+
+
+
+
+
+csa35
+
+
+
+
+
+
+
+
+
+
+
+Plasma and tissue kallikreins have also been recognized to be one of the activators of prorenin to renin. PMID: 12793984
+
+
+
+
+
+PMID:12793984
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa415
+
+
+
+
+
+
+
+
+sa197
+
+
+
+
+
+
+
+
+sa251
+
+
+
+
+
+
+
+
+
+
+
+Thrombin catalyzes the proteolytic activation of factor VIII, cleaving two sites in the heavy chain and one site in the light chain of the procofactor.
+PMID:15746105
+
+
+
+
+
+PMID:15746105
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.3867403314917155,-0.20441988950277334
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa180
+
+
+
+
+
+
+
+
+sa179
+
+
+
+
+
+
+sa183
+
+
+
+
+
+
+
+
+sa181
+
+
+
+
+
+
+
+
+
+
+
+AT-III inhibits thrombin,factors IXa, Xa and XIa. PMID: 15853774
+
+
+
+
+
+PMID:15853774
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa203
+
+
+
+
+
+
+
+
+sa181
+
+
+
+
+
+
+
+
+sa202
+
+
+
+
+
+
+sa355
+
+
+
+
+
+
+
+
+
+
+
+This study was undertaken to confirm a previous preliminary observation that hog pancreas kallikrein (EC 3.4.21.35) directly liberated an angiotensin-like substance from human plasma protein Cohn fraction IV-4 at an acidic pH of 4.0-5.0. The amino acid composition of the isolated pressor substance (residues/mol) was: Asp, 1.03; Val, 1.03; Ile, 1.00; Tyr, 0.69; Phe, 1.04; His, 0.91; Arg, 0.86; Pro, 0.86. This composition was identical with that of angiotensin. Since the reaction mixture was not contaminated with common proteolytic enzymes, such as trypsin, chymotrypsin, renin, cathepsin D and proangiotensin-converting enzyme, and other enzymes activated by kallikrein, it is clear that hog kallikrein directly produces angiotensin in vitro. PMID:6555043
+
+
+
+
+
+PMID:190881, PMID:10969042
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa195
+
+
+
+
+
+
+
+
+sa194
+
+
+
+
+
+
+
+
+sa198
+
+
+
+
+
+
+
+
+
+
+
+Patients who had thrombotic events displayed higher monocyte CD25 (IL2RA) levels (6.2%) than those without symptoms (1.3%) and controls (2.6%), p=0.0006. PMID: 20483636
+
+
+
+
+
+PMID:20483636
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa306
+
+
+
+
+
+
+
+
+sa271
+
+
+
+
+
+
+
+
+
+
+
+PAI-1 specifically and rapidly inhibits uPA and tissue-type PA (tPA). PMID: 21199867
+
+
+
+
+
+PMID:21199867
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa356
+
+
+
+
+
+
+
+
+sa236
+
+
+
+
+
+
+
+
+sa224
+
+
+
+
+
+
+
+
+
+
+
+Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. PMID:21304106
+
+
+
+
+
+PMID:21304106
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.40000000000000036,0.0
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa170
+
+
+
+
+
+
+
+
+sa165
+
+
+
+
+
+
+sa171
+
+
+
+
+
+
+
+
+sa167
+
+
+
+
+
+
+
+
+
+
+
+Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. PMID:21304106
+F2(Thrombin) increases activation of coagulation factor F11. PMID:8631976
+
+
+
+
+
+PMID:21304106, PMID:8631976
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+-0.11688311688311614,0.6363636363636349
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa165
+
+
+
+
+
+
+
+
+sa172
+
+
+
+
+
+
+sa173
+
+
+
+
+
+
+
+
+sa181
+
+
+
+
+
+
+
+
+
+
+
+C4 complement component was activated by MASP2. PMID: 21664989
+
+
+
+
+
+PMID:21664989
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.5625000000000027,1.7763568394002505E-15
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa363
+
+
+
+
+
+
+
+
+sa365
+
+
+
+
+
+
+sa364
+
+
+
+
+
+
+
+
+sa357
+
+
+
+
+
+
+
+
+
+
+
+SERPINE1 forms complex with PLAT. PMID: 22449964
+
+
+
+
+
+PMID:22449964
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.2866242038216562,0.1019108280254768
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa224
+
+
+
+
+
+
+sa225
+
+
+
+
+
+
+
+
+csa16
+
+
+
+
+
+
+
+
+
+
+
+Heme binds to factor VIII and inhibits its interaction with activated factor IX.
