Commit 707a6f98 authored by Marek Ostaszewski's avatar Marek Ostaszewski
Browse files

Merge branch 'check-for-fairdom' into 'master'

FH images updated

See merge request !303
parents b354e4fb ec4bc8fb
......@@ -6,7 +6,15 @@
<head>
<title/>
</head>
<body>Vidisha Singh, GenHotel Laboratory, University of Evry-Paris Saclay, Evry, France
<body>1. Vidisha Singh, GenHotel Laboratory, University of Evry-Paris Saclay, Évry, France
<br/>
<br/>
2. Anna Niarakis, University of Évry Val d&apos;Essonne, Évry, France
<br/>
<br/>
3. Sara Sadat Aghamiri, Institut de Recherche Saint Louis, Paris, France
<br/>
<br/>
Apoptosis pathway for Covid-19 maps project is constructed by using the review paper of Fung&amp;Liu,2019,Annu rev micro (PMID=31226023).
KEGG pathway database is used to add reactions between the elements.
Map is constructed in the form of a cell including plasma membrane, cytoplasm in addition to extracellular space.
......@@ -5351,7 +5359,7 @@ RefSeq_ID: NM_004346
</celldesigner:connectScheme>
<celldesigner:line width="3.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_csa5" aliases="csa5" targetLineIndex="0,6" editPoints="0.20158047427614134,0.29459979474951203 0.882686272470504,-0.17144815327770746">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_csa5" aliases="csa5" targetLineIndex="0,6" editPoints="0.20158047427614134,0.29459979474951203 0.882686272470504,-0.17144815327770724">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -5364,7 +5372,7 @@ RefSeq_ID: NM_004346
</celldesigner:linkTarget>
<celldesigner:line width="3.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s62" aliases="sa29" targetLineIndex="0,7" editPoints="0.0025603618302030284,0.020742578188163385 0.9875528009624709,-0.10084004386176115">
<celldesigner:modification type="INHIBITION" modifiers="s62" aliases="sa29" targetLineIndex="0,7" editPoints="0.0025603618302030284,0.020742578188163385 0.9875528009624711,-0.10084004386176115">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -6406,7 +6414,7 @@ RefSeq_ID: NM_004346
</celldesigner:linkTarget>
<celldesigner:line width="3.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s69" aliases="sa19" targetLineIndex="0,5" editPoints="0.013955318258961569,-0.03569852388404193 0.8813937501171103,0.3034017544903995">
<celldesigner:modification type="CATALYSIS" modifiers="s69" aliases="sa19" targetLineIndex="0,5" editPoints="0.013955318258961569,-0.03569852388404193 0.8813937501171101,0.3034017544903991">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -6844,7 +6852,7 @@ RefSeq_ID: NM_004346
</celldesigner:connectScheme>
<celldesigner:line width="3.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s62" aliases="sa29" targetLineIndex="0,3" editPoints="0.6794464356812968,-0.07759858476959725 0.6794964190556598,-0.07716093470611796">
<celldesigner:modification type="INHIBITION" modifiers="s62" aliases="sa29" targetLineIndex="0,3" editPoints="0.6794464356812968,-0.07759858476959725 0.6794964190556598,-0.07716093470611884">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -6937,7 +6945,7 @@ RefSeq_ID: NM_004346
</celldesigner:connectScheme>
<celldesigner:line width="3.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s59" aliases="sa10" targetLineIndex="0,4" editPoints="0.025074785173922365,-0.06420579998106613 0.8927389189501427,0.27464975144842074">
<celldesigner:modification type="CATALYSIS" modifiers="s59" aliases="sa10" targetLineIndex="0,4" editPoints="0.025074785173922365,-0.06420579998106613 0.8927389189501428,0.2746497514484205">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -6950,7 +6958,7 @@ RefSeq_ID: NM_004346
</celldesigner:linkTarget>
<celldesigner:line width="3.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_csa6" aliases="csa6" targetLineIndex="0,5" editPoints="0.004975583313117982,-0.034104005508753255 0.9841340245141668,0.10874972466929189">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_csa6" aliases="csa6" targetLineIndex="0,5" editPoints="0.004975583313117982,-0.034104005508753255 0.9841340245141669,0.10874972466929189">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -7064,7 +7072,7 @@ RefSeq_ID: NM_004346
</celldesigner:connectScheme>
<celldesigner:line width="3.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s69" aliases="sa19" targetLineIndex="0,5" editPoints="0.1181559623063737,-0.12090390319447364 0.629649225070838,0.3789639842628292">
<celldesigner:modification type="CATALYSIS" modifiers="s69" aliases="sa19" targetLineIndex="0,5" editPoints="0.1181559623063737,-0.12090390319447408 0.6296492250708381,0.3789639842628292">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......
