HMOX1_Pathway_stable.sif 12.5 KB
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# Generated by CaSQ v0.9.7
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Nrf2/Maf_complex POSITIVE HMOX1_rna
NRF2_phosphorylated_Nucleus POSITIVE Nrf2/Maf_complex
NRF2_phosphorylated_Nucleus POSITIVE SLC40A1_rna
NRF2_phosphorylated_Nucleus POSITIVE FTH1_rna
NRF2_phosphorylated_Nucleus POSITIVE FTL_rna
NRF2_phosphorylated_Nucleus POSITIVE FECH_rna
NRF2_phosphorylated_Nucleus POSITIVE BLVRA_rna
NRF2_phosphorylated_Nucleus POSITIVE BLVRB_rna
MAF POSITIVE Nrf2/Maf_complex
MAF POSITIVE BACH1/Maf_complex
BACH1/Maf_complex NEGATIVE HMOX1_rna
BACH1 POSITIVE BACH1/Maf_complex
Ubiquitin_Ligase_Complex_complex_Cytosol POSITIVE Ubiquitin_Ligase_Complex_complex_Cytosol
CAND1 NEGATIVE Ubiquitin_Ligase_Complex_complex_Cytosol
CUL3:RBX1_complex POSITIVE Ubiquitin_Ligase_Complex_complex_Cytosol
NRF2_empty POSITIVE Ubiquitin_Ligase_Complex_complex_Cytosol
NRF2_empty POSITIVE NRF2_phosphorylated_Cytosol
KEAP1 POSITIVE Ubiquitin_Ligase_Complex_complex_Cytosol
Dimethly_fumarate_drug NEGATIVE Ubiquitin_Ligase_Complex_complex_Cytosol
Ubiquitin_Ligase_Complex_complex_Cytosol POSITIVE Ubiquitin_Ligase_Complex_complex_Cytosol
Ubiquitin_Ligase_Complex_complex_Cytosol POSITIVE NRF2_ubiquitinated
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SLC40A1:CP:Cu2+_complex POSITIVE Fe2+_ion_default_compartment
SLC40A1:CP:Cu2+_complex POSITIVE Fe3+_ion_default_compartment
SLC40A1:CP:Cu2+_complex POSITIVE H2O_simple_molecule_default_compartment
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SLC40A1_rna POSITIVE SLC40A1:CP:Cu2+_complex
TFRC:holoTF_complex_Cytosol POSITIVE TFRC:holoTF_complex_Endosome_Lumen
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TFRC:TF_complex_Cytosol POSITIVE TFRC:holoTF_complex_Cytosol
TFRC:TF_complex_Cytosol POSITIVE Transferrin
Fe3+_ion_default_compartment POSITIVE TFRC:holoTF_complex_Cytosol
Fe3+_ion_default_compartment POSITIVE Fe2+_ion_default_compartment
Transferrin POSITIVE TFRC:holoTF_complex_Cytosol
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TFRC:holoTF_complex_Endosome_Lumen POSITIVE TFRC:TF_complex_Endosome_Lumen
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TFRC:holoTF_complex_Endosome_Lumen POSITIVE Fe3+_ion_Endosome_Lumen
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TFRC:TF_complex_Endosome_Lumen POSITIVE TFRC:TF_complex_Cytosol
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TXNIP:NLRP3_complex POSITIVE NLRP3_Cytosol_active
NLRP3_Cytosol POSITIVE TXNIP:NLRP3_complex
NLRP3_Cytosol POSITIVE NLRP3_Cytosol_active
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TXNIP POSITIVE TXNIP:NLRP3_complex
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TXNIP POSITIVE Thioredoxin:TXNIP_complex
NLRP3:SUGT1:HSP90_complex POSITIVE NLRP3:SUGT1:HSP90_complex
NLRP3:SUGT1:HSP90_complex POSITIVE NLRP3_Cytosol
NLRP3_rna POSITIVE NLRP3:SUGT1:HSP90_complex
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BLVRA:Zn2+_complex POSITIVE NADP+_simple_molecule
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BLVRA:Zn2+_complex POSITIVE Bilirubin_simple_molecule
BLVRA_rna POSITIVE BLVRA:Zn2+_complex
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Thioredoxin:TXNIP_complex POSITIVE TXNIP
Thioredoxin:TXNIP_complex POSITIVE TXN_Cytosol
TXN_Cytosol POSITIVE Thioredoxin:TXNIP_complex
TXN_Cytosol POSITIVE TXN_Cytosol
