ER_Stress_stable.sbml.sif 6.12 KB
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ERN1:Unfolded protein_complex POSITIVE TRAF2:ERN1_complex
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BAK1:ERN1_complex POSITIVE TRAF2:ERN1_complex
BAX:ERN1_complex POSITIVE TRAF2:ERN1_complex
BCL2 NEGATIVE TRAF2:ERN1_complex
BCL2L1 NEGATIVE TRAF2:ERN1_complex
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Persistant ER Stress_phenotype NEGATIVE TRAF2:ERN1_complex
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BAX POSITIVE TRAF2:ERN1_complex
BAK1 POSITIVE TRAF2:ERN1_complex
UPR_phenotype POSITIVE TRAF2:ERN1_complex
TRAF2_Cytoplasm POSITIVE TRAF2:ERN1_complex
MAP3K5_phosphorylated POSITIVE TRAF2:ERN1_complex
XBP1_rna POSITIVE TRAF2:ERN1_complex
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Unfolded protein_Endoplasmic Reticulum POSITIVE ERN1:Unfolded protein_complex
CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex POSITIVE Persistant ER Stress_phenotype
EIF2AK3:EIF2AK3_complex POSITIVE Persistant ER Stress_phenotype
ERN1:BCL2L11_complex NEGATIVE Persistant ER Stress_phenotype
ERN1:BBC3_complex NEGATIVE Persistant ER Stress_phenotype
DDIT3_rna POSITIVE Persistant ER Stress_phenotype
ER Stress_phenotype POSITIVE Persistant ER Stress_phenotype
TRIM13 POSITIVE CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex
Apoptosis_phenotype POSITIVE CASP8:FADD:MAP1LC3A:SQSTM1:ATG5_complex
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EIF2AK3 POSITIVE EIF2AK3:EIF2AK3_complex
Unfolded protein_Endoplasmic Reticulum POSITIVE EIF2AK3:EIF2AK3_complex
retrograde transport from ER to cytosol_phenotype POSITIVE EIF2AK3:EIF2AK3_complex
UPR_phenotype POSITIVE EIF2AK3:EIF2AK3_complex
EIF2S1_phosphorylated POSITIVE EIF2AK3:EIF2AK3_complex
accumulation of misfolded protein in ER_phenotype POSITIVE Unfolded protein_Endoplasmic Reticulum
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Ternary Complex_complex POSITIVE EIF2:GDP:Met-tRNA_complex
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EIF2S2 POSITIVE EIF2:GDP:Met-tRNA_complex
EIF2S3:GDP_complex POSITIVE EIF2:GDP:Met-tRNA_complex
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EIF2B_complex POSITIVE Ternary Complex_complex
Translation initiation_phenotype POSITIVE Ternary Complex_complex
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EIF2-P:GDP_complex POSITIVE EIF2S2
EIF2S1_phosphorylated POSITIVE EIF2-P:GDP_complex
ATF4_rna POSITIVE EIF2-P:GDP_complex
EIF2S1 POSITIVE EIF2S1_phosphorylated
GCN2:ATP_complex POSITIVE EIF2S1_phosphorylated
EIF2AK2 POSITIVE EIF2S1_phosphorylated
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DNAJC3_Cytoplasm NEGATIVE EIF2S1_phosphorylated
ERN1 POSITIVE ERN1:BCL2L11_complex
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BCL2L11_Endoplasmic Reticulum POSITIVE ERN1:BCL2L11_complex
XBP1_rna POSITIVE ERN1:BCL2L11_complex
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ERN1:BBC3_complex POSITIVE ERN1
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BBC3 POSITIVE ERN1:BBC3_complex
XBP1_rna POSITIVE ERN1:BBC3_complex
CAPN1 POSITIVE CAPN1:Ca2+_complex
Ca2+_ion_Cytoplasm POSITIVE CAPN1:Ca2+_complex
high Ca2+ cytosolic concentration_phenotype POSITIVE CAPN1:Ca2+_complex
cleaved~CASP4 POSITIVE CAPN1:Ca2+_complex
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TMBIM6 POSITIVE Ca2+_ion_Cytoplasm
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RYR1 POSITIVE Ca2+_ion_Cytoplasm
ITPR POSITIVE Ca2+_ion_Cytoplasm
high Ca2+ cytosolic concentration_phenotype POSITIVE Ca2+_ion_Cytoplasm
release of ER Ca2+_phenotype POSITIVE high Ca2+ cytosolic concentration_phenotype
ATF6:HSPA5_complex POSITIVE ATF6_Endoplasmic Reticulum
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Unfolded protein_Endoplasmic Reticulum POSITIVE ATF6_Endoplasmic Reticulum
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retrograde transport from ER to cytosol_phenotype POSITIVE ATF6_Endoplasmic Reticulum
ATF6_Golgi POSITIVE ATF6_Endoplasmic Reticulum
HSPA5 POSITIVE ATF6:HSPA5_complex
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HSPA5 POSITIVE Unfolded protein_Endoplasmic Reticulum
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protein ubiquitination and destruction_phenotype POSITIVE retrograde transport from ER to cytosol_phenotype
