Pyrimidine_deprivation_stable.xml 455 KB
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" level="2" version="4">
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<model metaid="pyrimidine_deprivation" id="pyrimidine_deprivation">
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<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body>
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  Author:
  Zsolt Bocskei, Sanofi R and D, France
  Description:
  Pyrimidine deprivation and immune response related to human coronavirus infection
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</body>
</html>
</notes>
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<annotation>
<celldesigner:extension>
<celldesigner:modelVersion>4.0</celldesigner:modelVersion>
<celldesigner:modelDisplay sizeX="3288" sizeY="1434"/>
<celldesigner:listOfIncludedSpecies>
<celldesigner:species id="s_id_sa108" name="cGAMP">
<celldesigner:notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body>
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SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa108">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
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</body>
</html>
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</celldesigner:notes>
<celldesigner:annotation>
<celldesigner:complexSpecies>s_id_csa4</celldesigner:complexSpecies>
<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cGAMP</celldesigner:name>
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</celldesigner:annotation>
</celldesigner:species>
<celldesigner:species id="s_id_sa107" name="STING">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa107">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa4</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa107</celldesigner:proteinReference>
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<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa106" name="cGAMP">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa106">
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</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa3</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cGAMP</celldesigner:name>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa105" name="STING">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
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<body>
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SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa105">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
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</body>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa3</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa105</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa139" name="cGAMP">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa139">
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</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa16</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cGAMP</celldesigner:name>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa138" name="STING">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa16</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p_s_id_sa138</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa132" name="LC3">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
LC3 and Autophagy
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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</rdf:RDF>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa13</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa132</celldesigner:proteinReference>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa131" name="cGAMP">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa13</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cGAMP</celldesigner:name>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa130" name="STING">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 1
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa13</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa130</celldesigner:proteinReference>
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<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa101" name="cGAS">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
Symbol: CGAS
Name: cyclic GMP-AMP synthase
Previous Symbols: C6orf150, MB21D1
HGNC_ID: 21367
EntrezGene_ID: 115004
RefSeq_ID: NM_138441
SemanticZoomLevelVisibility: 1
SemanticZoomLevelTransparency: 0
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<rdf:li rdf:resource="urn:miriam:hgnc.symbol:CGAS"/>
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<rdf:li rdf:resource="urn:miriam:refseq:NM_138441"/>
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</rdf:Description>
</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa1</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p_s_id_sa101</celldesigner:proteinReference>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa102" name="dsDNA">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
SemanticZoomLevelVisibility: 1
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
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</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa1</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>dsDNA</celldesigner:name>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa134" name="MRE11">
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<celldesigner:notes>
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<body>
Symbol: MRE11
Name: MRE11 homolog, double strand break repair nuclease
Previous Symbols: MRE11A
Synonyms: ATLD
HGNC_ID: 7230
EntrezGene_ID: 4361
RefSeq_ID: NM_005591
SemanticZoomLevelVisibility: 1
SemanticZoomLevelTransparency: 0
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<rdf:Description rdf:about="#s_id_sa134">
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<rdf:li rdf:resource="urn:miriam:ncbigene:4361"/>
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<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ensembl:ENSG00000020922"/>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:refseq:NM_005591"/>
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<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc:7230"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<dcterms:modified rdf:parseType="Resource"/>
</rdf:Description>
</rdf:RDF>
</body>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s136</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa134</celldesigner:proteinReference>
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<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa158" name="dsDNA">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 1
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa158">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
</body>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s136</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
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<celldesigner:name>dsDNA</celldesigner:name>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa127" name="cGAMP">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa127">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa11</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>cGAMP</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa126" name="STING">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa126">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa11</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa126</celldesigner:proteinReference>
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<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa109" name="TBK1">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
Symbol: TBK1
Name: TANK binding kinase 1
Synonyms: NAK
HGNC_ID: 11584
EntrezGene_ID: 29110
RefSeq_ID: NM_013254
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa109">
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc.symbol:TBK1"/></rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ensembl:ENSG00000183735"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:uniprot:Q9UHD2"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:refseq:NM_013254"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc:11584"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ncbigene:29110"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<dcterms:modified rdf:parseType="Resource"/>
</rdf:Description>
</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa5</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p_s_id_sa109</celldesigner:proteinReference>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa161" name="RAD50">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
Symbol: RAD50
Name: RAD50 double strand break repair protein
Synonyms: RAD50-2, hRad50
HGNC_ID: 9816
EntrezGene_ID: 10111
RefSeq_ID: NM_005732
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
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<rdf:Description rdf:about="#s_id_sa161">