+PMID:22471307
+
+
+
+
+
+PMID:22471307
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.5434782608695663,0.041806020066889715
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa175
+
+
+
+
+
+
+sa180
+
+
+
+
+
+
+
+
+csa12
+
+
+
+
+
+
+
+
+
+
+
+F5a interacts with F10a. PMID:2303476
+
+
+
+
+
+PMID:2303476
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.5199999999999987,-7.105427357601002E-15
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa176
+
+
+
+
+
+
+sa201
+
+
+
+
+
+
+
+
+csa13
+
+
+
+
+
+
+
+
+
+
+
+Human Factor V was activated by Factor X and Thrombin. PMID: 2322551
+Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.PMID: 6282863
+PROC inhibits activation of coagulation factor F5a. PMID:6572921
+
+
+
+
+
+PMID:2322551
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa200
+
+
+
+
+
+
+
+
+sa201
+
+
+
+
+
+
+
+
+csa25
+
+
+
+
+
+
+sa205
+
+
+
+
+
+
+
+
+
+
+
+CBP2(SERPINH1) peptidase was activated by thrombin. PMID:23809134
+
+
+
+
+
+PMID:23809134
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa226
+
+
+
+
+
+
+
+
+sa227
+
+
+
+
+
+
+
+
+sa181
+
+
+
+
+
+
+
+
+
+
+
+The effects of IL-1β, IL-6 and IL-8 at low physiological levels, representative of chronic inflammation, by using scanning electron microscopy and thromboelastography were investigated. All three interleukins caused the viscoelastic properties to display an increased hypercoagulability of whole blood and pathology of both erythrocytes and platelets. The most pronounced changes were noted where all three cytokines caused platelet hyper-activation and spreading. PMID: 27561337
+
+
+
+
+
+PMID:27561337
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa244
+
+
+
+
+
+
+
+
+sa271
+
+
+
+
+
+
+
+
+
+
+
+The effects of IL-1β, IL-6 and IL-8 at low physiological levels, representative of chronic inflammation, by using scanning electron microscopy and thromboelastography were investigated. All three interleukins caused the viscoelastic properties to display an increased hypercoagulability of whole blood and pathology of both erythrocytes and platelets. The most pronounced changes were noted where all three cytokines caused platelet hyper-activation and spreading. PMID: 27561337
+
+
+
+
+
+PMID:27561337
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.743677764752336,-0.43660181740953075
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa242
+
+
+
+
+
+
+
+
+sa271
+
+
+
+
+
+
+
+
+
+
+
+TNFα accelerates thrombus formation in an in vivo model of arteriolar thrombosis. PMID: 23079185
+
+
+
+
+
+PMID:27561337
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa238
+
+
+
+
+
+
+
+
+sa271
+
+
+
+
+
+
+
+
+
+
+
+The effects of IL-1β, IL-6 and IL-8 at low physiological levels, representative of chronic inflammation, by using scanning electron microscopy and thromboelastography were investigated. All three interleukins caused the viscoelastic properties to display an increased hypercoagulability of whole blood and pathology of both erythrocytes and platelets. The most pronounced changes were noted where all three cytokines caused platelet hyper-activation and spreading. PMID: 27561337
+
+
+
+
+
+PMID:27561337
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa304
+
+
+
+
+
+
+
+
+sa271
+
+
+
+
+
+
+
+
+
+
+
+Fibrin formation involves thrombin-mediated proteolytic cleavage and removal of N-terminal fibrinopeptides from the Aα and Bβ chains.PMID: 28228446
+Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.PMID: 6282863
+
+
+
+
+
+PMID:28228446
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa17
+
+
+
+
+
+
+
+
+sa395
+
+
+
+
+
+
+
+
+sa203
+
+
+
+
+
+
+csa25
+
+
+
+
+
+
+
+
+
+
+
