Commit 85e77931 authored by Marek Ostaszewski's avatar Marek Ostaszewski
Browse files

Merge branch 'casq' into 'master'

CaSQ version update

See merge request !229
parents bd26dd5c 30dace67
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......@@ -2392,7 +2571,7 @@ The first step requires cleavage of C5 into the small anaphylatoxin C5a and the
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......@@ -2473,7 +2652,7 @@ The level of SERPINF2-Plasmin Complex (PIC) was higher in COVID-19 patients were
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......@@ -2713,6 +2892,45 @@ PMID:15746105
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Renin provides only one known function, to cleave the 10-amino acid precursor peptide angiotensin I (Ang-I),1 from the N terminus of mature angiotensinogen (AGT). PMID:10585461
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......@@ -3391,7 +3609,7 @@ C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b. P
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</p>
<p>There was co-localization of COVID-19 spike glycoproteins with C4d and C5b-9 in the interalveolar septa and the cutaneous microvasculature of 2 cases examined. PMID: 32299776
</p>
......@@ -3433,6 +3651,48 @@ C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b. P
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</p>
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</rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa389"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa388" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa389_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa389" qual:transitionEffect="assignmentLevel" qual:id="tr_sa389_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa388</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>The C4d deposits in lung transplants were associated with septal capillary necrosis and deposition of IgG, C1q, C3, and or C5b-9. PMID:19362461
</p>
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</rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa390"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa32" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa390_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa390" qual:transitionEffect="assignmentLevel" qual:id="tr_sa390_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>csa32</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>The pulmonary findings of covid-19 cases were accompanied by significant deposits of terminal complement components C5b-9 (membrane attack complex), C4d, and mannose binding lectin (MBL)-associated serine protease (MASP)2, in the microvasculature, consistent with sustained, systemic activation of the complement pathways in covid-19 patients with microvascular injury and thrombosis. PMID: 32299776
</p>
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The role of ACE2 active‐site residues was explored by site‐directed mutagenesis. Arg273 was found to be critical for substrate binding such that its replacement causes enzyme activity to be abolished. Although both His505 and His345 are involved in catalysis, it is His345 and not His505 that acts as the hydrogen bond donor/acceptor in the formation of the tetrahedral peptide intermediate. The difference in chloride sensitivity between ACE2 and ACE was investigated, and the absence of a second chloride‐binding site (CL2) in ACE2 confirmed. Thus ACE2 has only one chloride‐binding site (CL1) whereas ACE has two sites. PMID: 16008552
</p>
......@@ -3540,6 +3800,34 @@ ACE catalyses degradation of Bradykinin in human plasma. PMID:10749699
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