This diff is collapsed.
......@@ -6,7 +6,20 @@
<head>
<title/>
</head>
<body>Authors: Goar Frishman, Helmholtz Zentrum München / Institute of Experimental Genetics, Germany
<body>Authors:
<br/>
Goar Frishman, Helmholtz Zentrum München /Institute of Experimental Genetics, Munich, Germany
<br/>
<br/>
Gisela Fobo, Helmholtz Zentrum München / Institute of Experimental Genetics, Munich, Germany
<br/>
<br/>
Corinna Montrone, Helmholtz Zentrum München / Institute of Experimental Genetics, Munich, Germany
<br/>
<br/>
Marek Ostaszewski, Luxembourg Centre for Systems Biomedicine (LCSB), Luxembourg
<br/>
<br/>
Description: Thrombosis model of COVID-19
</body>
</html>
......@@ -5811,26 +5824,6 @@ Long Name: FibrinogenSynonym: Factor IAccession: P00406
</celldesigner:extension>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Description rdf:about="#RAS_complete2">
<dc:creator>
<rdf:Bag>
<rdf:li rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Frishman</vCard:Family>
<vCard:Given>Goar</vCard:Given>
</vCard:N>
<vCard:EMAIL>goar.frischmann@helmholtz-muenchen.de</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>Institute of Experimental Genetics (IEG), Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany</vCard:Orgname>
</vCard:ORG>
</rdf:li>
</rdf:Bag>
</dc:creator>
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2020-06-15T12:13:29Z</dcterms:W3CDTF>
</dcterms:created>
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2020-06-15T12:13:29Z</dcterms:W3CDTF>
</dcterms:modified>
<bqmodel:is>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:pubmed:29287092"/>
......@@ -11536,7 +11529,7 @@ Urokinase-type plasminogen activater catalyses plasmin formation from plasminoge
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s30" aliases="sa173" targetLineIndex="-1,5" editPoints="-0.026179829464382576,0.11366570869708012 0.9234438731152792,0.3323859091326048">
<celldesigner:modification type="CATALYSIS" modifiers="s30" aliases="sa173" targetLineIndex="-1,5" editPoints="-0.02617982946438302,0.11366570869708206 0.9234438731152792,0.3323859091326048">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
......@@ -11549,7 +11542,7 @@ Urokinase-type plasminogen activater catalyses plasmin formation from plasminoge
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s8" aliases="sa167" targetLineIndex="-1,4" editPoints="-0.01808473654036913,0.07812129441935052 0.9310508802940529,0.2978420210037205">
<celldesigner:modification type="CATALYSIS" modifiers="s8" aliases="sa167" targetLineIndex="-1,4" editPoints="-0.01808473654036924,0.0781212944193509 0.9310508802940529,0.2978420210037205">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
......@@ -11802,7 +11795,7 @@ Bovine-activated protein C also decreased PAI activity of whole blood and of ser
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s245" aliases="sa194" targetLineIndex="-1,3" editPoints="0.0016133689402022533,0.020057887222875714 0.4981142538972234,-0.019878477842482423 0.5029291862795537,0.039982207648618595">
<celldesigner:modification type="CATALYSIS" modifiers="s245" aliases="sa194" targetLineIndex="-1,3" editPoints="0.0016133689402022533,0.020057887222876047 0.4981142538972234,-0.019878477842482423 0.5029291862795537,0.039982207648618595">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
......@@ -11957,7 +11950,7 @@ Bovine-activated protein C also decreased PAI activity of whole blood and of ser
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s302" aliases="sa181" targetLineIndex="-1,3" editPoints="0.6772173941087232,0.41411812687727867 0.9180621317816282,0.3293104155457769">
<celldesigner:modification type="CATALYSIS" modifiers="s302" aliases="sa181" targetLineIndex="-1,3" editPoints="0.6772173941087232,0.41411812687727867 0.91806213178163,0.3293104155457751">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -14328,7 +14321,7 @@ Whole blood from 24 patients admitted at the intensive care unit because of Covi
