From 766e3f1fb228c7e1c4faa16fff3a5940559dba72 Mon Sep 17 00:00:00 2001
From: Laurent Heirendt <laurent.heirendt@uni.lu>
Date: Mon, 14 Feb 2022 14:23:28 +0100
Subject: [PATCH 1/3] draft of page

---
 frozen/image.png    | Bin 0 -> 7778 bytes
 frozen/xfh3-a153.md |  27 +++++++++++++++++++++++++++
 2 files changed, 27 insertions(+)
 create mode 100644 frozen/image.png
 create mode 100644 frozen/xfh3-a153.md

diff --git a/frozen/image.png b/frozen/image.png
new file mode 100644
index 0000000000000000000000000000000000000000..94fe1a398987248a64ad4f35c40714f2f9ec083a
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diff --git a/frozen/xfh3-a153.md b/frozen/xfh3-a153.md
new file mode 100644
index 0000000..921ab3c
--- /dev/null
+++ b/frozen/xfh3-a153.md
@@ -0,0 +1,27 @@
+---
+layout: default
+order: -1
+title: "Cell cycle arrest of neural progenitors causes reduced amounts of dopaminergic neurons in GBA associated Parkinson’s disease"
+permalink: /frozen/fvy2-hh91
+---
+
+{% rtitle Cell cycle arrest of neural progenitors causes reduced amounts of dopaminergic neurons in GBA associated Parkinson’s disease %}
+Isabel Rosety, Alise Zagare, Claudia Saraiva, Sarah Nicklas, Paul Antony, Catarina Almeida, Enrico Glaab, Rashi Halder, Javier Jarazo, Silvia Bolognin, Rejko Krüger, Thomas Sauter,  Jens Schwamborn
+{% endrtitle %}
+
+{% rgridblock a-unique-id %}
+{% rblock  Manuscript %}
+A preprint of the manuscript is available <a href="">here</a>.
+{% endrblock %}
+
+
+{% rblock Data %}
+The data is available <a href="">here</a>.
+{% endrblock %}
+
+
+{% rblock source code %}
+The source code is available <a href="">here</a>.
+{% endrblock %}
+
+{% endrgridblock %}
-- 
GitLab


From 401da2e8cae79f97bedbf37314f97f0530d7f656 Mon Sep 17 00:00:00 2001
From: Laurent Heirendt <laurent.heirendt@uni.lu>
Date: Mon, 14 Feb 2022 14:24:40 +0100
Subject: [PATCH 2/3] delete uploaded img and change doi

---
 frozen/image.png    | Bin 7778 -> 0 bytes
 frozen/xfh3-a153.md |   2 +-
 2 files changed, 1 insertion(+), 1 deletion(-)
 delete mode 100644 frozen/image.png

diff --git a/frozen/image.png b/frozen/image.png
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diff --git a/frozen/xfh3-a153.md b/frozen/xfh3-a153.md
index 921ab3c..5204090 100644
--- a/frozen/xfh3-a153.md
+++ b/frozen/xfh3-a153.md
@@ -2,7 +2,7 @@
 layout: default
 order: -1
 title: "Cell cycle arrest of neural progenitors causes reduced amounts of dopaminergic neurons in GBA associated Parkinson’s disease"
-permalink: /frozen/fvy2-hh91
+permalink: /frozen/xfh3-a153
 ---
 
 {% rtitle Cell cycle arrest of neural progenitors causes reduced amounts of dopaminergic neurons in GBA associated Parkinson’s disease %}
-- 
GitLab


From 00ef003d91eae6bc7327e839dab9ad2b84d4ebd6 Mon Sep 17 00:00:00 2001
From: Matthieu Gobin <matthieu.gobin@uni.lu>
Date: Tue, 29 Mar 2022 09:10:15 +0200
Subject: [PATCH 3/3] Update frozen/xfh3-a153.md

---
 frozen/xfh3-a153.md | 17 +++++++----------
 1 file changed, 7 insertions(+), 10 deletions(-)

diff --git a/frozen/xfh3-a153.md b/frozen/xfh3-a153.md
index 5204090..92d2544 100644
--- a/frozen/xfh3-a153.md
+++ b/frozen/xfh3-a153.md
@@ -1,27 +1,24 @@
 ---
 layout: default
 order: -1
-title: "Cell cycle arrest of neural progenitors causes reduced amounts of dopaminergic neurons in GBA associated Parkinson’s disease"
+title: "Cell cycle arrest of neural progenitors causes impaired dopaminergic neuronal differentiation in GBA associated Parkinson’s disease midbrain organoids"
 permalink: /frozen/xfh3-a153
 ---
 
-{% rtitle Cell cycle arrest of neural progenitors causes reduced amounts of dopaminergic neurons in GBA associated Parkinson’s disease %}
-Isabel Rosety, Alise Zagare, Claudia Saraiva, Sarah Nicklas, Paul Antony, Catarina Almeida, Enrico Glaab, Rashi Halder, Javier Jarazo, Silvia Bolognin, Rejko Krüger, Thomas Sauter,  Jens Schwamborn
+{% rtitle Cell cycle arrest of neural progenitors causes impaired dopaminergic neuronal differentiation in GBA associated Parkinson’s disease midbrain organoids %}
+Isabel Rosety, Alise Zagare, Claudia Saraiva, Sarah Nickels, Paul Antony, Catarina Almeida, Enrico Glaab, Rashi Halder, Javier Jarazo, Thomas Rauen, Hans R. Schöler, Silvia Bolognin, Thomas Sauter, Rejko Krüger, Jens Schwamborn
 {% endrtitle %}
 
-{% rgridblock a-unique-id %}
-{% rblock  Manuscript %}
-A preprint of the manuscript is available <a href="">here</a>.
+{% rblock Abstract %}
+The mechanisms underlying Parkinson's disease (PD) etiology are only partially understood despite intensive research conducted in the field. Recent evidence suggests that early neurodevelopmental defects might play a role in cellular susceptibility to neurodegeneration. To study the early developmental contribution of GBA mutations in PD we used patient-derived iPSCs carrying a heterozygous N370S mutation in the GBA gene. Patient-specific midbrain organoids displayed GBA-PD relevant phenotypes such as reduction of GCase activity, autophagy impairment and mitochondrial dysfunction. Genome-scale metabolic (GEM) modeling predicted changes in lipid metabolism which were validated with lipidomics analysis, showing significant differences in the lipidome of GBA-PD. In addition, patient-specific midbrain organoids exhibited an increase in the neural progenitor population showing signs of cellular senescence. This was accompanied by a decrease in the number and complexity of dopaminergic neurons. These results provide insights into how GBA mutations may lead to neurodevelopmental defects thereby predisposing to PD pathology.
 {% endrblock %}
 
-
 {% rblock Data %}
-The data is available <a href="">here</a>.
+The complete Dataset is available [here](https://webdav-r3lab.uni.lu/public/data/xfh3-a153/). It is subdivided into originals (raw data) and partials (analysis) specific to each figure and supplementary figure present in the manuscript. 
 {% endrblock %}
 
-
 {% rblock source code %}
-The source code is available <a href="">here</a>.
+The scripts used to analyse the data are available [here](https://gitlab.lcsb.uni.lu/dvb/rosety_2022). 
 {% endrblock %}
 
 {% endrgridblock %}
-- 
GitLab