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Pyrin_trimer_complex POSITIVE PSTPIP1_trimer:Pyrin_trimer_complex
Pyrin_trimer_complex POSITIVE Pyrin_trimer:ASC_complex
PSTPIP1 POSITIVE PSTPIP1_trimer:Pyrin_trimer_complex
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ASC POSITIVE Pyrin_trimer:ASC_complex
ASC POSITIVE NLRP3_oligomer:ASC:Caspase1_complex
NLRP3_oligomer:ASC:Caspase1_complex POSITIVE NLRP3_oligomer:ASC:Caspase1_complex
NLRP3_oligomer:ASC:Caspase1_complex POSITIVE CASP1(120-197):CASP1(317-404)_complex
NLRP3_oligomer:ASC:Caspase1_complex POSITIVE CASP1_Cytosol
NLRP3_oligomer:ASC:Caspase1_complex POSITIVE CASP1_Cytosol
NLRP3_Cytosol_active POSITIVE NLRP3_oligomer:ASC:Caspase1_complex
CTSG POSITIVE NLRP3_oligomer:ASC:Caspase1_complex
CTSG POSITIVE CASP1(120-197):CASP1(317-404)_complex
CTSG POSITIVE CASP1_Cytosol
CTSG POSITIVE CASP1_Cytosol
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Ferritin_complex POSITIVE Fe(3+)O(OH)_simple_molecule
FTH1_rna POSITIVE Ferritin_complex
FTL_rna POSITIVE Ferritin_complex
Bilirubin_simple_molecule POSITIVE ALB/BIL_complex
ABCC1 POSITIVE ALB/BIL_complex
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Caspase-1_Tetramer_complex POSITIVE proIL-1B_Cytosol
Caspase-1_Tetramer_complex POSITIVE proIL-18_Cytosol
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Caspase-1_Tetramer_complex POSITIVE IL-1B_Cytosol
Caspase-1_Tetramer_complex POSITIVE IL-18_Cytosol
CASP1(120-197):CASP1(317-404)_complex POSITIVE Caspase-1_Tetramer_complex
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Heme_simple_molecule_Cytosol POSITIVE Biliverdin_simple_molecule
Heme_simple_molecule_Cytosol POSITIVE H2O_simple_molecule_Cytosol
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Heme_simple_molecule_Cytosol POSITIVE NADP+_simple_molecule
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Heme_simple_molecule_Cytosol POSITIVE Fe2+_ion_Cytosol
Heme_simple_molecule_Cytosol POSITIVE CO_simple_molecule
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Heme_simple_molecule_Cytosol POSITIVE Heme_simple_molecule_default_compartment
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Heme_simple_molecule_Cytosol POSITIVE ADP_simple_molecule
Heme_simple_molecule_Cytosol POSITIVE Pi_simple_molecule
Heme_simple_molecule_Mitochondrial_Matrix POSITIVE Heme_simple_molecule_Cytosol
Heme_simple_molecule_Mitochondrial_Matrix NEGATIVE dALA_simple_molecule_Mitochondrial_Matrix
Heme_simple_molecule_Mitochondrial_Matrix NEGATIVE CO2_simple_molecule_Mitochondrial_Matrix
Heme_simple_molecule_Mitochondrial_Matrix NEGATIVE CoA-SH_simple_molecule
FLVCR1-2 POSITIVE Heme_simple_molecule_Cytosol
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Biliverdin_simple_molecule POSITIVE NADP+_simple_molecule
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Biliverdin_simple_molecule POSITIVE Bilirubin_simple_molecule
O2_simple_molecule_Cytosol POSITIVE Biliverdin_simple_molecule
O2_simple_molecule_Cytosol POSITIVE H2O_simple_molecule_Cytosol
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O2_simple_molecule_Cytosol POSITIVE NADP+_simple_molecule
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O2_simple_molecule_Cytosol POSITIVE Fe2+_ion_Cytosol
O2_simple_molecule_Cytosol POSITIVE CO_simple_molecule
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O2_simple_molecule_Cytosol POSITIVE Fe(3+)O(OH)_simple_molecule