+The first step requires cleavage of C5 (purple) into the small anaphylatoxin C5a and the large fragment C5b by the C5 convertase (turquoise). C6 (yellow) binds the labile C5b intermediate, resulting in a stable C5b6 complex. C7 (green) binds C5b6, anchoring the newly formed C5b7 complex to the membrane surface. C8, a heterotrimeric protein composed of C8α (orange), C8β (red) and C8γ (dark blue), is incorporated into the assembly precursor forming C5b8 and marking the first membrane penetrating event. Finally, multiple copies of C9 (light blue) join the assembly and span membrane, resulting in the final membrane attack complex (MAC). PMID: 28630159
+
+
+
+
+
+PMID:28630159
+TRUNCATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.3462603878116344,0.5263157894736841
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa314
+
+
+
+
+
+
+
+
+sa315
+
+
+
+
+
+
+sa253
+
+
+
+
+
+
+
+
+csa35
+
+
+
+
+
+
+csa27
+
+
+
+
+
+
+
+
+
+
+
+The first step requires cleavage of C5 (purple) into the small anaphylatoxin C5a and the large fragment C5b by the C5 convertase (turquoise). C6 (yellow) binds the labile C5b intermediate, resulting in a stable C5b6 complex. C7 (green) binds C5b6, anchoring the newly formed C5b7 complex to the membrane surface. C8, a heterotrimeric protein composed of C8α (orange), C8β (red) and C8γ (dark blue), is incorporated into the assembly precursor forming C5b8 and marking the first membrane penetrating event. Finally, multiple copies of C9 (light blue) join the assembly and span membrane, resulting in the final membrane attack complex (MAC). PMID: 28630159
+
+
+
+
+
+PMID:28630159
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.4576271186440677,0.22598870056496523
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa315
+
+
+
+
+
+
+sa318
+
+
+
+
+
+
+
+
+csa28
+
+
+
+
+
+
+
+
+
+
+
+The first step requires cleavage of C5 (purple) into the small anaphylatoxin C5a and the large fragment C5b by the C5 convertase (turquoise). C6 (yellow) binds the labile C5b intermediate, resulting in a stable C5b6 complex. C7 (green) binds C5b6, anchoring the newly formed C5b7 complex to the membrane surface. C8, a heterotrimeric protein composed of C8α (orange), C8β (red) and C8γ (dark blue), is incorporated into the assembly precursor forming C5b8 and marking the first membrane penetrating event. Finally, multiple copies of C9 (light blue) join the assembly and span membrane, resulting in the final membrane attack complex (MAC). PMID: 28630159
+
+
+
+
+
+PMID:28630159
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.25660909411349664,0.4402537892139655
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa28
+
+
+
+
+
+
+sa321
+
+
+
+
+
+
+
+
+csa29
+
+
+
+
+
+
+
+
+
+
+
+The first step requires cleavage of C5 (purple) into the small anaphylatoxin C5a and the large fragment C5b by the C5 convertase (turquoise). C6 (yellow) binds the labile C5b intermediate, resulting in a stable C5b6 complex. C7 (green) binds C5b6, anchoring the newly formed C5b7 complex to the membrane surface. C8, a heterotrimeric protein composed of C8α (orange), C8β (red) and C8γ (dark blue), is incorporated into the assembly precursor forming C5b8 and marking the first membrane penetrating event. Finally, multiple copies of C9 (light blue) join the assembly and span membrane, resulting in the final membrane attack complex (MAC). PMID: 28630159
+
+
+
+
+
+PMID:28630159
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.5269343780607247,-0.06990695396669988
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa29
+
+
+
+
+
+
+csa30
+
+
+
+
+
+
+
+
+csa31
+
+
+
+
+
+
+
+
+
+
+
+The first step requires cleavage of C5 (purple) into the small anaphylatoxin C5a and the large fragment C5b by the C5 convertase (turquoise). C6 (yellow) binds the labile C5b intermediate, resulting in a stable C5b6 complex. C7 (green) binds C5b6, anchoring the newly formed C5b7 complex to the membrane surface. C8, a heterotrimeric protein composed of C8α (orange), C8β (red) and C8γ (dark blue), is incorporated into the assembly precursor forming C5b8 and marking the first membrane penetrating event. Finally, multiple copies of C9 (light blue) join the assembly and span membrane, resulting in the final membrane attack complex (MAC). PMID: 28630159