ATF6_Golgi NEGATIVE retrograde transport from ER to cytosol_phenotype
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XBP1_rna POSITIVE XBP1_Cytoplasm
DDIT3_rna POSITIVE XBP1_Cytoplasm
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ATF6_Nucleus POSITIVE XBP1_rna
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XBP1_Cytoplasm POSITIVE UPR_phenotype
accumulation of misfolded protein in ER_phenotype POSITIVE UPR_phenotype
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ATF6_Golgi POSITIVE UPR_phenotype
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ERAD_phenotype POSITIVE XBP1_Cytoplasm
ER Stress_phenotype POSITIVE accumulation of misfolded protein in ER_phenotype
ERAD_phenotype POSITIVE accumulation of misfolded protein in ER_phenotype
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ATF6_Golgi POSITIVE ATF6_Golgi
MBTPS2 POSITIVE ATF6_Golgi
ATF6_Nucleus POSITIVE ATF6_Golgi
MAP3K4_phosphorylated POSITIVE MAPK8_phosphorylated
MAP3K5_phosphorylated POSITIVE MAPK8_phosphorylated
BAX_phosphorylated POSITIVE MAPK8_phosphorylated
AP-1_phosphorylated_phosphorylated POSITIVE MAPK8_phosphorylated
BCL2L11_phosphorylated POSITIVE MAPK8_phosphorylated
BID_phosphorylated POSITIVE MAPK8_phosphorylated
CDK5 POSITIVE MAP3K4_phosphorylated
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MAPK14_phosphorylated_Cytoplasm POSITIVE MAP3K5_phosphorylated
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TRAF2_Cytoplasm POSITIVE MAP3K5_phosphorylated
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Apoptosis_phenotype POSITIVE MAPK14_phosphorylated_Cytoplasm
BAX_phosphorylated POSITIVE MAPK14_phosphorylated_Cytoplasm
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DDIT3_phosphorylated POSITIVE Apoptosis_phenotype
BAX_phosphorylated POSITIVE Apoptosis_phenotype
BCL2L11_phosphorylated POSITIVE Apoptosis_phenotype
BID_phosphorylated POSITIVE Apoptosis_phenotype
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TRIB3 POSITIVE Apoptosis_phenotype
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cleaved~CASP3 POSITIVE Apoptosis_phenotype
cleaved~CASP9 POSITIVE Apoptosis_phenotype
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Cell survival_phenotype POSITIVE Apoptosis_phenotype
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DDIT3 POSITIVE DDIT3_phosphorylated
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MAPK14_phosphorylated_Cytoplasm POSITIVE DDIT3_phosphorylated
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BCL2_rna NEGATIVE DDIT3_phosphorylated
release of ER Ca2+_phenotype POSITIVE BAX_phosphorylated
BCL2L11_Cytoplasm POSITIVE BCL2L11_phosphorylated
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TRIB3_rna POSITIVE TRIB3
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CASP3 POSITIVE cleaved~CASP3
cleaved~CASP4 POSITIVE cleaved~CASP3
CASP9 POSITIVE cleaved~CASP9
cleaved~CASP4 POSITIVE cleaved~CASP9
DDIT3_rna POSITIVE DDIT3
PPP1R15A_rna POSITIVE DDIT3
ERO1A_rna POSITIVE DDIT3
AP-1_phosphorylated_phosphorylated POSITIVE DDIT3
TRIB3_rna POSITIVE DDIT3
ER Stress_phenotype POSITIVE ATF6_Golgi
ATF6_Golgi POSITIVE ATF6_Golgi
CDK5 POSITIVE ER Stress_phenotype
MBTPS1 POSITIVE ATF6_Golgi
DDIT3_rna POSITIVE ATF6_Nucleus
ERO1A_rna POSITIVE ATF6_Nucleus
DNAJC3_rna POSITIVE ATF6_Nucleus
HYOU1_rna POSITIVE ATF6_Nucleus
ATF4 POSITIVE DDIT3_rna
ATF4_rna POSITIVE ATF4
PPP1R15A_rna POSITIVE ATF4
PPP1R15A POSITIVE EIF2S1
EIF2AK1 POSITIVE EIF2S1
presence of dsRNA_phenotype POSITIVE EIF2AK2
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DNAJC3_Cytoplasm NEGATIVE EIF2AK2
DNAJC3_rna POSITIVE DNAJC3_Cytoplasm
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PPP1R15A_rna POSITIVE PPP1R15A
ERO1A_rna POSITIVE ERO1A_Cytoplasm
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Ca2+_ion_Mitochondria POSITIVE release of ER Ca2+_phenotype
ITPR POSITIVE Ca2+_ion_Mitochondria
MAM_phenotype POSITIVE Ca2+_ion_Mitochondria
s619_complex POSITIVE Ca2+_ion_Mitochondria
TMBIM6 POSITIVE ITPR
ERO1A_Endoplasmic Reticulum POSITIVE ITPR
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ERO1A_Endoplasmic Reticulum POSITIVE hyperoxidation_phenotype
PPP2CA POSITIVE BCL2L11_Cytoplasm
CASP4 POSITIVE cleaved~CASP4
HYOU1 POSITIVE HYOU1_rna