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ncbigene:10111"/></rdf:Bag>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:refseq:NM_005732"/>
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</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:uniprot:Q92878"/>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc.symbol:RAD50"/>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ensembl:ENSG00000113522"/>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc:9816"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<dcterms:modified rdf:parseType="Resource"/>
</rdf:Description>
</rdf:RDF>
</body>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa24</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>p_s_id_sa161</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa160" name="MRE11">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
Symbol: MRE11
Name: MRE11 homolog, double strand break repair nuclease
Previous Symbols: MRE11A
Synonyms: ATLD
HGNC_ID: 7230
EntrezGene_ID: 4361
RefSeq_ID: NM_005591
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa160">
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc.symbol:MRE11"/></rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ncbigene:4361"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:uniprot:P49959"/>
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<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ensembl:ENSG00000020922"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:refseq:NM_005591"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc:7230"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<dcterms:modified rdf:parseType="Resource"/>
</rdf:Description>
</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa24</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa160</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa159" name="dsDNA">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa159">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
</body>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa24</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>dsDNA</celldesigner:name>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa125" name="RAD50">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
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<body>
Symbol: RAD50
Name: RAD50 double strand break repair protein
Synonyms: RAD50-2, hRad50
HGNC_ID: 9816
EntrezGene_ID: 10111
RefSeq_ID: NM_005732
SemanticZoomLevelVisibility: 1
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa125">
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ncbigene:10111"/></rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:refseq:NM_005732"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:uniprot:Q92878"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc.symbol:RAD50"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ensembl:ENSG00000113522"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc:9816"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<dcterms:modified rdf:parseType="Resource"/>
</rdf:Description>
</rdf:RDF>
</body>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa10</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa125</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa123" name="dsDNA">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
SemanticZoomLevelVisibility: 1
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa123">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa10</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>SIMPLE_MOLECULE</celldesigner:class>
<celldesigner:name>dsDNA</celldesigner:name>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa124" name="MRE11">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
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<body>
Symbol: MRE11
Name: MRE11 homolog, double strand break repair nuclease
Previous Symbols: MRE11A
Synonyms: ATLD
HGNC_ID: 7230
EntrezGene_ID: 4361
RefSeq_ID: NM_005591
SemanticZoomLevelVisibility: 1
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa124">
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc.symbol:MRE11"/></rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ncbigene:4361"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:uniprot:P49959"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:ensembl:ENSG00000020922"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:refseq:NM_005591"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<bqbiol:isDescribedBy>
<rdf:Bag>
<rdf:li rdf:resource="urn:miriam:hgnc:7230"/>
</rdf:Bag>
</bqbiol:isDescribedBy>
<dcterms:modified rdf:parseType="Resource"/>
</rdf:Description>
</rdf:RDF>
</body>
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</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa10</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa124</celldesigner:proteinReference>
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<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s133" name=" RRM1">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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</head>
<body/>
</html>
</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s135</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr61</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s134" name="RRM2">
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<html xmlns="http://www.w3.org/1999/xhtml">
<head>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s135</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>pr62</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s139" name="TBK1">
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<body>
Symbol: TBK1
Name: TANK binding kinase 1
Synonyms: NAK
HGNC_ID: 11584
EntrezGene_ID: 29110
RefSeq_ID: NM_013254
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
</body>
</html>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa20</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa80</celldesigner:proteinReference>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
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<celldesigner:species id="s_id_sa149" name="STING_p">
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<celldesigner:notes>
<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa149">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
</body>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa20</celldesigner:complexSpecies>
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<celldesigner:speciesIdentity>
<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa110</celldesigner:proteinReference>
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<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
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<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
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</celldesigner:state>
</celldesigner:speciesIdentity>
</celldesigner:annotation>
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<celldesigner:species id="s_id_sa110" name="STING_p">
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<celldesigner:notes>
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<head>
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa110">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
</body>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa5</celldesigner:complexSpecies>
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<celldesigner:class>PROTEIN</celldesigner:class>
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<celldesigner:proteinReference>p_s_id_sa110</celldesigner:proteinReference>
<celldesigner:state>
<celldesigner:homodimer>2</celldesigner:homodimer>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="phosphorylated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
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</celldesigner:speciesIdentity>
</celldesigner:annotation>
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<celldesigner:species id="s_id_sa112" name="NFKB1">
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa112">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
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</celldesigner:notes>
<celldesigner:annotation>
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<celldesigner:complexSpecies>s_id_csa6</celldesigner:complexSpecies>
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<celldesigner:class>PROTEIN</celldesigner:class>
<celldesigner:proteinReference>pr64</celldesigner:proteinReference>
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</celldesigner:annotation>
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<celldesigner:species id="s_id_sa111" name="RELA">
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<html xmlns="http://www.w3.org/1999/xhtml">
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<body>
SemanticZoomLevelVisibility: 3
SemanticZoomLevelTransparency: 0
<rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#s_id_sa111">
<dcterms:modified rdf:parseType="Resource"/></rdf:Description>
</rdf:RDF>
</body>
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