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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" level="2" version="4">
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<model metaid="RAS_complete2" id="Coagulation_goar">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body>Authors: Goar Frishman
Description: Thrombosis model of COVID-19
</body>
</html>
</notes>
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<annotation>
<celldesigner:extension>
<celldesigner:modelVersion>4.0</celldesigner:modelVersion>
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<celldesigner:modelDisplay sizeX="7000" sizeY="20000"/>
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<celldesigner:listOfIncludedSpecies>
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<celldesigner:species id="s253" name="F8a">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s435</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr31</celldesigner:proteinReference>
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<celldesigner:state>
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<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
</celldesigner:listOfStructuralStates>
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</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s252" name="F9a">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
Ang I can be cleaved by NEP to Ang (1–7).
ACE and NEP hydrolysed Ang I efficiently, whereas ACE2 hydrolysed Ang I only very slowly.
PMID:15283675
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s435</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr16</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
</celldesigner:listOfStructuralStates>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s258" name="F10a">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s314</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr29</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
</celldesigner:listOfStructuralStates>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s259" name="F5a">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr38</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
</celldesigner:listOfStructuralStates>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s265" name="Antithrombin">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
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<celldesigner:species id="s266" name="Thrombin">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:proteinReference>pr32</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
</celldesigner:listOfStructuralStates>
</celldesigner:state>
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</celldesigner:speciesIdentity>
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
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<celldesigner:species id="s25" name="FGA">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
Long Name:  FibrinogenSynonym:  Factor IAccession:  P00406
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:class>PROTEIN</celldesigner:class>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
Long Name:  FibrinogenSynonym:  Factor IAccession:  P00406
</body>
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</html>
</celldesigner:notes>
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<title/>
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<body>
Long Name:  FibrinogenSynonym:  Factor IAccession:  P00406
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</html>
</celldesigner:notes>
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<celldesigner:species id="s370" name="Thrombin">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:state>
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<celldesigner:listOfStructuralStates>
<celldesigner:structuralState structuralState="active"/>
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</celldesigner:state>
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<celldesigner:species id="s371" name="Thrombomodulin">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
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</celldesigner:notes>
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Long Name:  High molecular weight kininogenSynonym:  Fitzgerald, Flaujeac Williams factor,HMWK,contact activation cofactor,plasma thromboplastin antecedentAccession:  P00413
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<celldesigner:complexSpecies>s513</celldesigner:complexSpecies>
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mouse IDs are still missing and most of the viral proteins are from Sars-Cov...    
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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Reorganization and the coagulation pathway    
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<celldesigner:proteinReference>pr109</celldesigner:proteinReference>
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mouse IDs are still missing and most of the viral proteins are from Sars-Cov...    
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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Reorganization and the coagulation pathway    
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<celldesigner:species id="s531" name="ITGA2">
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mouse IDs are still missing and most of the viral proteins are from Sars-Cov...    
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
Marek Ostaszewski's avatar
Reorganization and the coagulation pathway    
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<celldesigner:complexSpecies>s533</celldesigner:complexSpecies>
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mouse IDs are still missing and most of the viral proteins are from Sars-Cov...    
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr112</celldesigner:proteinReference>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
Marek Ostaszewski's avatar
Reorganization and the coagulation pathway    
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<celldesigner:species id="s532" name="ITGB1">
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mouse IDs are still missing and most of the viral proteins are from Sars-Cov...    
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
Marek Ostaszewski's avatar
Reorganization and the coagulation pathway    
Marek Ostaszewski committed
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<celldesigner:complexSpecies>s533</celldesigner:complexSpecies>
Matti Hoch's avatar
mouse IDs are still missing and most of the viral proteins are from Sars-Cov...    
Matti Hoch committed
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
Marek Ostaszewski's avatar
Reorganization and the coagulation pathway    
Marek Ostaszewski committed
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<celldesigner:proteinReference>pr113</celldesigner:proteinReference>
Matti Hoch's avatar
mouse IDs are still missing and most of the viral proteins are from Sars-Cov...    
Matti Hoch committed
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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Reorganization and the coagulation pathway    
Marek Ostaszewski committed
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<celldesigner:species id="s541" name="FGA">
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mouse IDs are still missing and most of the viral proteins are from Sars-Cov...    
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
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