+
+
+
+
+
+PMID:28630159
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.6870540265035672,0.11009174311926806
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa31
+
+
+
+
+
+
+sa337
+
+
+
+
+
+
+
+
+csa32
+
+
+
+
+
+
+
+
+
+
+
+SARS-COV-2 infection icreases the level of Angiotesin II in blood plasma. PMID: 32048163
+
+
+
+
+
+PMID:32048163
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa195
+
+
+
+
+
+
+
+
+sa194
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+
+
+
+The binding of COVI-19 to the Toll Like Receptor (TLR) causes the release of pro-IL-1β which is cleaved by caspase-1, followed by inflammasome activation and production of active mature IL-1β which is a mediator of lung inflammation, fever and fibrosis. PMID: 32171193
+
+
+
+
+
+PMID:32171193
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa416
+
+
+
+
+
+
+
+
+sa244
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+
+
+
+The values of D-dimer, fibrin/fibrinogen degradation products (FDP), and fibrinogen (FIB) in all SARS-CoV-2 cases were substantially higher than those in healthy controls. PMID:32172226
+
+
+
+
+
+PMID:32172226
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.3875005792251255,-0.20873098210837915 0.6123995366198994,0.20878478568670378
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+sa210
+
+
+
+
+
+
+
+
+
+
+
+The values of D-dimer, fibrin/fibrinogen degradation products (FDP), and fibrinogen (FIB) in all SARS-CoV-2 cases were substantially higher than those in healthy controls. PMID:2117226
+
+
+
+
+
+PMID:32172226
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.5091257066516187,0.49991671454164055
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+csa17
+
+
+
+
+
+
+
+
+
+
+
+A meta-analysis on COVID-19 patients was performed, comparing 21 studies, totaling 3377 patients and 33 laboratory parameters. Patients with severe and fatal disease had significantly increased white blood cell (WBC) count, and decreased lymphocyte and platelet counts compared to non-severe disease and survivors. Inflammatory biomarkers such as IL-6, IL-10 and serum ferritin were highly upregulated in patients with severe and fatal disease. PMID:32286245
+
+
+
+
+
+PMID:32286245
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa416
+
+
+
+
+
+
+
+
+sa242
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+
+
+
+A meta-analysis on COVID-19 patients was performed, comparing 21 studies, totaling 3377 patients and 33 laboratory parameters. Patients with severe and fatal disease had significantly increased white blood cell (WBC) count, and decreased lymphocyte and platelet counts compared to non-severe disease and survivors. Inflammatory biomarkers such as IL-8, IL2R, IL-1B, IL-6, IL-10 and serum ferritin were highly upregulated in patients with severe and fatal disease. PMID:32286245
+
+
+
+
+
+PMID:32286245
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa416
+
+
+
+
+
+
+
+
+sa304
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+
+
+
+A meta-analysis on COVID-19 patients was performed, comparing 21 studies, totaling 3377 patients and 33 laboratory parameters. Patients with severe and fatal disease had significantly increased white blood cell (WBC) count, and decreased lymphocyte and platelet counts compared to non-severe disease and survivors. Inflammatory biomarkers such as IL-8, IL2R, IL-1B, IL-6, IL-10 and serum ferritin were highly upregulated in patients with severe and fatal disease. PMID:32286245
+
+
+
+
+
+PMID:32286245
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa416
+
+
+
+
+
+
+
+
+sa306
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+
+
+
+Plasminogen was activated activation by purified plasma kallikrein. PMID: 3850647.
