HMOX1_Pathway_stable.sif 12.8 KB
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# Generated by CaSQ v0.9.12
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Nrf2/Maf_complex POSITIVE HMOX1_rna
NRF2_phosphorylated_nucleus POSITIVE Nrf2/Maf_complex
NRF2_phosphorylated_nucleus POSITIVE SLC40A1_rna
NRF2_phosphorylated_nucleus POSITIVE FTH1_rna
NRF2_phosphorylated_nucleus POSITIVE FTL_rna
NRF2_phosphorylated_nucleus POSITIVE FECH_rna
NRF2_phosphorylated_nucleus POSITIVE BLVRA_rna
NRF2_phosphorylated_nucleus POSITIVE BLVRB_rna
MAF POSITIVE Nrf2/Maf_complex
MAF POSITIVE BACH1/Maf_complex
BACH1/Maf_complex NEGATIVE HMOX1_rna
BACH1 POSITIVE BACH1/Maf_complex
Ubiquitin_Ligase_Complex_complex_cell POSITIVE Ubiquitin_Ligase_Complex_complex_cell
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E2_ubiquitinated POSITIVE Ubiquitin_Ligase_Complex_complex_cell
Ubiquitin_Ligase_Complex_complex_cell POSITIVE Ubiquitin_Ligase_Complex_complex_cell
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Ubiquitin_Ligase_Complex_complex_cell POSITIVE Ubiquitin_Ligase_Complex_complex_cell
Ubiquitin_Ligase_Complex_complex_cell POSITIVE NRF2_ubiquitinated
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NRF2:KEAP1_complex POSITIVE Ubiquitin_Ligase_Complex_complex_cell
NRF2_empty POSITIVE NRF2:KEAP1_complex
NRF2_empty POSITIVE NRF2_phosphorylated_cell
KEAP1 POSITIVE NRF2:KEAP1_complex
Dimethly_fumarate_drug NEGATIVE NRF2:KEAP1_complex
Neddylated_CUL3:RBX1_complex POSITIVE Ubiquitin_Ligase_Complex_complex_cell
CUL3:RBX1_complex POSITIVE Neddylated_CUL3:RBX1_complex
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SLC40A1:CP:Cu2+_complex POSITIVE Fe2+_ion_default_compartment
SLC40A1:CP:Cu2+_complex POSITIVE Fe3+_ion_default_compartment
SLC40A1:CP:Cu2+_complex POSITIVE H2O_simple_molecule_default_compartment
SLC40A1_rna POSITIVE SLC40A1:CP:Cu2+_complex
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CAND1 NEGATIVE Ubiquitin_Ligase_Complex_complex_cell
holoTF_complex POSITIVE TFRC:holoTF_complex_cell
Fe3+_ion_default_compartment POSITIVE holoTF_complex
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Fe3+_ion_default_compartment POSITIVE Fe2+_ion_default_compartment
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Transferrin POSITIVE holoTF_complex
TFRC:holoTF_complex_cell POSITIVE TFRC:holoTF_complex_endosome
TFRC POSITIVE TFRC:holoTF_complex_cell
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TFRC:holoTF_complex_endosome POSITIVE TFRC:TF_complex_endosome
TFRC:holoTF_complex_endosome POSITIVE Fe3+_ion_endosome
TFRC:TF_complex_endosome POSITIVE TFRC:TF_complex_cell
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TFRC:TF_complex_cell POSITIVE Transferrin
TFRC:TF_complex_cell POSITIVE TFRC
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TXNIP:NLRP3_complex POSITIVE NLRP3_cell_active
NLRP3_cell POSITIVE TXNIP:NLRP3_complex
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NLRP3_cell POSITIVE NLRP3:SUGT1:HSP90_complex
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NLRP3_cell POSITIVE NLRP3_cell_active
TXNIP POSITIVE TXNIP:NLRP3_complex