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s633" aliases="sa499" targetLineIndex="-1,2" editPoints="0.9335426024492415,-0.04929285246589665">
<celldesigner:modification type="INHIBITION" modifiers="s633" aliases="sa499" targetLineIndex="-1,2" editPoints="0.9335426024492413,-0.049292852465896875">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -14653,7 +14646,7 @@ The entry of SARS-CoV2 into the cells through membrane fusion markedly down-regu
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s114" aliases="sa394" targetLineIndex="-1,2" editPoints="-0.004348307867793277,0.029357298452784786 0.4129447201394558,0.09116538885924586 0.4387606333332468,-0.08312895540157905">
<celldesigner:modification type="CATALYSIS" modifiers="s114" aliases="sa394" targetLineIndex="-1,2" editPoints="-0.004348307867793055,0.029357298452783454 0.4129447201394585,0.0911653888592463 0.4387606333332468,-0.08312895540157905">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
......@@ -14813,7 +14806,7 @@ The entry of SARS-CoV2 into the cells through membrane fusion markedly down-regu
<celldesigner:lineDirection index="2" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.24966304198037093,-0.09429814922950519 0.780545255157403,-0.11263481593025215</celldesigner:editPoints>
<celldesigner:editPoints>0.2496630419803707,-0.09429814922950519 0.7805452551574033,-0.11263481593025215</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:reactantLink>
</celldesigner:listOfReactantLinks>
......@@ -14979,7 +14972,7 @@ The entry of SARS-CoV2 into the cells through membrane fusion markedly down-regu
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s633" aliases="sa499" targetLineIndex="-1,3" editPoints="0.30372910129062414,-0.39491242384733205 0.932058292060011,0.08833866906034427">
<celldesigner:modification type="TRIGGER" modifiers="s633" aliases="sa499" targetLineIndex="-1,3" editPoints="0.3037291012906348,-0.39491242384734626 0.9320582920600115,0.08833866906034338">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -16537,7 +16530,7 @@ The level of SERPINF2-Plasmin Complex (PIC) was higher in COVID-19 patients were
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s493" aliases="csa32" targetLineIndex="-1,2" editPoints="0.44376341235667205,-0.5431449488140254 1.0434523827954993,-0.053183614448907846">
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s493" aliases="csa32" targetLineIndex="-1,2" editPoints="0.44376341235667227,-0.5431449488140254 1.0434523827954993,-0.053183614448907846">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -18150,7 +18143,7 @@ The docking of Arg2 of angiotensin II with Asp281 of AT1 receptor is essential f
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s484" aliases="sa402" targetLineIndex="-1,3" editPoints="-0.029503079881576966,-0.005525241829534733 -0.06707472432241235,0.19509570136518317 0.9285441691304336,0.38155200282460666">
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s484" aliases="sa402" targetLineIndex="-1,3" editPoints="-0.029503079881577077,-0.0055252418295347605 -0.06707472432241246,0.19509570136518334 0.9285441691304336,0.38155200282460666">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -18499,7 +18492,7 @@ The stimulation of aldosterone secretion is mediated via the type 1 AI1 (ATl) re
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s633" aliases="sa480" targetLineIndex="-1,2" editPoints="0.07463510130783613,-0.15639527528886177 0.8891399125754769,0.23230348170620285">
<celldesigner:modification type="TRIGGER" modifiers="s633" aliases="sa480" targetLineIndex="-1,2" editPoints="0.07463510130783302,-0.15639527528885555 0.8891399125754769,0.23230348170620285">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -18679,7 +18672,7 @@ Ang II activates PAI-1 gene expression through the AT1 receptor and involves the
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s591" aliases="sa503" targetLineIndex="-1,3" editPoints="0.5633571349938431,0.21315584452831904 0.688590260819899,-0.11782722153683822">