+
+
+
+
+
+PMID:3850647
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa211
+
+
+
+
+
+
+
+
+sa212
+
+
+
+
+
+
+
+
+sa213
+
+
+
+
+
+
+sa236
+
+
+
+
+
+
+sa167
+
+
+
+
+
+
+sa173
+
+
+
+
+
+
+
+
+
+
+
+Antithrombin interacts with thrombin. PMID: 22930518
+
+
+
+
+
+PMID:3850647
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.5430107526881756,0.22311827956989205
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa202
+
+
+
+
+
+
+sa181
+
+
+
+
+
+
+
+
+csa14
+
+
+
+
+
+
+
+
+
+
+
+Conversion of prothrombin to thrombin catalyzes by F5a-F10a complex. PMID:4430674,PMID:3818642
+
+
+
+
+
+PMID:4430674,PMID:3818642
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa182
+
+
+
+
+
+
+
+
+sa203
+
+
+
+
+
+
+
+
+csa13
+
+
+
+
+
+
+
+
+
+
+
+PROC decreases activity of F8. PMID:1547220
+
+
+
+
+
+PMID:547220
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa205
+
+
+
+
+
+
+
+
+sa180
+
+
+
+
+
+
+
+
+
+
+
+The accumulated excess of angiotensin II enhances a greater expression of PAI-1 in the endothelium.PMID:7884001
+
+
+
+
+
+PMID:7884001
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa194
+
+
+
+
+
+
+
+
+sa224
+
+
+
+
+
+
+
+
+
+
+
+Thrombomodulin binds to thrombin at an anion-binding exosite on the carboxyl-terminal side of the substrate binding cleft. This interaction interferes with the recognition and cleavage of fibrinogen, factor V, and the platelet thrombin receptor. PMID: 8388351
+Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and Factor V activation. PMID: 6282863
+
+
+
+
+
+PMID:8388351
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+-0.0716145833333327,0.4479166666666674
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa181
+
+
+
+
+
+
+sa301
+
+
+
+
+
+
+
+
+csa25
+
+
+
+
+
+
+
+
+
+
+
+Factor IX Activation by Factor XIa proceeds without release of a free intermediate. PMID:9100000
+
+
+
+
+
+PMID:9100000
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa174
+
+
+
+
+
+
+
+
+sa175
+
+
+
+
+
+
+
+
+sa173
+
+
+
+
+
+
+
+
+
+
+
+KNG1 forms complex with KLKB1. PMID: 7944388
+
+
+
+
+
+PMID:9744388
+HETERODIMER_ASSOCIATION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+-0.6848484848484908,0.5212121212121197
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa167
+
+
+
+
+
+
+sa169
+
+
+
+
+
+
+
+
+csa11
+
+
+
+
+
+
+
+
+sa165
+
+
+
+
+
+
+
+
+
+
+
+Extensive C4d deposition localized to the interalveolar septal capillaries and in microvasculature was then demonstrated in covid-19 patients. PMID: 32299776
+
+
+
+
+
+PMID:32299776
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa357
+
+
+
+
+
+
+
+
+sa417
+
+
+
+
+
+
+
+
+
+
+
+Deposits of C4d, mannose-binding lectin, C1q, IgM, and C5b-9 were scored in the glomeruli, peritubular capillaries, and arterioles. Notably, C4d deposits were present in 88.1% of TMA cases, and the various clinical conditions had distinct staining patterns within the various compartments of the renal vasculature. Classical pathway activation was observed in 90.5% of TMA cases. Complement activation has a major role in thrombotic microangiopathy (TMA), a disorder that can occur in a variety of clinical conditions. PMID: 25573909
+
+
+
+
+
+PMID:25573909
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.11452927189270054,0.2054107993865033 0.8773782406322505,-0.2199248558700937
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa387
+
+
+
+
+
+
+
+
+sa271
+
+
+
+
+
+
+
+
+
+
+
+Complement C5b-9 increases plasminogen binding and activation on human endothelial cells. PMID: 9012652
+
+
+
+
+
+PMID:9012652
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.4301378574154905,-0.49509522420793084
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa32
+
+
+
+
+
+
+
+
+sa211
+
+
+
+
+
+
+
+
+
+
+
+C5b-9 deposits were present in 78.6% of thrombotic microangiopathy cases and in 39.6% of controls (n=53), but the staining pattern differed between cases and controls. PMID: 25573909
+
+
+
+
+
+PMID:25573909
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.0921651942652768,-0.23110078562039627 0.9549414605814293,0.11298260630328194
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa32
+
+
+
+
+
+
+
+
+sa271
+
+
+
+
+
+
+
+
+
+
+
+In an arterial thrombosis model, plasminogen activator administration increased C5a levels. PMID: 27077125
+
+
+
+
+
+PMID:27077125
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+0.1989097522870435,-0.24472389868713007 0.8010902477129569,0.24472389868713007
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa212