TXNIP POSITIVE Thioredoxin:TXNIP_complex
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NLRP3:SUGT1:HSP90_complex POSITIVE SUGT1:HSP90AB1_complex
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NLRP3:SUGT1:HSP90_complex POSITIVE NLRP3_cell
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SUGT1:HSP90AB1_complex POSITIVE NLRP3:SUGT1:HSP90_complex
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BLVRA:Zn2+_complex POSITIVE NADP+_simple_molecule
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BLVRA:Zn2+_complex POSITIVE Bilirubin_simple_molecule_cell
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BLVRA_rna POSITIVE BLVRA:Zn2+_complex
Thioredoxin:TXNIP_complex POSITIVE TXNIP
Thioredoxin:TXNIP_complex POSITIVE TXN_cell
TXN_cell POSITIVE Thioredoxin:TXNIP_complex
TXN_cell POSITIVE TXN_cell
Pyrin_trimer_complex POSITIVE PSTPIP1_trimer:Pyrin_trimer_complex
Pyrin_trimer_complex POSITIVE Pyrin_trimer:ASC_complex
PSTPIP1 POSITIVE PSTPIP1_trimer:Pyrin_trimer_complex
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NLRP3_oligomer:ASC_complex POSITIVE NLRP3_oligomer:ASC:Caspase1_complex
NLRP3_cell_active POSITIVE NLRP3_oligomer:ASC_complex
ASC POSITIVE NLRP3_oligomer:ASC_complex
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ASC POSITIVE Pyrin_trimer:ASC_complex
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NLRP3_oligomer:ASC:Caspase1_complex POSITIVE NLRP3_oligomer:ASC_complex
NLRP3_oligomer:ASC:Caspase1_complex POSITIVE CASP1_cell
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NLRP3_oligomer:ASC:Caspase1_complex POSITIVE CASP1_cell
NLRP3_oligomer:ASC:Caspase1_complex POSITIVE CASP1_cell
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NLRP3_oligomer:ASC:Caspase1_complex POSITIVE CASP1_cell
CTSG POSITIVE NLRP3_oligomer:ASC_complex
CTSG POSITIVE CASP1_cell
CTSG POSITIVE CASP1_cell
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CTSG POSITIVE CASP1_cell
CTSG POSITIVE CASP1_cell
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CASP1_cell POSITIVE NLRP3_oligomer:ASC:Caspase1_complex
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Ferritin_complex POSITIVE Fe(3+)O(OH)_simple_molecule
FTH1_rna POSITIVE Ferritin_complex
FTL_rna POSITIVE Ferritin_complex
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Bilirubin_simple_molecule_default_compartment POSITIVE ALB/BIL_complex
ALB POSITIVE ALB/BIL_complex
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Caspase-1_Tetramer_complex POSITIVE proIL-1B_cell
Caspase-1_Tetramer_complex POSITIVE proIL-18_cell
Caspase-1_Tetramer_complex POSITIVE IL-1B_cell
Caspase-1_Tetramer_complex POSITIVE IL-18_cell
CASP1(120-197):CASP1(317-404)_complex POSITIVE Caspase-1_Tetramer_complex
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CASP1_cell POSITIVE CASP1(120-197):CASP1(317-404)_complex
CASP1_cell POSITIVE CASP1(120-197):CASP1(317-404)_complex
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Heme_simple_molecule_cell POSITIVE Biliverdin_simple_molecule
Heme_simple_molecule_cell POSITIVE H2O_simple_molecule_cell