<celldesigner:modification type="CATALYSIS" modifiers="s591" aliases="sa503" targetLineIndex="-1,3" editPoints="0.563357134993842,0.2131558445283186 0.688590260819899,-0.11782722153683822">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -18692,7 +18685,7 @@ Ang II activates PAI-1 gene expression through the AT1 receptor and involves the
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s245" aliases="sa194" targetLineIndex="-1,7" editPoints="0.492247647371195,0.10327891906957709 0.534412151455719,-0.0976854028381432">
<celldesigner:modification type="CATALYSIS" modifiers="s245" aliases="sa194" targetLineIndex="-1,7" editPoints="0.4922476473711952,0.1032789190695772 0.534412151455719,-0.0976854028381432">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -18718,7 +18711,7 @@ Ang II activates PAI-1 gene expression through the AT1 receptor and involves the
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s318" aliases="sa242" targetLineIndex="-1,4" editPoints="0.41765053551955766,-0.18826141101187188 0.5865247332187282,0.1863793543229093">
<celldesigner:modification type="CATALYSIS" modifiers="s318" aliases="sa242" targetLineIndex="-1,4" editPoints="0.41765053551955855,-0.18826141101187233 0.5865247332187282,0.1863793543229093">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -18731,7 +18724,7 @@ Ang II activates PAI-1 gene expression through the AT1 receptor and involves the
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s611" aliases="sa519" targetLineIndex="-1,5" editPoints="0.557420006968067,0.17888046775689953 0.6507867841740036,-0.11206526965836722">
<celldesigner:modification type="CATALYSIS" modifiers="s611" aliases="sa519" targetLineIndex="-1,5" editPoints="0.5574200069680673,0.17888046775689959 0.6507867841740036,-0.11206526965836722">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -18927,7 +18920,7 @@ The mRNA expression of MR (Nr3c2) in the renal medulla was 40% lower in Agtr1a-/
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s630" aliases="sa509" targetLineIndex="-1,3" editPoints="0.11582088640995591,0.38650066299811536 1.033420977725375,0.1115276393515161">
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s630" aliases="sa509" targetLineIndex="-1,3" editPoints="0.11582088640995636,0.38650066299811736 1.033420977725375,0.1115276393515161">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -18940,7 +18933,7 @@ The mRNA expression of MR (Nr3c2) in the renal medulla was 40% lower in Agtr1a-/
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s611" aliases="sa519" targetLineIndex="-1,2" editPoints="0.29693340967640935,0.30328889640099116 0.8075207773548527,-0.1965989986771282">
<celldesigner:modification type="CATALYSIS" modifiers="s611" aliases="sa519" targetLineIndex="-1,2" editPoints="0.2969334096764191,0.3032888964010005 0.8075207773548532,-0.19659899867712777">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -19036,7 +19029,7 @@ The mRNA expression of MR (Nr3c2) in the renal medulla was 40% lower in Agtr1a-/
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s245" aliases="sa194" targetLineIndex="-1,2" editPoints="0.36923363549503474,0.1625382292525005 0.5315582216364723,-0.2062100790493231">
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s245" aliases="sa194" targetLineIndex="-1,2" editPoints="0.36923363549502586,0.16253822925249672 0.5315582216364718,-0.2062100790493233">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......
......@@ -10,6 +10,8 @@
Authors:
Luis Cristobal Monraz Gomez, Inna Kuperstein, Institut Curie
Barbara Brauner, Andreas Ruepp, Helmholtz Zentrum München / Institute of Experimental Genetics, Germany
<br/>
<br/>
DESCRIPTION:
This diagram depicts the activity of the Unfolded Protein Response (UPR) that leads to endoplasmic reticulum stress and further apoptosis.
During the Sars-CoV-2 infection, this mechanism is activated in the infected cells of the host.
