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......@@ -12,6 +12,12 @@ This website is under version control on the [LCSB Gitlab](https://gitlab.lcsb.u
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<h3>2022</h3>
<ul>
<li><a href="{{ '/frozen/hr67-ba06' | relative_url }}">Age at onset as stratifier in idiopathic Parkinson's disease – effect of ageing and polygenic risk score on clinical phenotypes</a></li>
</ul>
<h3>2021</h3>
<ul>
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---
layout: default
date: 2022-04-14
order: -1
title: "Age at onset as stratifier in idiopathic Parkinson's disease effect of ageing and polygenic risk score on clinical phenotypes"
permalink: /frozen/hr67-ba06
published: true
---
{% rtitle {{ page.title }} %}
Lukas Pavelka, Armin Rauschenberger, Zied Landoulsi, Sinthuja PACHCHEK, Patrick May, Enrico Glaab, , Rejko Krueger on behalf of the NCER-PD Consortium
Several phenotypic differences observed in Parkinson’s disease (PD) patients
have been linked to age at onset (AAO). We endeavoured to find out whether
these differences are due to the ageing process itself by using a combined
dataset of idiopathic PD (n=430) and healthy controls (HC; n=556) excluding
carriers of known PD-linked genetic mutations in both groups. We found several
significant effects of AAO on motor and non-motor symptoms in PD, but when
comparing the effects of age on these symptoms with HC (using age at
assessment, AAA), only positive associations of AAA with burden of motor
symptoms and cognitive impairment were significantly different between PD vs
HC. Furthermore, we explored a potential effect of polygenic risk score (PRS)
on clinical phenotype and identified a significant inverse correlation of AAO
and PRS in PD. No significant association between PRS and severity of clinical
symptoms was found. We conclude that the observed non-motor phenotypic
differences in PD based son AAO are largely driven by the ageing process itself
and not by a specific profile of neurodegeneration linked to AAO in the
idiopathic PD patients.
{% endrtitle %}
{% rgridblock %}
{% rblock Data | fas fa-database %}
The datasets for this manuscript are not publicly available as they are linked to the Luxembourg Parkinson’s Study and its internal regulations. Requests to access the datasets should be directed to the Executive Committee of NCER-PD, mean of contact via email: <a href="mailto:request.ncer-pd@uni.lu">request.ncer-pd@uni.lu</a>.
{% endrblock %}
{% rblock source code %}
The source code is available <a href="https://gitlab.lcsb.uni.lu/TNG/papers/aao-prs-luxpark">here</a>.
{% endrblock %}
{% endrgridblock %}
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