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title: Midbrain organoids represent a physiologically relevant model that recapitulates PD-associated genetic signatures during early development
permalink: /frozen/rc4f-nk07
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{% rtitle Midbrain organoids represent a physiologically relevant model that recapitulates PD-associated genetic signatures during early development %}
Alise Zagare1,*, Kyriaki Barmpa1,*, Semra Smajic1, Lisa Smits1, Kamil Grzyb1, Anne Grünewald1, Alexander Skupin1, Sarah Louise Nickels1,° and Jens Christian Schwamborn1,2,°
1 Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
2 OrganoTherapeurtics
*,° These authors share authorship
° Corresponding author: Sarah L. Nickels, Jens Christian Schwamborn
permalink: [doi:10.17881/rc4f-nk07](https://doi.org/10.17881/rc4f-nk07)
{% endrtitle %}
{% rblock Abstract %}
Modeling neurodegenerative diseases, such as Parkinson’s, can be difficult, since human brain physiology and disease complexity are not reached in the majority of commonly used laboratory models. Here we question the potency of human-derived midbrain organoids in Parkinson’s disease research by following two different approaches; by investigating their similarity to the developing human midbrain and their ability to recapitulate the disease phenotype. We integrate the transcriptomes of midbrain organoids and human embryonic midbrain to show that organoids represent an accurate system for disease modeling. They reflect not only the human midbrain development but also depict the Parkinson’s disease associated genetic signature. Our work heightens the beneficial contributions of organoids as an appropriate model for studying diseases in vitro.
{% endrblock %}
{% rblock Raw Data %}
The complete Dataset is available [here](). It is subdivided into originals (raw data) and partials (analysis) specific to each figure and supplementary present in the manuscript.
{% endrblock %}
{% rblock Scripts %}
The source code used to make the analysis/figures of the publication is available [on Github](https://github.com/LCSB-DVB/Zagare_Barmpa_2021).
{% endrblock %}
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