......@@ -14084,7 +14086,7 @@ MFN2, a dynamin-related GTPase identified at the ER surface, contributes to ER a
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s_id_path_1_sa110" aliases="path_1_sa110" targetLineIndex="-1,2" editPoints="0.18786056381776417,-0.21534982576088219 0.7557211266312427,0.2800237141205268">
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s_id_path_1_sa110" aliases="path_1_sa110" targetLineIndex="-1,2" editPoints="0.18786056381776461,-0.21534982576088263 0.7557211266312431,0.28002371412052635">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
......@@ -14726,7 +14728,7 @@ MFN2, a dynamin-related GTPase identified at the ER surface, contributes to ER a
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa21" aliases="path_0_csa21" targetLineIndex="-1,6" editPoints="-0.026506693546639593,0.20688912688464822 0.38584233660142786,0.6292547326638422 0.9783696252844702,0.050779474542452796">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa21" aliases="path_0_csa21" targetLineIndex="-1,6" editPoints="-0.02650669354663915,0.20688912688464822 0.38584233660142786,0.6292547326638422 0.9783696252844707,0.05077947454245302">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -14764,7 +14766,7 @@ MFN2, a dynamin-related GTPase identified at the ER surface, contributes to ER a
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s_id_path_0_sa624" aliases="path_0_sa515" targetLineIndex="0,7" editPoints="0.4682443681564852,0.10346102485340869 0.5246131562296359,-0.146913975961942 0.879041196092218,-0.06860125992155619">
<celldesigner:modification type="INHIBITION" modifiers="s_id_path_0_sa624" aliases="path_0_sa515" targetLineIndex="0,7" editPoints="0.4682443681564856,0.10346102485340869 0.5246131562296363,-0.14691397596194178 0.879041196092218,-0.06860125992155619">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
......@@ -15200,7 +15202,7 @@ When ER is under stress or when ER Ca2+ is depleted, SigR1 switches its interact
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.5717131474103585,-0.006972111553785965</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s_id_path_1_sa69" aliases="path_1_sa69" targetLineIndex="0,5" editPoints="0.648268819758753,-0.18021969338635924">
<celldesigner:modification type="TRIGGER" modifiers="s_id_path_1_sa69" aliases="path_1_sa69" targetLineIndex="0,5" editPoints="0.648268819758753,-0.18021969338635946">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -16262,7 +16264,7 @@ Time course studies analyzing the expression of Mfn2 and known ER stress protein
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa494" aliases="path_0_sa494" targetLineIndex="0,7" editPoints="0.0934866972366919,-0.12797270940717942 0.8668714060438933,-0.14950939735213264">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa494" aliases="path_0_sa494" targetLineIndex="0,7" editPoints="0.09348669723669012,-0.12797270940717898 0.8668714060438916,-0.1495093973521322">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -16358,7 +16360,7 @@ Time course studies analyzing the expression of Mfn2 and known ER stress protein
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa107" aliases="path_0_sa107" targetLineIndex="0,3" editPoints="0.8043694745801191,0.16929296208332278 0.9236868335300756,0.04583386032558634">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa107" aliases="path_0_sa107" targetLineIndex="0,3" editPoints="0.8043694745801186,0.16929296208332278 0.9236868335300756,0.04583386032558634">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
......@@ -16560,7 +16562,7 @@ Induction of ER stress with either thapsigargin or tunicamycin in mouse embryoni
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa6" aliases="path_0_csa6" targetLineIndex="0,5" editPoints="-0.05034452601038342,-0.12565074513755145 0.3655594403950584,-0.2922911262319794 0.5542336841963007,0.17860533859918434">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa6" aliases="path_0_csa6" targetLineIndex="0,5" editPoints="-0.05034452601038342,-0.12565074513755134 0.3655594403950586,-0.2922911262319793 0.5542336841963007,0.17860533859918434">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -17482,7 +17484,7 @@ Induction of ER stress with either thapsigargin or tunicamycin in mouse embryoni
<celldesigner:editPoints>0.2891039470782282,-0.04261219030692409</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa19" aliases="path_0_csa19" targetLineIndex="0,5" editPoints="-0.019323638470526205,0.05134136303185599 0.8565949409505915,0.38101578067145425">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa19" aliases="path_0_csa19" targetLineIndex="0,5" editPoints="-0.019323638470526205,0.05134136303185599 0.8565949409505915,0.38101578067145603">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -17495,7 +17497,7 @@ Induction of ER stress with either thapsigargin or tunicamycin in mouse embryoni
