ER_Stress_stable.xml 586 KB
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<?xml version="1.0" encoding="UTF-8"?>
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<sbml xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" level="2" version="4">
<model metaid="Endoplasmic_Stress" id="rcd_ER_STRESS">
<notes>
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<html xmlns="http://www.w3.org/1999/xhtml">
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<body>ER_STRESS
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AUTHORS: LUIS CRISTOBAL MONRAZ GOMEZ, INSTITUTE CURIE; INNA KUPERSTEIN, INSTITUTE CURIE
DESCRIPTION: This diagram depicts the activity of the Unfolded Protein Response (UPR) that leads to endoplasmic reticulum stress and further apoptosis. 
During the Sars-CoV-2 infection, this mechanism is activated in the infected cells of the host. 
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</body>
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</html>
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</notes>
<annotation>
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<celldesigner:modelDisplay sizeX="2443" sizeY="2406"/>
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<celldesigner:listOfIncludedSpecies>
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<celldesigner:speciesIdentity>
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<celldesigner:proteinReference>pr27</celldesigner:proteinReference>
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<celldesigner:speciesIdentity>
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<celldesigner:state>
<celldesigner:listOfModifications>
<celldesigner:modification residue="rs1" state="ubiquitinated"/>
</celldesigner:listOfModifications>
</celldesigner:state>
997
998
999
</celldesigner:speciesIdentity>
</celldesigner:annotation>
</celldesigner:species>
1000
<celldesigner:species id="s753" name="ITPR">
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