NADPH_simple_molecule POSITIVE Biliverdin_simple_molecule
NADPH_simple_molecule POSITIVE H2O_simple_molecule_Cytosol
NADPH_simple_molecule POSITIVE NADP+_simple_molecule
NADPH_simple_molecule POSITIVE Fe2+_ion_Cytosol
NADPH_simple_molecule POSITIVE CO_simple_molecule
NADPH_simple_molecule POSITIVE Bilirubin_simple_molecule
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HMOX1_Cytosol_active POSITIVE Biliverdin_simple_molecule
HMOX1_Cytosol_active POSITIVE H2O_simple_molecule_Cytosol
HMOX1_Cytosol_active POSITIVE NADP+_simple_molecule
HMOX1_Cytosol_active POSITIVE Fe2+_ion_Cytosol
HMOX1_Cytosol_active POSITIVE CO_simple_molecule
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PRIN9_simple_molecule_Mitochondrial_Matrix POSITIVE Heme_simple_molecule_Mitochondrial_Matrix
PRIN9_simple_molecule_Mitochondrial_Matrix POSITIVE H+_ion_Mitochondrial_Matrix
Fe2+_ion_Mitochondrial_Matrix POSITIVE Heme_simple_molecule_Mitochondrial_Matrix
Fe2+_ion_Mitochondrial_Matrix POSITIVE H+_ion_Mitochondrial_Matrix
FECH POSITIVE Heme_simple_molecule_Mitochondrial_Matrix
FECH POSITIVE H+_ion_Mitochondrial_Matrix
Pb2+_ion NEGATIVE Heme_simple_molecule_Mitochondrial_Matrix
Pb2+_ion NEGATIVE H+_ion_Mitochondrial_Matrix
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H2O_simple_molecule_Cytosol POSITIVE HMBL_simple_molecule
H2O_simple_molecule_Cytosol POSITIVE NH4+_ion
H2O_simple_molecule_Cytosol POSITIVE Heme_simple_molecule_default_compartment
H2O_simple_molecule_Cytosol POSITIVE ADP_simple_molecule
H2O_simple_molecule_Cytosol POSITIVE Pi_simple_molecule
dALA_simple_molecule_Cytosol POSITIVE H2O_simple_molecule_Cytosol
dALA_simple_molecule_Cytosol POSITIVE PBG_simple_molecule
dALA_simple_molecule_Cytosol POSITIVE H+_ion_Cytosol
ALAD:Zn2+_complex POSITIVE H2O_simple_molecule_Cytosol
ALAD:Zn2+_complex POSITIVE PBG_simple_molecule
ALAD:Zn2+_complex POSITIVE H+_ion_Cytosol
BLVRB POSITIVE NADP+_simple_molecule
BLVRB POSITIVE Bilirubin_simple_molecule
Fe2+_ion_Cytosol POSITIVE Fe2+_ion_Cytosol
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Fe2+_ion_Cytosol POSITIVE Fe2+_ion_default_compartment
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Fe2+_ion_Cytosol POSITIVE Fe(3+)O(OH)_simple_molecule
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Fe2+_ion_Cytosol POSITIVE Reactive_Oxygen_Species_simple_molecule
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Fe2+_ion_default_compartment POSITIVE Fe2+_ion_Cytosol
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Fe2+_ion_default_compartment POSITIVE Fe3+_ion_default_compartment
Fe2+_ion_default_compartment POSITIVE H2O_simple_molecule_default_compartment
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SLC11A2 POSITIVE Fe2+_ion_Cytosol
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Fe2+_ion_Endosome_Lumen POSITIVE Fe2+_ion_Cytosol
MCOLN1 POSITIVE Fe2+_ion_Cytosol
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HMOX1_Cytosol POSITIVE HMOX1_Cytosol_active
HMOX1_rna POSITIVE HMOX1_Cytosol
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CO_simple_molecule NEGATIVE Reactive_Oxygen_Species_simple_molecule
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BLVRB_rna POSITIVE BLVRB
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ORF9c POSITIVE ABCC1
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NRF2_phosphorylated_Cytosol POSITIVE NRF2_phosphorylated_Nucleus
