Commit 4d6f3a23 authored by Jeremy Zucker's avatar Jeremy Zucker
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merged master into il6-amp

parents c807a0fb 4492ce99
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Rank Cell line Perturbagen Dose(um) Duration(h) Enrichment Score Perturbed Genes
1 VCAP BRD-K67414432 10.0 24 2/11 0.923 BAD, CASP3
2 VCAP gefitinib 10.0 24 1/3 0.818 CASP3
3 PC3 ici-162,846 10.0 24 1/3 0.818 BAX
4 MCF7 t_0901317 10.0 24 1/4 0.524 BAD
5 MCF7 e6_berbamine 10.0 24 1/5 0.350 BAD
6 VCAP zd_7155_hydrochloride 10.0 6 1/5 0.350 BAX
7 HCC515 lfm-a13 111.11 24 1/6 0.231 BAD
8 ASC BRD-K25311561 10.0 24 1/6 0.231 BAD
9 VCAP BRD-K61717269 10.0 24 4/111 0.154 BAD, BAX, BID, CASP3
10 PC3 anisomycin 10.0 6 2/28 0.147 BAD, CASP3
11 VCAP BRD-K31706415 10.0 24 2/28 0.147 BAD, CASP3
12 MCF7 ci_976 80.0 24 1/7 0.147 BAD
13 VCAP pyrimethamine 10.0 24 1/7 0.147 BAD
14 MCF7 cv_1808 10.0 6 1/7 0.147 BAX
15 MCF7 cp_55,940 10.0 24 1/8 0.091 BAD
16 MCF7 BRD-K35004659 10.0 6 1/8 0.091 BAD
17 VCAP resveratrol 10.0 6 1/8 0.091 BAD
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Rank Cell line Perturbagen Dose(um) Duration(h) Enrichment Score Perturbed Genes
1 PC3 psoromic_acid 10.0 24 1/6 0.667 BCL2
2 A549 BMS-777607 10 24 1/6 0.667 BAX
3 HCC515 BRD-K73285375 10.0 6 2/26 0.561 BAD, BAX
4 VCAP latanoprost 10.0 24 2/26 0.561 BAX, BID
5 A549 KIN001-220 0.37 24 1/7 0.456 BAX
6 VCAP s1475 10.0 6 1/7 0.456 BAX
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Rank Cell line Perturbagen Dose(um) Duration(h) Enrichment Score Perturbed Genes
1 VCAP BRD-K67414432 10.0 24 2/21 0.875 BAD, CASP3
2 VCAP gefitinib 10.0 24 1/7 0.542 CASP3
3 HEPG2 BRD-K05649647 20.0 6 3/68 0.472 BAD, BCL2, CASP8
4 HCC515 lfm-a13 111.11 24 1/10 0.250 BAD
5 VCAP latanoprost 10.0 24 2/43 0.208 BAX, BID
6 HCC515 gw_843682x 10.0 24 2/43 0.208 BAD, BID
7 VCAP BRD-K31706415 10.0 24 2/47 0.153 BAD, CASP3
8 VCAP zd_7155_hydrochloride 10.0 6 1/12 0.139 BAX
9 A549 BMS-777607 10 24 1/12 0.139 BAX
10 A549 KIN001-220 0.37 24 1/13 0.083 BAX
11 A549 ON-01910 0.12 24 1/13 0.083 BAX
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Term id Term Definition Enrichment Corrected pvalue
GO:0097191 extrinsic apoptotic signaling pathway 11/96 0.0013
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 9/85 0.0023
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 7/33 0.0031
GO:0097190 apoptotic signaling pathway 12/282 0.0038
GO:0051402 neuron apoptotic process 7/44 0.004
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 9/125 0.006
GO:0070997 neuron death 7/52 0.0062
GO:0010952 positive regulation of peptidase activity 10/190 0.0067
GO:0010950 positive regulation of endopeptidase activity 9/171 0.0092
GO:2001056 positive regulation of cysteine-type endopeptidase activity 9/142 0.0103
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 9/210 0.0104
GO:2001235 positive regulation of apoptotic signaling pathway 9/183 0.0105
GO:2000116 regulation of cysteine-type endopeptidase activity 9/234 0.0128
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 5/36 0.0139
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 5/45 0.014
GO:0045862 positive regulation of proteolysis 10/355 0.016
GO:0097193 intrinsic apoptotic signaling pathway 7/149 0.0171
GO:0001836 release of cytochrome c from mitochondria 4/22 0.0179
GO:2001236 regulation of extrinsic apoptotic signaling pathway 7/157 0.0185
GO:1901216 positive regulation of neuron death 6/96 0.0187
GO:2001234 negative regulation of apoptotic signaling pathway 8/230 0.0189
GO:2001233 regulation of apoptotic signaling pathway 10/410 0.0198
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 6/105 0.0226
GO:0071887 leukocyte apoptotic process 4/25 0.023
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c 3/7 0.0239
GO:0071550 death-inducing signaling complex assembly 3/8 0.026
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 5/64 0.0271
GO:0043068 positive regulation of programmed cell death 12/678 0.0278
GO:0052547 regulation of peptidase activity 10/446 0.0281
GO:0006915 apoptotic process 14/920 0.0283
GO:0043065 positive regulation of apoptotic process 12/670 0.0288
GO:0043029 T cell homeostasis 4/34 0.0307
GO:0032025 response to cobalt ion 3/10 0.0322
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 5/70 0.0325
GO:0046902 regulation of mitochondrial membrane permeability 5/77 0.0355
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3/11 0.0357
GO:0010942 positive regulation of cell death 12/729 0.037
GO:0097202 activation of cysteine-type endopeptidase activity 3/14 0.0386
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 4/38 0.0388
GO:0097345 mitochondrial outer membrane permeabilization 3/15 0.041
GO:0090559 regulation of membrane permeability 5/87 0.0411
GO:0012501 programmed cell death 14/1050 0.0413
GO:0052548 regulation of endopeptidase activity 9/420 0.0414
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3/17 0.0421
GO:0002260 lymphocyte homeostasis 4/54 0.0436
GO:0008219 cell death 14/1085 0.0443
GO:0010822 positive regulation of mitochondrion organization 5/115 0.0445
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process 3/21 0.0454
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 4/59 0.0458
GO:0043525 positive regulation of neuron apoptotic process 4/60 0.0462
GO:1903749 positive regulation of establishment of protein localization to mitochondrion 4/58 0.0469
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Term id Term Definition Enrichment Corrected pvalue
GO:0031264 death-inducing signaling complex 5/9 0.0101
GO:0031265 CD95 death-inducing signaling complex 3/6 0.0205
GO:0005741 mitochondrial outer membrane 6/186 0.0267
GO:0031968 organelle outer membrane 6/210 0.0394
GO:0019867 outer membrane 6/212 0.0492
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