Heme_simple_molecule_cell POSITIVE NADP+_simple_molecule
Heme_simple_molecule_cell POSITIVE Fe2+_ion_cell
Heme_simple_molecule_cell POSITIVE CO_simple_molecule
Heme_simple_molecule_cell POSITIVE Heme_simple_molecule_default_compartment
Heme_simple_molecule_cell POSITIVE ADP_simple_molecule
Heme_simple_molecule_cell POSITIVE Pi_simple_molecule
Heme_simple_molecule_mitochondrial_matrix POSITIVE Heme_simple_molecule_cell
Heme_simple_molecule_mitochondrial_matrix NEGATIVE dALA_simple_molecule_mitochondrial_matrix
Heme_simple_molecule_mitochondrial_matrix NEGATIVE CO2_simple_molecule_mitochondrial_matrix
Heme_simple_molecule_mitochondrial_matrix NEGATIVE CoA-SH_simple_molecule
FLVCR1-2 POSITIVE Heme_simple_molecule_cell
Biliverdin_simple_molecule POSITIVE NADP+_simple_molecule
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Biliverdin_simple_molecule POSITIVE Bilirubin_simple_molecule_cell
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O2_simple_molecule_cell POSITIVE Biliverdin_simple_molecule
O2_simple_molecule_cell POSITIVE H2O_simple_molecule_cell
O2_simple_molecule_cell POSITIVE NADP+_simple_molecule
O2_simple_molecule_cell POSITIVE Fe2+_ion_cell
O2_simple_molecule_cell POSITIVE CO_simple_molecule
O2_simple_molecule_cell POSITIVE Fe(3+)O(OH)_simple_molecule
NADPH_simple_molecule POSITIVE Biliverdin_simple_molecule
NADPH_simple_molecule POSITIVE H2O_simple_molecule_cell
NADPH_simple_molecule POSITIVE NADP+_simple_molecule
NADPH_simple_molecule POSITIVE Fe2+_ion_cell
NADPH_simple_molecule POSITIVE CO_simple_molecule
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NADPH_simple_molecule POSITIVE Bilirubin_simple_molecule_cell
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HMOX1_cell_active POSITIVE Biliverdin_simple_molecule
HMOX1_cell_active POSITIVE H2O_simple_molecule_cell
HMOX1_cell_active POSITIVE NADP+_simple_molecule
HMOX1_cell_active POSITIVE Fe2+_ion_cell
HMOX1_cell_active POSITIVE CO_simple_molecule
PRIN9_simple_molecule_mitochondrial_matrix POSITIVE Heme_simple_molecule_mitochondrial_matrix
PRIN9_simple_molecule_mitochondrial_matrix POSITIVE H+_ion_mitochondrial_matrix
Fe2+_ion_mitochondrial_matrix POSITIVE Heme_simple_molecule_mitochondrial_matrix
Fe2+_ion_mitochondrial_matrix POSITIVE H+_ion_mitochondrial_matrix
FECH POSITIVE Heme_simple_molecule_mitochondrial_matrix
FECH POSITIVE H+_ion_mitochondrial_matrix
Pb2+_ion NEGATIVE Heme_simple_molecule_mitochondrial_matrix
Pb2+_ion NEGATIVE H+_ion_mitochondrial_matrix
H2O_simple_molecule_cell POSITIVE HMBL_simple_molecule
H2O_simple_molecule_cell POSITIVE NH4+_ion
H2O_simple_molecule_cell POSITIVE Heme_simple_molecule_default_compartment
H2O_simple_molecule_cell POSITIVE ADP_simple_molecule
H2O_simple_molecule_cell POSITIVE Pi_simple_molecule
dALA_simple_molecule_cell POSITIVE H2O_simple_molecule_cell
dALA_simple_molecule_cell POSITIVE PBG_simple_molecule
dALA_simple_molecule_cell POSITIVE H+_ion_cell
ALAD:Zn2+_complex POSITIVE H2O_simple_molecule_cell
ALAD:Zn2+_complex POSITIVE PBG_simple_molecule
ALAD:Zn2+_complex POSITIVE H+_ion_cell
BLVRB POSITIVE NADP+_simple_molecule