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa20" aliases="path_0_csa20" targetLineIndex="0,5" editPoints="0.08670262932488892,-0.049682489272161234 0.3338911899745165,0.381694812093583">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa20" aliases="path_0_csa20" targetLineIndex="0,5" editPoints="0.08670262932488981,-0.04968248927216301 0.3338911899745174,0.38169481209358125">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -17520,7 +17522,7 @@ Induction of ER stress with either thapsigargin or tunicamycin in mouse embryoni
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="INHIBITION" modifiers="s_id_path_0_sa153" aliases="path_0_sa153" targetLineIndex="0,4" editPoints="0.5545976137091699,-0.2637770510427231">
<celldesigner:modification type="INHIBITION" modifiers="s_id_path_0_sa153" aliases="path_0_sa153" targetLineIndex="0,4" editPoints="0.5545976137091664,-0.26377705104272664">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -18172,7 +18174,7 @@ Induction of ER stress with either thapsigargin or tunicamycin in mouse embryoni
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa203" aliases="path_0_sa5" targetLineIndex="-1,5" editPoints="0.21669195102075278,0.13457141950250673">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa203" aliases="path_0_sa5" targetLineIndex="-1,5" editPoints="0.21669195102075234,0.1345714195025085">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -18184,7 +18186,7 @@ Induction of ER stress with either thapsigargin or tunicamycin in mouse embryoni
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa231" aliases="path_0_sa231" targetLineIndex="-1,4" editPoints="0.22755104611469967,-0.2727442235654145">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa231" aliases="path_0_sa231" targetLineIndex="-1,4" editPoints="0.22755104611469967,-0.2727442235654163">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -18381,7 +18383,7 @@ Induction of ER stress with either thapsigargin or tunicamycin in mouse embryoni
<celldesigner:editPoints>0.21999999999999886,0.019999999999992468 0.8399999999999892,0.02000000000000668</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa487" aliases="path_0_sa487" targetLineIndex="0,5" editPoints="-0.034103944463756974,0.3038776437226307 0.914446013962575,0.41033264550218895">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_sa487" aliases="path_0_sa487" targetLineIndex="0,5" editPoints="-0.03410394446375875,0.3038776437226298 0.9144460139625732,0.41033264550218806">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -18604,7 +18606,7 @@ Induction of ER stress with either thapsigargin or tunicamycin in mouse embryoni
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa6" aliases="path_0_csa6" targetLineIndex="0,5" editPoints="0.26300107945926676,-0.38387932260465707 0.8280411155895389,0.0028575663845904486">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa6" aliases="path_0_csa6" targetLineIndex="0,5" editPoints="0.263001079459267,-0.3838793226046575 0.8280411155895389,0.0028575663845904486">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -21253,7 +21255,7 @@ When ER is under stress or when ER Ca2+ is depleted, SigR1 switches its interact
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa56" aliases="path_0_csa56" targetLineIndex="0,3" editPoints="0.9461818117065341,0.21347315726722726">
<celldesigner:modification type="CATALYSIS" modifiers="s_id_path_0_csa56" aliases="path_0_csa56" targetLineIndex="0,3" editPoints="0.9461818117065306,0.21347315726722726">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -21351,7 +21353,7 @@ When ER is under stress or when ER Ca2+ is depleted, SigR1 switches its interact
<celldesigner:editPoints num0="0" num1="0" num2="1" tShapeIndex="0">0.5261092897526014,0.2553596552644555 288.0941176470592,-135.09411764705897</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s_id_path_1_sa69" aliases="path_1_sa69" targetLineIndex="0,3" editPoints="0.7158383421414372,-0.23654576642111547">
<celldesigner:modification type="TRIGGER" modifiers="s_id_path_1_sa69" aliases="path_1_sa69" targetLineIndex="0,3" editPoints="0.7158383421414376,-0.23654576642111547">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -23572,7 +23574,7 @@ A soluble form of ACE2, lacking its cytosolic and transmembrane domains, has bee
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.16406731700871902,0.3049799612437256</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="INHIBITION" modifiers="s_id_path_1_sa180" aliases="path_1_sa180" targetLineIndex="2,3" editPoints="0.8870003363184593,0.3167700876603138">
<celldesigner:modification type="INHIBITION" modifiers="s_id_path_1_sa180" aliases="path_1_sa180" targetLineIndex="2,3" editPoints="0.8870003363184595,0.3167700876603138">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -23696,7 +23698,7 @@ A soluble form of ACE2, lacking its cytosolic and transmembrane domains, has bee
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:GateMember>
<celldesigner:GateMember type="TRIGGER" aliases="sa279" targetLineIndex="-1,0" editPoints="0.21096497373037099,0.07549629570037897 0.8958802013818288,0.30279373427313266">
<celldesigner:GateMember type="TRIGGER" aliases="sa279" targetLineIndex="-1,0" editPoints="0.21096497373037099,0.07549629570037908 0.8958802013818288,0.3027937342731328">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......