miRNA-155_rna NEGATIVE BACH1
FECH_rna POSITIVE FECH
PRIN9_simple_molecule_Mitochondrion POSITIVE PRIN9_simple_molecule_Mitochondrial_Matrix
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H+_ion_Mitochondrial_Matrix POSITIVE dALA_simple_molecule_Mitochondrial_Matrix
H+_ion_Mitochondrial_Matrix POSITIVE CO2_simple_molecule_Mitochondrial_Matrix
H+_ion_Mitochondrial_Matrix POSITIVE CoA-SH_simple_molecule
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dALA_simple_molecule_Mitochondrial_Matrix POSITIVE dALA_simple_molecule_Cytosol
SUCC-CoA_simple_molecule POSITIVE dALA_simple_molecule_Mitochondrial_Matrix
SUCC-CoA_simple_molecule POSITIVE CO2_simple_molecule_Mitochondrial_Matrix
SUCC-CoA_simple_molecule POSITIVE CoA-SH_simple_molecule
Gly_simple_molecule POSITIVE dALA_simple_molecule_Mitochondrial_Matrix
Gly_simple_molecule POSITIVE CO2_simple_molecule_Mitochondrial_Matrix
Gly_simple_molecule POSITIVE CoA-SH_simple_molecule
ALAS1:ALAS2_complex POSITIVE dALA_simple_molecule_Mitochondrial_Matrix
ALAS1:ALAS2_complex POSITIVE CO2_simple_molecule_Mitochondrial_Matrix
ALAS1:ALAS2_complex POSITIVE CoA-SH_simple_molecule
Panhematin_drug NEGATIVE dALA_simple_molecule_Mitochondrial_Matrix
Panhematin_drug NEGATIVE CO2_simple_molecule_Mitochondrial_Matrix
Panhematin_drug NEGATIVE CoA-SH_simple_molecule
PBG_simple_molecule POSITIVE HMBL_simple_molecule
PBG_simple_molecule POSITIVE NH4+_ion
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H+_ion_Cytosol POSITIVE Fe(3+)O(OH)_simple_molecule
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HMBL_simple_molecule POSITIVE URO3_simple_molecule
HMBS:DIPY_complex POSITIVE HMBL_simple_molecule
HMBS:DIPY_complex POSITIVE NH4+_ion
URO3_simple_molecule POSITIVE COPRO3_simple_molecule_Cytosol
UROS POSITIVE URO3_simple_molecule
COPRO3_simple_molecule_Cytosol POSITIVE COPRO3_simple_molecule_Mitochondrion
UROD POSITIVE COPRO3_simple_molecule_Cytosol
COPRO3_simple_molecule_Mitochondrion POSITIVE PPGEN9_simple_molecule
COPRO3_simple_molecule_Mitochondrion POSITIVE CO2_simple_molecule_Mitochondrion
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COPRO3_simple_molecule_Mitochondrion POSITIVE H2O2_simple_molecule
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PPGEN9_simple_molecule POSITIVE PRIN9_simple_molecule_Mitochondrion
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PPGEN9_simple_molecule POSITIVE H2O2_simple_molecule
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O2_simple_molecule_Mitochondrion POSITIVE PPGEN9_simple_molecule
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O2_simple_molecule_Mitochondrion POSITIVE PRIN9_simple_molecule_Mitochondrion
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O2_simple_molecule_Mitochondrion POSITIVE CO2_simple_molecule_Mitochondrion
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O2_simple_molecule_Mitochondrion POSITIVE H2O2_simple_molecule
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CPOX POSITIVE PPGEN9_simple_molecule
CPOX POSITIVE CO2_simple_molecule_Mitochondrion
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CPOX POSITIVE H2O2_simple_molecule
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PPO:FAD_complex POSITIVE PRIN9_simple_molecule_Mitochondrion
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PPO:FAD_complex POSITIVE H2O2_simple_molecule