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BLVRB POSITIVE Bilirubin_simple_molecule_cell
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Fe2+_ion_cell POSITIVE Fe2+_ion_cell
Fe2+_ion_cell POSITIVE Fe2+_ion_default_compartment
Fe2+_ion_cell POSITIVE Fe(3+)O(OH)_simple_molecule
Fe2+_ion_cell POSITIVE Reactive_Oxygen_Species_simple_molecule
Fe2+_ion_default_compartment POSITIVE Fe2+_ion_cell
Fe2+_ion_default_compartment POSITIVE Fe3+_ion_default_compartment
Fe2+_ion_default_compartment POSITIVE H2O_simple_molecule_default_compartment
SLC11A2 POSITIVE Fe2+_ion_cell
Fe2+_ion_endosome POSITIVE Fe2+_ion_cell
MCOLN1 POSITIVE Fe2+_ion_cell
HMOX1_cell POSITIVE HMOX1_cell_active
HMOX1_rna POSITIVE HMOX1_cell
CO_simple_molecule NEGATIVE Reactive_Oxygen_Species_simple_molecule
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Bilirubin_simple_molecule_cell POSITIVE Bilirubin_simple_molecule_default_compartment
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BLVRB_rna POSITIVE BLVRB
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ABCC1 POSITIVE Bilirubin_simple_molecule_default_compartment
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ORF9c POSITIVE ABCC1
NRF2_phosphorylated_cell POSITIVE NRF2_phosphorylated_nucleus
miRNA-155_rna NEGATIVE BACH1
FECH_rna POSITIVE FECH
PRIN9_simple_molecule_mitochondrion POSITIVE PRIN9_simple_molecule_mitochondrial_matrix
H+_ion_mitochondrial_matrix POSITIVE dALA_simple_molecule_mitochondrial_matrix
H+_ion_mitochondrial_matrix POSITIVE CO2_simple_molecule_mitochondrial_matrix
H+_ion_mitochondrial_matrix POSITIVE CoA-SH_simple_molecule
dALA_simple_molecule_mitochondrial_matrix POSITIVE dALA_simple_molecule_cell
SUCC-CoA_simple_molecule POSITIVE dALA_simple_molecule_mitochondrial_matrix
SUCC-CoA_simple_molecule POSITIVE CO2_simple_molecule_mitochondrial_matrix
SUCC-CoA_simple_molecule POSITIVE CoA-SH_simple_molecule
Gly_simple_molecule POSITIVE dALA_simple_molecule_mitochondrial_matrix
Gly_simple_molecule POSITIVE CO2_simple_molecule_mitochondrial_matrix
Gly_simple_molecule POSITIVE CoA-SH_simple_molecule
ALAS1:ALAS2_complex POSITIVE dALA_simple_molecule_mitochondrial_matrix
ALAS1:ALAS2_complex POSITIVE CO2_simple_molecule_mitochondrial_matrix
ALAS1:ALAS2_complex POSITIVE CoA-SH_simple_molecule
Panhematin_drug NEGATIVE dALA_simple_molecule_mitochondrial_matrix
Panhematin_drug NEGATIVE CO2_simple_molecule_mitochondrial_matrix
Panhematin_drug NEGATIVE CoA-SH_simple_molecule
PBG_simple_molecule POSITIVE HMBL_simple_molecule
PBG_simple_molecule POSITIVE NH4+_ion
H+_ion_cell POSITIVE Fe(3+)O(OH)_simple_molecule
HMBL_simple_molecule POSITIVE URO3_simple_molecule
HMBS:DIPY_complex POSITIVE HMBL_simple_molecule
HMBS:DIPY_complex POSITIVE NH4+_ion
URO3_simple_molecule POSITIVE COPRO3_simple_molecule_cell
UROS POSITIVE URO3_simple_molecule
COPRO3_simple_molecule_cell POSITIVE COPRO3_simple_molecule_mitochondrion
UROD POSITIVE COPRO3_simple_molecule_cell
COPRO3_simple_molecule_mitochondrion POSITIVE PPGEN9_simple_molecule
COPRO3_simple_molecule_mitochondrion POSITIVE CO2_simple_molecule_mitochondrion