......@@ -6,8 +6,10 @@
<head>
<title/>
</head>
<body>Author(s):
Description:
<body>Author(s): Julia Somers, Oregon Health &amp; Science University (OHSU), Portland, Oregon
<br/>
<br/>
Emek Demir, Oregon Health &amp; Science University (OHSU), Portland, Oregon
</body>
</html>
</notes>
......@@ -13572,7 +13574,7 @@ Description:
<celldesigner:editPoints>0.1135425268373158,-8.881784197001252E-16 0.1135425268373158,-8.881784197001252E-16</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s132" aliases="csa11" targetLineIndex="-1,3" editPoints="0.5836025582484758,-0.014871380911785081 0.5842514710034443,0.01059411863575832">
<celldesigner:modification type="CATALYSIS" modifiers="s132" aliases="csa11" targetLineIndex="-1,3" editPoints="0.5836025582484723,-0.014871380911785081 0.5842514710034408,0.01059411863575832">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -14799,7 +14801,7 @@ PMID: 30692038
<celldesigner:editPoints>0.2848950163017364,-0.31346648414010225 0.4662158725902853,-0.1491273012096479 0.6383807308983805,-0.3390824839881317</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s170" aliases="sa164" targetLineIndex="-1,2" editPoints="0.4581471997483506,0.1389911126072061 0.5424275840557433,-0.1388167366850528">
<celldesigner:modification type="CATALYSIS" modifiers="s170" aliases="sa164" targetLineIndex="-1,2" editPoints="0.45814719974834883,0.1389911126072061 0.5424275840557415,-0.13881673668505456">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
......@@ -15966,7 +15968,7 @@ https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="CATALYSIS" modifiers="s238" aliases="csa22" targetLineIndex="-1,2" editPoints="0.2367110912018866,-0.557184079841635 1.0838209287490992,-0.19730248726159338">
<celldesigner:modification type="CATALYSIS" modifiers="s238" aliases="csa22" targetLineIndex="-1,2" editPoints="0.2367110912018875,-0.5571840798416368 1.0838209287491,-0.19730248726159338">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
......@@ -17515,7 +17517,7 @@ https://www.biorxiv.org/content/10.1101/2020.03.22.002386v3
<celldesigner:lineDirection index="2" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.09866123535015614,-0.46535293680604184 1.0556449667941497,-0.26245919812610197</celldesigner:editPoints>
<celldesigner:editPoints>0.09866123535015525,-0.4653529368060454 1.0556449667941497,-0.2624591981261055</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000" type="Straight"/>
</celldesigner:productLink>
</celldesigner:listOfProductLinks>
......
<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" level="2" version="4">
<model metaid="NLRP3_Activation_COVID19" id="NLRP3_Activation_COVID19">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body>Authors:
<br/>
Julia Somers, Oregon Health &amp; Science University (OHSU), Portland, Oregon
<br/>
<br/>
Gökçe Yağmur Summak, Ankara University, Ankara, Turkey
<br/>
<br/>
Ebru Kocakaya, Ankara University, Ankara, Turkey
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:modelVersion>4.0</celldesigner:modelVersion>
......
