Unverified Commit 1d0d6386 authored by Paul Macklin's avatar Paul Macklin Committed by GitHub
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Update about.html

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......@@ -5,47 +5,40 @@ and an immune response. It is being rapidly prototyped and refined with communit
<p><b>Please note that this is a stochastic model: for some simulation runs, you may see the immune system fail to respond. Users are encouraged to try the simulation multiple times.</b></p>
<p>This multiscale simulator combines several modules:</p>
<p>This multiscale simulator combines several model components:</p>
<ul>
<li><strong>Tissue:</strong> Virus, cell debris, and chemokines diffuse within the extracellular space.
They may also “decay” to reflect removal by interstitial flow into nearby blood vessels or airways. </li>
<br/>
<li><strong>ACE2 receptor dynamics:</strong> Virions bind to ACE2 receptors on the surface, which
are internalized (endocytosed) into cells. After virions are released from internalized receptors, they
can return to the surface. </li>
<br/>
<li><strong>Viral replication:</strong> Internalized virus is uncoated to expose viral RNA, which synthesizes
viral proteins that are assembled into virions. Assembled virions are transported to the cell surface to be exported
to the tissue (exocytosed). </li>
<br/>
<li><strong>Single-cell response:</strong> Infected cells secrete a chemokine that may attract immune cells. In a simple
pharmacodynamics response (to assembled virions), infected cells can undergo apoptosis. Apoptosed cells release some or
all of their internal contents, notably including virions. </li>
<br/>
<li><strong><span style="background-color: red; color: white; padding-left: 0.1in; padding-right: 0.1in">
<strong>Immune response (new in version 3)</strong></span>:</strong> </li>
<br/>
<ul>
<ul>
<li><strong>Resident (and recruited) macrophages</strong> seek apoptotic cells. They phagocytose (ingest) dead cells
upon contact and activate. </li>
upon contact and activate. They also break down ("digest") ingested materials. </li>
<br/>
<li><strong>Activated macrophages</strong> release a pro-inflammatory cytokine to recruit other immune cells, while
seeking both apoptotic and infected cells by chemotaxis. Activated macrophages can “wear out” and apoptose after phagocytosing
too much material.</li>
<br/>
<li><strong>Neutrophils</strong> are recruited by accumulated pro-inflammatory cytokine. They seek apoptotic cells,
phagocytose them, and activate. Activated neutrophils seek both apoptotic and infected cells. Neutrophils also capture
extracellular virions. </li>
<br/>
<li><strong>CD8<sup>+</sup> T cells</strong> are recruited by accumulated pro-inflammatory cytokine. They seek and adhere to infected cells. After sufficient contact time with one or more CD8<sup>+</sup> T cells, infected cells undergo apoptosis. </li>
<li><strong>CD8<sup>+</sup> T cells</strong> are recruited by accumulated pro-inflammatory cytokine.
They seek and adhere to infected cells. After sufficient contact time with one or more CD8<sup>+</sup> T cells, infected cells undergo apoptosis. </li>
</ul>
</ul>
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