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Lipid_Peroxide_simple_molecule POSITIVE Ferroptosis_phenotype
Lipid_Peroxide_simple_molecule POSITIVE Lipid_alcohol_simple_molecule
Poly-unsaturated_fatty_acid_simple_molecule POSITIVE Lipid_Peroxide_simple_molecule
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Reactive_Oxygen_Species_simple_molecule POSITIVE Lipid_Peroxide_simple_molecule
Reactive_Oxygen_Species_simple_molecule POSITIVE TXNIP
Reactive_Oxygen_Species_simple_molecule POSITIVE TXN_Cytosol
Reactive_Oxygen_Species_simple_molecule POSITIVE NLRP3_Cytosol_active
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SLC40A1:HEPH:Cu2+_complex POSITIVE Fe2+_ion_default_compartment
SLC40A1:HEPH:Cu2+_complex POSITIVE Fe3+_ion_default_compartment
SLC40A1:HEPH:Cu2+_complex POSITIVE H2O_simple_molecule_default_compartment
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e-_ion_default_compartment POSITIVE Fe2+_ion_default_compartment
CYBRD1:Heme_complex POSITIVE Fe2+_ion_default_compartment
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O2_simple_molecule_default_compartment POSITIVE Fe3+_ion_default_compartment
O2_simple_molecule_default_compartment POSITIVE H2O_simple_molecule_default_compartment
H+_ion_default_compartment POSITIVE Fe3+_ion_default_compartment
H+_ion_default_compartment POSITIVE H2O_simple_molecule_default_compartment
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GPX4 POSITIVE Lipid_alcohol_simple_molecule
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ORF3a POSITIVE HMOX1_Cytosol_active
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PKC POSITIVE NRF2_phosphorylated_Cytosol
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CK2 POSITIVE NRF2_phosphorylated_Cytosol
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FLVCR1-1 POSITIVE Heme_simple_molecule_default_compartment
ATP_simple_molecule POSITIVE Heme_simple_molecule_default_compartment
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ATP_simple_molecule POSITIVE ADP_simple_molecule
ATP_simple_molecule POSITIVE Pi_simple_molecule
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ABCG2 POSITIVE Heme_simple_molecule_default_compartment
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ABCG2 POSITIVE ADP_simple_molecule
ABCG2 POSITIVE Pi_simple_molecule
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Fe3+_ion_Endosome_Lumen POSITIVE Fe2+_ion_Endosome_Lumen
e-_ion_Endosome_Lumen POSITIVE Fe2+_ion_Endosome_Lumen
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STEAP3 POSITIVE Fe2+_ion_Endosome_Lumen
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Nf-KB_Complex_complex POSITIVE NLRP3_rna
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proIL-1B_Cytosol POSITIVE proIL-1B_Cytosol
proIL-1B_Cytosol POSITIVE IL-1B_Cytosol
proIL-18_Cytosol POSITIVE proIL-18_Cytosol
proIL-18_Cytosol POSITIVE IL-18_Cytosol
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IL-1B_Cytosol POSITIVE IL-1B_default_compartment
IL-18_Cytosol POSITIVE IL-18_default_compartment
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SARS_E POSITIVE NLRP3_Cytosol_active
PAMPs_phenotype POSITIVE NLRP3_Cytosol_active
DAMPs_phenotype POSITIVE NLRP3_Cytosol_active
SARS_Orf3a POSITIVE NLRP3_Cytosol_active
NLRP3_Elicitor_Small_Molecules_simple_molecule POSITIVE NLRP3_Cytosol_active
NLRP3_Elicitor_Proteins POSITIVE NLRP3_Cytosol_active