<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" level="2" version="4">
<model metaid="IFN_lambda_signaling" id="IFN_lambda_signaling">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body>Authors:
<br/>
Marius Rameil, University of Bonn, Bonn, Germany
<br/>
<br/>
Vanessa Nakonecnij, University of Bonn, Bonn, Germany
<br/>
<br/>
Marta Conti, University of Bonn, Bonn, Germany
</body>
</html>
</notes>
<annotation>
<celldesigner:extension>
<celldesigner:modelVersion>4.0</celldesigner:modelVersion>
......@@ -7783,7 +7800,7 @@ Uniprot: K4LC41
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s352" aliases="csa60" targetLineIndex="-1,2" editPoints="0.5288090696591414,-0.10519655125611838">
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s352" aliases="csa60" targetLineIndex="-1,2" editPoints="0.5288090696591397,-0.10519655125611882">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......
......@@ -6,8 +6,18 @@
<head>
<title/>
</head>
<body>Sara Sadat AGHAMIRI, Computational Systems Biology Engineer; Institut national de la santé et de la recherche médicale- INSERM; Laboratoire de recherche européen pour la polyarthrite rhumatoïde-GenHotel; Team of Dr Anna Niarakis
///Description from Fung and Liu, 2019:
<body>Authors:
<br/>
Sara Sadat Aghamiri, Computational Systems Biology Engineer; Institut national de la santé et de la recherche médicale- INSERM; Laboratoire de recherche européen pour la polyarthrite rhumatoïde-GenHotel
<br/>
<br/>
Vidisha Singh, GenHotel Laboratory, University of Evry-Paris Saclay, Évry, France
<br/>
<br/>
Anna Niarakis, University of Évry Val d&apos;Essonne, Évry, France
<br/>
<br/>
Description from Fung and Liu, 2019:
Mild HCoVs such as HCoV-229E typically induce a high level of IFN-I production. SARS-CoV and MERS-CoV were shown to utilize mechanisms to suppress the activation of host innate immune response. Several structural proteins (M and N), nonstructural proteins (nsp1 and nsp3), and accessory proteins of SARS-CoV and/or MERS-CoV were identified as interferon antagonists.
Innate immunity plays critical for the initial detection and restriction of pathogens and activation of the adaptive immune response. Effective activation of innate immunity relies on the:
Recognition pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs)
......@@ -10897,7 +10907,7 @@ SIGNOR-SCISOVG
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="CATALYSIS" modifiers="s2444" aliases="sa321" targetLineIndex="-1,4" editPoints="0.13061532092094597,-0.27120164055236273 0.9364716242765421,0.1169124558984409">
<celldesigner:modification type="CATALYSIS" modifiers="s2444" aliases="sa321" targetLineIndex="-1,4" editPoints="0.13061532092094685,-0.27120164055236184 0.9364716242765421,0.1169124558984409">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -11183,7 +11193,7 @@ SIGNOR-SCISOVG
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s2649" aliases="csa46" targetLineIndex="-1,0" editPoints="-9.437770376619081E-4,-0.031959520375829276 0.9969952791393479,-0.053084511279577806">
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s2649" aliases="csa46" targetLineIndex="-1,0" editPoints="-9.437770376619081E-4,-0.031959520375829276 0.9969952791393478,-0.053084511279577806">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -11315,7 +11325,7 @@ SIGNOR-SCISOVG
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s2649" aliases="csa46" targetLineIndex="-1,0" editPoints="-0.0011851776873832431,-0.040546431023312124 0.9969187799351733,-0.05913477819371682">
<celldesigner:modification type="PHYSICAL_STIMULATION" modifiers="s2649" aliases="csa46" targetLineIndex="-1,0" editPoints="-0.0011851776873832431,-0.040546431023312124 0.9969187799351735,-0.05913477819371682">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
......@@ -11866,7 +11876,7 @@ SIGNOR-SCISOVG
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>