+
+
+
+
+
+
+
+
+sa253
+
+
+
+
+
+
+
+
+
+
+
+IL-6 (19.23%), IL-10 (50%), TNF-alpha (11.54%) and IFN-gamma (19.23%) were elevated 6 infants with SARS-CoV-2 infection in Wuhan. PMID:32504360
+
+
+
+
+
+PMID:32504360
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa416
+
+
+
+
+
+
+
+
+sa238
+
+
+
+
+
+
+
+
+sa207
+
+
+
+
+
+
+
+
+
+
+
+The fibrin monomers spontaneously polymerize end to end in a half-staggered,overlapping manner to form double-strandedfibrin protofibrils. PMID: 29096812
+Fibrin strength is enhanced byfactor XIIIa, a transglutaminase activatedby thrombin, which cross-links the D do-mains of adjacentfibrin monomers, as wellas thea-chains of opposing monomers to formD-dimer anda-polymers, respectively. PMID: 7577232
+
+
+
+
+
+PMID:29096812
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa395
+
+
+
+
+
+
+
+
+sa424
+
+
+
+
+
+
+
+
+sa425
+
+
+
+
+
+
+
+
+
+
+
+D-dimer is generated when the cross-linkedfibrinnetwork undergoes plasmin-mediated degradation. PMID: 29096812
+CBP2 peptidase removes C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. PMID:10574983
+
+
+
+
+
+PMID:29096812
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+sa424
+
+
+
+
+
+
+
+
+sa210
+
+
+
+
+
+
+
+
+sa212
+
+
+
+
+
+
+sa227
+
+
+
+
+
+
+
+
+PMID:19286885
+KNOWN_TRANSITION_OMITTED
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa40
+
+
+
+
+
+
+
+
+sa440
+
+
+
+
+
+
+
+
+
+
+
+GPVI and α2β1 to primary hemostasis confirm that collagen binding by VWF, GPVI, and α2β1 have major roles in thrombus formation. PMID: 25051961
+
+
+
+
+
+PMID:25051961
+STATE_TRANSITION
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+csa40
+
+
+
+
+
+
+
+
+sa430
+
+
+
+
+
+
+
+
+
+
+
+GPVI and α2β1 to primary hemostasis confirm that collagen binding by VWF, GPVI, and α2β1 have major roles in thrombus formation. PMID: 25051961
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+GPVI and α2β1 to primary hemostasis confirm that collagen binding by VWF, GPVI, and α2β1 have major roles in thrombus formation. PMID: 25051961
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+GPVI and α2β1 to primary hemostasis confirm that collagen binding by VWF, GPVI, and α2β1 have major roles in thrombus formation. PMID: 25051961
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diff --git a/Curation/Coagulation pathway/Coagulation-pathway2 copy.xml b/Curation/Coagulation pathway/Coagulation-pathway2 copy.xml
new file mode 100644
index 0000000000000000000000000000000000000000..459adc22d8ceb5f6543c3aed69ac930bd3ab4c28
--- /dev/null
+++ b/Curation/Coagulation pathway/Coagulation-pathway2 copy.xml
@@ -0,0 +1,14588 @@
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+Authors: Goar Frishman
+Description: Thrombosis model of COVID-19
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+Ang I can be cleaved by NEP to Ang (1–7).
+ACE and NEP hydrolysed Ang I efficiently, whereas ACE2 hydrolysed Ang I only very slowly.
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+Frishman
+Goar
+
+goar.frischmann@helmholtz-muenchen.de
+
+Institute of Experimental Genetics (IEG), Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany
+
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+2020-06-15T12:13:29Z
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+2020-06-15T12:13:29Z
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+Ang I can be cleaved by NEP to Ang (1–7).
+ACE and NEP hydrolysed Ang I efficiently, whereas ACE2 hydrolysed Ang I only very slowly.
+PMID:15283675
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+Long Name: High molecular weight kininogenSynonym: Fitzgerald, Flaujeac Williams factor,HMWK,contact activation cofactor,plasma thromboplastin antecedentAccession: P00413
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+Long Name: kallikreinSynonym: Fletcher factorAccession: P00437
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+Long Name: KininogenSynonym: Alpha-2-thiol proteinase inhibitor,KNGAccession: P00451
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+Long Name: Activated Protein CSynonym: FXIV,anticoagulant protein C,autoprothrombin IIA,vitamin K-dependent protein CAccession: P00423
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+Long Name: FibrinogenSynonym: Factor IAccession: P00406
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+Long Name: FibrinogenSynonym: Factor IAccession: P00406
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