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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" level="2" version="4">
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<model metaid="RAS_complete2" id="Coagulation_goar">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>Authors:
<br/>
Goar Frishman, Helmholtz Zentrum München /Institute of Experimental Genetics, Munich, Germany
<br/>
<br/>
Gisela Fobo, Helmholtz Zentrum München / Institute of Experimental Genetics, Munich, Germany
<br/>
<br/>
Corinna Montrone, Helmholtz Zentrum München / Institute of Experimental Genetics, Munich, Germany
<br/>
<br/>
Marek Ostaszewski, Luxembourg Centre for Systems Biomedicine (LCSB), Luxembourg
<br/>
<br/>
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Description: Thrombosis model of COVID-19
</body>
</html>
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<annotation>
<celldesigner:extension>
<celldesigner:modelVersion>4.0</celldesigner:modelVersion>
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<celldesigner:modelDisplay sizeX="7000" sizeY="20000"/>
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<celldesigner:listOfIncludedSpecies>
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<celldesigner:species id="s253" name="F8a">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s435</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr31</celldesigner:proteinReference>
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<celldesigner:state>
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<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
</celldesigner:listOfStructuralStates>
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</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s252" name="F9a">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
Ang I can be cleaved by NEP to Ang (1–7).
ACE and NEP hydrolysed Ang I efficiently, whereas ACE2 hydrolysed Ang I only very slowly.
PMID:15283675
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s435</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr16</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
</celldesigner:listOfStructuralStates>
</celldesigner:state>
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</celldesigner:speciesIdentity>
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr29</celldesigner:proteinReference>
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<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
</celldesigner:listOfStructuralStates>
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</celldesigner:speciesIdentity>
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:proteinReference>pr38</celldesigner:proteinReference>
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<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
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</celldesigner:speciesIdentity>
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<celldesigner:notes>
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<celldesigner:notes>
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<celldesigner:proteinReference>pr32</celldesigner:proteinReference>
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<celldesigner:structuralState structuralState="active"/>
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</celldesigner:speciesIdentity>
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<celldesigner:notes>
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<body>
Long Name:  FibrinogenSynonym:  Factor IAccession:  P00406
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</html>
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<body>
Long Name:  FibrinogenSynonym:  Factor IAccession:  P00406
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</html>
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<body>
Long Name:  FibrinogenSynonym:  Factor IAccession:  P00406
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</html>
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<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
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Long Name:  High molecular weight kininogenSynonym:  Fitzgerald, Flaujeac Williams factor,HMWK,contact activation cofactor,plasma thromboplastin antecedentAccession:  P00413
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<celldesigner:notes>
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Long Name:  FibrinogenSynonym:  Factor IAccession:  P00406
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<celldesigner:complexSpecies>s545</celldesigner:complexSpecies>
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<celldesigner:species id="s542" name="FGB">
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<html xmlns="http://www.w3.org/1999/xhtml">
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Long Name:  FibrinogenSynonym:  Factor IAccession:  P00406
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</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s545</celldesigner:complexSpecies>
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<html xmlns="http://www.w3.org/1999/xhtml">
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Long Name:  FibrinogenSynonym:  Factor IAccession:  P00406
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</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s545</celldesigner:complexSpecies>
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<celldesigner:complexSpecies>s493</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr70</celldesigner:proteinReference>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s573" name="C9">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body/>
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mouse IDs are still missing and most of the viral proteins are from Sars-Cov...  
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s493</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr76</celldesigner:proteinReference>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s576" name="C7">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body/>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s575</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr72</celldesigner:proteinReference>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
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<celldesigner:species id="s577" name="C8A">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body/>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s575</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr73</celldesigner:proteinReference>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
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<celldesigner:species id="s578" name="C8G">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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