COPRO3_simple_molecule_mitochondrion POSITIVE H2O2_simple_molecule
PPGEN9_simple_molecule POSITIVE PRIN9_simple_molecule_mitochondrion
PPGEN9_simple_molecule POSITIVE H2O2_simple_molecule
O2_simple_molecule_mitochondrion POSITIVE PPGEN9_simple_molecule
O2_simple_molecule_mitochondrion POSITIVE PRIN9_simple_molecule_mitochondrion
O2_simple_molecule_mitochondrion POSITIVE CO2_simple_molecule_mitochondrion
O2_simple_molecule_mitochondrion POSITIVE H2O2_simple_molecule
CPOX POSITIVE PPGEN9_simple_molecule
CPOX POSITIVE CO2_simple_molecule_mitochondrion
CPOX POSITIVE H2O2_simple_molecule
PPO:FAD_complex POSITIVE PRIN9_simple_molecule_mitochondrion
PPO:FAD_complex POSITIVE H2O2_simple_molecule
Lipid_Peroxide_simple_molecule POSITIVE Ferroptosis_phenotype
Lipid_Peroxide_simple_molecule POSITIVE Lipid_alcohol_simple_molecule
Poly-unsaturated_fatty_acid_simple_molecule POSITIVE Lipid_Peroxide_simple_molecule
Reactive_Oxygen_Species_simple_molecule POSITIVE Lipid_Peroxide_simple_molecule
Reactive_Oxygen_Species_simple_molecule POSITIVE TXNIP
Reactive_Oxygen_Species_simple_molecule POSITIVE TXN_cell
Reactive_Oxygen_Species_simple_molecule POSITIVE NLRP3_cell_active
SLC40A1:HEPH:Cu2+_complex POSITIVE Fe2+_ion_default_compartment
SLC40A1:HEPH:Cu2+_complex POSITIVE Fe3+_ion_default_compartment
SLC40A1:HEPH:Cu2+_complex POSITIVE H2O_simple_molecule_default_compartment
e-_ion_default_compartment POSITIVE Fe2+_ion_default_compartment
CYBRD1:Heme_complex POSITIVE Fe2+_ion_default_compartment
O2_simple_molecule_default_compartment POSITIVE Fe3+_ion_default_compartment
O2_simple_molecule_default_compartment POSITIVE H2O_simple_molecule_default_compartment
H+_ion_default_compartment POSITIVE Fe3+_ion_default_compartment
H+_ion_default_compartment POSITIVE H2O_simple_molecule_default_compartment
GPX4 POSITIVE Lipid_alcohol_simple_molecule
ORF3a POSITIVE HMOX1_cell_active
PKC POSITIVE NRF2_phosphorylated_cell
CK2 POSITIVE NRF2_phosphorylated_cell
FLVCR1-1 POSITIVE Heme_simple_molecule_default_compartment
ATP_simple_molecule POSITIVE Heme_simple_molecule_default_compartment
ATP_simple_molecule POSITIVE ADP_simple_molecule
ATP_simple_molecule POSITIVE Pi_simple_molecule
ABCG2 POSITIVE Heme_simple_molecule_default_compartment
ABCG2 POSITIVE ADP_simple_molecule
ABCG2 POSITIVE Pi_simple_molecule
Fe3+_ion_endosome POSITIVE Fe2+_ion_endosome
e-_ion_endosome POSITIVE Fe2+_ion_endosome
STEAP3 POSITIVE Fe2+_ion_endosome
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NLRP3_rna POSITIVE NLRP3_cell
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Nf-KB_Complex_complex POSITIVE NLRP3_rna
proIL-1B_cell POSITIVE proIL-1B_cell
proIL-1B_cell POSITIVE IL-1B_cell
proIL-18_cell POSITIVE proIL-18_cell
proIL-18_cell POSITIVE IL-18_cell
IL-1B_cell POSITIVE IL-1B_default_compartment
IL-18_cell POSITIVE IL-18_default_compartment
SARS_E POSITIVE NLRP3_cell_active
PAMPs_phenotype POSITIVE NLRP3_cell_active
DAMPs_phenotype POSITIVE NLRP3_cell_active
SARS_Orf3a POSITIVE NLRP3_cell_active
NLRP3_Elicitor_Small_Molecules_simple_molecule POSITIVE NLRP3_cell_active
NLRP3_Elicitor_Proteins POSITIVE NLRP3_cell_active